Stochastic Ion Channel Gating in Dendritic Neurons: Morphology Dependence and Probabilistic Synaptic Activation of Dendritic Spikes

Robert C. Cannon; Cian O'Donnell; Matthew F. Nolan

doi:10.1371/journal.pcbi.1000886

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Open Access

Peer-reviewed

Research Article

Stochastic Ion Channel Gating in Dendritic Neurons: Morphology Dependence and Probabilistic Synaptic Activation of Dendritic Spikes

Robert C. Cannon ,

Contributed equally to this work with: Robert C. Cannon, Cian O'Donnell

Affiliation Textensor Limited, Edinburgh, United Kingdom
⨯
Cian O'Donnell ,

Contributed equally to this work with: Robert C. Cannon, Cian O'Donnell

Affiliation Neuroinformatics Doctoral Training Centre, University of Edinburgh, Edinburgh, United Kingdom
⨯
Matthew F. Nolan

* E-mail: mattnolan@ed.ac.uk

Affiliation Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom
⨯

Stochastic Ion Channel Gating in Dendritic Neurons: Morphology Dependence and Probabilistic Synaptic Activation of Dendritic Spikes

Robert C. Cannon,
Cian O'Donnell,
Matthew F. Nolan

Published: August 12, 2010
https://doi.org/10.1371/journal.pcbi.1000886

About the Authors

Robert C. Cannon

Contributed equally to this work with: Robert C. Cannon, Cian O'Donnell

Affiliation Textensor Limited, Edinburgh, United Kingdom

Cian O'Donnell

Contributed equally to this work with: Robert C. Cannon, Cian O'Donnell

Affiliation Neuroinformatics Doctoral Training Centre, University of Edinburgh, Edinburgh, United Kingdom

Matthew F. Nolan

* E-mail: mattnolan@ed.ac.uk

Affiliation Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RCC CO MFN. Performed the experiments: RCC CO MFN. Analyzed the data: RCC CO MFN. Contributed reagents/materials/analysis tools: RCC MFN. Wrote the paper: MFN. Designed and developed simulation tools: RCC.

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Neuronal dendrites
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Ion channel gating
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Ion channels
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Action potentials
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Membrane potential
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Neuronal morphology
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Neurons
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Single channel recording
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