Table of Contents: November 2006

A dynamic tuning process restricts the responsiveness of autoreactive T cells, but its relative inefficiency in abrogating effector functionality results in arthritis and autoantibody production (bottom panels). Singh et al. examine the separable contributions of intrinsic and extrinsic regulatory processes to the control of peripheral autoimmunity.

Image Credit: Nevil Singh


ONE for All: The Next Step for PLoS

Catriona J MacCallum


Bushes in the Tree of Life

Antonis Rokas, Sean B Carroll

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BioGeomancer: Automated Georeferencing to Map the World's Biodiversity Data

Robert P Guralnick, John Wieczorek, Reed Beaman, Robert J Hijmans, the BioGeomancer Working Group

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Two-Step Recruitment of RNA-Directed DNA Methylation to Tandem Repeats

Simon W.-L Chan, Xiaoyu Zhang, Yana V Bernatavichute, Steven E Jacobsen

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A Role for PCNA Ubiquitination in Immunoglobulin Hypermutation

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Human Immunodeficiency Virus Impairs Reverse Cholesterol Transport from Macrophages

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Assembly Factor Omp85 Recognizes Its Outer Membrane Protein Substrates by a Species-Specific C-Terminal Motif

Viviane Robert, Elena B Volokhina, Freya Senf, Martine P Bos, Patrick Van Gelder, Jan Tommassen

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The Liganding of Glycolipid Transfer Protein Is Controlled by Glycolipid Acyl Structure

Lucy Malinina, Margarita L Malakhova, Alex T Kanack, Min Lu, Ruben Abagyan, Rhoderick E Brown, Dinshaw J Patel

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Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins

D. Thomas Rutkowski, Stacey M Arnold, Corey N Miller, Jun Wu, Jack Li, Kathryn M Gunnison, Kazutoshi Mori, Amir A. Sadighi Akha, David Raden, Randal J Kaufman

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Ablation of PGC-1β Results in Defective Mitochondrial Activity, Thermogenesis, Hepatic Function, and Cardiac Performance

Christopher J Lelliott, Gema Medina-Gomez, Natasa Petrovic, Adrienn Kis, Helena M Feldmann, Mikael Bjursell, Nadeene Parker, Keira Curtis, Mark Campbell, Ping Hu, Dongfang Zhang, Sheldon E Litwin, Vlad G Zaha, Kimberly T Fountain, Sihem Boudina, Mercedes Jimenez-Linan, Margaret Blount, Miguel Lopez, Aline Meirhaeghe, Mohammad Bohlooly-Y, Leonard Storlien, Maria Strömstedt, Michael Snaith, Matej Orešič, E. Dale Abel, Barbara Cannon, Antonio Vidal-Puig

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Plasticity of Astrocytic Coverage and Glutamate Transporter Expression in Adult Mouse Cortex

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Rapid Redistribution of Synaptic PSD-95 in the Neocortex In Vivo

Noah W Gray, Robby M Weimer, Ingrid Bureau, Karel Svoboda

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Intracellular Demography and the Dynamics of Salmonella enterica Infections

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The Marine Viromes of Four Oceanic Regions

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Conservation Planning for Ecosystem Services

Kai M. A Chan, M. Rebecca Shaw, David R Cameron, Emma C Underwood, Gretchen C Daily

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Correction: Preserving Genome Integrity: The DdrA Protein of Deinococcus radiodurans R1

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