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Open Access
Peer-reviewed
Research Article
Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells
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Jinlong Yin ,
Contributed equally to this work with: Jinlong Yin, Gunwoo Park
Affiliations Department of System Cancer Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea, Specific Organs Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea
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Gunwoo Park ,
Contributed equally to this work with: Jinlong Yin, Gunwoo Park
Affiliations Department of System Cancer Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea, Specific Organs Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea
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Tae Hoon Kim,
Affiliation Specific Organs Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea
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Jun Hee Hong,
Affiliation Specific Organs Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea
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Youn-Jae Kim,
Affiliation Specific Organs Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea
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Xiong Jin,
Affiliation Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University, Seoul, Korea
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Sangjo Kang,
Affiliation Specific Organs Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea
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Ji-Eun Jung,
Affiliations Specific Organs Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea, Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University, Seoul, Korea
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Jeong-Yub Kim,
Affiliations Divisions of Radiation Cancer Research, Research Center for Radio-Senescence, Korea Institute of Radiological and Medical Sciences, Seoul, Korea, Department of Pathology, College of Medicine, Korea University, Seoul, Korea
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Hyeongsun Yun,
Affiliations Department of System Cancer Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea, Specific Organs Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea
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Jeong Eun Lee,
Affiliations Department of System Cancer Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea, Cancer Cell and Molecular Biology Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea
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Minkyung Kim,
Affiliation Department of System Cancer Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea
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Junho Chung,
Affiliations Department of Biochemistry and Molecular Biology, Seoul National University, College of Medicine, Seoul, Korea, Department of Cancer Biology, Seoul National University College of Medicine, Seoul, Korea
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Hyunggee Kim,
Affiliation Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University, Seoul, Korea
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Ichiro Nakano,
Affiliations Department of Neurological Surgery, The Ohio State University, Columbus, Ohio, United States of America, James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America
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Ho-Shin Gwak,
Affiliation Specific Organs Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea
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Heon Yoo,
Affiliations Department of System Cancer Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea, Specific Organs Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea
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Byong Chul Yoo,
Affiliation Colorectal Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyangi, Korea
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Jong Heon Kim,
Affiliations Department of System Cancer Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea, Cancer Cell and Molecular Biology Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea
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Eun-Mi Hur,
Affiliations Center for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Korea, Department of Neuroscience, Korea University of Science and Technology, Daejeon, Korea
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Jeongwu Lee ,
¶‡ JL is joint senior author on this work.
Affiliation Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
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Seung-Hoon Lee ,
* E-mail: nslsh@ncc.re.kr (SHL); mjpark@kcch.re.kr (MJP); jbp@ncc.re.kr (JBP)
Affiliations Department of System Cancer Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea, Specific Organs Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea
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Myung-Jin Park ,
* E-mail: nslsh@ncc.re.kr (SHL); mjpark@kcch.re.kr (MJP); jbp@ncc.re.kr (JBP)
Affiliation Divisions of Radiation Cancer Research, Research Center for Radio-Senescence, Korea Institute of Radiological and Medical Sciences, Seoul, Korea
⨯ - [ ... ],
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Jong Bae Park
* E-mail: nslsh@ncc.re.kr (SHL); mjpark@kcch.re.kr (MJP); jbp@ncc.re.kr (JBP)
Affiliations Department of System Cancer Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea, Specific Organs Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea
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Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells
- Jinlong Yin,
- Gunwoo Park,
- Tae Hoon Kim,
- Jun Hee Hong,
- Youn-Jae Kim,
- Xiong Jin,
- Sangjo Kang,
- Ji-Eun Jung,
- Jeong-Yub Kim,
- Hyeongsun Yun
- Published: May 20, 2015
- https://doi.org/10.1371/journal.pbio.1002152