Advertisement

Table of Contents: April 2008

The photograph shows a magnified view of a microfluidic chip in which billions of RNA enzymes were made to undergo hundreds of generations of Darwinian evolution, all under computer control. The active circuit, filled with blue dye, is 1 cm in diameter and contains five microvalves that are operated pneumatically (see Paegel and Joyce, e85).

Image Credit: Photograph by Brian Paegel, The Scripps Research Institute

Editorials

Unsolved Mysteries

Book Reviews/Science in the Media

Bioethics Grows Up

Arthur Caplan

Community Pages

Rethinking Outreach: Teaching the Process of Science through Modeling

Tim Herman, Shannon Colton, Margaret Franzen

Research Articles

Climate Change, Humans, and the Extinction of the Woolly Mammoth

David Nogués-Bravo, Jesús Rodríguez, Joaquín Hortal, Persaram Batra, Miguel B Araújo

Related Articles

  1. What Killed the Woolly Mammoth?

Compilation and Network Analyses of Cambrian Food Webs

Jennifer A Dunne, Richard J Williams, Neo D Martinez, Rachel A Wood, Douglas H Erwin

Chromosomal Gene Movements Reflect the Recent Origin and Biology of Therian Sex Chromosomes

Lukasz Potrzebowski, Nicolas Vinckenbosch, Ana Claudia Marques, Frédéric Chalmel, Bernard Jégou, Henrik Kaessmann

Rapid Encoding and Perception of Novel Odors in the Rat

Daniel W Wesson, Ryan M Carey, Justus V Verhagen, Matt Wachowiak

Related Articles

  1. How Quickly Can a Rat Perceive Novel Odors?

Modelling within-Host Spatiotemporal Dynamics of Invasive Bacterial Disease

Andrew J Grant, Olivier Restif, Trevelyan J McKinley, Mark Sheppard, Duncan J Maskell, Pietro Mastroeni

Control of Apoptosis by Asymmetric Cell Division

Julia Hatzold, Barbara Conradt

A Microtubule Interactome: Complexes with Roles in Cell Cycle and Mitosis

Julian R Hughes, Ana M Meireles, Katherine H Fisher, Angel Garcia, Philip R Antrobus, Alan Wainman, Nicole Zitzmann, Charlotte Deane, Hiroyuki Ohkura, James G Wakefield

Polycomb Repressive Complex 2 (PRC2) Restricts Hematopoietic Stem Cell Activity

Ian J Majewski, Marnie E Blewitt, Carolyn A de Graaf, Edward J McManus, Melanie Bahlo, Adrienne A Hilton, Craig D Hyland, Gordon K Smyth, Jason E Corbin, Donald Metcalf, Warren S Alexander, Douglas J Hilton

Related Articles

  1. Polycomb Group Genes: Keeping Stem Cell Activity in Balance

Gene–Environment Interaction in Yeast Gene Expression

Erin N Smith, Leonid Kruglyak

Iroquois Complex Genes Induce Co-Expression of rhodopsins in Drosophila

Esteban O Mazzoni, Arzu Celik, Mathias F Wernet, Daniel Vasiliauskas, Robert J Johnston, Tiffany A Cook, Franck Pichaud, Claude Desplan

Related Articles

  1. One Rhodopsin per Photoreceptor: Iro-C Genes Break the Rule

Reconstitution of DNA Strand Exchange Mediated by Rhp51 Recombinase and Two Mediators

Yumiko Kurokawa, Yasuto Murayama, Nami Haruta-Takahashi, Itaru Urabe, Hiroshi Iwasaki

Host PrP Glycosylation: A Major Factor Determining the Outcome of Prion Infection

Nadia L Tuzi, Enrico Cancellotti, Herbert Baybutt, Lorraine Blackford, Barry Bradford, Chris Plinston, Anne Coghill, Patricia Hart, Pedro Piccardo, Rona M Barron, Jean C Manson

High-Throughput SHAPE Analysis Reveals Structures in HIV-1 Genomic RNA Strongly Conserved across Distinct Biological States

Kevin A Wilkinson, Robert J Gorelick, Suzy M Vasa, Nicolas Guex, Alan Rein, David H Mathews, Morgan C Giddings, Kevin M Weeks

Darwinian Evolution on a Chip

Brian M Paegel, Gerald F Joyce

Related Articles

  1. Man versus Machine versus Ribozyme

Cooperative Retraction of Bundled Type IV Pili Enables Nanonewton Force Generation

Nicolas Biais, Benoît Ladoux, Dustin Higashi, Magdalene So, Michael Sheetz