Table of Contents: September 2008

Reticulovesicular network of modified endoplamic reticulum (ER) associated with severe acute respiratory syndrome (SARS)-coronavirus replication. Electron tomography was used to generate a three-dimensional reconstruction of the reticulovesicular network of modified ER induced in Vero E6 cells upon infection with SARS-coronavirus. SARS-coronavirus replication and transcription are associated with this membrane network, which is composed of a large number of conspicuous double membrane vesicles (outer membrane, gold; inner membrane, silver) of which the outer membranes are continuous with convoluted membranes (bronze) and ER cisternae. The surface-rendered model shown here is superimposed on a 1.2-nm-thick tomographic slice. (See Knoops et al., e226)

Image Credit: Illustration by Kèvin Knoops


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