Advertisement
Table of Contents

October 2008

Cover

A colony of stem cells reprogrammed to a pluripotent state from adult brain cells.
Issue Image

2i-iPS cell colony. Inhibitors of the Mek/Erk and GSK3 pathways (2i) in the absence of serum promote the generation of induced pluripotent stem (iPS) cell colonies, shown here. These cells show expression of a pluripotency reporter (green) and reactivation of the silent X chromosome, as demonstrated by the lack of the nuclear red staining body (trimethyl H3K27). For comparison, a cluster of non-reprogrammed cells (non-green) displaying a silent X chromosome (red nuclear body) is shown in the bottom right-hand corner (see Silva et al., e253).

Image Credit: Illustration by Jose Silva and Ornella Barrandon

Editorial

PLoS Biology at 5: The Future Is Open Access

Theodora Bloom, Christine Ferguson, Liza Gross, Catriona J MacCallum, Jami Milton, Robert Shields, Stephanie Wai, Janelle Weaver, Liz Williams

PLOS Biology: published October 28, 2008 | https://doi.org/10.1371/journal.pbio.0060267

Synopses

Rethinking Dams: Pacific Salmon Recovery May Rest on Other Factors

Liza Gross

PLOS Biology: published October 28, 2008 | https://doi.org/10.1371/journal.pbio.0060279

Related Articles

  1. Survival of Migrating Salmon Smolts in Large Rivers With and Without Dams

Brain Growth Receptors Control Lifespan

Richard Robinson

PLOS Biology: published October 28, 2008 | https://doi.org/10.1371/journal.pbio.0060274

Related Articles

  1. Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism

A New View of Embryogenesis—Connective Fibers Join the Dance

William Mair

PLOS Biology: published October 14, 2008 | https://doi.org/10.1371/journal.pbio.0060268

Related Articles

  1. The ECM Moves during Primitive Streak Formation—Computation of ECM Versus Cellular Motion

A Shortcut to Immortality: Rapid Reprogramming with Tissue Cells

Liza Gross

PLOS Biology: published October 21, 2008 | https://doi.org/10.1371/journal.pbio.0060275

Related Articles

  1. Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition

Feature

Arctic Sentinels

Hannah Hoag

PLOS Biology: published October 21, 2008 | https://doi.org/10.1371/journal.pbio.0060259

Perspective

Is Bayh-Dole Good for Developing Countries? Lessons from the US Experience

Anthony D So, Bhaven N Sampat, Arti K Rai, Robert Cook-Deegan, Jerome H Reichman, Robert Weissman, Amy Kapczynski

PLOS Biology: published October 28, 2008 | https://doi.org/10.1371/journal.pbio.0060262

Primers

Using Both Sides of Your Brain: The Case for Rapid Interhemispheric Switching

Marc F Schmidt

PLOS Biology: published October 28, 2008 | https://doi.org/10.1371/journal.pbio.0060269

Related Articles

  1. Rapid Interhemispheric Switching during Vocal Production in a Songbird

Stem Cells Have Different Needs for REST

Ola Hermanson

PLOS Biology: published October 28, 2008 | https://doi.org/10.1371/journal.pbio.0060271

Related Articles

  1. REST Regulates Distinct Transcriptional Networks in Embryonic and Neural Stem Cells

Seeking Membranes: Positive-Strand RNA Virus Replication Complexes

Mark R Denison

PLOS Biology: published October 28, 2008 | https://doi.org/10.1371/journal.pbio.0060270

Related Articles

  1. SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum

Research Articles

Survival of Migrating Salmon Smolts in Large Rivers With and Without Dams

David W Welch, Erin L Rechisky, Michael C Melnychuk, Aswea D Porter, Carl J Walters, Shaun Clements, Benjamin J Clemens, R. Scott McKinley, Carl Schreck

PLOS Biology: published October 28, 2008 | https://doi.org/10.1371/journal.pbio.0060265

Related Articles

  1. Correction: Survival of Migrating Salmon Smolts in Large Rivers With and Without Dams
  2. Rethinking Dams: Pacific Salmon Recovery May Rest on Other Factors

High Rate of Recent Transposable Element–Induced Adaptation in Drosophila melanogaster

Josefa González, Kapa Lenkov, Mikhail Lipatov, J. Michael Macpherson, Dmitri A Petrov

PLOS Biology: published October 21, 2008 | https://doi.org/10.1371/journal.pbio.0060251

Evolutionary Plasticity of Polycomb/Trithorax Response Elements in Drosophila Species

Arne Hauenschild, Leonie Ringrose, Christina Altmutter, Renato Paro, Marc Rehmsmeier

PLOS Biology: published October 28, 2008 | https://doi.org/10.1371/journal.pbio.0060261

Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism

Laurent Kappeler, Carlos De Magalhaes Filho, Joëlle Dupont, Patricia Leneuve, Pascale Cervera, Laurence Périn, Catherine Loudes, Annick Blaise, Rüdiger Klein, Jacques Epelbaum, Yves Le Bouc, Martin Holzenberger

PLOS Biology: published October 28, 2008 | https://doi.org/10.1371/journal.pbio.0060254

Related Articles

  1. Brain Growth Receptors Control Lifespan

Rapid Interhemispheric Switching during Vocal Production in a Songbird

Claude Z. H Wang, Joshua A Herbst, Georg B Keller, Richard H. R Hahnloser

PLOS Biology: published October 14, 2008 | https://doi.org/10.1371/journal.pbio.0060250

Related Articles

  1. Using Both Sides of Your Brain: The Case for Rapid Interhemispheric Switching

The ECM Moves during Primitive Streak Formation—Computation of ECM Versus Cellular Motion

Evan A Zamir, Brenda J Rongish, Charles D Little

PLOS Biology: published October 14, 2008 | https://doi.org/10.1371/journal.pbio.0060247

Related Articles

  1. A New View of Embryogenesis—Connective Fibers Join the Dance

Structural Homeostasis: Compensatory Adjustments of Dendritic Arbor Geometry in Response to Variations of Synaptic Input

Marco Tripodi, Jan Felix Evers, Alex Mauss, Michael Bate, Matthias Landgraf

PLOS Biology: published October 28, 2008 | https://doi.org/10.1371/journal.pbio.0060260

The Timing of Differentiation of Adult Hippocampal Neurons Is Crucial for Spatial Memory

Stefano Farioli-Vecchioli, Daniele Saraulli, Marco Costanzi, Simone Pacioni, Irene Cinà, Massimiliano Aceti, Laura Micheli, Alberto Bacci, Vincenzo Cestari, Felice Tirone

PLOS Biology: published October 7, 2008 | https://doi.org/10.1371/journal.pbio.0060246

REST Regulates Distinct Transcriptional Networks in Embryonic and Neural Stem Cells

Rory Johnson, Christina Hui-leng Teh, Galih Kunarso, Kee Yew Wong, Gopalan Srinivasan, Megan L Cooper, Manuela Volta, Sarah Su-ling Chan, Leonard Lipovich, Steven M Pollard, R. Krishna Murthy Karuturi, Chia-lin Wei, Noel J Buckley, Lawrence W Stanton

PLOS Biology: published October 28, 2008 | https://doi.org/10.1371/journal.pbio.0060256

Related Articles

  1. Stem Cells Have Different Needs for REST

Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation

Ichiro Hiratani, Tyrone Ryba, Mari Itoh, Tomoki Yokochi, Michaela Schwaiger, Chia-Wei Chang, Yung Lyou, Tim M Townes, Dirk Schübeler, David M Gilbert

PLOS Biology: published October 7, 2008 | https://doi.org/10.1371/journal.pbio.0060245

Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition

Jose Silva, Ornella Barrandon, Jennifer Nichols, Jitsutaro Kawaguchi, Thorold W Theunissen, Austin Smith

PLOS Biology: published October 21, 2008 | https://doi.org/10.1371/journal.pbio.0060253

Related Articles

  1. A Shortcut to Immortality: Rapid Reprogramming with Tissue Cells

An Autonomous Circadian Clock in the Inner Mouse Retina Regulated by Dopamine and GABA

Guo-Xiang Ruan, Gregg C Allen, Shin Yamazaki, Douglas G McMahon

PLOS Biology: published October 14, 2008 | https://doi.org/10.1371/journal.pbio.0060249

Profound Context-Dependent Plasticity of Mitral Cell Responses in Olfactory Bulb

Wilder Doucette, Diego Restrepo

PLOS Biology: published October 28, 2008 | https://doi.org/10.1371/journal.pbio.0060258

The Desensitization Gating of the MthK K+ Channel Is Governed by Its Cytoplasmic Amino Terminus

Mario Meng-Chiang Kuo, Innokentiy Maslennikov, Brent Molden, Senyon Choe

PLOS Biology: published October 28, 2008 | https://doi.org/10.1371/journal.pbio.0060223

Diverse RNA-Binding Proteins Interact with Functionally Related Sets of RNAs, Suggesting an Extensive Regulatory System

Daniel J Hogan, Daniel P Riordan, André P Gerber, Daniel Herschlag, Patrick O Brown

PLOS Biology: published October 28, 2008 | https://doi.org/10.1371/journal.pbio.0060255

Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements

Matthew L Hemming, Joshua E Elias, Steven P Gygi, Dennis J Selkoe

PLOS Biology: published October 21, 2008 | https://doi.org/10.1371/journal.pbio.0060257

The Nucleosome-Remodeling ATPase ISWI Is Regulated by Poly-ADP-Ribosylation

Anna Sala, Gaspare La Rocca, Giosalba Burgio, Elena Kotova, Dario Di Gesù, Marianna Collesano, Antonia M. R Ingrassia, Alexei V Tulin, Davide F. V Corona

PLOS Biology: published October 14, 2008 | https://doi.org/10.1371/journal.pbio.0060252