About the Authors

Chao Cheng

Affiliations Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America

Koon-Kiu Yan

Affiliations Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America

Woochang Hwang

Affiliation Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Jiang Qian

Affiliation Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Nitin Bhardwaj

Affiliations Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America

Joel Rozowsky

Affiliations Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America

Zhi John Lu

Affiliations Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America

Wei Niu

Affiliation Department of Genetics, Yale University, New Haven, Connecticut, United States of America

Pedro Alves

Affiliation Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America

Masaomi Kato

Affiliation Department of Molecular Cellular Developmental Biology, Yale University, New Haven, Connecticut, United States of America

Michael Snyder

Affiliation Department of Genetics, Stanford University, Stanford, California, United States of America

Mark Gerstein

mark.gerstein@yale.edu

Affiliations Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America, Department of Computer Science, Yale University, New Haven, Connecticut, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CC KY MG. Performed the experiments: WN MS MK. Analyzed the data: CC KY JQ WH ZJL PA JR NB. Contributed reagents/materials/analysis tools: WN MS MK. Wrote the paper: CC KY MG.