аЯрЁБс > ўџ ўџџџ џџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџьЅС @ јП 0C jbjbqq ` і і 0= џџ џџ џџ l Ђ Ђ Ђ Ђ Ђ Ђ Ђ ц ц ц ц ц , , ц & R Z Z Z Z Z Z Z Т Ф Ф Ф Ф Ф Ф , + K № Ђ Z Z Z Z Z № Ђ Ђ Z Z R Z В Ђ Z Ђ Z в № Ж Ю Ђ Ђ Ђ Ђ Z Т T r Ђ Ђ ц > tрzХ ц ц В ц ь К , г г ц У х Genetic Interaction from Figure 7(4)Citationbmp4(shh ADDIN EN.CITE ADDIN EN.CITE.DATA [1]bmp4(dlx2 ADDIN EN.CITE Thomas200061261261217Thomas, B. L.Liu, J. K.Rubenstein, J. L.Sharpe, P. T.Department of Craniofacial Development, GKT Dental Institute, King's College, University of London, London, SE1 9RT, UK. bthomas@hgmp.mrc.ac.ukIndependent regulation of Dlx2 expression in the epithelium and mesenchyme of the first branchial archDevelopmentDevelopment217-241272AnimalsBone Morphogenetic Proteins/metabolismBranchial Region/*embryologyDNA-Binding Proteins/*geneticsEmbryonic and Fetal Development/geneticsEpithelium/embryologyFibroblast Growth Factors/metabolismGene Expression Regulation, Developmental/*genetics*Homeodomain ProteinsIn Situ HybridizationLac OperonMesoderm/metabolismMiceMice, TransgenicResearch Support, Non-U.S. Gov'tSignal TransductionTooth/embryology2000Jan10603340http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10603340[2]bmp4-/barx1 ADDIN EN.CITE Tucker199828428428417Tucker, A. S.Matthews, K. L.Sharpe, P. T.Department of Craniofacial Development, Guy's, King's, and St. Thomas' School of Dentistry, Guy's Hospital, London SE1 9RT, UK.Transformation of tooth type induced by inhibition of BMP signalingScience1136-82825391AnimalsBody PatterningBone Morphogenetic Proteins/*physiologyGene Expression Regulation, Developmental*Genes, HomeoboxHomeodomain Proteins/*genetics/physiologyIncisor/*embryologyMaleMandible/embryologyMesoderm/metabolism/transplantationMiceMolar/*embryology*OdontogenesisOncogene Proteins/geneticsProteins/metabolism/pharmacologySignal TransductionSupport, Non-U.S. Gov'tTissue CultureTooth Germ/embryologyTranscription Factors/*genetics1998Nov 69804553http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9804553[3]bmp4-/pax9 ADDIN EN.CITE ADDIN EN.CITE.DATA [4, 5]bmp2-/pax9 ADDIN EN.CITE ADDIN EN.CITE.DATA [5, 6]pitx2/-/bmp4 ADDIN EN.CITE ADDIN EN.CITE.DATA [7]eda(shh ADDIN EN.CITE ADDIN EN.CITE.DATA [8]edar((shhHair/Feather ADDIN EN.CITE ADDIN EN.CITE.DATA [9]eda(edarTooth and salivary gland ADDIN EN.CITE ADDIN EN.CITE.DATA [10, 11]hox(shhInferred ADDIN EN.CITE ADDIN EN.CITE.DATA [12]hox(barx1Inferred ADDIN EN.CITE Salsi200824772477247717Salsi, V.Vigano, M. A.Cocchiarella, F.Mantovani, R.Zappavigna, V.Department of Animal Biology, University of Modena and Reggio Emilia, Via G. Campi 213/d, Modena 41100, Italy.Hoxd13 binds in vivo and regulates the expression of genes acting in key pathways for early limb and skeletal patterningDev BiolDev Biol497-50731722008May 151095-564X (Electronic)18407260http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18407260S0012-1606(08)00173-5 [pii]
10.1016/j.ydbio.2008.02.048eng[13]hox(runx2Inferred ADDIN EN.CITE ADDIN EN.CITE.DATA [14, 15]runx2((fgf ADDIN EN.CITE ADDIN EN.CITE.DATA [16]fgf(pax9 ADDIN EN.CITE ADDIN EN.CITE.DATA [4, 5]fgf(barx1 ADDIN EN.CITE Tucker199828428428417Tucker, A. S.Matthews, K. L.Sharpe, P. T.Department of Craniofacial Development, Guy's, King's, and St. Thomas' School of Dentistry, Guy's Hospital, London SE1 9RT, UK.Transformation of tooth type induced by inhibition of BMP signalingScience1136-82825391AnimalsBody PatterningBone Morphogenetic Proteins/*physiologyGene Expression Regulation, Developmental*Genes, HomeoboxHomeodomain Proteins/*genetics/physiologyIncisor/*embryologyMaleMandible/embryologyMesoderm/metabolism/transplantationMiceMolar/*embryology*OdontogenesisOncogene Proteins/geneticsProteins/metabolism/pharmacologySignal TransductionSupport, Non-U.S. Gov'tTissue CultureTooth Germ/embryologyTranscription Factors/*genetics1998Nov 69804553http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9804553[3]fgf(dlx2 ADDIN EN.CITE Thomas200061261261217Thomas, B. L.Liu, J. K.Rubenstein, J. L.Sharpe, P. T.Department of Craniofacial Development, GKT Dental Institute, King's College, University of London, London, SE1 9RT, UK. bthomas@hgmp.mrc.ac.ukIndependent regulation of Dlx2 expression in the epithelium and mesenchyme of the first branchial archDevelopmentDevelopment217-241272AnimalsBone Morphogenetic Proteins/metabolismBranchial Region/*embryologyDNA-Binding Proteins/*geneticsEmbryonic and Fetal Development/geneticsEpithelium/embryologyFibroblast Growth Factors/metabolismGene Expression Regulation, Developmental/*genetics*Homeodomain ProteinsIn Situ HybridizationLac OperonMesoderm/metabolismMiceMice, TransgenicResearch Support, Non-U.S. Gov'tSignal TransductionTooth/embryology2000Jan10603340http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10603340[2]fgf(pitx2 ADDIN EN.CITE ADDIN EN.CITE.DATA [7]wnt/Bcat-/shh ADDIN EN.CITE Sarkar200030830830817Sarkar, L.Cobourne, M.Naylor, S.Smalley, M.Dale, T.Sharpe, P. T.Department of Craniofacial Development, GKT Dental Institute, Guy's Hospital, London SE1 9RT, United Kingdom.Wnt/Shh interactions regulate ectodermal boundary formation during mammalian tooth developmentProc Natl Acad Sci U S A4520-4979AnimalsDrosophilaEctoderm/cytology/*physiologyEmbryoEmbryonic Induction*Gene Expression Regulation, DevelopmentalMammalsMiceMitogens/genetics*OdontogenesisProteins/*genetics/metabolismProto-Oncogene Proteins/*genetics/metabolismTooth Germ/cytology/*physiology*Trans-Activators*Zebrafish Proteins2000Apr 2510781055http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10781055[17]runx2(shh ADDIN EN.CITE ADDIN EN.CITE.DATA [16]
Supplementary Table 2: Referenced molecular interactions during tooth development, as shown in Figure 7(4).
ADDIN EN.REFLIST 1. Y Zhang, Z Zhang, X Zhao, X Yu, Y Hu, B Geronimo, SH Fromm, YP Chen: A new function of BMP4: dual role for BMP4 in regulation of Sonic hedgehog expression in the mouse tooth germ. Development 2000, 127:1431-43.
2. BL Thomas, JK Liu, JL Rubenstein, PT Sharpe: Independent regulation of Dlx2 expression in the epithelium and mesenchyme of the first branchial arch. Development 2000, 127:217-24.
3. AS Tucker, KL Matthews, PT Sharpe: Transformation of tooth type induced by inhibition of BMP signaling. Science 1998, 282:1136-8.
4. H Peters, A Neubuser, K Kratochwil, R Balling: Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities. Genes Dev 1998, 12:2735-47.
5. A Neubuser, H Peters, R Balling, GR Martin: Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Cell 1997, 90:247-55.
6. S Vainio, I Karavanova, A Jowett, I Thesleff: Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell 1993, 75:45-58.
7. TR St Amand, Y Zhang, EV Semina, X Zhao, Y Hu, L Nguyen, JC Murray, Y Chen: Antagonistic signals between BMP4 and FGF8 define the expression of Pitx1 and Pitx2 in mouse tooth-forming anlage. Dev Biol 2000, 217:323-32.
8. M Pummila, I Fliniaux, R Jaatinen, MJ James, J Laurikkala, P Schneider, I Thesleff, ML Mikkola: Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression. Development 2007, 134:117-25.
9. R Schmidt-Ullrich, DJ Tobin, D Lenhard, P Schneider, R Paus, C Scheidereit: NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth. Development 2006, 133:1045-57.
10. AS Tucker, DJ Headon, P Schneider, BM Ferguson, P Overbeek, J Tschopp, PT Sharpe: Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis. Development 2000, 127:4691-700.
11. J Pispa, ML Mikkola, T Mustonen, I Thesleff: Ectodysplasin, Edar and TNFRSF19 are expressed in complementary and overlapping patterns during mouse embryogenesis. Gene Expr Patterns 2003, 3:675-9.
12. V Knezevic, R De Santo, K Schughart, U Huffstadt, C Chiang, KA Mahon, S Mackem: Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop. Development 1997, 124:4523-36.
13. V Salsi, MA Vigano, F Cocchiarella, R Mantovani, V Zappavigna: Hoxd13 binds in vivo and regulates the expression of genes acting in key pathways for early limb and skeletal patterning. Dev Biol 2008, 317:497-507.
14. MQ Hassan, S Saini, JA Gordon, AJ van Wijnen, M Montecino, JL Stein, GS Stein, JB Lian: Molecular Switches Involving Homeodomain Proteins, HOXA10 and RUNX2 Regulate Osteoblastogenesis. Cells Tissues Organs 2008.
15. MQ Hassan, R Tare, SH Lee, M Mandeville, B Weiner, M Montecino, AJ van Wijnen, JL Stein, GS Stein, JB Lian: HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes. Mol Cell Biol 2007, 27:3337-52.
16. T Aberg, XP Wang, JH Kim, T Yamashiro, M Bei, R Rice, HM Ryoo, I Thesleff: Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol 2004, 270:76-93.
17. L Sarkar, M Cobourne, S Naylor, M Smalley, T Dale, PT Sharpe: Wnt/Shh interactions regulate ectodermal boundary formation during mammalian tooth development. Proc Natl Acad Sci U S A 2000, 97:4520-4.
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