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Table of Contents: May 2005

Clockwise to center: A library of small molecules (yellow) was screened using a cellmicroscopy-based assay to identify one with interesting biological activity. The protein it bound (and inhibited) was affinity purified, and its structure is shown in yellow. Solving the crystal structure of the small molecule/protein complex (bottom) informed the design of better inhibitors (gray).

Image Credit: Cover design by Daniel Rauh; molecular images created with PyMOL software; central fluorescence micrograph courtesy of Nico Stuurman. See Tanaka et al.

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Asifa Akhtar, Giacomo Cavalli

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An Unbiased Cell Morphology–Based Screen for New, Biologically Active Small Molecules

Masahiro Tanaka, Raynard Bateman, Daniel Rauh, Eugeni Vaisberg, Shyam Ramachandani, Chao Zhang, Kirk C Hansen, Alma L Burlingame, Jay K Trautman, Kevan M Shokat, Cynthia L Adams

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