June 2006

The image was produced by confocal laser scanning microscopy of XY mouse embryonic gonads at 12.5 days post-coitum. Sertoli cells, stained by indirect fluorescence for SOX9 (purple), enclose gonocytes marked by PECAM (green) in testis cords. Testicular vasculature outside cords is visualized by endothelial cell staining for PECAM (See Capel et al.).

Image Credit: Photograph by Yuna Kim

Editorial

Instituting Change

Hemai Parthasarathy

PLOS Biology: published June 13, 2006 | https://doi.org/10.1371/journal.pbio.0040224

Feature

Restoring Nature's Backbone

Henry Nicholls

PLOS Biology: published June 13, 2006 | https://doi.org/10.1371/journal.pbio.0040202

Primer

DNA Repair: Dynamic Defenders against Cancer and Aging

Jill O Fuss, Priscilla K Cooper

PLOS Biology: published June 13, 2006 | https://doi.org/10.1371/journal.pbio.0040203

Community Page

Leveraging the Knowledge of Our Peers: Online Communities Hold the Promise to Enhance Scientific Research

Thomas J Sharpton, Arpan A Jhaveri

PLOS Biology: published June 13, 2006 | https://doi.org/10.1371/journal.pbio.0040199

Research Articles

X Chromosomes Alternate between Two States prior to Random X-Inactivation

Susanna Mlynarczyk-Evans, Morgan Royce-Tolland, Mary Kate Alexander, Angela A Andersen, Sundeep Kalantry, Joost Gribnau, Barbara Panning

PLOS Biology: published May 9, 2006 | https://doi.org/10.1371/journal.pbio.0040159

Chromosomal Distribution of PcG Proteins during Drosophila Development

Nicolas Nègre, Jérôme Hennetin, Ling V Sun, Sergey Lavrov, Michel Bellis, Kevin P White, Giacomo Cavalli

PLOS Biology: published April 20, 2006 | https://doi.org/10.1371/journal.pbio.0040170

High Guanine and Cytosine Content Increases mRNA Levels in Mammalian Cells

Grzegorz Kudla, Leszek Lipinski, Fanny Caffin, Aleksandra Helwak, Maciej Zylicz

PLOS Biology: published May 23, 2006 | https://doi.org/10.1371/journal.pbio.0040180

Linking Splicing to Pol II Transcription Stabilizes Pre-mRNAs and Influences Splicing Patterns

Martin J Hicks, Chin-Rang Yang, Matthew V Kotlajich, Klemens J Hertel

PLOS Biology: published May 2, 2006 | https://doi.org/10.1371/journal.pbio.0040147

Dynamic Interaction of TTDA with TFIIH Is Stabilized by Nucleotide Excision Repair in Living Cells

Giuseppina Giglia-Mari, Catherine Miquel, Arjan F Theil, Pierre-Olivier Mari, Deborah Hoogstraten, Jessica M. Y Ng, Christoffel Dinant, Jan H. J Hoeijmakers, Wim Vermeulen

PLOS Biology: published May 9, 2006 | https://doi.org/10.1371/journal.pbio.0040156