A new study explains how nonregenerating inner ear hair cells maintain lifelong mechanosensitivity. The image illustrates tiny extracellular tip links that "pull" mechanotransduction channels in the hair cells. These links are continually stressed by loud sounds and regenerated throughout an organism's life. The study revealed an unexpected mechanism of two-step remodeling of the tip link molecular components during tip link regeneration. See Indzhykulian et al. in this issue.
Image Credit: Gregory Frolenkov
Synopses
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