About the Authors

John M. Higgins

Affiliations School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

David T. Eddington

Address Current address: Department of Bioengineering, University of Illinois Chicago, Chicago, Illinois, United States of America

Affiliation Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Sangeeta N. Bhatia

Affiliations Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

L. Mahadevan

lm@seas.harvard.edu

Affiliations School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JMH DTE SNB LM. Performed the experiments: JMH. Analyzed the data: JMH LM. Contributed reagents/materials/analysis tools: JMH DTE SNB LM. Wrote the paper: JMH LM.