Skip to main content
Advertisement
Table of Contents

October 2004

Recent discoveries show that prion phenomena in both humans and yeast are determined by amyloid-like conformations of misfolded proteins, and similar conformations are associated with noninfectious diseases such as Alzheimer's. Shown are AFM images of new amyloid growth from the ends of epitope-labeled seeds encapsulated in diagrams of yeast cells. (See Collins, et al.)

Image Credit: Image by Angela DePace

Message from PLoS

Open Access As Public Policy

Andy Gass

Essay

Diversifying Selection in Plant Breeding

Susan McCouch

Unsolved Mystery

Why Are So Many Bird Flowers Red?

Miguel A Rodríguez-Gironés, Luis Santamaría

Journal Club

Hearing: Travelling Wave or Resonance?

Andrew Bell

Community Page

Research Articles

Loss of Skeletal Muscle HIF-1α Results in Altered Exercise Endurance

Steven D Mason, Richard A Howlett, Matthew J Kim, I. Mark Olfert, Michael C Hogan, Wayne McNulty, Reed P Hickey, Peter D Wagner, C. Ronald Kahn, Frank J Giordano, Randall S Johnson

Related Articles

Genetic Analysis of Pathways Regulated by the von Hippel-Lindau Tumor Suppressor in Caenorhabditis elegans

Tammie Bishop, Kah Weng Lau, Andrew C. R Epstein, Stuart K Kim, Min Jiang, Delia O'Rourke, Christopher W Pugh, Jonathan M Gleadle, Martin S Taylor, Jonathan Hodgkin, Peter J Ratcliffe

Related Articles

Sterol-Derived Hormone(s) Controls Entry into Diapause in Caenorhabditis elegans by Consecutive Activation of DAF-12 and DAF-16

Vitali Matyash, Eugeni V Entchev, Fanny Mende, Michaela Wilsch-Bräuninger, Christoph Thiele, Arndt W Schmidt, Hans-Joachim Knölker, Samuel Ward, Teymuras V Kurzchalia

Related Articles

Mechanism of Association and Reciprocal Activation of Two GTPases

Shu-ou Shan, Robert M Stroud, Peter Walter

Related Articles

Mechanism of Prion Propagation: Amyloid Growth Occurs by Monomer Addition

Sean R Collins, Adam Douglass, Ronald D Vale, Jonathan S Weissman

Related Articles

Population History and Natural Selection Shape Patterns of Genetic Variation in 132 Genes

Joshua M Akey, Michael A Eberle, Mark J Rieder, Christopher S Carlson, Mark D Shriver, Deborah A Nickerson, Leonid Kruglyak

Related Articles

Genetic Response to Climatic Change: Insights from Ancient DNA and Phylochronology

Elizabeth A Hadly, Uma Ramakrishnan, Yvonne L Chan, Marcel van Tuinen, Kim O'Keefe, Paula A Spaeth, Chris J Conroy

Related Articles

Genomic Insights into Methanotrophy: The Complete Genome Sequence of Methylococcus capsulatus (Bath)

Naomi Ward, Øivind Larsen, James Sakwa, Live Bruseth, Hoda Khouri, A. Scott Durkin, George Dimitrov, Lingxia Jiang, David Scanlan, Katherine H Kang, Matt Lewis, Karen E Nelson, Barbara Methé, Martin Wu, John F Heidelberg, Ian T Paulsen, Derrick Fouts, Jacques Ravel, Hervé Tettelin, Qinghu Ren, Tim Read, Robert T DeBoy, Rekha Seshadri, Steven L Salzberg, Harald B Jensen, Nils Kåre Birkeland, William C Nelson, Robert J Dodson, Svenn H Grindhaug, Ingeborg Holt, Ingvar Eidhammer, Inge Jonasen, Susan Vanaken, Terry Utterback, Tamara V Feldblyum, Claire M Fraser, Johan R Lillehaug, Jonathan A Eisen

Related Articles

Molecular Signatures of Proliferation and Quiescence in Hematopoietic Stem Cells

Teresa A Venezia, Akil A Merchant, Carlos A Ramos, Nathan L Whitehouse, Andrew S Young, Chad A Shaw, Margaret A Goodell

Related Articles

A Neuroeconomics Approach to Inferring Utility Functions in Sensorimotor Control

Konrad P Körding, Izumi Fukunaga, Ian S Howard, James N Ingram, Daniel M Wolpert

Related Articles

Identification of Birds through DNA Barcodes

Paul D. N Hebert, Mark Y Stoeckle, Tyler S Zemlak, Charles M Francis

Related Articles

The Program of Gene Transcription for a Single Differentiating Cell Type during Sporulation in Bacillus subtilis

Patrick Eichenberger, Masaya Fujita, Shane T Jensen, Erin M Conlon, David Z Rudner, Stephanie T Wang, Caitlin Ferguson, Koki Haga, Tsutomu Sato, Jun S Liu, Richard Losick

Related Articles

Correspondence and Other Communications

Book Review%2FScience in the Media

Language Evolution

Szabolcs Számadó, Eörs Szathmáry