About the Authors

Kay Hamacher, Joanna Trylska, J. Andrew McCammon
Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America

Kay Hamacher, Joanna Trylska, J. Andrew McCammon
Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, United States of America

Joanna Trylska
Interdisciplinary Centre for Mathematical and Computational Modelling, Warsaw University, Warsaw, Poland

J. Andrew McCammon
Howard Hughes Medical Institute and Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America

Corresponding Author

hamacher_at_ctbp.ucsd .edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KH, JT, and JAM formulated the project. KH wrote the software, performed all the computations, and performed the sensitivity analysis. KH and JT analyzed the results. JT prepared the 30S subunit structure for computations and designed the computational validation experiments. KH, JT, and JAM wrote the paper.