Table of Contents: September 2016

Transformed mutant cells (pro-tumor cells) can evolve through a multistep process in which they become tumorigenic and invasive. Many genes that are involved in the different steps towards cancer development have been identified; however, how certain mutant cells destroy normal tissue organization and undergo uncontrolled proliferation during the initial stages of this process remains largely unclear. A genetic study by Tamori et al. in the wing imaginal discs of the fruit fly Drosophila reveals a mechanism of tumorigenesis by which pro-tumor cells initiate dysplastic tumor growth at specific "hotspot" locations in epithelial tissues. The image shows a transmission electron micrograph showing the basal side of epithelial cells in the hotspot of wild-type wing discs. Cells have been pseudo-colored to distinguish them from each other, and circular cross-sections of filopodial protrusions are colored bright red.

Image Credit: pbio.1002537


Citation Metrics: A Primer on How (Not) to Normalize

John P. A. Ioannidis, Kevin Boyack, Paul F. Wouters

Research Articles

Differential Activation Patterns in the Same Brain Region Led to Opposite Emotional States

Kazuhisa Shibata, Takeo Watanabe, Mitsuo Kawato, Yuka Sasaki

Decoding Spontaneous Emotional States in the Human Brain

Philip A. Kragel, Annchen R. Knodt, Ahmad R. Hariri, Kevin S. LaBar

Related Articles

  1. Seven Glimpses into the Emotional Brain

Action Enhances Acoustic Cues for 3-D Target Localization by Echolocating Bats

Melville J. Wohlgemuth, Ninad B. Kothari, Cynthia F. Moss

Disruption of an Evolutionarily Novel Synaptic Expression Pattern in Autism

Xiling Liu, Dingding Han, Mehmet Somel, Xi Jiang, Haiyang Hu, Patricia Guijarro, Ning Zhang, Amanda Mitchell, Tobias Halene, John J. Ely, Chet C. Sherwood, Patrick R. Hof, Zilong Qiu, Svante Pääbo, Schahram Akbarian, Philipp Khaitovich

Related Articles

  1. In Search of Autism’s Roots

Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release

Varun K. Gupta, Ulrike Pech, Anuradha Bhukel, Andreas Fulterer, Anatoli Ender, Stephan F. Mauermann, Till F. M. Andlauer, Emmanuel Antwi-Adjei, Christine Beuschel, Kerstin Thriene, Marta Maglione, Christine Quentin, René Bushow, Martin Schwärzel, Thorsten Mielke, Frank Madeo, Joern Dengjel, André Fiala, Stephan J. Sigrist

Dscam1 Forms a Complex with Robo1 and the N-Terminal Fragment of Slit to Promote the Growth of Longitudinal Axons

Maryam Alavi, Minmin Song, Gracie L. Andrews King, Taylor Gillis, Robert Propst, Matthew Lamanuzzi, Adam Bousum, Amanda Miller, Ryan Allen, Thomas Kidd

Sequence-Specific Targeting of Bacterial Resistance Genes Increases Antibiotic Efficacy

Dilay Hazal Ayhan, Yusuf Talha Tamer, Mohammed Akbar, Stacey M. Bailey, Michael Wong, Seth M. Daly, David E. Greenberg, Erdal Toprak

Related Articles

  1. Understanding and overcoming antibiotic resistance

Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects

Rosaysela Santos, Shimako Kawauchi, Russell E. Jacobs, Martha E. Lopez-Burks, Hojae Choi, Jamie Wikenheiser, Benedikt Hallgrimsson, Heather A. Jamniczky, Scott E. Fraser, Arthur D. Lander, Anne L. Calof

Related Articles

  1. The Hole and the Whole: Lessons from Manipulation of Nipbl Deficiency

Sexual Fate Change of XX Germ Cells Caused by the Deletion of SMAD4 and STRA8 Independent of Somatic Sex Reprogramming

Quan Wu, Kurumi Fukuda, Yuzuru Kato, Zhi Zhou, Chu-Xia Deng, Yumiko Saga

Mitogen-Activated Protein Kinase Cascade MKK7-MPK6 Plays Important Roles in Plant Development and Regulates Shoot Branching by Phosphorylating PIN1 in Arabidopsis

Weiyan Jia, Baohua Li, Shujia Li, Yan Liang, Xiaowei Wu, Mei Ma, Jiyao Wang, Jin Gao, Yueyue Cai, Yuanya Zhang, Yingchun Wang, Jiayang Li, Yonghong Wang

EDA-Fibronectin Originating from Osteoblasts Inhibits the Immune Response against Cancer

Stephanie Rossnagl, Eva Altrock, Carla Sens, Sabrina Kraft, Katrin Rau, Michael D. Milsom, Thomas Giese, Yvonne Samstag, Inaam A. Nakchbandi

Mitochondrial 16S rRNA Is Methylated by tRNA Methyltransferase TRMT61B in All Vertebrates

Dan Bar-Yaacov, Idan Frumkin, Yuka Yashiro, Takeshi Chujo, Yuma Ishigami, Yonatan Chemla, Amit Blumberg, Orr Schlesinger, Philipp Bieri, Basil Greber, Nenad Ban, Raz Zarivach, Lital Alfonta, Yitzhak Pilpel, Tsutomu Suzuki, Dan Mishmar

Related Articles

  1. Correction: Mitochondrial 16S rRNA Is Methylated by tRNA Methyltransferase TRMT61B in All Vertebrates

Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation

Xin Sun, Kai Fu, Andrea Hodgson, Eric M. Wier, Matthew G. Wen, Olena Kamenyeva, Xue Xia, Lily Y. Koo, Fengyi Wan

Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3

Yihong Guan, Delai Huang, Feng Chen, Ce Gao, Ting Tao, Hui Shi, Shuyi Zhao, Zuyuan Liao, Li Jan Lo, Yingchun Wang, Jun Chen, Jinrong Peng

Research Matters

Chasing Ecological Interactions

Pedro Jordano