Table of Contents: May 2005

Clockwise to center: A library of small molecules (yellow) was screened using a cellmicroscopy-based assay to identify one with interesting biological activity. The protein it bound (and inhibited) was affinity purified, and its structure is shown in yellow. Solving the crystal structure of the small molecule/protein complex (bottom) informed the design of better inhibitors (gray).

Image Credit: Cover design by Daniel Rauh; molecular images created with PyMOL software; central fluorescence micrograph courtesy of Nico Stuurman. See Tanaka et al.


Community Page

The Epigenome Network of Excellence

Asifa Akhtar, Giacomo Cavalli

Research Articles

An Unbiased Cell Morphology–Based Screen for New, Biologically Active Small Molecules

Masahiro Tanaka, Raynard Bateman, Daniel Rauh, Eugeni Vaisberg, Shyam Ramachandani, Chao Zhang, Kirk C Hansen, Alma L Burlingame, Jay K Trautman, Kevan M Shokat, Cynthia L Adams

Related Articles

  1. Automated Imaging Screen Reveals Promising Drug Candidates

Structure of the Mg-Chelatase Cofactor GUN4 Reveals a Novel Hand-Shaped Fold for Porphyrin Binding

Mark A Verdecia, Robert M Larkin, Jean-Luc Ferrer, Roland Riek, Joanne Chory, Joseph P Noel

Related Articles

  1. The Hand That Protects: Structural Insights into a Porphyrin-Binding Protein

Evolutionary Origins of Genomic Repertoires in Bacteria

Emmanuelle Lerat, Vincent Daubin, Howard Ochman, Nancy A Moran

Related Articles

  1. Where Do All Those Genes Come From?

Systematic Association of Genes to Phenotypes by Genome and Literature Mining

Jan O Korbel, Tobias Doerks, Lars J Jensen, Carolina Perez-Iratxeta, Szymon Kaczanowski, Sean D Hooper, Miguel A Andrade, Peer Bork

Related Articles

  1. A Novel Data-Mining Approach Systematically Links Genes to Traits

Three-Dimensional Maps of All Chromosomes in Human Male Fibroblast Nuclei and Prometaphase Rosettes

Andreas Bolzer, Gregor Kreth, Irina Solovei, Daniela Koehler, Kaan Saracoglu, Christine Fauth, Stefan Müller, Roland Eils, Christoph Cremer, Michael R Speicher, Thomas Cremer

Related Articles

  1. The Nuclear Landscape: A 3D Map of Human Chromosomes

A Combinatorial Code for Splicing Silencing: UAGG and GGGG Motifs

Kyoungha Han, Gene Yeo, Ping An, Christopher B Burge, Paula J Grabowski

Related Articles

  1. Exon Silencing Regulated by a Trio of Short RNA Motifs

Subversion of Cellular Autophagosomal Machinery by RNA Viruses

William T Jackson, Thomas H Giddings Jr, Matthew P Taylor, Sara Mulinyawe, Marlene Rabinovitch, Ron R Kopito, Karla Kirkegaard

Related Articles

  1. Virus Subverts Cellular Defense for Reproduction and Escape

Regulatory Variation at Glypican-3 Underlies a Major Growth QTL in Mice

Fiona Oliver, Julian K Christians, Xiaojun Liu, Susan Rhind, Vinesh Verma, Claire Davison, Steve D. M Brown, Paul Denny, Peter D Keightley

Related Articles

  1. Growth Disorder Gene Plays a Big Role in Normal Size Variation

A Developmental Switch in the Response of DRG Neurons to ETS Transcription Factor Signaling

Simon Hippenmeyer, Eline Vrieseling, Markus Sigrist, Thomas Portmann, Celia Laengle, David R Ladle, Silvia Arber

Related Articles

  1. A Developmental Switch in Neuronal Differentiation

The Neural Substrates of Infant Sleep in Rats

Karl Æ Karlsson, Andrew J Gall, Ethan J Mohns, Adele M. H Seelke, Mark S Blumberg

Related Articles

  1. Functional Implications of Sleep Development
  2. Infant Sleep: A Precursor to Adult Sleep?

Book Review%2FScience in the Media

Explorer Naturalists

Fernando E Vega