Table of Contents: April 2007

An embryo of the cnidarian Clytia hemisphaerica fixed during gastrulation, showing cell boundaries (red), nuclei (blue), and cilia (green). Two distinct Frizzled family receptors produced from RNAs with opposite localizations in the egg provide the spatial cues to specify the gastrulation site and the polarized orientation of the cilia (see Momose and Houliston, e70).

Image Credit: Confocal image by Tsuyoshi Momose


Does Medicine without Evolution Make Sense?

Catriona J MacCallum


Law, Responsibility, and the Brain

Dean Mobbs, Hakwan C Lau, Owen D Jones, Christopher D Frith

Research Articles

H2A.Z-Mediated Localization of Genes at the Nuclear Periphery Confers Epigenetic Memory of Previous Transcriptional State

Donna Garvey Brickner, Ivelisse Cajigas, Yvonne Fondufe-Mittendorf, Sara Ahmed, Pei-Chih Lee, Jonathan Widom, Jason H Brickner

An Aromatic Sensor with Aversion to Damaged Strands Confers Versatility to DNA Repair

Olivier Maillard, Szilvia Solyom, Hanspeter Naegeli

Enhancement of SMN2 Exon 7 Inclusion by Antisense Oligonucleotides Targeting the Exon

Yimin Hua, Timothy A Vickers, Brenda F Baker, C. Frank Bennett, Adrian R Krainer

Transcript Specificity in Yeast Pre-mRNA Splicing Revealed by Mutations in Core Spliceosomal Components

Jeffrey A Pleiss, Gregg B Whitworth, Megan Bergkessel, Christine Guthrie

Superfamily Assignments for the Yeast Proteome through Integration of Structure Prediction with the Gene Ontology

Lars Malmström, Michael Riffle, Charlie E. M Strauss, Dylan Chivian, Trisha N Davis, Richard Bonneau, David Baker

Protein Oxidation Implicated as the Primary Determinant of Bacterial Radioresistance

Michael J Daly, Elena K Gaidamakova, Vera Y Matrosova, Alexander Vasilenko, Min Zhai, Richard D Leapman, Barry Lai, Bruce Ravel, Shu-Mei W Li, Kenneth M Kemner, James K Fredrickson

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  1. Paradox Resolved? The Strange Case of the Radiation-Resistant Bacteria

Intramolecular and Intermolecular Interactions of Protein Kinase B Define Its Activation In Vivo

Véronique Calleja, Damien Alcor, Michel Laguerre, Jongsun Park, Borivoj Vojnovic, Brian A Hemmings, Julian Downward, Peter J Parker, Banafshé Larijani

DNA-Dependent Protein Kinase Inhibits AID-Induced Antibody Gene Conversion

Adam J. L Cook, Joanna M Raftery, K. K. Edwin Lau, Andrew Jessup, Reuben S Harris, Shunichi Takeda, Christopher J Jolly

Modification of a Hydrophobic Layer by a Point Mutation in Syntaxin 1A Regulates the Rate of Synaptic Vesicle Fusion

Robert D Lagow, Hong Bao, Evan N Cohen, Richard W Daniels, Aleksej Zuzek, Wade H Williams, Gregory T Macleod, R. Bryan Sutton, Bing Zhang

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  1. Correction: Modification of a Hydrophobic Layer by a Point Mutation in Syntaxin 1A Regulates the Rate of Synaptic Vesicle Fusion

Fly Photoreceptors Demonstrate Energy-Information Trade-Offs in Neural Coding

Jeremy E Niven, John C Anderson, Simon B Laughlin

Elucidating the Ticking of an In Vitro Circadian Clockwork

Tetsuya Mori, Dewight R Williams, Mark O Byrne, Ximing Qin, Martin Egli, Hassane S Mchaourab, Phoebe L Stewart, Carl Hirschie Johnson

Glucocorticoids Play a Key Role in Circadian Cell Cycle Rhythms

Thomas Dickmeis, Kajori Lahiri, Gabriela Nica, Daniela Vallone, Cristina Santoriello, Carl J Neumann, Matthias Hammerschmidt, Nicholas S Foulkes

Cdk5 Is Involved in BDNF-Stimulated Dendritic Growth in Hippocampal Neurons

Zelda H Cheung, Wing Hong Chin, Yu Chen, Yu Pong Ng, Nancy Y Ip

Independently Evolving Species in Asexual Bdelloid Rotifers

Diego Fontaneto, Elisabeth A Herniou, Chiara Boschetti, Manuela Caprioli, Giulio Melone, Claudia Ricci, Timothy G Barraclough

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Survey Sequencing and Comparative Analysis of the Elephant Shark (Callorhinchus milii) Genome

Byrappa Venkatesh, Ewen F Kirkness, Yong-Hwee Loh, Aaron L Halpern, Alison P Lee, Justin Johnson, Nidhi Dandona, Lakshmi D Viswanathan, Alice Tay, J. Craig Venter, Robert L Strausberg, Sydney Brenner

Forest Elephant Crisis in the Congo Basin

Stephen Blake, Samantha Strindberg, Patrick Boudjan, Calixte Makombo, Inogwabini Bila-Isia, Omari Ilambu, Falk Grossmann, Lambert Bene-Bene, Bruno de Semboli, Valentin Mbenzo, Dino S'hwa, Rosine Bayogo, Liz Williamson, Mike Fay, John Hart, Fiona Maisels

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  1. In the Shadows of the Congo Basin Forest, Elephants Fall to the Illegal Ivory Trade


An Incentive Solution to the Peer Review Problem

Marc Hauser, Ernst Fehr

Book Review%2FScience in the Media

Big Pharma (The Play)

Lisa Bero