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Stephen Abolins, Luke Lazarou, Laura Weldon, Louise Hughes, Elizabeth C. King, Paul Drescher, Michael J. O. Pocock, Julius C. R. Hafalla, Eleanor M. Riley, Mark Viney
The ecology of immune state in a wild mammal, Mus musculus domesticus
www.ploscompbiol.org
www.ploscompbiol.org
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Q
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[()4()11()6( )8()9(\n)7()4()1()-4()]TJ
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(1)Tj
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1.0091 0 Td
(1.18)Tj
1.8482 0 Td
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2.3414 0 Td
(and)Tj
1.7121 0 Td
(the)Tj
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(7.4)Tj
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(younger)Tj
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(S1)Tj
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(\).)Tj
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(a)Tj
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(of)Tj
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[()26(\r)-13()10()6()6()1()4()]TJ
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(79%\))Tj
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[()47(\r)3()4()7()11()12(\n)11( )8()]TJ
4.269 0 Td
[()18()-4()]TJ
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[()1()4()12()12()18()-4()]TJ
/F6 1 Tf
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(mites)Tj
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(67%;)Tj
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(S1)Tj
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(\).)Tj
2.6532 0 Td
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(7)Tj
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(microbial)Tj
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(infec-)Tj
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(tions)Tj
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(\(Noro,)Tj
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(and)Tj
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1.7121 0 Td
[()47(\r)3()7()11()10()4()10()6()]TJ
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[()11()4()12()6()11()18()-4()]TJ
/F6 1 Tf
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(previous)Tj
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(26)Tj
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(,)Tj
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(knowledge,)Tj
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(mice)Tj
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(S1)Tj
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(\).)Tj
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(mice)Tj
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(\(number)Tj
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4.0932 0 Td
(and)Tj
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(age)Tj
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1.525 0 Td
[()]TJ
/F6 1 Tf
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(=)Tj
0.7937 0 Td
(0.27)Tj
1.8482 0 Td
(and)Tj
-36.0111 -1.2983 Td
(0.3,)Tj
/F12 1 Tf
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[()]TJ
/F14 1 Tf
0 Tc
0.686 0 Td
(<)Tj
/F6 1 Tf
-0.01 Tc
0.9921 0 Td
(0.0001,)Tj
/F12 1 Tf
3.0104 0 Td
[()]TJ
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0.737 0 Td
(=)Tj
0.7937 0 Td
(214)Tj
1.6327 0 Td
(and)Tj
1.7121 0 Td
(209)Tj
1.6271 0 Td
(for)Tj
1.372 0 Td
(males)Tj
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(and)Tj
1.7122 0 Td
(females,)Tj
3.3958 0 Td
(respectively,)Tj
0.83 0.64 0.02 0 k
5.0287 0 Td
(S2)Tj
1.1622 0 Td
(Data)Tj
0 g
(\).)Tj
-0.004 Tc
-26.7362 -1.3039 Td
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(each)Tj
2.0296 0 Td
(mouse,)Tj
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(a)Tj
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(large)Tj
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(immune)Tj
3.6283 0 Td
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(a)Tj
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(cross-sectional)Tj
-29.7749 -1.2982 Td
(study)Tj
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(design)Tj
2.812 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(S1)Tj
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(Text)Tj
0 g
(\))Tj
2.3585 0 Td
([)Tj
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(1)Tj
0 g
(];)Tj
1.5987 0 Td
(here)Tj
1.9672 0 Td
(we)Tj
1.3266 0 Td
(focus)Tj
2.3301 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(\(1\))Tj
1.3776 0 Td
(serum)Tj
2.7213 0 Td
(concentration)Tj
5.8223 0 Td
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(immunoglobulin)Tj
-29.9733 -1.2983 Td
(\(Ig\))Tj
1.7064 0 Td
(G)Tj
0.9354 0 Td
(and)Tj
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(IgE)Tj
1.5931 0 Td
(and)Tj
1.7291 0 Td
(acute)Tj
2.3301 0 Td
(phase)Tj
2.4831 0 Td
(proteins)Tj
3.515 0 Td
(\(serum)Tj
3.0614 0 Td
(amyloid)Tj
3.4752 0 Td
(P)Tj
0.7824 0 Td
(and)Tj
1.7291 0 Td
(haptoglobin\),)Tj
5.6069 0 Td
(\(2\))Tj
1.3776 0 Td
(faecal)Tj
2.4718 0 Td
(con-)Tj
-34.5257 -1.3039 Td
(centrations)Tj
4.6998 0 Td
(of)Tj
1.0148 0 Td
(IgA,)Tj
1.9332 0 Td
(and)Tj
1.7291 0 Td
(\(3\))Tj
1.3776 0 Td
(numbers,)Tj
4.0025 0 Td
(proportions,)Tj
5.2214 0 Td
(and)Tj
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(ex)Tj
1.1112 0 Td
(vivo)Tj
1.8992 0 Td
(activation)Tj
4.1556 0 Td
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(of)Tj
1.0148 0 Td
(splenic)Tj
3.0047 0 Td
(T)Tj
-35.3931 -1.2983 Td
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1.7291 0 Td
(B)Tj
0.7993 0 Td
(cells,)Tj
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(regulatory)Tj
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(T)Tj
0.8334 0 Td
(cells)Tj
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(\(T)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 327.0047 172.3464 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
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(regs)Tj
ET
Q
q
1 j
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BT
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(\),)Tj
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(NK)Tj
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2.262 0 Td
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(short-term)Tj
4.5467 0 Td
(perturbations)Tj
5.6522 0 Td
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(individuals')Tj
4.8642 0 Td
(immune)Tj
3.6227 0 Td
(state)Tj
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(would)Tj
2.7156 0 Td
(not)Tj
-35.5915 -1.2983 Td
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1.6781 0 Td
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6.1002 0 Td
(approach,)Tj
4.1781 0 Td
(studies)Tj
2.9877 0 Td
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2.4378 0 Td
[()29()4()1()20()12(\n)7()-4()]TJ
3.7076 0 Td
[()15()-8()20( )8()9(\n)7()-4()]TJ
/F6 1 Tf
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3.3222 0 Td
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(humans)Tj
-33.2557 -1.3039 Td
(have)Tj
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(the)Tj
1.4683 0 Td
(longer)Tj
2.7836 0 Td
(term,)Tj
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(parameters)Tj
4.6771 0 Td
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(largely)Tj
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(temporally)Tj
4.541 0 Td
(stable)Tj
-32.4223 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(28)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(29)Tj
0 g
(],)Tj
3.2541 0 Td
(suggesting)Tj
4.3994 0 Td
(that)Tj
1.7801 0 Td
(our)Tj
1.6271 0 Td
(data)Tj
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(geographically)Tj
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(clustered)Tj
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(\()Tj
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(Fig)Tj
-35.2456 -1.3039 Td
(1)Tj
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(\),)Tj
1.2585 0 Td
(we)Tj
1.3266 0 Td
(first)Tj
1.8085 0 Td
(wanted)Tj
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(understand)Tj
4.7905 0 Td
(the)Tj
1.4682 0 Td
(extent)Tj
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(sites.)Tj
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(analysis)Tj
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(of)Tj
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(immunological)Tj
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(data,)Tj
2.1373 0 Td
(revealing)Tj
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(3)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 129.8268 23.6976 re
W* n
q
129.7701 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 478.4314 745.7952 cm
BT
/F0 1 Tf
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(mouse)Tj
3.1749 0 Td
(immunoecolo)Tj
5.8465 0 Td
(gy)Tj
ET
Q
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1 j
1 J
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36 48.0002 m
576 48.0002 l
576 47.5002 l
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