Iterative sure independence screening EM-Bayesian LASSO algorithm for multi-locus genome-wide association studies

Cox Lwaka Tamba; Yuan-Li Ni; Yuan-Ming Zhang

doi:10.1371/journal.pcbi.1005357

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Open Access

Peer-reviewed

Research Article

Iterative sure independence screening EM-Bayesian LASSO algorithm for multi-locus genome-wide association studies

Cox Lwaka Tamba,

Affiliations State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing, China, Department of Mathematics, Egerton University, Egerton, Kenya
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Yuan-Li Ni,

Affiliation State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing, China
⨯
Yuan-Ming Zhang

* E-mail: soyzhang@njau.edu.cn, soyzhang@mail.hzau.edu.cn

Affiliations State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing, China, Statistical Genomics Lab, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China
⨯

Iterative sure independence screening EM-Bayesian LASSO algorithm for multi-locus genome-wide association studies

Cox Lwaka Tamba,
Yuan-Li Ni,
Yuan-Ming Zhang

Published: January 31, 2017
https://doi.org/10.1371/journal.pcbi.1005357

About the Authors

Cox Lwaka Tamba

Affiliations State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing, China, Department of Mathematics, Egerton University, Egerton, Kenya

Yuan-Li Ni

Affiliation State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing, China

Yuan-Ming Zhang

* E-mail: soyzhang@njau.edu.cn, soyzhang@mail.hzau.edu.cn

Affiliations State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing, China, Statistical Genomics Lab, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: YMZ. Data curation: CLT. Formal analysis: CLT. Funding acquisition: YMZ. Investigation: CLT YMZ. Methodology: YMZ CLT. Project administration: YMZ. Resources: CLT. Software: YLN CLT. Supervision: YMZ. Validation: CLT. Visualization: YLN. Writing – original draft: CLT. Writing – review & editing: YMZ.

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Genome-wide association studies
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Single nucleotide polymorphisms
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Monte Carlo method
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Arabidopsis thaliana
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Phenotypes
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Simulation and modeling
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Research errors
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Algorithms
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