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Table of Contents: November 2010

The regulation of cell shape and size is important for a wide variety of biological processes. A study conducted at University College London (see Picone et al., e1000542) reveals that microtubules (shown in green) impose unexpected limits on cell geometry, which enable cells to regulate their length. Since cells are the building blocks and architects of tissue morphogenesis, such intrinsically defined limits may be important for development and homeostasis in multicellular eukaryotes.

Image Credit: Remigio Picone, Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London

Essays

Functional Brain Imaging in the Clinical Assessment of Consciousness

Michael S. Rafii, James B. Brewer

Book Reviews/Science in the Media

The Alarming Proximity of Parasites

Frédéric Thomas

Research Articles

Ancient DNA from European Early Neolithic Farmers Reveals Their Near Eastern Affinities

Wolfgang Haak, Oleg Balanovsky, Juan J. Sanchez, Sergey Koshel, Valery Zaporozhchenko, Christina J. Adler, Clio S. I. Der Sarkissian, Guido Brandt, Carolin Schwarz, Nicole Nicklisch, Veit Dresely, Barbara Fritsch, Elena Balanovska, Richard Villems, Harald Meller, Kurt W. Alt, Alan Cooper, the Genographic Consortium

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Tokameh Mahmoudi, Sylvia F. Boj, Pantelis Hatzis, Vivian S. W. Li, Nadia Taouatas, Robert G. J. Vries, Hans Teunissen, Harry Begthel, Jeroen Korving, Shabaz Mohammed, Albert J. R. Heck, Hans Clevers

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Quantitative Control of Organ Shape by Combinatorial Gene Activity

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Genetic Control of Organ Shape and Tissue Polarity

Amelia A. Green, J. Richard Kennaway, Andrew I. Hanna, J. Andrew Bangham, Enrico Coen

A Polarised Population of Dynamic Microtubules Mediates Homeostatic Length Control in Animal Cells

Remigio Picone, Xiaoyun Ren, Kenzo D. Ivanovitch, Jon D. W. Clarke, Rachel A. McKendry, Buzz Baum

Control of Directed Cell Migration In Vivo by Membrane-to-Cortex Attachment

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Phenotypic Consequences of Copy Number Variation: Insights from Smith-Magenis and Potocki-Lupski Syndrome Mouse Models

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Co-Evolution of Transcriptional Silencing Proteins and the DNA Elements Specifying Their Assembly

Oliver A. Zill, Devin Scannell, Leonid Teytelman, Jasper Rine

The DNA Methylome of Human Peripheral Blood Mononuclear Cells

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Control of Transcription by Cell Size

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Regulation of Na+/K+ ATPase Transport Velocity by RNA Editing

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