Table of Contents: December 2012

This immunofluorescence image shows humans fibroblasts infected with a mutant of the intracellular parasite Toxoplasma gondii. This mutant fails to express the striated fiber protein TgSFA3, and as a consequence does not initiate daughter cell formation during mitosis. Note that in this mutant, parasite cells contain two nuclei. Nuclei are shown in blue, and the outline of the parasites is shown in green with a red apical cap (pellicle components IMC1 and ISP1, respectively). See Francia et al. (e1001444) in this issue.

Image Credit: Maria Francia & Boris Striepen, University of Georgia.

Community Pages

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

Hina Kalra, Richard J. Simpson, Hong Ji, Elena Aikawa, Peter Altevogt, Philip Askenase, Vincent C. Bond, Francesc E. Borràs, Xandra Breakefield, Vivian Budnik, Edit Buzas, Giovanni Camussi, Aled Clayton, Emanuele Cocucci, Juan M. Falcon-Perez, Susanne Gabrielsson, Yong Song Gho, Dwijendra Gupta, H. C. Harsha, An Hendrix, Andrew F. Hill, Jameel M. Inal, Guido Jenster, Eva-Maria Krämer-Albers, Sai Kiang Lim, Alicia Llorente, Jan Lötvall, Antonio Marcilla, Lucia Mincheva-Nilsson, Irina Nazarenko, Rienk Nieuwland, Esther N. M. Nolte-'t Hoen, Akhilesh Pandey, Tushar Patel, Melissa G. Piper, Stefano Pluchino, T. S. Keshava Prasad, Lawrence Rajendran, Graca Raposo, Michel Record, Gavin E. Reid, Francisco Sánchez-Madrid, Raymond M. Schiffelers, Pia Siljander, Allan Stensballe, Willem Stoorvogel, Douglas Taylor, Clotilde Thery, Hadi Valadi, Bas W. M. van Balkom, Jesús Vázquez, Michel Vidal, Marca H. M. Wauben, María Yáñez-Mó, Margot Zoeller, Suresh Mathivanan

The Human Brain Online: An Open Resource for Advancing Brain Research

Sara Ball, Terri L. Gilbert, Caroline C. Overly

Research Articles

Reconstruction of Ancestral Metabolic Enzymes Reveals Molecular Mechanisms Underlying Evolutionary Innovation through Gene Duplication

Karin Voordeckers, Chris A. Brown, Kevin Vanneste, Elisa van der Zande, Arnout Voet, Steven Maere, Kevin J. Verstrepen

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Growth Cone MKK7 mRNA Targeting Regulates MAP1b-Dependent Microtubule Bundling to Control Neurite Elongation

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The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein

Xin Xiong, Yan Hao, Kan Sun, Jiaxing Li, Xia Li, Bibhudatta Mishra, Pushpanjali Soppina, Chunlai Wu, Richard I. Hume, Catherine A. Collins

Cell Division in Apicomplexan Parasites Is Organized by a Homolog of the Striated Rootlet Fiber of Algal Flagella

Maria E. Francia, Carly N. Jordan, Jay D. Patel, Lilach Sheiner, Jessica L. Demerly, Justin D. Fellows, Jessica Cruz de Leon, Naomi S. Morrissette, Jean-François Dubremetz, Boris Striepen

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Crag Is a GEF for Rab11 Required for Rhodopsin Trafficking and Maintenance of Adult Photoreceptor Cells

Bo Xiong, Vafa Bayat, Manish Jaiswal, Ke Zhang, Hector Sandoval, Wu-Lin Charng, Tongchao Li, Gabriela David, Lita Duraine, Yong-Qi Lin, G. Gregory Neely, Shinya Yamamoto, Hugo J. Bellen

The Mechanism of Toxicity in HET-S/HET-s Prion Incompatibility

Carolin Seuring, Jason Greenwald, Christian Wasmer, Roger Wepf, Sven J. Saupe, Beat H. Meier, Roland Riek

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Order–Disorder Transitions Govern Kinetic Cooperativity and Allostery of Monomeric Human Glucokinase

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