About the Authors

Peter Buske, Jörg Galle, Markus Loeffler
Interdisciplinary Centre for Bioinformatics, University Leipzig, Leipzig, Germany

Nick Barker, Hans Clevers
Hubrecht Institute, University Medical Center, Utrecht, The Netherlands

Gabriela Aust
Center of Surgery, Research Laboratories, University Leipzig, Leipzig, Germany

Markus Loeffler
Institute for Medical Informatics, Statistics and Epidemiology, University Leipzig, Leipzig, Germany

Corresponding Author

buske@izbi.uni-leipzig.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NB HC. Performed the experiments: NB GA. Analyzed the data: PB JG. Wrote the paper: JG ML. Performed all simulations: PB. Designed the model: JG. Provided essential ideas regarding the model design: HC ML.