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Table of Contents: August 2012

The formation of blood vessel networks in the midbrain is captured during development with in vivo long-term serial confocal imaging of intact transgenic zebrafish Tg(kdrl:eGFP), in which vascular endothelial cells express green fluorescent protein. The fate of each vessel segment and endothelial cell is traced in the 3-dimensional vasculature. Besides angiogenic sprouting (filopodium-like process), developing brain vasculature also undergoes extensive blood flow-driven vessel pruning (collapse-like segment), which simplifies the vessel network. This picture represents a projected image of the midbrain vasculature in a larval zebrafish. See Chen et al. (e1001374) in this issue.

Image Credit: Jiulin Du

Perspectives

Inclusion of Residual Tissue in Biobanks: Opt-In or Opt-Out?

Noor A. A. Giesbertz, Annelien L. Bredenoord, Johannes J. M. van Delden

Obituaries

Emil Wolfgang Menzel, Jr. (1929–2012): Chimpanzee Renaissance Man

William D. Hopkins, David A. Washburn

Community Pages

The Human Microbiome Project: A Community Resource for the Healthy Human Microbiome

Dirk Gevers, Rob Knight, Joseph F. Petrosino, Katherine Huang, Amy L. McGuire, Bruce W. Birren, Karen E. Nelson, Owen White, Barbara A. Methé, Curtis Huttenhower

Research Articles

Haemodynamics-Driven Developmental Pruning of Brain Vasculature in Zebrafish

Qi Chen, Luan Jiang, Chun Li, Dan Hu, Ji-wen Bu, David Cai, Jiu-lin Du

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