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Current Issue March 2017

04/17/2017

research article

Probabilistic fluorescence-based synapse detection


Synapses are fundamental not only to synaptic network function but also to network development, adaptation, and memory. Despite their obvious importance, mammalian synapse populations have so far resisted detailed quantitative study. Simhal et al. describe new probabilistic image analysis methods suitable for single-synapse analysis of synapse populations in both animal and human brains, in health and disorder.

Image credit: Simhal et al.

Probabilistic fluorescence-based synapse detection

04/20/2017

research article

Oncodomains: A protein domain-centric framework for analyzing rare variants in tumor samples

Traditional methods for identifying somatic variants that drive cancer are ‘gene-centric’ in that they consider only somatic variants within a particular gene and make no comparison to other similar genes in the same family that may play a similar role in cancer. Peterson et al. present oncodomain hotspots, a new ‘domain-centric’ method for identifying clusters of somatic mutations across entire gene families using protein domain models.

Image credit: Peterson et al.

Oncodomains: A protein domain-centric framework for analyzing rare variants in tumor samples

04/18/2017

research article

Robust information propagation through noisy neural circuits

Much work in neuroscience has investigated the factors that affect the amount of information contained in peripheral sensory areas. Zylberberg et al. focus on a less investigated question - how much of that information makes it through subsequent processing stages?

Robust information propagation through noisy neural circuits

Image credit: dierk schaefer/ Flickr

04/19/2017

plos science wednesday

Reddit AMA


Shashwath and Godfrey discuss their PLOS ONE paper assessing the long-term impact of the use of alcohol and marijuana on college students' academic performance.

Reddit AMA

Image credit: PLOS

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