About the Authors

Xiaolin Cheng, J. Andrew McCammon
Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, United States of America

Xiaolin Cheng, Barry Grant, J. Andrew McCammon
NSF Center for Theoretical Biophysics, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America

Hailong Wang, Steven M Sine
Receptor Biology Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

J. Andrew McCammon
Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America

Corresponding Author

xcheng@mccammon.ucsd.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

XC, HW, SMS, and JAM conceived and designed the experiments. XC and HW performed the experiments. XC and HW analyzed the data. XC, BG, SMS, and JAM wrote the paper.