Table of Contents: July 2009

Biopsies of human ciliated airway epithelial cell cultures derived from a cystic fibrosis (CF) patient, after CFTR gene delivery, using a novel viral vector that targets human ciliated cells after lumenal delivery. CFTR protein expression (red) was found at the lumenal surface of ciliated epithelial cells where it restored the ability of CF airway cultures to regulate fluid and mucus transport. Ciliated cells transduced by the virus vector are identified with virus-specific antibodies (green). Cell nuclei are in blue. The restoration of CFTR function to CF ciliated epithelial cells fully corrected hallmark features of CF-related pathophysiology in vitro (see Zhang et al., e1000155).

Image Credit: Liqun Zhang, University of North Carolina at Chapel Hill.

Research Articles

Time-Warp–Invariant Neuronal Processing

Robert Gütig, Haim Sompolinsky

Influence of Dopaminergically Mediated Reward on Somatosensory Decision-Making

Burkhard Pleger, Christian C. Ruff, Felix Blankenburg, Stefan Klöppel, Jon Driver, Raymond J. Dolan

Natural Killer Cell Signal Integration Balances Synapse Symmetry and Migration

Fiona J. Culley, Matthew Johnson, J. Henry Evans, Sunil Kumar, Rupert Crilly, Juan Casasbuenas, Tim Schnyder, Maryam Mehrabi, Mahendra P. Deonarain, Dmitry S. Ushakov, Veronique Braud, Günter Roth, Roland Brock, Karsten Köhler, Daniel M. Davis

CFTR Delivery to 25% of Surface Epithelial Cells Restores Normal Rates of Mucus Transport to Human Cystic Fibrosis Airway Epithelium

Liqun Zhang, Brian Button, Sherif E. Gabriel, Susan Burkett, Yu Yan, Mario H. Skiadopoulos, Yan Li Dang, Leatrice N. Vogel, Tristan McKay, April Mengos, Richard C. Boucher, Peter L. Collins, Raymond J. Pickles

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