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Table of Contents

November 2015

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Parasitic Worm Illuminates the Memory IgE Response
Issue Image

A study by Adriana Turqueti-Neves, David Voehringer and colleagues reveals that repertoires of IgE—the class of antibody that mediates allergic reactions—closely resemble those of IgG1, suggesting that the memory IgE response unfolds from IgG1-switched B cells (and not from IgM-expressing B cells) in response to T cell-derived cytokines. The image shows free-living larval stages of the gastroingestinal helminth Nippostrongylus brasiliensis which was used to study the IgE response in mice. The original picture was taken with a 5x objective under a light microscope and colored using Adobe Photoshop software.

Image Credit: David Voehringer

Synopses

A New Role Discovered for a Well-Known Clock Protein

Richard Robinson

PLOS Biology: published November 12, 2015 | https://doi.org/10.1371/journal.pbio.1002294

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Toxoplasma’s Taste for Exotic Fat

Roland G. Roberts

PLOS Biology: published November 13, 2015 | https://doi.org/10.1371/journal.pbio.1002289

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How Bats Land Upside Down

Robin Meadows

PLOS Biology: published November 16, 2015 | https://doi.org/10.1371/journal.pbio.1002298

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Perspective

Public Data Archiving in Ecology and Evolution: How Well Are We Doing?

Dominique G. Roche, Loeske E. B. Kruuk, Robert Lanfear, Sandra A. Binning

PLOS Biology: published November 10, 2015 | https://doi.org/10.1371/journal.pbio.1002295

Primers

Understanding How Exercise Promotes Cognitive Integrity in the Aging Brain

Benjamin M. Laitman, Gareth R. John

PLOS Biology: published November 11, 2015 | https://doi.org/10.1371/journal.pbio.1002300

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Tandem Domains with Tuned Interactions Are a Powerful Biological Design Principle

Ruth Nussinov, Chung-Jung Tsai

PLOS Biology: published November 30, 2015 | https://doi.org/10.1371/journal.pbio.1002306

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Community Page

Computing Workflows for Biologists: A Roadmap

Ashley Shade, Tracy K. Teal

PLOS Biology: published November 24, 2015 | https://doi.org/10.1371/journal.pbio.1002303

Research Articles

The Extracellular Domains of IgG1 and T Cell-Derived IL-4/IL-13 Are Critical for the Polyclonal Memory IgE Response In Vivo

Adriana Turqueti-Neves, Manuel Otte, Christian Schwartz, Michaela Erika Renate Schmitt, Cornelia Lindner, Oliver Pabst, Philipp Yu, David Voehringer

PLOS Biology: published November 2, 2015 | https://doi.org/10.1371/journal.pbio.1002290

Evolution of Robustness to Protein Mistranslation by Accelerated Protein Turnover

Dorottya Kalapis, Ana R. Bezerra, Zoltán Farkas, Peter Horvath, Zoltán Bódi, Andreea Daraba, Béla Szamecz, Ivo Gut, Mónica Bayes, Manuel A. S. Santos, Csaba Pál

PLOS Biology: published November 6, 2015 | https://doi.org/10.1371/journal.pbio.1002291

Mechanical Coupling between Endoderm Invagination and Axis Extension in Drosophila

Claire M. Lye, Guy B. Blanchard, Huw W. Naylor, Leila Muresan, Jan Huisken, Richard J. Adams, Bénédicte Sanson

PLOS Biology: published November 6, 2015 | https://doi.org/10.1371/journal.pbio.1002292

CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock

Teruya Tamaru, Mitsuru Hattori, Kousuke Honda, Yasukazu Nakahata, Paolo Sassone-Corsi, Gijsbertus T. J. van der Horst, Takeaki Ozawa, Ken Takamatsu

PLOS Biology: published November 12, 2015 | https://doi.org/10.1371/journal.pbio.1002293

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Phosphatidylthreonine and Lipid-Mediated Control of Parasite Virulence

Ruben D. Arroyo-Olarte, Jos F. Brouwers, Arunakar Kuchipudi, J. Bernd Helms, Aindrila Biswas, Ildiko R. Dunay, Richard Lucius, Nishith Gupta

PLOS Biology: published November 13, 2015 | https://doi.org/10.1371/journal.pbio.1002288

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Falling with Style: Bats Perform Complex Aerial Rotations by Adjusting Wing Inertia

Attila J. Bergou, Sharon M. Swartz, Hamid Vejdani, Daniel K. Riskin, Lauren Reimnitz, Gabriel Taubin, Kenneth S. Breuer

PLOS Biology: published November 16, 2015 | https://doi.org/10.1371/journal.pbio.1002297

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Quantifying the Determinants of Evolutionary Dynamics Leading to Drug Resistance

Guillaume Chevereau, Marta Dravecká, Tugce Batur, Aysegul Guvenek, Dilay Hazal Ayhan, Erdal Toprak, Tobias Bollenbach

PLOS Biology: published November 18, 2015 | https://doi.org/10.1371/journal.pbio.1002299

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Evolutionary Conservation and Diversification of Puf RNA Binding Proteins and Their mRNA Targets

Gregory J. Hogan, Patrick O. Brown, Daniel Herschlag

PLOS Biology: published November 20, 2015 | https://doi.org/10.1371/journal.pbio.1002307

Neonatal Restriction of Tactile Inputs Leads to Long-Lasting Impairments of Cross-Modal Processing

Kay Sieben, Malte Bieler, Brigitte Röder, Ileana L. Hanganu-Opatz

PLOS Biology: published November 24, 2015 | https://doi.org/10.1371/journal.pbio.1002304

Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα

Madoka Akimoto, Eric Tyler McNicholl, Avinash Ramkissoon, Kody Moleschi, Susan S. Taylor, Giuseppe Melacini

PLOS Biology: published November 30, 2015 | https://doi.org/10.1371/journal.pbio.1002305

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