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Table of Contents: September 2009

This 3-D snapshot of a simulation of actin-based bead motility shows a bead having just broken symmetry and about to move off on its "comet tail." The network is deposited symmetrically on the bead surface, as in an in vitro system. The simulation shows that the viscoelastic properties of the network are sufficient to explain the symmetry-breaking and motility phenomena seen in vitro.  The network is shown colored by strain (blue = low, red = high). (See Dayel et al., e1000201.)

Image Credit: Mark J. Dayel, University of California Berkeley

Perspectives

Book Reviews/Science in the Media

Research Articles

A Disease-Mediated Trophic Cascade in the Serengeti and its Implications for Ecosystem C

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Marcos Nahmad, Angelike Stathopoulos

Loss of Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) Reveals a Requirement for MAPK Signalling in Mouse Sex Determination

Debora Bogani, Pam Siggers, Rachel Brixey, Nick Warr, Sarah Beddow, Jessica Edwards, Debbie Williams, Dagmar Wilhelm, Peter Koopman, Richard A. Flavell, Hongbo Chi, Harry Ostrer, Sara Wells, Michael Cheeseman, Andy Greenfield

Dual Regulation by Pairs of Cyclin-Dependent Protein Kinases and Histone Deacetylases Controls G1 Transcription in Budding Yeast

Dongqing Huang, Supipi Kaluarachchi, Dewald van Dyk, Helena Friesen, Richelle Sopko, Wei Ye, Nazareth Bastajian, Jason Moffat, Holly Sassi, Michael Costanzo, Brenda J. Andrews

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The Mechanochemistry of Endocytosis

Jian Liu, Yidi Sun, David G. Drubin, George F. Oster

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Regulated RalBP1 Binding to RalA and PSD-95 Controls AMPA Receptor Endocytosis and LTD

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Negative Regulation of Active Zone Assembly by a Newly Identified SR Protein Kinase

Ervin L. Johnson III, Richard D. Fetter, Graeme W. Davis

Biphasic Synaptic Ca Influx Arising from Compartmentalized Electrical Signals in Dendritic Spines

Brenda L. Bloodgood, Andrew J. Giessel, Bernardo L. Sabatini

In Silico Reconstitution of Actin-Based Symmetry Breaking and Motility

Mark J. Dayel, Orkun Akin, Mark Landeryou, Viviana Risca, Alex Mogilner, R. Dyche Mullins

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Exploration of Uncharted Regions of the Protein Universe

Lukasz Jaroszewski, Zhanwen Li, S. Sri Krishna, Constantina Bakolitsa, John Wooley, Ashley M. Deacon, Ian A. Wilson, Adam Godzik

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