About the Authors

James P Carson

To whom correspondence should be addressed. E-mail: james.carson@bcm.edu

Affiliations Program in Structural and Computational Biology and Molecular Biophysics, National Center for Macromolecular Imaging, Baylor College of Medicine, Houston, Texas, United States of America , Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America

Tao Ju

Affiliation Department of Computer Science, Rice University, Houston, Texas, United States of America

Hui-Chen Lu

Address ¤ Current address: The Cain Foundation Laboratories, Department of Pediatrics, Division of Neuroscience and Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America

Affiliation Division of Neuroscience and Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America

Christina Thaller

Affiliation Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America

Mei Xu

Affiliation Department of Biology, Georgia State University, Atlanta, Georgia, United States of America

Sarah L Pallas

Affiliation Department of Biology, Georgia State University, Atlanta, Georgia, United States of America

Michael C Crair

Affiliation Division of Neuroscience and Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America

Joe Warren

Affiliation Department of Computer Science, Rice University, Houston, Texas, United States of America

Wah Chiu

Affiliations Program in Structural and Computational Biology and Molecular Biophysics, National Center for Macromolecular Imaging, Baylor College of Medicine, Houston, Texas, United States of America , Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America

Gregor Eichele

Affiliation Max Planck Institute of Experimental Endocrinology, Hanover, Germany

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JPC, TJ, HCL, JW, WC, and GE conceived and designed the experiments. JPC, HCL, CT, and MX performed the experiments. JPC, HCL, and GE analyzed the data. JPC, TJ, HCL, CT, MX, SLP, MCC, JW, WC, and GE contributed reagents/materials/analysis tools. JPC, TJ, HCL, CT, MX, SLP, MCC, JW, WC, and GE wrote the paper.