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Table of Contents: December 2010

In this issue of PLoS Biology, Williamson et al., e1000553, propose that a neuron-specific protein degradation pathway is required for the spatiotemporal regulation of guidance receptors during development of the Drosophila visual system. The picture shows a preparation of the eye of the fruit fly, Drosophila melanogaster. The eye is imaged from the inside and fluorescently labeled for the light sensitive rhabdomeres using Phalloidin. A confocal maximum projection visualization was false-colored to distinguish rhabdomere cross-sections (center, blue) from tangential sections (orange). The Drosophila eye forms a stereotyped pattern during development and extends axons into the brain using specialized guidance cues.

Image Credit: Ryan Williamson and Robin Hiesinger, UT Southwestern Medical Center, United States of America

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