Advertisement

Table of Contents: August 2004

Sites of retroviral integration are shown arrayed on the human chromosomes. Orange "lollipops" indicate sites of HIV integration; green, MLV; and pink, ASLV. The density of genes on each chromosome is shown by the blue shading. The background shows a high-density microarray such as those used to study the relationship between integration and gene activity. (See Mitchell, et al.)

Image Credit: Chromosome image by Huaming Chen, Salk Institute. Design by Jamie Simon, Salk Institute

Essays

Extinction, Slime, and Bottoms

Sean Nee

Features

Opening a Window to the Autistic Brain

Kendall Powell

Book Reviews/Science in the Media

Mutants on the Small Screen

Jonathan Hodgkin

Journal Clubs

Research Articles

Retroviral DNA Integration: ASLV, HIV, and MLV Show Distinct Target Site Preferences

Rick S Mitchell, Brett F Beitzel, Astrid R. W Schroder, Paul Shinn, Huaming Chen, Charles C Berry, Joseph R Ecker, Frederic D Bushman

Related Articles

  1. Retrovirus Integration into the Human Genome

The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response

Jan Karlseder, Kristina Hoke, Olga K Mirzoeva, Christopher Bakkenist, Michael B Kastan, John H. J Petrini, Titia de Lange

Related Articles

  1. Inhibition of the DNA Damage Pathway by a Telomere-Binding Protein

A Focused and Efficient Genetic Screening Strategy in the Mouse: Identification of Mutations That Disrupt Cortical Development

Konstantinos Zarbalis, Scott R May, Yiguo Shen, Marc Ekker, John L. R Rubenstein, Andrew S Peterson

Related Articles

  1. Finding Mutations That Disrupt Cortical Development

The Zebrafish moonshine Gene Encodes Transcriptional Intermediary Factor 1γ, an Essential Regulator of Hematopoiesis

David G Ransom, Nathan Bahary, Knut Niss, David Traver, Caroline Burns, Nikolaus S Trede, Noelle Paffett-Lugassy, Walter J Saganic, C. Anthoney Lim, Candace Hersey, Yi Zhou, Bruce A Barut, Shuo Lin, Paul D Kingsley, James Palis, Stuart H Orkin, Leonard I Zon

Related Articles

  1. A Red-Blooded Transcription Factor