Caspases promote apoptotic cell death by cleaving cellular proteins. Multiple caspase cascades are shown to be required for the non-apoptotic process of sperm development. The cover shows images of Drosophila testes labeled with several different antibodies. Coincidentally, when these are viewed as letters they spell "PLoS". (See Huh, et al.)
Image Credit: Cover image provided by Jun R. Huh, California Institute of Technology. Additional photo manipulation by John Heisch, John Heisch Design
Editorial
PLoS Biology in Action
PLOS Biology: published January 20, 2004 | https://doi.org/10.1371/journal.pbio.0020025
Essay
Science on the Rise in Developing Countries
PLOS Biology: published January 20, 2004 | https://doi.org/10.1371/journal.pbio.0020001
Features
In Methuselah's Mould
PLOS Biology: published January 20, 2004 | https://doi.org/10.1371/journal.pbio.0020012
RNAi Therapeutics: How Likely, How Soon?
PLOS Biology: published January 20, 2004 | https://doi.org/10.1371/journal.pbio.0020028
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Journal Club
Channelling Evolution
PLOS Biology: published January 20, 2004 | https://doi.org/10.1371/journal.pbio.0020019
Primer
The Proteasome and the Delicate Balance between Destruction and Rescue
PLOS Biology: published January 20, 2004 | https://doi.org/10.1371/journal.pbio.0020013
Community Page
Science and Technology Communication for Development
PLOS Biology: published January 20, 2004 | https://doi.org/10.1371/journal.pbio.0020011
Research Articles
Multiple Apoptotic Caspase Cascades Are Required in Nonapoptotic Roles for Drosophila Spermatid Individualization
PLOS Biology: published December 15, 2003 | https://doi.org/10.1371/journal.pbio.0020015
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Dorsoventral Patterning of the Mouse Coat by Tbx15
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Contribution of Noncentrosomal Microtubules to Spindle Assembly in Drosophila Spermatocytes
PLOS Biology: published January 20, 2004 | https://doi.org/10.1371/journal.pbio.0020008
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Protein Interaction Networks by Proteome Peptide Scanning
PLOS Biology: published January 20, 2004 | https://doi.org/10.1371/journal.pbio.0020014
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PLOS Biology: published November 24, 2003 | https://doi.org/10.1371/journal.pbio.0020002
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Looking from the Past to the Future
PLOS Biology: published January 20, 2004 | https://doi.org/10.1371/journal.pbio.0020010