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Table of Contents: November 2006

A dynamic tuning process restricts the responsiveness of autoreactive T cells, but its relative inefficiency in abrogating effector functionality results in arthritis and autoantibody production (bottom panels). Singh et al. examine the separable contributions of intrinsic and extrinsic regulatory processes to the control of peripheral autoimmunity.

Image Credit: Nevil Singh

Editorials

ONE for All: The Next Step for PLoS

Catriona J MacCallum

Essays

Bushes in the Tree of Life

Antonis Rokas, Sean B Carroll

Community Pages

BioGeomancer: Automated Georeferencing to Map the World's Biodiversity Data

Robert P Guralnick, John Wieczorek, Reed Beaman, Robert J Hijmans, the BioGeomancer Working Group

Research Articles

Two-Step Recruitment of RNA-Directed DNA Methylation to Tandem Repeats

Simon W.-L Chan, Xiaoyu Zhang, Yana V Bernatavichute, Steven E Jacobsen

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  1. siRNAs and DNA Methylation Do a Two-Step to Silence Tandem Sequences

Target DNA Structure Plays a Critical Role in RAG Transposition

Jennifer E Posey, Malgorzata J Pytlos, Richard R Sinden, David B Roth

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  1. Can DNA Distortion Turn RAG into a Potent Transposase?

A Role for PCNA Ubiquitination in Immunoglobulin Hypermutation

Hiroshi Arakawa, George-Lucian Moldovan, Huseyin Saribasak, Nesibe Nur Saribasak, Stefan Jentsch, Jean-Marie Buerstedde

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  1. Borrowing a DNA Repair Enzyme to Fine-Tune Antibody Specificity

Human Immunodeficiency Virus Impairs Reverse Cholesterol Transport from Macrophages

Zahedi Mujawar, Honor Rose, Matthew P Morrow, Tatiana Pushkarsky, Larisa Dubrovsky, Nigora Mukhamedova, Ying Fu, Anthony Dart, Jan M Orenstein, Yuri V Bobryshev, Michael Bukrinsky, Dmitri Sviridov

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  1. HIV–Cholesterol Connection Suggests a New Antiretroviral Strategy
  2. Does HIV Cause Cardiovascular Disease?

Assembly Factor Omp85 Recognizes Its Outer Membrane Protein Substrates by a Species-Specific C-Terminal Motif

Viviane Robert, Elena B Volokhina, Freya Senf, Martine P Bos, Patrick Van Gelder, Jan Tommassen

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  1. Picking the Right Parts at the Beta Barrel Factory

The Liganding of Glycolipid Transfer Protein Is Controlled by Glycolipid Acyl Structure

Lucy Malinina, Margarita L Malakhova, Alex T Kanack, Min Lu, Ruben Abagyan, Rhoderick E Brown, Dinshaw J Patel

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  1. Too Long, Too Short, or Just Right: Glycosphingolipid–Protein Binding Varies with Acyl Chain Length

Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins

D. Thomas Rutkowski, Stacey M Arnold, Corey N Miller, Jun Wu, Jack Li, Kathryn M Gunnison, Kazutoshi Mori, Amir A. Sadighi Akha, David Raden, Randal J Kaufman

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  1. Apoptosis Versus Survival: When in Doubt, Choose Both

Ablation of PGC-1β Results in Defective Mitochondrial Activity, Thermogenesis, Hepatic Function, and Cardiac Performance

Christopher J Lelliott, Gema Medina-Gomez, Natasa Petrovic, Adrienn Kis, Helena M Feldmann, Mikael Bjursell, Nadeene Parker, Keira Curtis, Mark Campbell, Ping Hu, Dongfang Zhang, Sheldon E Litwin, Vlad G Zaha, Kimberly T Fountain, Sihem Boudina, Mercedes Jimenez-Linan, Margaret Blount, Miguel Lopez, Aline Meirhaeghe, Mohammad Bohlooly-Y, Leonard Storlien, Maria Strömstedt, Michael Snaith, Matej Orešič, E. Dale Abel, Barbara Cannon, Antonio Vidal-Puig

Related Articles

  1. PGC-1β: A Regulator of Mitochondrial Function with Subtle Roles in Energy Metabolism

Plasticity of Astrocytic Coverage and Glutamate Transporter Expression in Adult Mouse Cortex

Christel Genoud, Charles Quairiaux, Pascal Steiner, Harald Hirling, Egbert Welker, Graham W Knott

Related Articles

  1. “Supporting” Players Take the Lead in Protecting the Overstimulated Brain

Rapid Redistribution of Synaptic PSD-95 in the Neocortex In Vivo

Noah W Gray, Robby M Weimer, Ingrid Bureau, Karel Svoboda

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  1. Kinetics of Synaptic Protein Turnover Regulate Synaptic Size

Intracellular Demography and the Dynamics of Salmonella enterica Infections

Sam P Brown, Stephen J Cornell, Mark Sheppard, Andrew J Grant, Duncan J Maskell, Bryan T Grenfell, Pietro Mastroeni

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  1. Charting the Spread of Salmonella Infection

The Marine Viromes of Four Oceanic Regions

Florent E Angly, Ben Felts, Mya Breitbart, Peter Salamon, Robert A Edwards, Craig Carlson, Amy M Chan, Matthew Haynes, Scott Kelley, Hong Liu, Joseph M Mahaffy, Jennifer E Mueller, Jim Nulton, Robert Olson, Rachel Parsons, Steve Rayhawk, Curtis A Suttle, Forest Rohwer

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  1. Metagenomics Offers a Big-Picture View of the Diversity and Distribution of Marine Viruses

Conservation Planning for Ecosystem Services

Kai M. A Chan, M. Rebecca Shaw, David R Cameron, Emma C Underwood, Gretchen C Daily

Related Articles

  1. Assessing Ecosystem Services to Identify Conservation Priorities

Corrections

Correction: Preserving Genome Integrity: The DdrA Protein of Deinococcus radiodurans R1

Dennis R Harris, Masashi Tanaka, Sergei V Saveliev, Edmond Jolivet, Ashlee M Earl, Michael M Cox, John R Battista

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  1. Preserving Genome Integrity: The DdrA Protein of Deinococcus radiodurans R1