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October 2009

Each colony has thousands of female workers, one queen, and a few hundred males (drones). This strong sex bias relies on an unusual sex determination system. Gempe et al. (e1000222) show key functions for the regulation of two genes: csd, which establishes the decision between males and females by allelic combination, and fem, which memorizes the sexual decision by a positive regulatory feedback loop that operates throughout development.

Image Credit: Björn Schmitt, Heinrich-Heine-Universität Düsseldorf

Editorial

Genomics of Emerging Infectious Disease: A PLoS Collection

Jonathan A. Eisen, Catriona J. MacCallum

Perspectives

Can an Infectious Disease Genomics Project Predict and Prevent the Next Pandemic?

Rajesh Gupta, Mark H. Michalski, Frank R. Rijsberman

The Role of Genomics in the Identification, Prediction, and Prevention of Biological Threats

W. Florian Fricke, David A. Rasko, Jacques Ravel

Research Articles

Sex Determination in Honeybees: Two Separate Mechanisms Induce and Maintain the Female Pathway

Tanja Gempe, Martin Hasselmann, Morten Schiøtt, Gerd Hause, Marianne Otte, Martin Beye

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