About the Authors

Jacek Puchałka, Miguel Godinho, Agata Bielecka, Vítor A. P. Martins dos Santos
Synthetic and Systems Biology Group, Helmholtz Center for Infection Research (HZI), Braunschweig, Germany

Matthew A. Oberhardt, Jason A. Papin
Department of Biomedical Engineering, University of Virginia, Health System, Charlottesville, Virginia, United States of America

Daniela Regenhardt, Kenneth N. Timmis
Environmental Microbiology Group, Helmholtz Center for Infection Research (HZI), Braunschweig, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JP MAO KNT JAP VAPMdS. Analyzed the data: JP MAO. Wrote the paper: JP MAO JAP VAPMdS. Performed the computational experiments: JP. Developed the computational platform: MG. Characterized the mutants and carried out wet lab experiments: AB. Produced the mutants: DR. Contributed to data interpretation: KNT.