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Simulations might also apply to PC12 cells....

Posted by Bossi on 16 Oct 2008 at 21:28 GMT

....where EGF and insulin receptor overexpression switches MAPK signalling from transient to sustained.

PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation.
Curr Biol. 1994 Aug 1;4(8):702-8.

EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor.
Curr Biol. 1994 Aug 1;4(8):694-701.