Sampling Realistic Protein Conformations Using Local Structural Bias

Thomas Hamelryck; John T Kent; Anders Krogh

doi:10.1371/journal.pcbi.0020131

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Open Access

Peer-reviewed

Research Article

Sampling Realistic Protein Conformations Using Local Structural Bias

Thomas Hamelryck ,

*To whom correspondence should be addressed. E-mail: thamelry@binf.ku.dk

Affiliation Bioinformatics Center, Institute of Molecular Biology and Physiology, University of Copenhagen, Copenhagen, Denmark
⨯
John T Kent,

Affiliation The Department of Statistics, The University of Leeds, Leeds, West Yorkshire, United Kingdom
⨯
Anders Krogh

Affiliation Bioinformatics Center, Institute of Molecular Biology and Physiology, University of Copenhagen, Copenhagen, Denmark
⨯

Sampling Realistic Protein Conformations Using Local Structural Bias

Thomas Hamelryck,
John T Kent,
Anders Krogh

Published: September 22, 2006
https://doi.org/10.1371/journal.pcbi.0020131

About the Authors

Thomas Hamelryck

*To whom correspondence should be addressed. E-mail: thamelry@binf.ku.dk

Affiliation Bioinformatics Center, Institute of Molecular Biology and Physiology, University of Copenhagen, Copenhagen, Denmark

John T Kent

Affiliation The Department of Statistics, The University of Leeds, Leeds, West Yorkshire, United Kingdom

Anders Krogh

Affiliation Bioinformatics Center, Institute of Molecular Biology and Physiology, University of Copenhagen, Copenhagen, Denmark

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

TH conceived and implemented FB5–HMM and wrote the article. JTK devised the sampling method for the FB5 distribution. AK suggested using FwBt for sampling and provided advice during the course of the project.

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Protein structure
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Protein structure prediction
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Protein sequencing
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Probability distribution
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Crystal structure
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Hidden Markov models
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Protein structure determination
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Dihedral angles
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