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Table of Contents: February 2004

The cover shows a degraded version of a natural image—in this case, an African lion—used to investigate neural correlates of learning. Monkeys were trained to identify such images and accompanying changes in the activity of visual cortext neurons were recorded. (See Rainer, et al.)

Image Credit: The cover image was provided by Gregor Rainer, Max Planck Institute for Biological Cynbernetics, and it is based on a public domain photo by Ken Stansell, U.S. Fish and Wildlife Service

Editorial

PLoS Medicine

Barbara Cohen

Essay

A New Trade Framework for Global Healthcare R&D

Tim Hubbard, James Love

Unsolved Mystery

What Causes Stuttering?

Christian Büchel, Martin Sommer

Journal Club

Community Pages

Bridging the Science–Policy Divide

Walter V Reid

Quality Information for Improved Health

Patricia L Thibodeau, Carla J Funk

Research Articles

Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection

Laura Papagno, Celsa A Spina, Arnaud Marchant, Mariolina Salio, Nathalie Rufer, Susan Little, Tao Dong, Gillian Chesney, Anele Waters, Philippa Easterbrook, P. Rod Dunbar, Dawn Shepherd, Vincenzo Cerundolo, Vincent Emery, Paul Griffiths, Christopher Conlon, Andrew J McMichael, Douglas D Richman, Sarah L Rowland-Jones, Victor Appay

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pRb Inactivation in Mammary Cells Reveals Common Mechanisms for Tumor Initiation and Progression in Divergent Epithelia

Karl Simin, Hua Wu, Lucy Lu, Dan Pinkel, Donna Albertson, Robert D Cardiff, Terry Van Dyke

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Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds

Howard Y Chang, Julie B Sneddon, Ash A Alizadeh, Ruchira Sood, Rob B West, Kelli Montgomery, Jen-Tsan Chi, Matt van de Rijn, David Botstein, Patrick O Brown

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Lefty Blocks a Subset of TGFβ Signals by Antagonizing EGF-CFC Coreceptors

Simon K Cheng, Felix Olale, Ali H Brivanlou, Alexander F Schier

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Book Review%2FScience in the Media

Dissecting the Urge to Create

Nancy C Andreasen