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Table of Contents: January 2004

Caspases promote apoptotic cell death by cleaving cellular proteins. Multiple caspase cascades are shown to be required for the non-apoptotic process of sperm development. The cover shows images of Drosophila testes labeled with several different antibodies. Coincidentally, when these are viewed as letters they spell "PLoS". (See Huh, et al.)

Image Credit: Cover image provided by Jun R. Huh, California Institute of Technology. Additional photo manipulation by John Heisch, John Heisch Design

Editorials

PLoS Biology in Action

Barbara Cohen

Essays

Science on the Rise in Developing Countries

Milena Holmgren, Stefan A Schnitzer

Features

In Methuselah's Mould

Bill O'Neill

Book Reviews/Science in the Media

Looking from the Past to the Future

Frederick J Friend

Journal Clubs

Channelling Evolution

Jeremy E Niven

Primers

Community Pages

Research Articles

Multiple Apoptotic Caspase Cascades Are Required in Nonapoptotic Roles for Drosophila Spermatid Individualization

Jun R Huh, Stephanie Y Vernooy, Hong Yu, Nieng Yan, Yigong Shi, Ming Guo, Bruce A Hay

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Dorsoventral Patterning of the Mouse Coat by Tbx15

Sophie I Candille, Catherine D. Van Raamsdonk, Changyou Chen, Sanne Kuijper, Yanru Chen-Tsai, Andreas Russ, Frits Meijlink, Gregory S Barsh

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Protein Interaction Networks by Proteome Peptide Scanning

Christiane Landgraf, Simona Panni, Luisa Montecchi-Palazzi, Luisa Castagnoli, Jens Schneider-Mergener, Rudolf Volkmer-Engert, Gianni Cesareni

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  1. Researchers Add to Proteomics Toolbox

Long-Lasting Novelty-Induced Neuronal Reverberation during Slow-Wave Sleep in Multiple Forebrain Areas

Sidarta Ribeiro, Damien Gervasoni, Ernesto S Soares, Yi Zhou, Shih-Chieh Lin, Janaina Pantoja, Michael Lavine, Miguel A. L Nicolelis

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  1. Brain Activity during Slow-Wave Sleep Points to Mechanism for Memory