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Table of Contents

August 2004

Cover

The sites of retorvirus integration overlayed on a schematic of the human genome.
Issue Image

Sites of retroviral integration are shown arrayed on the human chromosomes. Orange "lollipops" indicate sites of HIV integration; green, MLV; and pink, ASLV. The density of genes on each chromosome is shown by the blue shading. The background shows a high-density microarray such as those used to study the relationship between integration and gene activity. (See Mitchell, et al.)

Image Credit: Chromosome image by Huaming Chen, Salk Institute. Design by Jamie Simon, Salk Institute

Essay

Extinction, Slime, and Bottoms

Sean Nee

PLOS Biology: published August 17, 2004 | https://doi.org/10.1371/journal.pbio.0020272

Feature

Opening a Window to the Autistic Brain

Kendall Powell

PLOS Biology: published August 17, 2004 | https://doi.org/10.1371/journal.pbio.0020267

Journal Club

Grafting the Way to the Systemic Silencing Signal in Plants

Kriton Kalantidis

PLOS Biology: published August 17, 2004 | https://doi.org/10.1371/journal.pbio.0020224

Primers

Mouse Models of Human Autoimmune Diseases: Essential Tools That Require the Proper Controls

Laurence Morel

PLOS Biology: published August 17, 2004 | https://doi.org/10.1371/journal.pbio.0020241

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Innate Immunity in Fruit Flies: A Textbook Example of Genomic Recycling

Shubha Govind, Ross H Nehm

PLOS Biology: published August 17, 2004 | https://doi.org/10.1371/journal.pbio.0020276

Unraveling the Molecular Basis for Regenerative Cellular Plasticity

Shannon J Odelberg

PLOS Biology: published August 17, 2004 | https://doi.org/10.1371/journal.pbio.0020232

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  1. The Regenerative Plasticity of Isolated Urodele Myofibers and Its Dependence on Msx1

Community Page

A New Model for Open Sharing: Massachusetts Institute of Technology's OpenCourseWare Initiative Makes a Difference

Anne H Margulies

PLOS Biology: published August 17, 2004 | https://doi.org/10.1371/journal.pbio.0020200

Research Articles

Nicotine's Defensive Function in Nature

Anke Steppuhn, Klaus Gase, Bernd Krock, Rayko Halitschke, Ian T Baldwin

PLOS Biology: published August 17, 2004 | https://doi.org/10.1371/journal.pbio.0020217

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  1. Correction: Nicotine's Defensive Function in Nature
  2. Correction: Nicotine's Defensive Function in Nature
  3. Nicotine Keeps Leaf-Loving Herbivores at Bay

Spontaneous Autoimmunity in 129 and C57BL/6 Mice—Implications for Autoimmunity Described in Gene-Targeted Mice

Anne E Bygrave, Kirsten L Rose, Josefina Cortes-Hernandez, Joanna Warren, Robert J Rigby, H. Terence Cook, Mark J Walport, Timothy J Vyse, Marina Botto

PLOS Biology: published August 17, 2004 | https://doi.org/10.1371/journal.pbio.0020243

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  1. Mouse Models of Human Autoimmune Diseases: Essential Tools That Require the Proper Controls
  2. Deconstructing Genetic Contributions to Autoimmunity in Mouse Models

Functional Dissection of an Innate Immune Response by a Genome-Wide RNAi Screen

Edan Foley, Patrick H O'Farrell

PLOS Biology: published June 22, 2004 | https://doi.org/10.1371/journal.pbio.0020203

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Cellular Immune Response to Parasitization in Drosophila Requires the EBF Orthologue Collier

Michèle Crozatier, Jean-Michel Ubeda, Alain Vincent, Marie Meister

PLOS Biology: published August 17, 2004 | https://doi.org/10.1371/journal.pbio.0020196

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  1. A Protein Required for Fruitflies to Dispatch Wasp Parasites

Cellular and Genetic Analysis of Wound Healing in Drosophila Larvae

Michael J Galko, Mark A Krasnow

PLOS Biology: published July 20, 2004 | https://doi.org/10.1371/journal.pbio.0020239

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Retroviral DNA Integration: ASLV, HIV, and MLV Show Distinct Target Site Preferences

Rick S Mitchell, Brett F Beitzel, Astrid R. W Schroder, Paul Shinn, Huaming Chen, Charles C Berry, Joseph R Ecker, Frederic D Bushman

PLOS Biology: published August 17, 2004 | https://doi.org/10.1371/journal.pbio.0020234

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  1. Retrovirus Integration into the Human Genome

p19 Arf Suppresses Growth, Progression, and Metastasis of Hras-Driven Carcinomas through p53-Dependent and -Independent Pathways

Karen S Kelly-Spratt, Kay E Gurley, Yutaka Yasui, Christopher J Kemp

PLOS Biology: published August 17, 2004 | https://doi.org/10.1371/journal.pbio.0020242

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  1. Deterministic Tumor Evolution

The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response

Jan Karlseder, Kristina Hoke, Olga K Mirzoeva, Christopher Bakkenist, Michael B Kastan, John H. J Petrini, Titia de Lange

PLOS Biology: published August 17, 2004 | https://doi.org/10.1371/journal.pbio.0020240

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  1. Inhibition of the DNA Damage Pathway by a Telomere-Binding Protein

Evidence for Widespread Convergent Evolution around Human Microsatellites

Edward J Vowles, William Amos

PLOS Biology: published August 17, 2004 | https://doi.org/10.1371/journal.pbio.0020199

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  1. Evolution's “Molecular Clock”: Not So Dependable After All?

The Regenerative Plasticity of Isolated Urodele Myofibers and Its Dependence on Msx1

Anoop Kumar, Cristiana P Velloso, Yutaka Imokawa, Jeremy P Brockes

PLOS Biology: published August 17, 2004 | https://doi.org/10.1371/journal.pbio.0020218

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  1. Regenerating Lost Muscle: Msx1 to the Rescue
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A Focused and Efficient Genetic Screening Strategy in the Mouse: Identification of Mutations That Disrupt Cortical Development

Konstantinos Zarbalis, Scott R May, Yiguo Shen, Marc Ekker, John L. R Rubenstein, Andrew S Peterson

PLOS Biology: published August 17, 2004 | https://doi.org/10.1371/journal.pbio.0020219

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  1. Finding Mutations That Disrupt Cortical Development

The Zebrafish moonshine Gene Encodes Transcriptional Intermediary Factor 1γ, an Essential Regulator of Hematopoiesis

David G Ransom, Nathan Bahary, Knut Niss, David Traver, Caroline Burns, Nikolaus S Trede, Noelle Paffett-Lugassy, Walter J Saganic, C. Anthoney Lim, Candace Hersey, Yi Zhou, Bruce A Barut, Shuo Lin, Paul D Kingsley, James Palis, Stuart H Orkin, Leonard I Zon

PLOS Biology: published August 17, 2004 | https://doi.org/10.1371/journal.pbio.0020237

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IRE1-Independent Gain Control of the Unfolded Protein Response

Jess H Leber, Sebastián Bernales, Peter Walter

PLOS Biology: published August 17, 2004 | https://doi.org/10.1371/journal.pbio.0020235

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  1. Gcn4p and Novel Upstream Activating Sequences Regulate Targets of the Unfolded Protein Response
  2. Yeast Use Dual Gain Controls to Amplify Protein Processing

Gcn4p and Novel Upstream Activating Sequences Regulate Targets of the Unfolded Protein Response

Christopher K Patil, Hao Li, Peter Walter

PLOS Biology: published August 17, 2004 | https://doi.org/10.1371/journal.pbio.0020246

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Synaptotagmin VII Restricts Fusion Pore Expansion during Lysosomal Exocytosis

Jyoti K Jaiswal, Sabyasachi Chakrabarti, Norma W Andrews, Sanford M Simon

PLOS Biology: published June 29, 2004 | https://doi.org/10.1371/journal.pbio.0020233

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Forgetting, Reminding, and Remembering: The Retrieval of Lost Spatial Memory

Livia de Hoz, Stephen J Martin, Richard G. M Morris

PLOS Biology: published August 17, 2004 | https://doi.org/10.1371/journal.pbio.0020225

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  1. How the Brain Retrieves Forgotten Memories

Book Review%2FScience in the Media

Mutants on the Small Screen

Jonathan Hodgkin

PLOS Biology: published August 17, 2004 | https://doi.org/10.1371/journal.pbio.0020262