ORF	Gene_name	Phenotypic_potential	AMS_PPI_degree	LC_SLI_degree	Haploid_fitness	Description
YDR532C	YDR532C	4.724	1	4	0.673	Protein of unknown function that localizes to the nuclear side of the spindle pole body and along short spindles; deletion mutants have short telomeres; forms a complex with Spc105p
YEL036C	ANP1	4.365	10	3	0.58	Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol
YIL040W	APQ12	4.334	NA	10	0.901	Protein involved in nucleocytoplasmic transport of mRNA
YEL044W	IES6	4.253	9	9	0.932	Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
YOR080W	DIA2	4.141	33	77	0.757	Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication, involved in invasive and pseudohyphal growth
YBL094C	YBL094C	4.125	NA	NA	0.899	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W
YLR233C	EST1	4.121	16	1	0.88	TLC1 RNA-associated factor involved in telomere length regulation as the recruitment subunit of the telomerase holoenzyme, has a possible role in activating Est2p-TLC1-RNA bound to the telomere
YLR182W	SWI6	4.061	11	37	0.914	Transcription cofactor, forms complexes with DNA-binding proteins Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; localization regulated by phosphorylation; potential Cdc28p substrate
YNL250W	RAD50	4.035	28	71	0.863	Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining
YNL139C	RLR1	3.969	15	4	0.77	Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids
YJL080C	SCP160	3.964	23	2	0.97	Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
YOL086C	ADH1	3.946	43	NA	0.376	Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YBL058W	SHP1	3.672	15	8	0.32	UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate
YDR245W	MNN10	3.619	10	18	0.785	Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family
YDR159W	SAC3	3.472	10	22	0.823	Nuclear pore-associated protein, forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus
YPR135W	CTF4	3.435	5	120	0.754	Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion
YER155C	BEM2	3.408	26	39	0.959	Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence
YGL173C	KEM1	3.348	60	26	0.634	Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance
YKL113C	RAD27	3.28	3	96	0.686	5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family
YML032C	RAD52	3.266	10	60	0.912	Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis
YHR191C	CTF8	3.244	3	74	NA	Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion
YDR369C	XRS2	3.206	9	30	0.906	Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling
YDR138W	HPR1	3.145	18	13	0.499	Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p
YDR200C	VPS64	3.135	6	4	0.69	Cytoplasmic protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p, Far7p, Far10p, and Far11p that is involved in pheromone-induced cell cycle arrest; also localized to the endoplasmic reticulum membrane
YNL059C	ARP5	3.128	16	NA	0.397	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
YDL116W	NUP84	3.125	17	18	0.709	Subunit of the nuclear pore complex (NPC), forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis
YDL115C	IWR1	3.102	14	5	0.752	Protein of unknown function, deletion causes hypersensitivity to the K1 killer toxin
YKL204W	EAP1	3.095	7	7	0.844	eIF4E-associated protein, binds eIF4E and inhibits cap-dependent translation, also functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade
YBR200W	BEM1	3.09	2	26	1.088	Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p
YER095W	RAD51	3.083	28	30	0.881	Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
YNL298W	CLA4	3.068	12	95	1.073	Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p
YAL047C	SPC72	2.992	8	2	0.72	Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization
YBR194W	SOY1	2.977	1	6	0.736	Protein proposed to be associated with the nuclear pore complex
YDL013W	HEX3	2.956	12	33	0.682	Protein containing a RING finger domain that interacts with Slx8p; mutant phenotypes and genetic interactions suggest a role in sumoylation and in genome stability
YLL002W	RTT109	2.891	1	6	0.764	Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase, acetylates H3-K56; plays a role in regulation of Ty1 transposition
YGL163C	RAD54	2.882	3	27	0.936	DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
YLR322W	YLR322W	2.766	NA	NA	0.581	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect
YGR006W	PRP18	2.749	3	3	0.955	Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing, recruited to the spliceosome by Slu7p
YDR320C	SWA2	2.689	4	8	0.755	Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
YBR112C	CYC8	2.686	3	NA	1.068	General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters
YMR116C	ASC1	2.677	48	4	0.883	WD repeat protein (G-beta like protein) involved in translation regulation; required for repression of Gcn4p activity in the absence of amino-acid starvation; core component of the ribosome; ortholog of mammalian RACK1
YOL072W	THP1	2.65	7	20	0.567	Nuclear pore-associated protein, forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus; contains a PAM domain implicated in protein-protein binding
YER070W	RNR1	2.63	7	1	0.555	Ribonucleotide-diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YHR010W	RPL27A	2.595	67	2	0.96	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein
YLR370C	ARC18	2.544	9	16	0.774	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YML112W	CTK3	2.542	6	21	0.555	Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing
YIL015W	BAR1	2.537	1	NA	1.002	Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest
YJL127C	SPT10	2.532	NA	4	0.785	Putative histone acetylase, sequence-specific activator of histone genes, binds specifically and highly cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box
YIL009C-A	EST3	2.518	1	NA	0.876	Component of the telomerase holoenzyme, involved in telomere replication
YBR081C	SPT7	2.489	33	21	NA	Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex
YMR078C	CTF18	2.443	9	75	0.812	Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint
YBL025W	RRN10	2.432	1	3	0.508	Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
YOL012C	HTZ1	2.42	36	79	0.857	Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
YPR120C	CLB5	2.401	8	15	0.907	B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
YKL139W	CTK1	2.371	19	33	0.765	Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing
YGL206C	CHC1	2.357	9	8	0.977	Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function
YDR264C	AKR1	2.325	5	2	0.517	Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats
YDR334W	SWR1	2.312	19	72	0.985	Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
YGR019W	UGA1	2.293	NA	2	0.996	Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization
YOL115W	PAP2	2.258	20	38	0.622	Catalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), a nuclear poly (A) polymerase complex involved in RNA quality control; catalyzes polyadenylation of unmodified tRNAs, and snoRNA and rRNA precursors; disputed role as a DNA polymerase
YMR198W	CIK1	2.253	3	37	0.865	Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1p
YPL078C	ATP4	2.237	3	1	0.978	Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YDL191W	RPL35A	2.214	9	4	0.589	Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein
YNL206C	RTT106	2.17	5	4	0.955	Protein with a role in regulation of Ty1 transposition
YJL204C	RCY1	2.169	1	3	0.746	F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
YKL048C	ELM1	2.169	3	23	1.004	Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring
YMR031W-A	YMR031W-A	2.152	NA	NA	0.948	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
YBR082C	UBC4	2.149	5	5	0.744	Ubiquitin-conjugating enzyme that mediates degradation of short-lived and abnormal proteins; interacts with E3-CaM in ubiquitinating calmodulin; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response
YKR082W	NUP133	2.146	17	53	0.657	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), localizes to both sides of the NPC, required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p
YDR173C	ARG82	2.144	1	NA	0.382	Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; putative nuclear lipid inositol PI3-kinase; regulates arginine-, phosphate-, and nitrogen-responsive genes
YMR091C	NPL6	2.143	34	7	0.866	Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length
YHR200W	RPN10	2.143	44	28	0.871	Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein
YPR164W	MMS1	2.127	5	9	0.889	Protein likely involved in protection against replication-dependent DNA damage; mutants are sensitive to methyl methanesulfonate (MMS); implicated in regulation of Ty1 transposition
YNL133C	FYV6	2.115	1	1	0.707	Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining
YPR072W	NOT5	2.068	6	10	1.011	Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
YBR172C	SMY2	2.035	1	NA	1.011	Protein of unknown function that interacts with Myo2p; has similarity to S. pombe Mpd2
YDR505C	PSP1	2.02	NA	NA	1.012	Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition
YMR219W	ESC1	2.016	4	NA	0.99	Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p
YOR327C	SNC2	2.002	NA	13	0.899	Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins
YJL006C	CTK2	1.999	6	22	NA	Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing; has similarity to cyclins
YNL138W	SRV2	1.986	14	5	1.091	CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis
YDL133W	YDL133W	1.984	NA	1	0.965	Putative protein of unknown function
YDR442W	YDR442W	1.982	NA	NA	0.851	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL148C	SPT20	1.969	22	10	1.049	Subunit of the SAGA transcriptional regulatory complex, involved in maintaining the integrity of the complex
YPL106C	SSE1	1.968	22	6	0.589	ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm
YGR262C	BUD32	1.958	28	NA	0.938	Protein kinase proposed to be involved in bud-site selection, telomere uncapping and elongation, and transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Gon7p
YNL224C	SQS1	1.952	5	NA	0.996	Protein of unknown function; overexpression antagonizes the suppression of splicing defects by spp382 mutants; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YGR105W	VMA21	1.945	5	7	1.014	Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
YOR258W	HNT3	1.934	NA	NA	1.069	Member of the third branch of the histidine triad (HIT) superfamily of nucleotide-binding proteins; similar to Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia
YNL065W	AQR1	1.921	1	NA	1.007	Plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine
YBR106W	PHO88	1.918	2	2	0.93	Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YJL140W	RPB4	1.903	22	9	0.499	RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; dispensable under some environmental conditions; involved in export of mRNA to cytoplasm under stress conditions; involved in telomere maintenance
YHR154W	RTT107	1.895	16	20	0.968	Protein implicated in Mms22-dependent DNA repair during S phase, DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition
YLR452C	SST2	1.89	8	6	0.955	GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family
YDR414C	ERD1	1.858	NA	5	0.951	Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
YER116C	SLX8	1.839	10	18	0.636	Protein containing a RING finger domain that interacts with Hex3p; mutant phenotypes and genetic interactions suggest a role in sumoylation and in genome stability
YPL268W	PLC1	1.824	1	7	1.055	Phosphoinositide-specific phospholipase C, hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in kinetochore function and pseudohyphal differentiation
YMR035W	IMP2	1.824	NA	3	1.085	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
YDR462W	MRPL28	1.817	26	1	0.832	Mitochondrial ribosomal protein of the large subunit
YFL010C	WWM1	1.813	NA	NA	1.027	WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes Gi phase growth arrest and clonal death that is suppressed by overexpression of MCA1
YPR070W	MED1	1.809	31	15	0.835	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YDR300C	PRO1	1.806	9	NA	1.02	Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis
YML128C	MSC1	1.804	NA	6	0.903	Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR358C	YLR358C	1.8	NA	NA	0.647	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSC2/YLR357W
YOL150C	YOL150C	1.798	NA	NA	1.009	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR231C	SWC5	1.793	16	71	0.907	Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
YPR141C	KAR3	1.792	1	89	0.831	Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate
YKL054C	DEF1	1.784	10	NA	0.807	RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex
YDR433W	YDR433W	1.773	NA	NA	1.027	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL015W	EDC3	1.771	8	2	0.981	Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies
YGR160W	YGR160W	1.767	NA	NA	0.738	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL223C	COG1	1.759	7	22	0.984	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YNL171C	YNL171C	1.753	NA	NA	0.751	Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YDL225W	SHS1	1.75	18	11	1.004	One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud neck which is necessary for normal morphogenesis and cytokinesis
YOR026W	BUB3	1.748	2	102	0.837	Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p
YJR074W	MOG1	1.746	2	3	0.912	Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
YLR234W	TOP3	1.743	1	35	0.872	DNA Topoisomerase III, conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially, involved in telomere stability and regulation of mitotic recombination
YJR055W	HIT1	1.74	NA	2	0.716	Protein of unknown function, required for growth at high temperature
YDR195W	REF2	1.732	24	3	0.218	RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes
YGR104C	SRB5	1.73	44	13	0.525	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in telomere maintenance
YLL020C	YLL020C	1.728	NA	NA	0.924	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1
YPR101W	SNT309	1.724	35	3	0.621	Component of NineTeen complex (NTC) containing Prp19p involved in mRNA splicing, interacts physically and genetically with Prp19p
YOR178C	GAC1	1.719	1	NA	1.03	Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YJR054W	YJR054W	1.718	NA	NA	0.9	Vacuolar protein of unknown function; potential Cdc28p substrate
YLR447C	VMA6	1.676	10	6	0.479	Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane
YCL029C	BIK1	1.662	7	40	0.921	Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170
YCR066W	RAD18	1.659	2	10	NA	Protein involved in postreplication repair; binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; forms heterodimer with Rad6p; contains RING-finger motif
YCL016C	DCC1	1.655	4	73	0.875	Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance
YCL037C	SRO9	1.655	29	7	0.833	Cytoplasmic RNA-binding protein that associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif
YOR144C	ELG1	1.654	5	37	0.974	Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; involved in homologous recombination-mediated DNA repair
YPL084W	BRO1	1.649	3	5	0.726	Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes
YJL184W	GON7	1.646	2	1	0.42	Protein proposed to be involved in the modification of N-linked oligosaccharides, osmotic stress response, telomere uncapping and elongation, transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Bud32p
YFR017C	YFR017C	1.644	2	NA	0.968	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YEL061C	CIN8	1.642	6	102	0.935	Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation
YOR241W	MET7	1.639	NA	3	0.67	Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA
YFR019W	FAB1	1.632	9	22	0.985	1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis
YGR036C	CAX4	1.631	NA	2	0.603	Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
YJL123C	YJL123C	1.627	6	4	0.937	Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); YJL123C is a non-essential gene
YLR399C	BDF1	1.626	22	9	0.783	Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p
YNR075W	COS10	1.62	NA	NA	1.004	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YMR205C	PFK2	1.619	14	2	0.944	Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YLR318W	EST2	1.612	NA	6	0.451	Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia
YOR369C	RPS12	1.611	3	NA	1.064	Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12
YHR167W	THP2	1.596	14	6	0.974	Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance
YMR142C	RPL13B	1.595	64	1	0.727	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein
YKL118W	YKL118W	1.594	NA	NA	0.701	Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2
YKL081W	TEF4	1.593	38	3	0.981	Translation elongation factor EF-1 gamma
YJR018W	YJR018W	1.586	NA	NA	NA	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR152W	YIM1	1.585	NA	1	1.04	Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGL174W	BUD13	1.578	9	2	0.796	Subunit of the RES complex, which is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern
YMR105C	PGM2	1.572	16	NA	1.065	Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase
YDR004W	RAD57	1.554	NA	16	0.923	Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
YMR039C	SUB1	1.551	2	3	1	Transcriptional coactivator, facilitates elongation by influencing enzymes that modify RNAP II, acts in a peroxide resistance pathway involving Rad2p; suppressor of TFIIB mutations
YBR133C	HSL7	1.551	2	5	NA	Protein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p
YGL070C	RPB9	1.544	26	15	0.747	RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site; involved in telomere maintenance
YMR060C	SAM37	1.543	NA	14	0.697	Component of the mitochondrial outer membrane sorting and assembly machinery (SAM) complex; required for the sorting of some proteins to the outer membrane after import by the TOM complex
YPL129W	TAF14	1.537	78	3	0.763	Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain
YJR049C	UTR1	1.532	NA	2	1.034	ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p)
YJR063W	RPA12	1.525	13	1	1.131	RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex
YNR051C	BRE5	1.524	17	28	0.825	Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A
YCR020W-B	HTL1	1.524	25	4	0.998	Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
YNR050C	LYS9	1.52	6	NA	0.826	Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, which is the seventh step in lysine biosynthesis pathway
YCR002C	CDC10	1.519	15	1	0.925	Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YOR035C	SHE4	1.513	3	11	0.893	Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization
YNL107W	YAF9	1.512	28	56	0.918	Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain
YER151C	UBP3	1.505	13	17	0.69	Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin
YAL048C	GEM1	1.503	2	NA	0.787	Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death
YIL134W	FLX1	1.502	NA	1	NA	Protein required for transport of flavin adenine dinucleotide (FAD), a synthesis product of riboflavin, across the mitochondrial membrane
YKL080W	VMA5	1.491	7	4	0.678	Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YML041C	VPS71	1.486	17	72	0.94	Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
YOL090W	MSH2	1.477	14	1	0.928	Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP
YMR032W	HOF1	1.471	NA	3	0.667	Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
YER044C	ERG28	1.47	NA	5	NA	Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p
YDR364C	CDC40	1.466	16	24	0.835	Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats
YJR075W	HOC1	1.466	4	47	0.989	Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
YJL115W	ASF1	1.466	19	59	0.762	Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed
YOL076W	MDM20	1.465	3	9	0.797	Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met; involved in mitochondrial inheritance and actin assembly
YOR332W	VMA4	1.46	17	1	1.023	Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YJL029C	VPS53	1.459	6	5	1.066	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting
YER016W	BIM1	1.457	11	158	0.921	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
YKL126W	YPK1	1.455	7	5	0.983	Serine/threonine protein kinase required for receptor-mediated endocytosis; involved in sphingolipid-mediated and cell integrity signaling pathways; localized to the bud neck, cytosol and plasma membrane; homolog of mammalian kinase SGK
YDR176W	NGG1	1.453	27	7	0.408	Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex
YFL023W	BUD27	1.452	2	5	0.971	Protein involved in bud-site selection, nutrient signaling, and gene expression controlled by the TOR kinase; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YEL003W	GIM4	1.451	6	128	0.985	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
YJR077C	MIR1	1.451	19	1	1.025	Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2 under normal conditions
YLR064W	YLR064W	1.447	1	NA	1.015	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR064W is not an essential gene
YMR150C	IMP1	1.444	NA	NA	0.972	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
YNL064C	YDJ1	1.441	6	24	0.695	Protein chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family
YPL006W	NCR1	1.441	NA	NA	0.983	Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein
YLR111W	YLR111W	1.44	NA	NA	0.886	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR299C	DYN3	1.438	NA	18	1.039	Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration
YLR427W	MAG2	1.435	25	NA	0.938	DNA-3-methyladenine glycosidase II that catalyzes of the hydrolysis of alkylated DNA
YEL046C	GLY1	1.432	5	1	0.938	Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis
YLR403W	SFP1	1.431	7	2	0.585	Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YBL006C	LDB7	1.427	1	4	0.824	Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
YNR057C	BIO4	1.425	NA	NA	0.897	Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels
YHR004C	NEM1	1.425	1	4	0.959	Catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme, which regulates nuclear growth by controlling recruitment of Pah1p onto promoters of phospholipid biosynthetic genes; required for normal nuclear envelope morphology and sporulation
YDL081C	RPP1A	1.423	4	NA	0.576	Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
YHR031C	RRM3	1.413	NA	29	0.97	DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p
YJR090C	GRR1	1.41	14	8	0.683	F-box protein component of the SCF ubiquitin-ligase complex, required for Cln1p and Cln2p degradation; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, and morphogenesis
YMR014W	BUD22	1.409	6	NA	1.105	Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YBR134W	YBR134W	1.409	NA	NA	0.992	Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YPR018W	RLF2	1.408	4	7	NA	Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin
YEL045C	YEL045C	1.408	NA	NA	0.21	Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress
YJR152W	DAL5	1.408	NA	NA	0.959	Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression
YPL271W	ATP15	1.406	NA	2	1.05	Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YPL024W	RMI1	1.405	NA	19	0.828	Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YMR017W	SPO20	1.405	NA	NA	1.066	Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YGL136C	MRM2	1.394	NA	NA	0.973	Mitochondrial 21S rRNA methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ
YJL047C	RTT101	1.392	12	6	0.914	Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; deletion phenotype suggests a role in anaphase progression; interacts with Mms22p and implicated in Mms22-dependent DNA repair; modified by the ubiquitin-like protein, Rub1p
YML028W	TSA1	1.388	8	27	0.99	Ubiquitous housekeeping thioredoxin peroxidase, reduces reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; mediates redox regulation of the nuclear localization of Yap1p; deletion results in mutator phenotype
YLR173W	YLR173W	1.388	NA	NA	1.02	Putative protein of unknown function
YLR021W	YLR021W	1.387	1	2	0.889	Putative protein of unknown function; mutant accumulates unusually high amounts of dityrosine in the soluble fraction though spores appear wild-type; YLR021W is not an essential gene; null mutant displays increased levels of spontaneous Rad52 foci
YCL007C	YCL007C	1.383	NA	NA	0.984	Dubious ORF unlikely to encode a protein; overlaps verified ORF YCL005W-A; mutations in YCL007C were thought to confer sensitivity to calcofluor white, but this phenotype was later shown to be due to the defect in YCL005W-A
YMR289W	ABZ2	1.378	1	NA	1.002	4-amino-4-deoxychorismate lyase, catalyzes the third step in para-aminobenzoic acid biosynthesis
YJR097W	JJJ3	1.376	NA	NA	1.023	Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YGR122W	YGR122W	1.374	NA	NA	0.941	Putative protein of unknown function; deletion mutants do not properly process Rim101p and have decreased resistance to rapamycin; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YOR039W	CKB2	1.373	29	3	0.835	Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases
YLR373C	VID22	1.366	1	16	0.875	Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles
YIL009W	FAA3	1.365	NA	NA	0.944	Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YOR371C	GPB1	1.358	NA	NA	1.058	Proposed beta subunit of the heterotrimeric G protein; interacts with the receptor Grp1p, affects signaling by altering the level of phosphorylation of PKS substrates; regulates pseudohyphal growth through cAMP levels; homolog of Gpb2p
YDL047W	SIT4	1.358	46	17	0.575	Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YBR092C	PHO3	1.356	NA	NA	1.012	Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
YHR108W	GGA2	1.355	3	5	0.98	Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi
YPR159W	KRE6	1.349	4	36	0.799	Protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; appears functionally redundant with Skn1p
YBR279W	PAF1	1.346	21	30	NA	RNAP II-associated protein; defines large complex biochemically and functionally distinct from the Srb-Mediator form of Pol II holoenzyme; required for full expression of a subset of cell cycle-regulated genes; homolog of human PD2/hPAF1
YHR183W	GND1	1.346	17	1	0.952	6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress
YER115C	SPR6	1.343	NA	1	0.951	Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation
YAL021C	CCR4	1.339	21	78	0.981	Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening
YER040W	GLN3	1.338	3	1	0.668	Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source
YDR523C	SPS1	1.336	22	NA	NA	Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis
YEL027W	CUP5	1.335	1	2	0.793	Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
YIL054W	YIL054W	1.334	NA	NA	0.983	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL062C	APM4	1.332	4	NA	1.068	Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport
YHR207C	SET5	1.329	NA	NA	1.01	Zinc-finger protein of unknown function, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus
YGR188C	BUB1	1.328	4	38	0.828	Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p
YMR283C	RIT1	1.327	NA	NA	1.014	2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA
YGL072C	YGL072C	1.327	NA	NA	0.846	Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1
YML111W	BUL2	1.322	1	NA	1.104	Component of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1
YOR358W	HAP5	1.321	2	5	0.963	Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex
YOL111C	MDY2	1.315	7	1	0.991	Protein required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes and interacts with YOR164C; contains a ubiquitin-like (UBL) domain
YNL264C	PDR17	1.313	1	5	1.145	Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
YPR124W	CTR1	1.313	2	1	0.962	High-affinity copper transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels
YKR014C	YPT52	1.311	8	3	1.065	GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis
YDL035C	GPR1	1.306	NA	NA	0.818	Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis
YHL037C	YHL037C	1.306	NA	NA	1.037	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR202W	ERG2	1.306	NA	11	0.888	C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
YGL076C	RPL7A	1.306	98	1	0.673	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
YDL182W	LYS20	1.298	19	NA	0.757	Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p
YBR179C	FZO1	1.297	1	NA	1.063	Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain
YLR110C	CCW12	1.297	NA	9	0.941	Cell wall protein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YKL119C	VPH2	1.295	4	2	0.868	Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)
YNL271C	BNI1	1.295	8	104	0.99	Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1
YPR163C	TIF3	1.293	2	4	0.763	Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA
YBL016W	FUS3	1.291	7	NA	0.94	Mitogen-activated protein kinase involved in mating pheromone response; activated by phosphorylation by Ste7p; provides specificity during the mating vs. filamentous growth response by phosphorylating transcriptional and cytoplasmic targets
YKR018C	YKR018C	1.291	2	NA	1.052	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YDR117C	TMA64	1.286	5	NA	0.932	Protein of unknown function that associates with ribosomes; has a putative RNA binding domain
YGR020C	VMA7	1.283	10	2	0.94	Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YOR376W	YOR376W	1.279	NA	NA	0.934	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
YGR007W	MUQ1	1.278	NA	NA	1.006	Choline phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases
YNL153C	GIM3	1.276	6	127	0.897	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
YNL080C	YNL080C	1.274	NA	2	0.645	Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene
YLR338W	YLR338W	1.274	NA	NA	0.536	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C
YBR235W	YBR235W	1.272	1	1	0.925	Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene
YDR276C	PMP3	1.272	NA	8	0.901	Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
YPR074C	TKL1	1.27	6	NA	0.886	Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YKL208W	CBT1	1.266	NA	NA	1.012	Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p
YOL143C	RIB4	1.266	4	NA	1.027	Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin
YLR200W	YKE2	1.261	8	156	0.859	Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
YKR007W	MEH1	1.261	2	NA	0.872	Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification
YLR357W	RSC2	1.261	32	7	0.631	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance
YAL007C	ERP2	1.261	24	NA	0.995	Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
YGL058W	RAD6	1.26	8	84	0.583	Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p)
YBR233W	PBP2	1.258	3	NA	0.893	RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length
YOR216C	RUD3	1.258	1	19	1.018	Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1
YKL167C	MRP49	1.257	23	NA	1.013	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
YIL145C	PAN6	1.256	NA	NA	0.986	Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
YIL154C	IMP2p	1.253	2	3	1.075	Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat
YCR086W	CSM1	1.25	5	29	1.034	Nucleolar protein that forms a complex with Lrs4p which binds Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation, may be involved in premeiotic DNA replication; possible role in telomere maintenance
YOR071C	THI71	1.25	NA	NA	1.025	Transporter of thiamine or related compound; shares sequence similarity to Thi7p; proposed to be involved in 5-fluorocytosine sensitivity
YLR295C	ATP14	1.246	1	1	1.007	Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YNL215W	IES2	1.245	13	7	0.762	Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
YML109W	ZDS2	1.243	9	1	1.089	Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; paralog of Zds1p
YLR180W	SAM1	1.24	52	1	0.922	S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YOR193W	PEX27	1.238	1	2	1.038	Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p
YBL088C	TEL1	1.23	3	2	0.986	Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene
YOR141C	ARP8	1.23	16	5	0.446	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
YKL010C	UFD4	1.225	20	1	0.991	Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins
YDR363W	ESC2	1.224	NA	43	0.964	Protein involved in mating-type locus silencing, interacts with Sir2p; probably functions to recruit or stabilize Sir proteins
YGL218W	YGL218W	1.223	NA	NA	0.599	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance
YDL135C	RDI1	1.221	NA	NA	0.555	Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42p
YGR092W	DBF2	1.221	29	15	0.855	Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis
YDR225W	HTA1	1.22	38	7	0.984	One of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YHR199C	FMP34	1.218	5	NA	0.999	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YCR094W	CDC50	1.218	NA	11	0.698	Endosomal protein that regulates cell polarity; similar to Ynr048wp and Lem3p
YCR077C	PAT1	1.218	30	15	0.822	Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p
YBR267W	REI1	1.217	7	NA	0.671	Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network
YLL030C	YLL030C	1.216	NA	NA	1.062	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR024C	UBR2	1.213	4	NA	0.907	Cytoplasmic ubiquitin-protein ligase (E3)
YER113C	YER113C	1.209	NA	NA	0.96	Non-essential golgi localized protein of unknown function; contains niine potential transmembrane domains and has similarity to the endosomal protein, Emp70p
YER142C	MAG1	1.209	16	NA	1.021	3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired
YCR034W	FEN1	1.208	NA	4	0.853	Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway
YPL174C	NIP100	1.207	3	34	0.866	Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)
YLR331C	YLR331C	1.206	NA	NA	1.008	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
YHR111W	UBA4	1.204	1	11	0.855	Protein that activates Urm1p before its conjugation to proteins (urmylation); one target is the thioredoxin peroxidase Ahp1p, suggesting a role of urmylation in the oxidative stress response
YDR241W	YDR241W	1.203	NA	NA	0.725	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YPL206C	YPL206C	1.203	1	NA	1.017	Protein that plays a role in metabolism of glycerophosphocholine to phosphatidylcholine; contains glycerophosphodiester phosphodiesterase motifs
YKL073W	LHS1	1.2	4	3	0.807	Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; member of the Hsp70 family; localizes to the lumen of the ER; regulated by the unfolded protein response pathway
YBR269C	FMP21	1.199	NA	NA	0.995	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL031C	PHO85	1.198	16	70	1.006	Cyclin-dependent kinase, with ten cyclin partners; involved in environmental stress response; in phosphate-rich conditions, Pho85p-Pho80p complex phosphorylates Pho4p which in turn represses PHO5
YPR131C	NAT3	1.198	6	4	0.325	Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met
YPL045W	VPS16	1.198	6	2	0.892	Subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; part of the Class C Vps complex essential for membrane docking and fusion at both the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
YMR166C	YMR166C	1.197	NA	1	0.945	Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
YPR057W	BRR1	1.197	8	2	0.855	snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed
YLL045C	RPL8B	1.196	116	NA	0.969	Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YDL151C	YDL151C	1.191	NA	NA	0.63	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YMR179W	SPT21	1.19	NA	5	0.663	Protein required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; involved in telomere maintenance
YDR149C	YDR149C	1.19	NA	NA	0.806	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR069C	HAM1	1.184	1	NA	1.059	Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine
YDR432W	NPL3	1.183	23	16	0.455	RNA-binding protein that carries poly(A)+ mRNA from the nucleus into the cytoplasm; dissociation from mRNAs is promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm
YGL199C	YGL199C	1.181	NA	NA	1.008	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W
YOL113W	SKM1	1.18	4	NA	1.008	Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; proposed to be a downstream effector of Cdc42p during polarized growth
YBL103C	RTG3	1.179	3	2	0.056	Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways
YAL040C	CLN3	1.177	NA	10	0.986	G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis
YGR217W	CCH1	1.177	NA	2	1.03	Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
YML003W	YML003W	1.176	NA	NA	1.038	Putative protein of unknown function
YGL240W	DOC1	1.176	12	18	0.645	Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis
YKL053C-A	MDM35	1.175	NA	1	0.958	Mitochondrial intermembrane space cysteine motif protein; mutation affects mitochondrial distribution and morphology
YJL023C	PET130	1.174	3	1	1.041	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR076W	RAD55	1.173	2	19	0.985	Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
YER014W	HEM14	1.173	NA	4	NA	Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX
YGR118W	RPS23A	1.173	19	1	0.809	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal
YJL048C	UBX6	1.169	NA	NA	0.991	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline
YLR242C	ARV1	1.167	NA	5	0.625	Protein required for normal intracellular sterol distribution and for sphingolipid metabolism; similar to Nup120p and C. elegans R05H5.5 protein
YMR307W	GAS1	1.167	3	57	0.96	Beta-1.3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor
YDL080C	THI3	1.166	3	3	0.991	Probable decarboxylase, required for expression of enzymes involved in thiamine biosynthesis; may have a role in catabolism of amino acids to long-chain and complex alcohols
YIL047C	SYG1	1.164	1	NA	1.021	Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency
YHR189W	PTH1	1.16	NA	1	0.99	One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for cell growth and for mitochondrial respiration
YJR092W	BUD4	1.159	6	NA	1.031	Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; potential Cdc28p substrate
YBL089W	AVT5	1.157	NA	NA	0.927	Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YLR188W	MDL1	1.157	NA	NA	1.023	Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress
YBR300C	YBR300C	1.157	NA	NA	1.002	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene
YOR366W	YOR366W	1.154	NA	NA	0.985	Hypothetical protein
YGL168W	HUR1	1.154	NA	14	0.72	Protein required for hydroxyurea resistance; has possible roles in DNA replication and maintenance of proper telomere length
YBL096C	YBL096C	1.153	NA	NA	0.958	Non-essential protein of unknown function
YPR076W	YPR076W	1.151	NA	NA	1.006	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR015C	MNN2	1.151	NA	5	0.997	Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
YLR174W	IDP2	1.15	1	NA	1.011	Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YCR084C	TUP1	1.149	11	1	NA	General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes
YOR182C	RPS30B	1.149	NA	1	0.811	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Ap and has similarity to rat S30 ribosomal protein
YMR238W	DFG5	1.147	NA	2	0.996	Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p
YMR073C	YMR073C	1.147	NA	3	0.973	Putative protein of unknown function; proposed to be involved in resistance to carboplatin and cisplatin; shares similarity to a human cytochrome oxidoreductase; null mutant displays increased levels of spontaneous Rad52 foci
YLL044W	YLL044W	1.146	NA	NA	1.024	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL8
YDR378C	LSM6	1.145	29	13	0.936	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YLR185W	RPL37A	1.143	3	1	0.791	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein
YNL147W	LSM7	1.142	26	19	0.915	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YER178W	PDA1	1.141	7	5	0.886	E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA, regulated by glucose
YOR023C	AHC1	1.141	4	5	1.056	Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
YOR305W	YOR305W	1.14	3	NA	0.589	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene
YPR032W	SRO7	1.135	3	2	0.911	Putative effector of Rab GTPase Sec4p, forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro77p and Drosophila lgl tumor suppressor
YAR030C	YAR030C	1.134	NA	NA	0.986	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9
YOR198C	BFR1	1.134	5	NA	0.941	Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity
YDR392W	SPT3	1.131	23	48	0.755	Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
YOL051W	GAL11	1.13	29	16	0.616	Component of the Mediator complex; interacts with RNA polymerase II and the general transcription factors to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YLR148W	PEP3	1.13	11	5	0.545	Vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis, forms complex with Pep5p that mediates protein transport to the vacuole
YLR047C	FRE8	1.129	NA	NA	0.959	Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p
YMR244W	YMR244W	1.127	NA	NA	1.01	Putative protein of unknown function
YML095C-A	YML095C-A	NA	NA	NA	NA	NA
YMR067C	UBX4	1.124	3	1	0.977	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
YMR190C	SGS1	1.122	2	43	0.883	Nucleolar DNA helicase of the RecQ family involved in maintenance of genome integrity, regulates chromosome synapsis and meiotic crossing over; has similarity to human BLM and WRN helicases implicated in Bloom and Werner syndromes
YJR043C	POL32	1.121	5	45	0.975	Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p
YLL006W	MMM1	1.121	NA	9	1.018	Mitochondrial outer membrane protein required for normal mitochondrial morphology and mtDNA stability; involved in tethering mitochondria to the actin cytoskeleton and in anchoring mtDNA nucleoids
YLR311C	YLR311C	1.118	NA	NA	0.94	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKR101W	SIR1	1.118	2	NA	0.958	Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin
YPR060C	ARO7	1.118	NA	NA	0.985	Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis
YFL001W	DEG1	1.116	NA	2	1.034	Non-essential tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm
YDR069C	DOA4	1.115	11	5	1.01	Ubiquitin hydrolase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
YGR272C	YGR272C	1.114	4	NA	0.403	Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YGL038C	OCH1	1.113	NA	4	0.777	Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins
YLR240W	VPS34	1.111	3	11	0.953	Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p
YDR252W	BTT1	1.111	3	NA	0.998	Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex (alpha, beta1, beta3) which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides
YBR298C	MAL31	1.111	NA	1	1.001	Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C
YPL069C	BTS1	1.11	NA	9	0.978	Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic
YAR020C	PAU7	1.11	NA	NA	0.986	Part of 23-member seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme
YLR146C	SPE4	1.109	1	NA	0.939	Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid
YDR204W	COQ4	1.108	NA	NA	0.983	Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
YOL122C	SMF1	1.107	NA	1	0.976	Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
YNR019W	ARE2	1.106	1	1	1.022	Acyl-CoA:sterol acyltransferase, isozyme of Are1p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen
YML013W	SEL1	1.106	6	2	0.916	Protein involved in ER-associated protein degradation; proposed to coordinate the assembly of proteins involved in ERAD; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain
YBL100C	YBL100C	1.105	NA	NA	0.769	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1
YPL132W	COX11	1.102	NA	2	1.005	Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
YCR045C	YCR045C	1.1	NA	NA	0.96	Putative protein of unknown function
YOL003C	PFA4	1.098	NA	2	0.996	Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
YKL002W	DID4	1.098	NA	NA	0.878	Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis
YNL003C	PET8	1.097	NA	2	1.009	S-adenosylmethionine transporter of the mitochondrial inner membrane, member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth
YNL307C	MCK1	1.097	11	13	0.971	Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family
YPR098C	YPR098C	1.095	NA	NA	0.983	Protein of unknown function, localized to the mitochondrial outer membrane
YMR256C	COX7	1.094	NA	NA	0.931	Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YIL141W	YIL141W	1.094	NA	NA	1.036	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR065W	CYT1	1.094	1	3	1.026	Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YLR285W	NNT1	1.091	NA	NA	1.002	Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determination
YKL140W	TGL1	1.09	1	NA	1.085	Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
YDL059C	RAD59	1.089	29	4	0.981	Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52p
YBR229C	ROT2	1.088	2	14	1.077	Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
YCR033W	SNT1	1.087	9	14	0.963	Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein
YHR127W	YHR127W	1.084	3	NA	1.023	Protein of unknown function; localizes to the nucleus
YOR127W	RGA1	1.082	5	6	0.978	GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth
YNL229C	URE2	1.082	5	2	0.795	Nitrogen catabolite repression regulator that acts by inhibition of GLN3 transcription in good nitrogen source; altered form of Ure2p creates [URE3] prion
YKL065C	YET1	1.081	NA	NA	0.99	Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YJR135C	MCM22	1.08	14	19	1.023	Protein involved in minichromosome maintenance; component of the kinetochore; binds to centromeric DNA in a Ctf19p-dependent manner
YLR287C	YLR287C	1.079	3	3	0.989	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene
YMR225C	MRPL44	1.076	2	NA	1.033	Mitochondrial ribosomal protein of the large subunit
YPL165C	SET6	1.076	NA	3	1.022	Protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability
YDR375C	BCS1	1.074	NA	NA	1.017	Protein of the mitochondrial inner membrane that functions as an ATP-dependent chaperone, required for the assembly of the cytochrome bc(1) complex from the Rip1p and Qcr10p proteins; member of the CDC48/PAS1/SEC18 ATPase family
YMR022W	QRI8	1.074	6	3	1.028	Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
YDR459C	PFA5	1.074	NA	NA	1.027	Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
YBL031W	SHE1	1.073	NA	1	0.985	Cytoskeletal protein of unknown function; overexpression causes growth arrest
YPR200C	ARR2	1.072	NA	NA	0.994	Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p
YKR024C	DBP7	1.071	19	3	0.602	Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
YEL030W	ECM10	1.071	25	NA	0.993	Heat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations
YGL003C	CDH1	1.07	8	14	0.887	Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including CDC20, ASE1, CIN8 and FIN1
YDR455C	YDR455C	1.069	NA	NA	0.991	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
YKL170W	MRPL38	1.069	3	NA	0.925	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels
YKL101W	HSL1	1.068	5	10	1.05	Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
YNL219C	ALG9	1.067	NA	2	1.019	Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
YPL239W	YAR1	1.067	1	1	0.714	Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
YGL251C	HFM1	1.067	3	NA	1.002	Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity
YMR241W	YHM2	1.066	4	NA	0.942	Mitochondrial DNA-binding protein, component of the mitochondrial nucleoid structure, involved in mtDNA replication and segregation of mitochondrial genomes; member of the mitochondrial carrier protein family
YLR329W	REC102	1.065	NA	1	1.01	Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination
YPL183W-A	YPL183W-A	1.064	2	1	1.027	Homolog of the prokaryotic ribosomal protein L36, likely to be a mitochondrial ribosomal protein coded in the nuclear genome
YCR027C	RHB1	1.062	NA	NA	0.933	Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins
YHR193C	EGD2	1.062	19	NA	NA	Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
YOL014W	YOL014W	1.062	NA	1	1.023	Putative protein of unknown function
YNL077W	APJ1	1.061	NA	NA	0.977	Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHL031C	GOS1	1.06	NA	9	0.892	v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28
YNL205C	YNL205C	1.059	NA	NA	1.037	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR048W	CYC1	1.059	NA	NA	1.005	Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YPL261C	YPL261C	1.056	NA	NA	1.051	Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W
YDR443C	SSN2	1.056	25	3	0.922	Protein required for stable association of Srb10p-Srb11p kinase with RNA polymerase holoenzyme; subunit of the RNA polymerase II mediator complex; essential for transcriptional regulation
YIL121W	QDR2	1.056	1	3	0.978	Multidrug transporter required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake; member of the major facilitator superfamily of transporters conferring multiple drug resistance (MFS-MDR)
YOR167C	RPS28A	1.055	NA	NA	0.946	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Bp and has similarity to rat S28 ribosomal protein
YJR025C	BNA1	1.054	1	1	1.038	3-hydroxyanthranilic acid dioxygenase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway
YDR024W	YDR024W	1.053	NA	NA	0.757	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin
YPR044C	YPR044C	1.052	NA	NA	0.795	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO
YHL025W	SNF6	1.052	14	NA	NA	Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p
YJL191W	RPS14B	1.051	25	1	0.991	Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Ap and similar to E. coli S11 and rat S14 ribosomal proteins
YLR266C	PDR8	1.051	NA	NA	1.002	Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon
YNR052C	POP2	1.05	13	72	0.74	RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation
YLR023C	IZH3	1.049	1	NA	1.002	Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
YLR065C	YLR065C	1.048	NA	2	1.018	Putative protein of unknown function; YLR065C is not an essential gene
YBR094W	YBR094W	1.047	5	19	0.973	Putative tubulin tyrosine ligase associated with P-bodies
YOL056W	GPM3	1.047	NA	NA	1.053	Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
YDL005C	MED2	1.045	29	9	NA	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YFR020W	YFR020W	1.045	NA	NA	0.955	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR185C	MBA1	1.045	2	NA	1.02	Protein involved in assembly of mitochondrial respiratory complexes; may act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane
YGR273C	YGR273C	1.044	NA	NA	1.034	Putative protein of unknown function; deletion mutant has no readily detectable phenotype
YOR349W	CIN1	1.044	4	46	0.983	Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
YBR116C	YBR116C	1.044	NA	NA	NA	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
YDR020C	YDR020C	1.041	NA	NA	0.968	Predicted protein shares weak similarity with uridine kinases and with phosphoribokinases; null exhibits no apparent phenotype
YLR374C	YLR374C	1.041	NA	NA	0.891	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W
YDL160C	DHH1	1.041	22	8	0.661	Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation
YLR320W	MMS22	1.041	18	32	0.793	Protein involved in resistance to ionizing radiation; acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks
YLR169W	YLR169W	1.04	NA	NA	0.969	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL315C	ATP11	1.039	2	NA	0.995	Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase
YML052W	SUR7	1.038	1	NA	1.044	Putative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
YOL091W	SPO21	1.037	NA	1	1.01	Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
YBR170C	NPL4	1.037	8	3	NA	Endoplasmic reticulum and nuclear membrane protein, forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation
YCL047C	YCL047C	1.037	1	NA	0.988	Putative protein of unknown function
YDR503C	LPP1	1.036	NA	NA	1.029	Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA
YJL060W	BNA3	1.036	1	1	0.993	Arylformamidase, involved in biosynthesis of nicotinic acid from tryptophan via kynurenine pathway; potential Cdc28p substrate
YDR123C	INO2	1.036	1	1	1.038	Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion
YHR100C	YHR100C	1.035	NA	NA	0.686	Putative protein of unknown function, required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR062C	YOR062C	1.034	NA	NA	0.997	Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YBR127C	VMA2	1.034	28	11	0.695	Subunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm
YOR025W	HST3	1.033	NA	12	0.971	Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
YNR020C	YNR020C	1.032	NA	1	0.643	Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex
YIL008W	URM1	1.032	NA	5	0.845	Ubiquitin-like protein with only weak sequence similarity to ubiquitin; depends on the E1-like activating enzyme Uba4p; molecular function of the Urm1p pathway is unknown, but it is required for normal growth, particularly at high temperature
YLR193C	UPS1	1.03	NA	NA	0.922	Mitochondrial intermembrane space protein that regulates alternative processing and sorting of Mgm1p and other proteins; required for normal mitochondrial morphology; ortholog of human PRELI
YDR493W	FMP36	1.03	NA	NA	1.04	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YCL056C	YCL056C	1.03	NA	1	1.023	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YML102C-A	YML102C-A	NA	NA	NA	NA	NA
YPL161C	BEM4	1.027	3	21	0.831	Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length
YHL033C	RPL8A	1.025	70	NA	0.9	Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YKL121W	YKL121W	1.025	NA	NA	1.055	Putative protein of unknown function
YBR021W	FUR4	1.025	NA	1	0.933	Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues
YBR099C	YBR099C	1.024	NA	NA	0.962	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
YOR264W	DSE3	1.024	NA	6	1.024	Daughter cell-specific protein, may help establish daughter fate
YHL012W	YHL012W	1.024	NA	NA	0.974	Putative protein of unknown function, has some homology to Ugp1p, which encodes UDP-glucose pyrophosphorylase
YJL101C	GSH1	1.024	5	3	0.704	Gamma glutamylcysteine synthetase, catalyzes the first step in the gamma-glutamyl cycle for glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury
YHR158C	KEL1	1.024	14	NA	0.991	Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate
YOR196C	LIP5	1.023	5	NA	0.946	Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase
YKL164C	PIR1	1.023	1	1	1.13	O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YLR120C	YPS1	1.023	NA	2	1.031	Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YAL020C	ATS1	1.022	1	1	0.9	Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle
YCR047C	BUD23	1.022	2	NA	0.659	Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YOR038C	HIR2	1.022	6	9	0.824	Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3, and H4 genes; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p
YLR244C	MAP1	1.021	1	1	0.811	Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p
YCR016W	YCR016W	1.021	8	NA	0.988	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; YCR016W is not an essential gene
YMR194W	RPL36A	1.02	83	NA	0.921	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA
YCL022C	YCL022C	1.02	NA	NA	1.005	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W
YHL013C	OTU2	1.019	NA	NA	0.928	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization
YGR222W	PET54	1.019	NA	NA	0.914	Protein required for splicing of the COX1 intron AI5 beta; also specifically required, together with Pet122p and Pet494p, for translation of the COX3 mRNA; located in the mitochondrial inner membrane
YKL053W	YKL053W	1.019	NA	NA	1.057	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1
YGL212W	VAM7	1.018	NA	5	0.861	Component of the vacuole SNARE complex involved in vacuolar morphogenesis; SNAP-25 homolog; functions with a syntaxin homolog Vam3p in vacuolar protein trafficking
YOR321W	PMT3	1.016	NA	1	1.041	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; target for new antifungals
YKR016W	FMP13	1.015	NA	NA	1.045	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR152C	RSR1	1.014	NA	1	1.063	GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
YJR060W	CBF1	1.014	3	15	0.766	Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA
YLL009C	COX17	1.013	NA	NA	0.874	Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase
YOL121C	RPS19A	1.012	3	1	0.804	Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Bp
YNL079C	TPM1	1.012	3	13	0.949	Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently
YLR218C	YLR218C	1.012	5	1	0.925	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR218C is not essential; mutants exhibit glycogen storage defects and growth defects on a non-fermentable carbon source
YER059W	PCL6	1.012	1	1	0.982	Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding
YDR226W	ADK1	1.011	8	NA	0.619	Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence
YDR174W	HMO1	1.01	72	3	0.51	Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
YLR181C	VTA1	1.009	2	NA	1.02	Multivesicular body (MVB) protein involved in endosomal protein sorting; binds to Vps20p and Vps4p; may regulate Vps4p function; bindsVps60p and may act at a late step in MVB formation; mutants show class E vacuolar-protein sorting defects
YLR414C	YLR414C	1.008	NA	NA	1.049	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the bud and cytoplasm; Hog1p is required for transcriptional induction in response to cell wall damage; YLR414C is not an essential gene
YBR276C	PPS1	1.007	1	NA	1.016	Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle
YML024W	RPS17A	1.007	28	19	0.67	Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Bp and has similarity to rat S17 ribosomal protein
YLR025W	SNF7	1.006	2	3	0.721	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
YDR485C	VPS72	1.006	13	70	0.954	Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
YLR406C	RPL31B	1.006	11	NA	0.954	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YHR018C	ARG4	1.003	2	NA	1	Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway
YER056C	FCY2	1.003	NA	NA	0.961	Purine-cytosine permease, mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation
YGL217C	YGL217C	1.003	NA	NA	1.044	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W
YIL011W	TIR3	1.003	NA	NA	1.004	Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
YGR268C	HUA1	1.002	NA	NA	0.976	Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
YKR097W	PCK1	1.002	NA	NA	1	Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YGR078C	PAC10	1.001	7	156	0.865	Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
YBR025C	YBR025C	1.001	21	NA	0.922	P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein levels are induced by hydrogen peroxide
YLR334C	YLR334C	1	NA	NA	1.029	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here
YLR061W	RPL22A	1	3	1	0.735	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein
YCL033C	YCL033C	1	NA	NA	0.998	Putative protein-methionine-R-oxide reductase; involved in response to oxidative stress; similar to mouse Sepx1p and fly SelRp; YCL033C is not an essential gene
YMR074C	YMR074C	0.9992	2	NA	1.014	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR074C is not an essential gene
YMR092C	AIP1	0.9985	1	3	0.984	Actin cortical patch component, interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats
YLR085C	ARP6	0.9969	18	98	0.846	Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
YOR331C	YOR331C	0.996	NA	NA	1.035	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W
YKL138C	MRPL31	0.996	1	NA	0.889	Mitochondrial ribosomal protein of the large subunit
YCR053W	THR4	0.9958	8	3	1.083	Threonine synthase, conserved protein that catalyzes formation of threonine from 0-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
YNL302C	RPS19B	0.9956	18	1	0.762	Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Ap
YIR023W	DAL81	0.9947	1	NA	NA	Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
YMR024W	MRPL3	0.9929	32	NA	0.874	Mitochondrial ribosomal protein of the large subunit
YGR010W	NMA2	0.9929	1	NA	1.03	Nicotinic acid mononucleotide adenylyltransferase, involved in NAD(+) salvage pathway
YJR033C	RAV1	0.9925	5	3	0.99	Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
YLR345W	YLR345W	0.9923	6	NA	0.992	Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene
YOL002C	IZH2	0.9922	NA	NA	1.037	Plasma membrane protein involved in zinc metabolism and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
YNR010W	CSE2	0.9921	29	12	0.896	Component of the Med9/10 module, which is a subcomplex within the RNA polymerase II Mediator complex; required for regulation of RNA polymerase II activity
YDR512C	EMI1	0.9904	NA	2	0.951	Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation
YGR132C	PHB1	0.9903	9	4	0.943	Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
YJL193W	YJL193W	0.9902	NA	NA	1.024	Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
YBR008C	FLR1	0.9893	NA	NA	0.97	Plasma membrane multidrug transporter, member of the major facilitator superfamily; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs
YLR072W	YLR072W	0.9887	4	NA	0.981	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene
YDL071C	YDL071C	0.9881	NA	NA	0.969	Hypothetical protein
YBL032W	HEK2	0.9879	31	NA	1.009	RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length
YDR254W	CHL4	0.9871	16	19	0.968	Outer kinetochore protein required for chromosome stability, interacts with kinetochore proteins Ctf19p, Ctf3p, and Iml3p; exhibits a two-hybrid interaction with Mif2p; association with CEN DNA requires Ctf19p
YJL071W	ARG2	0.9864	NA	NA	0.665	Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p
YDR529C	QCR7	0.986	1	NA	0.952	Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly
YPR045C	MNI2	0.9857	9	5	0.867	Deletion mutant is synthetically lethal with MEN mutants
YJL062W	LAS21	0.9847	NA	22	0.996	Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity
YGL127C	SOH1	0.9829	23	29	0.694	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits
YLR372W	SUR4	0.9818	NA	5	0.806	Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
YOR293W	RPS10A	0.9813	6	1	0.688	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10
YDR316W	OMS1	0.9808	5	NA	0.988	Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations
YKL174C	TPO5	0.9807	NA	NA	1.07	Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles
YLR423C	ATG17	0.98	9	1	0.941	Scaffold potein responsible for pre-autophagosomal structure organization; interacts with and is required for activation of Apg1p protein kinase; involved in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway
YNL246W	VPS75	0.9793	8	NA	0.866	NAP family histone chaperone; binds to histone H3-H4 tetramers and to histone acetyltransferase RTT109; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting
YDR461W	MFA1	0.9791	NA	NA	1.022	Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2
YJR153W	PGU1	0.9782	1	NA	1.06	Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
YJR010W	MET3	0.9779	NA	1	1.047	ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
YLR018C	POM34	0.9767	NA	12	0.971	Integral membrane protein of the nuclear pore; has an important role in maintaining the architecture of the pore complex
YJL007C	YJL007C	0.9765	NA	NA	1.015	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR195C	MSI1	0.9764	6	3	0.971	Subunit of chromatin assembly factor I (CAF-1), regulates the RAS/cAMP pathway via sequestration of Npr1p kinase; localizes to the nucleus and cytoplasm; homologous to human retinoblastoma binding proteins RbAp48 and RbAp46
YOR339C	UBC11	0.9759	NA	NA	1.058	Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2
YDR348C	YDR348C	0.9756	3	NA	0.958	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud neck; potential Cdc28p substrate
YMR016C	SOK2	0.9752	4	1	0.927	Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors
YMR276W	DSK2	0.975	5	NA	0.991	Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome
YMR125W	STO1	0.975	63	18	0.482	Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80
YJR108W	ABM1	0.9748	NA	NA	0.989	Protein of unknown function, required for normal microtubule organization
YPR073C	LTP1	0.9748	1	NA	1.02	Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine
YER139C	YER139C	0.9733	7	4	0.971	Putative protein of unknown function; YER139C has been shown to be required for growth at high temperatures; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YML100W-A	YML100W-A	0.9732	NA	NA	NA	Putative protein of unknown function
YHR095W	YHR095W	0.9727	NA	NA	1.001	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR092W	YPR092W	0.9721	NA	NA	1.012	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL042C	SIR2	0.9717	10	NA	0.938	Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan;  plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication
YMR216C	SKY1	0.9713	NA	5	0.86	SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1
YLR032W	RAD5	0.9708	2	10	0.935	Single-stranded DNA-dependent ATPase, involved in postreplication repair; contains RING finger domain
YDR260C	SWM1	0.9706	21	8	0.867	Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
YJR026W	YJR026W	NA	NA	NA	NA	NA
YCR037C	PHO87	0.9694	NA	1	NA	Low-affinity inorganic phosphate (Pi) transporter, involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments
YOL004W	SIN3	0.9681	38	25	0.717	Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity
YOL053W	YOL053W	0.9679	NA	NA	1.057	Putative protein of unknown function; YOL053W is not an essential gene
YLR391W	YLR391W	NA	NA	NA	NA	NA
YPL061W	ALD6	0.9677	12	NA	0.864	Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
YBR220C	YBR220C	0.9676	NA	NA	0.993	Putative protein of unknown function; YBR220C is not an essential gene
YDR380W	ARO10	0.9672	NA	NA	1.049	Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway
YPR100W	MRPL51	0.967	5	1	0.789	Mitochondrial ribosomal protein of the large subunit
YOR058C	ASE1	0.966	7	31	1.017	Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate
YMR031C	YMR031C	0.9651	14	NA	1.045	Putative protein of unknown function with similarity to YKL050C and USO1/YDL058W; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YMR031C is not an essential gene
YLR287C-A	RPS30A	0.965	48	1	0.824	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Bp and has similarity to rat S30 ribosomal protein
YMR172W	HOT1	0.9646	5	2	1.027	Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p
YIL017C	VID28	0.9641	7	2	0.946	Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm
YCR015C	YCR015C	0.964	1	NA	0.989	Putative protein of unknown function; YCR015C is not an essential gene
YFL025C	BST1	0.9638	NA	3	0.97	GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
YPL234C	TFP3	0.963	1	5	0.976	Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen
YNL336W	COS1	0.9623	NA	NA	1.072	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YIL087C	YIL087C	0.9621	NA	NA	0.998	Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR251W	PAM1	0.9619	2	NA	0.995	Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype
YNR074C	AIF1	0.9603	NA	NA	0.99	Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase
YJL164C	TPK1	0.9601	9	3	0.985	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p
YPR139C	VPS66	0.96	NA	NA	0.856	Cytoplasmic protein of unknown function involved in vacuolar protein sorting.
YDL232W	OST4	0.9592	NA	2	0.934	Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes protein asparagine-linked glycosylation; type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex
YBR278W	DPB3	0.9592	8	2	0.944	Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycle
YAR047C	YAR047C	0.9575	NA	NA	0.985	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR140W	SIP5	0.9561	5	NA	1.024	Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase
YOL089C	HAL9	0.9551	NA	NA	0.969	Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression
YPR122W	AXL1	0.9549	1	NA	1.039	Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells
YCL008C	STP22	0.9546	3	1	0.89	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
YLR268W	SEC22	0.9544	6	38	0.978	R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
YMR297W	PRC1	0.9538	5	NA	1.089	Vacuolar carboxypeptidase Y (proteinase C), involved in protein degradation in the vacuole and required for full protein degradation during sporulation
YJR053W	BFA1	0.9538	5	20	1.036	Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis
YPR068C	HOS1	0.9538	NA	NA	1.004	Putative class I histone deacetylase (HDAC) with sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; deletion results in increased histone acetylation at rDNA repeats; interacts with the Tup1p-Ssn6p corepressor complex
YDL101C	DUN1	0.9524	23	9	NA	Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair
YJL189W	RPL39	0.9519	1	NA	0.585	Protein component of the large (60S) ribosomal subunit, has similarity to rat L39 ribosomal protein; required for ribosome biogenesis; exhibits genetic interactions with SIS1 and PAB1
YLR087C	CSF1	0.9515	1	16	0.983	Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR113W	HOG1	0.9514	4	25	0.876	Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p
YGR182C	YGR182C	0.9512	NA	NA	0.998	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W
YLR384C	IKI3	0.9504	11	31	0.854	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
YHR178W	STB5	0.95	NA	11	0.987	Activator of multidrug resistance genes, forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a PDRE (pleotropic drug resistance element) in vitro; binds Sin3p in a two-hybrid assay
YLR367W	RPS22B	0.9491	39	NA	0.952	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins
YMR087W	YMR087W	0.9491	NA	NA	1.004	Putative ADP-ribose-1'"'-monophosphatase that converts ADP-ribose-1'"'-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain
YOR360C	PDE2	0.9491	3	5	1.041	High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon
YNL259C	ATX1	0.9485	NA	1	1.017	Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
YPR201W	ARR3	0.9485	NA	NA	NA	Arsenite transporter of the plasma membrane, required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite
YMR135C	GID8	0.9482	10	NA	1.015	Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YPR047W	MSF1	0.9476	3	NA	0.571	Mitochondrial phenylalanyl-tRNA synthetase alpha subunit, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase
YPL004C	LSP1	0.9476	45	NA	0.992	Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways
YCR036W	RBK1	0.9473	NA	NA	0.978	Putative ribokinase
YMR185W	YMR185W	0.9468	NA	NA	1.067	Putative protein of unknown function; essential gene required for viability
YNL121C	TOM70	0.9467	1	3	1.015	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
YAR037W	YAR037W	NA	NA	NA	NA	NA
YNL233W	BNI4	0.9459	2	23	1.048	Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p
YDL136W	RPL35B	0.9458	67	NA	0.812	Protein component of the large (60S) ribosomal subunit, identical to Rpl35Ap and has similarity to rat L35 ribosomal protein
YJL137C	GLG2	0.9457	3	NA	1.003	Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin
YJR139C	HOM6	0.9455	2	2	0.977	Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
YML081W	YML081W	0.9451	NA	NA	0.948	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene
YJR014W	TMA22	0.9446	5	NA	0.945	Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; has homology to human protein DRP1, which interacts with human Tma20p homolog MCT-1
YCR079W	AUP1	0.9438	15	NA	0.983	Phosphoprotein phosphatase type 2C similar to mammalian PP1Ks; involved in mitophagy; localized to mitochondrial inner membrane space; null mutant is sensitive to rapamycin
YDL113C	ATG20	0.9433	2	NA	0.611	Protein required for transport of aminopeptidase I (Lap4p) through the cytoplasm-to-vacuole targeting pathway; binds phosphatidylinositol-3-phosphate, involved in localization of membranes to the preautophagosome, potential Cdc28p substrate
YDR239C	YDR239C	0.9432	2	NA	1.018	Protein of unknown function that may interact with ribosomes, based on co-purification experiments
YER056C-A	RPL34A	0.9428	2	1	0.799	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein
YNL338W	YNL338W	0.9427	NA	NA	1.062	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
YLL018C-A	COX19	0.9427	NA	NA	NA	Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase
YAL022C	FUN26	0.9426	NA	NA	0.993	Nucleoside transporter with broad nucleoside selectivity; localized to intracellular membranes
YCR024C	SLM5	0.9425	2	3	0.863	Mitochondrial asparaginyl-tRNA synthetase
YLR330W	CHS5	0.9423	16	77	0.913	Protein involved in export from the Golgi to plasma membrane; involved in chitin biosynthesis through its role in Chs3p localization; interacts with Arf1p, Bch1p, Fmp50p, Bud7p, and Chs6p
YCR009C	RVS161	0.9417	32	53	0.96	Amphiphysin-like lipid raft protein; subunit of a complex (Rvs161p-Rvs167p) that regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress
YMR041C	YMR041C	0.9415	1	NA	1.04	NAD-dependent arabinose dehydrogenase, involved in biosynthesis of erythroascorbic acid; similar to plant L-galactose dehydrogenase
YAL067C	SEO1	0.9406	1	NA	0.971	Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YNL085W	MKT1	0.9398	26	NA	1.025	Protein that forms a complex with Pbp1p that may mediate posttranscriptional regulation of HO endonuclease; involved in propagation of M2 dsRNA satellite of L-A virus
YDR363W-A	SEM1	0.9383	37	24	0.885	Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1
YFL036W	RPO41	0.9383	NA	9	0.832	Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition
YGR012W	YGR012W	0.9381	2	NA	0.999	Putative cysteine synthase, localized to the mitochondrial outer membrane
YEL042W	GDA1	0.938	1	1	0.975	Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
YER110C	KAP123	0.9365	58	2	0.818	Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1
YGL077C	HNM1	0.9359	1	1	1.075	Choline transporter (permease) that also controls the uptake of nitrogen mustard; expression is co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
YDR253C	MET32	0.9355	NA	NA	1.005	Zinc-finger DNA-binding protein, involved in regulating expression of the methionine biosynthetic genes, similar to Met31p
YPR053C	YPR053C	0.9355	NA	NA	0.944	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C
YFR034C	PHO4	0.9351	125	NA	1.001	Basic helix-loop-helix (bHLH) transcription factor; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability
YJL198W	PHO90	0.9348	NA	1	1.035	Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YER182W	FMP10	0.9343	1	NA	1.006	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR301W	RAX1	0.933	NA	NA	0.999	Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
YGR025W	YGR025W	0.9328	NA	NA	1.065	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL115C	BEM3	0.9328	6	3	1.018	Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
YOL037C	YOL037C	0.9327	NA	NA	1.033	Hypothetical protein
YGL015C	YGL015C	0.9322	NA	1	1.06	Hypothetical protein
YKR094C	RPL40B	0.9317	NA	1	0.882	Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YBL024W	NCL1	0.9315	7	5	0.778	S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120
YJL166W	QCR8	0.9315	NA	1	0.933	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
YBR005W	RCR1	0.9311	NA	NA	0.964	Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane
YPL144W	YPL144W	0.9311	6	4	0.767	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutant is viable, exhibits shortened telomeres
YHL003C	LAG1	0.9308	NA	1	0.956	Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
YPL022W	RAD1	0.9307	30	7	0.993	Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein
YLR417W	VPS36	0.9306	1	4	0.729	Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
YJR149W	YJR149W	0.9294	NA	NA	1.04	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YKL159C	RCN1	0.9288	2	NA	1.115	Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region
YOR263C	YOR263C	0.9285	NA	NA	1.03	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W
YDL067C	COX9	0.9283	3	1	NA	Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YNL128W	TEP1	0.9278	3	NA	1.02	Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway; plays a role in normal sporulation
YLR315W	NKP2	0.9271	11	4	0.914	Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p)
YGL031C	RPL24A	0.9269	42	3	0.965	Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YDR017C	KCS1	0.9266	7	4	0.944	Inositol hexakisphosphate (IP6) kinase, also has inositol heptakisphosphate (IP7) kinase activity, required for proper vacuole morphology and involved in salt stress response; contains two leucine heptad repeats
YBR277C	YBR277C	0.9266	NA	NA	0.951	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W
YOR292C	YOR292C	0.9265	NA	NA	1.008	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene
YLR006C	SSK1	0.9264	5	2	0.921	Cytoplasmic response regulator, part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate
YHR026W	PPA1	0.9245	1	3	0.707	Subunit c'"' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain
YNL192W	CHS1	0.9243	4	61	0.925	Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor
YLR371W	ROM2	0.9231	14	13	0.868	GDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEP
YIL065C	FIS1	0.9216	2	1	0.772	Mitochondrial outer membrane protein involved in membrane fission, required for localization of Dnm1p and Mdv1p during mitochondrial division
YDR360W	YDR360W	0.9215	NA	NA	0.937	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C.
YDR335W	MSN5	0.9214	16	11	0.949	Karyopherin involved in nuclear import and export; shown to be responsible for nuclear import of replication protein A and for export of several proteins including Swi6p, Far1p, and Pho4p; cargo dissociation involves binding to RanGTP
YKR003W	OSH6	0.9203	2	NA	1.098	Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery
YLR445W	YLR445W	0.9202	NA	NA	0.938	Hypothetical protein
YER149C	PEA2	0.9198	1	12	1.018	Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth
YPL108W	YPL108W	0.9192	NA	NA	1.03	Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YLR365W	YLR365W	0.9191	NA	NA	1.034	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
YKL027W	YKL027W	0.9191	1	NA	1.008	Protein of unknown function, localized to the mitochondrial outer membrane
YBR297W	MAL33	0.9189	NA	1	0.995	MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C
YJL053W	PEP8	0.9186	4	3	0.934	Vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport
YMR173W-A	YMR173W-A	0.9185	NA	NA	1.008	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W
YOR172W	YRM1	0.9184	2	NA	1.02	Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes
YAL023C	PMT2	0.9183	2	7	0.973	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt1p, can instead interact with Pmt5p in some conditions; target for new antifungals
YJR044C	VPS55	0.9182	NA	NA	0.948	Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)
YHL039W	YHL039W	0.9178	2	NA	1.043	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YPL250C	ICY2	0.9177	NA	NA	1.041	Protein of unknown function; potential Cdc28p substrate
YBL015W	ACH1	0.9164	4	NA	0.981	Acetyl-coA hydrolase, primarily localized to mitochondria; required for acetate utilization and for diploid pseudohyphal growth
YDL069C	CBS1	0.9161	2	1	0.893	Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
YIL016W	SNL1	0.9161	1	NA	1.004	Protein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein
YLR207W	HRD3	0.9152	3	NA	1.009	Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events
YOR243C	PUS7	0.9152	10	1	0.995	Pseudouridine synthase, catalyzes pseudouridylation at position 35 in U2 snRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); Asp(256) mutation abolishes activity; conserved in archaea, some bacteria, and vertebrates
YNL248C	RPA49	0.9148	28	24	0.691	RNA polymerase I subunit A49
YJL099W	CHS6	0.9139	7	26	0.961	Member of the Chs5p-Arf1p-binding proteins (ChAPs), a group of 4 related, interacting proteins (Bch1p, Fmp50p, Bud7p, Chs6p) that mediate export of specific cargo proteins, including chitin synthase Chs3p, from the Golgi to plasma membrane
YLL043W	FPS1	0.9139	NA	10	0.855	Plasma membrane glycerol channel, member of the major intrinsic protein (MIP) family of channel proteins; involved in efflux of glycerol and in uptake of the trivalent metalloids arsenite and antimonite
YCR063W	BUD31	0.9134	25	NA	0.851	Protein involved in bud-site selection; analysis of integrated high-throughput datasets predicts an involvement in RNA splicing; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YGR027C	RPS25A	0.9128	11	NA	0.963	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein
YPL230W	YPL230W	0.9124	NA	NA	0.948	Putative protein of unknown function
YCL055W	KAR4	0.9121	NA	1	0.976	Transcription factor required for gene regulation in repsonse to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone
YLR170C	APS1	0.912	10	NA	0.979	Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
YOR359W	VTS1	0.9115	1	NA	0.926	Post-transcriptional gene regulator, RNA-binding protein containing a SAM domain; shows genetic interactions with Vti1p, which is a v-SNARE involved in cis-Golgi membrane traffic
YHR015W	MIP6	0.9108	1	NA	0.985	Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export
YLR053C	YLR053C	0.9106	NA	NA	0.969	Putative protein of unknown function
YLR349W	YLR349W	0.9105	NA	NA	0.998	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
YHR198C	FMP22	0.9104	1	NA	1.007	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL007W	CAP1	0.9099	16	12	0.954	Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches
YAR029W	YAR029W	0.9098	NA	NA	0.861	Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YNL214W	PEX17	0.9096	2	NA	1.045	Peroxisomal membrane protein component of the peroxisomal translocation machinery, required for peroxisome biogenesis, binds Pex14p
YDR275W	BSC2	0.9096	1	NA	1.015	Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YEL039C	CYC7	0.9093	1	1	1.007	Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YDL083C	RPS16B	0.9091	77	1	0.753	Protein component of the small (40S) ribosomal subunit; identical to Rps16Ap and has similarity to E. coli S9 and rat S16 ribosomal proteins
YDR125C	ECM18	0.9087	NA	NA	0.989	Protein of unknown function, similar to Rlp24p
YBR126C	TPS1	0.9083	34	3	0.962	Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway
YBL007C	SLA1	0.908	20	26	0.882	Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; contains 3 SH3 domains; interacts with proteins regulating actin dynamics and with proteins required for endocytosis
YMR007W	YMR007W	0.9072	NA	NA	1.041	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL062W	YBL062W	0.9071	NA	NA	0.972	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCR071C	IMG2	0.9069	29	1	0.974	Mitochondrial ribosomal protein of the small subunit
YLR273C	PIG1	0.9065	1	NA	1.012	Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase
YOL063C	CRT10	0.9064	2	NA	1.011	Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat
YPL213W	LEA1	0.9064	53	5	0.295	Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; invovled in telomere maintenance; putative homolog of human U2A' snRNP protein
YNR041C	COQ2	0.9059	NA	2	0.77	Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
YLR151C	PCD1	0.9057	NA	NA	1	Peroxisomal nudix pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids
YMR055C	BUB2	0.9053	1	25	0.997	Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage
YMR282C	AEP2	0.9051	2	2	0.877	Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
YCR031C	RPS14A	0.9049	81	3	0.868	Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
YJL158C	CIS3	0.9047	NA	3	1.043	Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YFL012W	YFL012W	0.9043	NA	NA	NA	Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin
YOR253W	NAT5	0.9038	4	NA	1.017	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YMR255W	GFD1	0.9033	3	NA	0.751	Coiled-coiled protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation
YGL246C	RAI1	0.9032	39	3	0.546	Nuclear protein that binds to and stabilizes the exoribonuclease Rat1p, required for pre-rRNA processing
YML102W	CAC2	0.9023	4	2	0.984	Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans
YOR192C	THI72	0.902	1	NA	1.052	Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YNL197C	WHI3	0.9016	1	NA	0.858	RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start
YKR006C	MRPL13	0.9011	24	NA	0.786	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
YIR026C	YVH1	0.9009	1	NA	0.618	Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; transcription induced by low temperature and nitrogen starvation; member of the dual-specificity family of protein phosphatases
YMR038C	CCS1	0.9008	2	37	NA	Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation
YHR005C	GPA1	0.9007	2	2	1.049	GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome
YAL035W	FUN12	0.8981	53	NA	0.988	GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2
YML062C	MFT1	0.8975	20	6	0.942	Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
YHR016C	YSC84	0.8972	3	1	NA	Protein involved in the organization of the actin cytoskeleton; contains SH3 domain similar to Rvs167p
YBL008W	HIR1	0.8962	6	16	0.946	Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3 and H4 genes; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores
YOR333C	YOR333C	0.8956	NA	NA	0.947	Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth
YJL218W	YJL218W	0.8955	NA	NA	1.054	Putative protein of unknown function, similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
YBL003C	HTA2	0.8954	115	NA	0.986	One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YDR525W	YDR525W	0.8953	NA	NA	0.964	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology
YIR005W	IST3	0.8952	16	2	0.833	Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing
YML110C	COQ5	0.8951	NA	NA	1.036	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; located in mitochondria
YLR136C	TIS11	0.8951	1	NA	0.998	mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis
YJR113C	RSM7	0.8946	31	NA	0.674	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein
YMR275C	BUL1	0.8939	3	1	0.829	Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex, functional homolog of Bul2p, disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases
YOL007C	CSI2	0.8936	NA	NA	0.811	Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene
YBR157C	ICS2	0.8929	NA	NA	0.978	Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
YOL110W	SHR5	0.8925	NA	NA	0.932	Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization
YOL064C	MET22	0.8922	1	4	0.974	Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway
YCR026C	NPP1	0.8916	NA	1	1.024	Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation
YOR245C	DGA1	0.8907	NA	NA	1.021	Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles
YHR064C	SSZ1	0.8905	58	1	NA	Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
YKR051W	YKR051W	0.8902	1	NA	0.999	Putative protein of unknown function
YBR281C	YBR281C	0.89	3	NA	0.976	Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
YNL073W	MSK1	0.8895	3	1	0.772	Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria
YKL023W	YKL023W	0.8894	7	NA	1.022	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YDR259C	YAP6	0.8887	NA	NA	1.013	Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YMR278W	YMR278W	0.8884	NA	NA	0.989	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR278W is not an essential gene
YIL105C	SLM1	0.8882	11	3	0.979	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; subunit of and phosphorylated by the TORC2 complex
YDR501W	PLM2	0.8881	1	NA	1.035	Protein required for partitioning of the 2-micron plasmid
YKR058W	GLG1	0.8879	3	NA	0.979	Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin
YDR491C	YDR491C	0.8875	NA	NA	1.022	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL040C	ISM1	0.8871	3	NA	0.858	Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
YIL107C	PFK26	0.887	7	NA	0.959	6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A
YBL087C	RPL23A	0.887	34	1	0.882	Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins
YAL005C	SSA1	0.8867	37	6	1.016	ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall
YOR213C	SAS5	0.8866	3	4	1.061	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which  acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity
YJL169W	YJL169W	0.8864	NA	NA	1.067	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
YER005W	YND1	0.8863	NA	NA	1.022	Apyrase with wide substrate specificity, involved in preventing the inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates which are inhibitors of glycotransferases; partially redundant with Gda1p
YGR252W	GCN5	0.8863	62	29	0.476	Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily
YKL177W	YKL177W	0.8861	NA	NA	1.088	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3
YJL092W	HPR5	0.8847	11	43	0.969	DNA helicase and DNA-dependent ATPase involved in DNA repair, required for proper timing of commitment to meiotic recombination and the transition from Meiosis I to Meiosis II; potential Cdc28p substrate
YPR049C	ATG11	0.8844	9	NA	0.589	Peripheral membrane protein required for delivery of aminopeptidase I (Lap4p) to the vacuole in the cytoplasm-to-vacuole targeting pathway; also required for peroxisomal degradation (pexophagy)
YGL024W	YGL024W	0.8836	NA	NA	0.596	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF PGD1/YGL025C
YLR418C	CDC73	0.883	26	117	0.683	Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenance
YGL060W	YBP2	0.8825	1	2	1.037	Protein with a role in resistance to oxidative stress; has similarity to Ybp1p, which is involved in regulation of the transcription factor Yap1p via oxidation of specific cysteine residues
YIR016W	YIR016W	0.8824	NA	NA	1.001	Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR016W is a non-essential gene
YPR117W	YPR117W	0.8819	3	NA	1.001	Putative protein of unknown function
YBR299W	MAL32	0.8816	1	NA	1.045	Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C
YDR507C	GIN4	0.8798	13	5	0.867	Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p
YDR049W	YDR049W	0.8797	5	NA	0.866	Zinc finger protein; putative transcription factor that may interact with proteins involved in histone acetylation or deacetylation; may be involved in altering acetylation on histone lysines
YDR488C	PAC11	0.8795	4	16	0.997	Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8
YGR282C	BGL2	0.8793	5	NA	0.927	Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance
YMR008C	PLB1	0.8792	2	NA	1.04	Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
YJL149W	YJL149W	0.8792	2	NA	0.957	Putative SCF ubiquitin ligase F-box protein of unknown function; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C; YJL149W is a non-essential gene
YBR223C	TDP1	0.878	5	1	0.926	Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3'-phosphotyrosyl bonds to generate 3'-phosphate DNA and tyrosine, involved in the repair of DNA lesions created by topoisomerase I
YKL178C	STE3	0.8778	NA	NA	1.058	Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR
YPR067W	ISA2	0.8777	8	NA	0.998	Protein required for maturation of mitochondrial and cytosolic Fe/S proteins, localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations
YER152C	YER152C	0.8774	NA	NA	1.035	Hypothetical protein
YDR525W-A	SNA2	0.8772	NA	NA	0.98	Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YJL186W	MNN5	0.8764	1	NA	1.006	Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
YJL212C	OPT1	0.876	NA	1	1.041	Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
YMR265C	YMR265C	0.8758	NA	NA	0.969	Putative protein of unknown function
YHL027W	RIM101	0.8757	NA	2	0.951	Transcriptional repressor involved in response to pH and in cell wall construction; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by proteolytic processing; similar to A. nidulans PacC
YJR128W	YJR128W	0.8753	NA	NA	1.035	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
YOR375C	GDH1	0.8752	8	1	0.894	NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YJL068C	YJL068C	0.8748	3	NA	0.997	Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
YML012W	ERV25	0.8746	17	NA	1.062	Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport
YMR153W	NUP53	0.8741	2	3	1.023	Subunit of the nuclear pore complex (NPC), interacts with karyopherin Kap121p or with Nup170p via overlapping regions of Nup53p, involved in activation of the spindle checkpoint mediated by the Mad1p-Mad2p complex
YIL070C	MAM33	0.8738	57	NA	1.013	Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R
YGR071C	YGR071C	0.8737	2	2	0.976	Putative protein of unknown function; deletion mutant has increased glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YBL037W	APL3	0.8735	6	NA	0.989	Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport
YDL118W	YDL118W	0.8732	NA	NA	0.915	Non-essential protein of unconfirmed function; mutants are defective in telomere maintenance, and are synthetically sick or lethal with alpha-synuclein
YFR010W	UBP6	0.8731	35	19	0.972	Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds
YAL009W	SPO7	0.8728	5	2	0.795	Regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, which regulates nuclear growth by controlling recruitment of Pah1p onto promoters of phospholipid biosynthetic genes; required for normal nuclear envelope morphology and sporulation
YJL059W	YHC3	0.8727	NA	2	1.007	Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis)
YIL098C	FMC1	0.8725	2	NA	0.937	Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p
YGR255C	COQ6	0.8721	2	NA	0.861	Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; located on the matrix side of the mitochondrial inner membrane
YMR224C	MRE11	0.872	9	40	0.86	Subunit of a complex with Rad50p and Xrs2p (RMX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for RMX function; widely conserved
YAL011W	SWC3	0.8719	14	66	0.928	Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
YML053C	YML053C	0.8714	NA	NA	1.05	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YML053C is not an essential gene
YDR231C	COX20	0.871	1	NA	0.969	Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YOR386W	PHR1	0.8706	3	NA	1.013	DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p
YGR015C	YGR015C	0.8705	NA	NA	1.005	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
YNL058C	YNL058C	0.8704	NA	1	0.973	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene
YIL112W	HOS4	0.8702	7	10	0.93	Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate
YLR388W	RPS29A	0.87	3	1	0.816	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins
YDR318W	MCM21	0.8699	11	21	0.987	Protein involved in minichromosome maintenance; component of the COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p) that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules
YOR078W	BUD21	0.8695	31	NA	0.815	Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern
YPL080C	YPL080C	0.8692	NA	NA	0.833	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL086W	SRX1	0.8687	NA	NA	1.036	Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants; conserved in higher eukaryotes
YPR039W	YPR039W	0.8683	NA	NA	1.014	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W
YLL040C	VPS13	0.8682	19	1	1.003	Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention
YHL045W	YHL045W	0.868	NA	NA	1	Putative protein of unknown function; not an essential gene
YDL129W	YDL129W	0.868	NA	NA	1.001	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene
YBR120C	CBP6	0.8679	2	2	0.872	Protein required for translation of the mitochondrial COB mRNA
YFL027C	GYP8	0.8674	NA	NA	0.976	GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport
YPL272C	YPL272C	0.8669	NA	NA	1.049	Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene
YOL013W-A	YOL013W-A	0.8667	NA	NA	0.972	Putative protein of unknown function; identified by SAGE
YNL116W	DMA2	0.8665	6	4	1.015	Protein involved in regulating spindle position and orientation, functionally redundant with Dma1p; homolog of S. pombe Dma1 and H. sapiens Chfr
YMR266W	RSN1	0.8662	1	5	0.983	Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant
YCR024C-A	PMP1	0.8661	NA	1	0.974	Small single-membrane span proteolipid that functions as a regulatory subunit of the plasma membrane H(+)-ATPase Pma1p, forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines
YCL048W	SPS22	0.866	2	NA	0.977	Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
YBR283C	SSH1	0.8659	3	2	0.971	Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential
YHR041C	SRB2	0.8653	34	22	0.627	General transcription factor, subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance
YKL114C	APN1	0.8634	5	4	1.018	Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine
YIL108W	YIL108W	0.8634	5	NA	0.963	Putative metalloprotease
YJR088C	YJR088C	0.8625	NA	1	0.971	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
YIR043C	YIR043C	NA	NA	NA	NA	NA
YBR058C	UBP14	0.8619	14	NA	0.971	Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T
YCR087W	YCR087W	0.8617	NA	NA	0.956	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene
YPR158W	YPR158W	0.8615	NA	NA	0.996	Putative protein of unknown function
YNL236W	SIN4	0.8613	33	9	0.917	Subunit of the Mediator complex; interacts with the RNA polymerase II holoenzyme to postively or negatively regulate transcription; dispensible for basal transcription
YOR123C	LEO1	0.861	13	19	0.953	Component of the Paf1 complex, which associates with RNA polymerase II and is involved in histone methylation
YDL021W	GPM2	0.8607	NA	NA	0.916	Homolog of Gpm1p phosphoglycerate mutase which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
YHL026C	YHL026C	0.8602	NA	NA	0.99	Putative protein of unknown function; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)
YNL329C	PEX6	0.8601	1	6	1.121	Peroxisomal membrane AAA-family ATPase peroxin required for peroxisome assembly, contains two 230 amino acid ATP-binding AAA cassettes, interacts with Pex1p
YJR070C	LIA1	0.8601	4	11	1.022	Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning
YDR310C	SUM1	0.86	3	20	0.952	Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; involved in telomere maintenance, regulated by the pachytene checkpoint
YNR013C	PHO91	0.8594	2	1	1.033	Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YNL238W	KEX2	0.8588	4	9	0.944	Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway
YDR332W	IRC3	0.8586	2	23	0.718	Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci
YCL005W	LDB16	0.8583	NA	NA	1.023	Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
YOR377W	ATF1	0.8582	NA	NA	0.992	Alcohol acetyltransferase with potential roles in lipid and sterol metabolism; responsible for the major part of volatile acetate ester production during fermentation
YJR052W	RAD7	0.8578	4	NA	1.021	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4)
YOL096C	COQ3	0.8575	NA	NA	0.903	O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex
YBR130C	SHE3	0.8573	9	NA	1.002	Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance
YJR119C	YJR119C	0.8565	3	NA	1.057	JmjC domain family histone demethylase specific for H3-K4 (lysine at position 4 of the histone H3 protein); removes methyl groups specifically added by Set1p methyltransferase
YPL072W	UBP16	0.8563	NA	NA	1.04	Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria
YCR028C-A	RIM1	0.8562	20	2	1.054	Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication
YMR090W	YMR090W	0.8561	NA	NA	1.026	Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene
YPL223C	GRE1	0.8559	NA	NA	1.048	Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YDL176W	YDL176W	0.8558	4	NA	0.992	Putative protein of unknown function; YDL176W is not an essential gene
YER111C	SWI4	0.8556	7	54	0.972	DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair
YEL056W	HAT2	0.8555	22	7	1.013	Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
YNL119W	NCS2	0.8553	2	3	0.883	Protein with a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YJR115W	YJR115W	0.8551	NA	NA	0.982	Putative protein of unknown function
YLR149C	YLR149C	0.855	1	NA	1.043	Putative protein of unknown function; YLR149C is not an essential gene
YHL005C	YHL005C	0.8549	NA	NA	0.942	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W
YGR063C	SPT4	0.8549	24	31	0.959	Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing; in addition, Spt4p is involved in kinetochore function and gene silencing
YPR195C	YPR195C	0.8547	NA	NA	0.983	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR088W	CTT1	0.8546	NA	NA	1.009	Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YLR094C	GIS3	0.8544	NA	1	1.033	Protein of unknown function
YLR052W	IES3	0.8538	22	5	0.697	Subunit of the INO80 chromatin remodeling complex
YFL031W	HAC1	0.8536	NA	3	0.967	bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway utilizing Ire1p, Trl1p and Ada5p facilitates efficient Hac1p synthesis
YOR296W	YOR296W	0.8531	NA	2	1.009	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene
YIL029C	YIL029C	0.8527	NA	NA	0.924	Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YKR031C	SPO14	0.8527	3	4	1.039	Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis
YLR096W	KIN2	0.8526	14	NA	0.99	Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p
YAL002W	VPS8	0.8525	6	9	0.879	Membrane-associated hydrophilic protein that interacts with the small GTPase, Vps21p, to facilitate soluble vacuolar protein localization; required for localization and trafficking of the CPY sorting receptor; contains a RING finger motif
YDR291W	HRQ1	0.8524	1	NA	1.012	Putative DNA helicase
YMR267W	PPA2	0.8523	1	5	0.832	Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate
YHR059W	FYV4	0.8517	3	2	0.948	Protein of unknown function, required for survival upon exposure to K1 killer toxin
YKL030W	YKL030W	0.8517	NA	NA	1.199	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene MAE1
YMR222C	FSH2	0.8512	NA	1	1.03	Serine hydrolase that localizes to the cytoplasm; sequence is similar to Fsh1p and Fsh3p
YFR013W	IOC3	0.8512	16	NA	NA	Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; has homology to Esc8p, which is involved in silencing
YOL093W	TRM10	0.851	NA	1	0.94	tRNA methyltransferase, methylates the N-1 position of guanosine in tRNAs
YAL027W	YAL027W	0.851	25	NA	1.02	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YAL027W is a non-essential gene
YJL067W	YJL067W	0.8509	NA	NA	0.986	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLL026W	HSP104	0.8506	27	NA	0.925	Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation
YPL098C	MGR2	0.8502	NA	NA	0.944	Protein required for growth of cells lacking the mitochondrial genome
YNL148C	ALF1	0.8502	NA	2	0.861	Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance
YDR116C	MRPL1	0.8501	31	2	0.952	Mitochondrial ribosomal protein of the large subunit
YBR037C	SCO1	0.85	NA	1	0.858	Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins
YML013C-A	YML013C-A	NA	NA	NA	NA	NA
YDR388W	RVS167	0.8493	110	61	0.981	Actin-associated protein, subunit of a complex (Rvs161p-Rvs167p) involved in regulation of actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; homolog of mammalian amphiphysin
YDL159W	STE7	0.8492	2	1	1.028	Signal transducing MAP kinase kinase involved in pheromone response, where it phosphorylates Fus3p, and in the pseudohyphal/invasive growth pathway, through phosphorylation of Kss1p; phosphorylated by Ste11p, degraded by ubiquitin pathway
YKR103W	NFT1	0.8492	1	NA	0.911	Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.
YDL185W	TFP1	0.8489	46	3	1.031	Vacuolar ATPase V1 domain subunit A containing the catalytic nucleotide binding sites; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
YNL289W	PCL1	0.8482	NA	2	1.092	Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
YCL057W	PRD1	0.8479	1	NA	0.989	Zinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins
YBR284W	YBR284W	0.8476	NA	NA	0.991	Putative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin
YGR056W	RSC1	0.8472	18	13	0.785	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
YGR259C	YGR259C	0.8469	NA	NA	0.974	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
YLR342W	FKS1	0.8461	22	81	0.775	Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling
YEL040W	UTR2	0.846	1	NA	1.007	Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance
YHR136C	SPL2	0.8459	NA	NA	1.025	Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YDR368W	YPR1	0.8457	NA	NA	1.052	2-methylbutyraldehyde reductase, may be involved in isoleucine catabolism
YDR065W	YDR065W	0.8457	1	1	0.889	Protein of unknown function, required for vacuolar acidification; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR382W	RPP2B	0.8456	64	NA	0.744	Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YMR063W	RIM9	0.8456	NA	NA	1.009	Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein
YBL098W	BNA4	0.8452	NA	1	1.006	Kynurenine 3-mono oxygenase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway
YDL049C	KNH1	0.845	NA	36	0.809	Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant
YBL053W	YBL053W	0.8442	NA	NA	1.006	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR287W	YDR287W	0.8441	1	1	1.008	Inositol monophosphatase
YOR165W	SEY1	0.8439	NA	NA	1.032	Protein of unknown function, contains two predicted GTP-binding motifs GXXXXGKS and DXXG near the N-terminus, homolog of the Arabidopsis gene RHD3 (Root Hair Defective)
YGR080W	TWF1	0.8436	NA	1	0.997	Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly
YPL071C	YPL071C	0.8435	NA	NA	0.984	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YIL110W	MNI1	0.8431	NA	1	0.86	Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; deletion mutant exhibits a weak vacuolar protein sorting defect, enhanced resistance to caspofungin, and is synthetically lethal with MEN mutants
YDR179W-A	YDR179W-A	0.8431	1	NA	0.966	Putative protein of unknown function
YDR234W	LYS4	0.8429	7	NA	0.967	Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
YDR198C	RKM2	0.8426	1	NA	1.028	Ribosomal protein lysine methyltransferase, responsible for epsilon-trimethylation of the lysine residue at position 10 of Rpl12Ap and Rpl12Bp
YER086W	ILV1	0.8425	21	NA	0.922	Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
YIL092W	YIL092W	0.8421	NA	NA	0.938	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YKL123W	YKL123W	0.842	NA	NA	1.099	Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4
YLR353W	BUD8	0.8417	NA	NA	1.023	Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
YMR164C	MSS11	0.8413	NA	1	1.008	Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of MUC1 and STA2 in response to nutritional signals
YBL066C	SEF1	0.8411	1	NA	0.945	Putative transcription factor, has homolog in Kluyveromyces lactis
YDL181W	INH1	0.8411	3	NA	0.641	Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase, inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p and both Inh1p and Stf1p exhibit the potential to form coiled-coil structures
YEL001C	YEL001C	0.8406	2	NA	0.995	Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52 foci
YPL193W	RSA1	0.8403	NA	4	0.706	Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly
YLR386W	VAC14	0.8401	7	12	0.93	Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p
YDL198C	GGC1	0.8399	NA	1	0.946	Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family
YDR031W	MIC14	0.8384	NA	NA	0.983	Mitochondrial intermembrane space cysteine motif protein of 14 kDa
YGL153W	PEX14	0.8382	7	1	1.071	Peroxisomal membrane protein that is a central component of the peroxisomal protein import machinery, interacts with PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p
YPL249C	GYP5	0.838	3	NA	1.05	GTPase-activating protein (GAP) for yeast Rab family members, involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p
YAL058C-A	YAL058C-A	NA	NA	NA	NA	NA
YPL037C	EGD1	0.8375	10	3	0.971	Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
YLL049W	LDB18	0.8374	NA	14	0.947	Protein of unknown function; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface
YBR182C	SMP1	0.8369	NA	NA	1.07	Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors
YMR257C	PET111	0.8367	1	NA	0.938	Specific translational activator for the COX2 mRNA, located in the mitochondrial inner membrane
YLL021W	SPA2	0.8366	10	16	0.905	Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
YLL010C	PSR1	0.8363	3	NA	0.996	Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
YDL068W	YDL068W	0.836	NA	NA	0.854	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
YMR214W	SCJ1	0.8358	7	5	0.981	One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
YBR097W	VPS15	0.8357	4	3	0.651	Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p
YOR255W	OSW1	0.8356	NA	NA	1.029	Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p
YML060W	OGG1	0.8352	2	NA	0.973	Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA
YDL110C	TMA17	0.8349	NA	NA	0.978	Protein of unknown function that associates with ribosomes
YOR312C	RPL20B	0.8347	66	6	0.594	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein
YOR309C	YOR309C	0.8347	NA	NA	0.82	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
YKL092C	BUD2	0.8346	2	1	1.052	GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types
YPR150W	YPR150W	0.8343	NA	NA	1.01	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C
YBR230C	OM14	0.8334	NA	NA	0.946	Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YER122C	GLO3	0.8328	5	14	0.856	ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p
YJL095W	BCK1	0.8328	10	45	0.982	Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
YNL252C	MRPL17	0.8327	30	1	0.899	Mitochondrial ribosomal protein of the large subunit
YKL218C	SRY1	0.8327	1	NA	1.052	3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YDL114W	YDL114W	0.8323	NA	NA	0.985	Putative protein of unknown function with similarity to acyl-carrier-protein reductases; YDL114W is not an essential gene
YIR030C	DCG1	0.8322	1	NA	1.028	Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain
YER061C	CEM1	0.832	NA	NA	0.798	Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration
YBR209W	YBR209W	0.8317	NA	NA	0.99	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR209W is not an essential gene
YGL220W	YGL220W	0.8316	3	1	0.736	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YGR276C	RNH70	0.8315	NA	2	1.054	3' exoribonuclease, required for 5S and tRNA-Arg3 maturation
YOR291W	YOR291W	0.8313	NA	NA	1.018	Putative protein of unknown function; shares sequence similarity with the type V P-type ATPase Spf1p; YOR291W is not an essential protein
YGL209W	MIG2	0.8309	NA	NA	1.009	Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YDR448W	ADA2	0.8306	38	3	0.459	Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes
YPL101W	ELP4	0.8306	9	35	0.89	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
YPL168W	YPL168W	0.8304	NA	NA	1.026	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated
YDL218W	YDL218W	0.8301	NA	NA	0.969	Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions
YBL095W	YBL095W	0.8301	NA	NA	0.963	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR132W	RPS23B	0.8299	3	NA	0.888	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Ap and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal
YMR148W	YMR148W	0.8294	NA	NA	1.025	Putative protein of unknown function; predicted to contain a transmembrane domain; YMR148W is not an essential gene
YHR152W	SPO12	0.8291	32	5	1.014	Nucleolar protein of unknown function, positive regulator of exit from mitosis; involved in regulating the release of Cdc14p from the nucleolus in early anaphase; proposed to play similar role in meiosis
YLR393W	ATP10	0.829	NA	2	0.968	Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6
YFR009W	GCN20	0.8288	23	NA	0.715	Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
YJL135W	YJL135W	0.8283	NA	NA	0.983	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
YKL109W	HAP4	0.8279	NA	NA	0.998	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YDR467C	YDR467C	0.8278	NA	NA	1.033	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR095C	RXT2	0.827	13	6	0.903	Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth
YDR415C	YDR415C	0.827	2	NA	1.04	Putative protein of unknown function
YDL122W	UBP1	0.8269	5	1	0.953	Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains
YNR048W	YNR048W	0.8264	NA	NA	1.06	Protein proposed to interact with phospholipid translocases, shares similarity to Cdc50p
YJR032W	CPR7	0.8262	12	16	0.7	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
YBR132C	AGP2	0.8258	NA	NA	0.776	High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
YMR237W	BCH1	0.8256	10	NA	1.033	Member of the Chs5p-Arf1p-binding proteins (ChAPs), a group of 4 related, interacting proteins (Bch1p, Fmp50p, Bud7p, Chs6p) that mediate export of specific cargo proteins, including chitin synthase Chs3p; may interact with ribosomes
YHR011W	DIA4	0.8255	5	2	0.981	Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth
YML070W	DAK1	0.8253	NA	NA	1.052	Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YPL258C	THI21	0.8253	5	NA	1.052	Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p
YCR025C	YCR025C	0.8252	NA	NA	0.993	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene
YNL169C	PSD1	0.8248	1	8	0.881	Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine
YML037C	YML037C	0.8242	NA	NA	1.038	Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
YMR312W	ELP6	0.8236	6	42	0.903	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
YER057C	HMF1	0.8236	1	NA	0.804	Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro
YPR160W	GPH1	0.8236	15	NA	0.774	Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YJL056C	ZAP1	0.8235	1	2	0.743	Zinc-regulated transcription factor, binds to zinc-responsive promoter elements to induce transcription of certain genes in the presence of zinc; regulates its own transcription; contains seven zinc-finger domains
YOL054W	PSH1	0.8235	23	1	1.031	Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding protein
YBR191W	RPL21A	0.8234	42	1	0.801	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Bp and has similarity to rat L21 ribosomal protein
YMR231W	PEP5	0.8234	6	5	0.825	Peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; forms complex with Pep3p that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, also interacts with Pep7p
YDR009W	GAL3	0.8226	1	NA	1.001	Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity
YBL022C	PIM1	0.8218	9	1	0.814	Mitochondrial ATP-dependent protease involved in intramitochondrial proteolysis; involved in degradation of misfolded proteins in mitochondria; required for bigenesis and maintenance of mitochondria
YLR325C	RPL38	0.8218	21	NA	0.978	Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
YHR067W	HTD2	0.8218	1	NA	0.893	Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology
YBL047C	EDE1	0.8215	12	14	0.904	Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins
YLR396C	VPS33	0.8212	7	3	0.926	ATP-binding protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at both the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
YIR033W	MGA2	0.8206	3	3	0.708	ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
YPL226W	NEW1	0.8204	15	NA	0.955	ATP binding cassette family member; Asn/Gln-rich rich region supports [NU+] prion formation, susceptibility to [PSI+] prion induction and aggregation of a fragment of the human Machado-Joseph Disease protein
YAL055W	PEX22	0.8202	NA	2	1.01	Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation
YBR128C	ATG14	0.8199	3	NA	0.975	Subunit of an autophagy-specific phosphatidylinositol 3-kinase complex (with Vps34p, Vps15p, and Vps30p) required for organization of a pre-autophagosomal structure; ATG14 transcription is activated by Gln3p during nitrogen starvation
YBR180W	DTR1	0.8198	1	NA	1.049	Multidrug resistance dityrosine transporter of the major facilitator superfamily, essential for spore wall synthesis, facilitates the translocation of bisformyl dityrosine through the prospore membrane
YDL057W	YDL057W	0.8195	NA	NA	0.848	Putative protein of unknown function; YDL057W is not an essential gene
YCL036W	GFD2	0.8194	1	NA	1.037	Protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation
YCL074W	YCL074W	NA	NA	NA	NA	NA
YHL017W	YHL017W	0.8193	NA	NA	0.97	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles
YDL107W	MSS2	0.8188	NA	1	0.913	Peripherally bound inner membrane protein of the mitochondrial matrix, required for export of C-terminal tail of Cox2p through the inner membrane
YDR323C	PEP7	0.8187	NA	6	0.508	Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
YML082W	YML082W	0.8173	NA	NA	0.981	Putative protein predicted to have carbon-sulfur lyase activity; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YNML082W is not an essential gene
YGR151C	YGR151C	0.8171	NA	NA	1.05	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C
YDR219C	MFB1	0.8164	2	NA	1.02	Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding
YJL118W	YJL118W	0.8164	1	NA	1.015	Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein
YGR221C	TOS2	0.8162	NA	NA	0.983	Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p
YJL161W	FMP33	0.8162	NA	NA	1.014	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YAL017W	PSK1	0.8158	11	NA	0.929	One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status
YLR062C	YLR062C	0.8158	NA	NA	0.744	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YNL134C	YNL134C	0.815	4	NA	1.007	Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS
YCR050C	YCR050C	0.8146	NA	NA	0.997	Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein
YOR096W	RPS7A	0.8143	120	1	0.727	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YIL053W	RHR2	0.814	8	2	0.493	Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YMR274C	RCE1	0.814	NA	4	1.007	Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone
YLL048C	YBT1	0.8139	2	NA	0.986	Transporter of the ATP-binding cassette (ABC) family involved in bile acid transport; similar to mammalian bile transporters
YOR350C	MNE1	0.8137	NA	1	0.991	Mitochondrial protein similar to Lucilia illustris mitochondrial cytochrome oxidase
YKL162C-A	YKL162C-A	0.8137	NA	NA	0.977	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR272C	SCS7	0.8132	NA	6	0.903	Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
YNL297C	MON2	0.813	2	15	1.008	Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins
YCL049C	YCL049C	0.8128	NA	NA	0.993	Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene;
YNL111C	CYB5	0.8123	1	NA	1.003	Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; required for sterol C5-6 and fatty acid desaturation
YNL335W	DDI3	0.8118	NA	NA	1.072	Hypothetical protein
YGL066W	SGF73	0.8116	25	6	0.832	73 kDa subunit of SAGA histone acetyltransferase complex; involved in formation of the preinitiation complex assembly at promoters
YER031C	YPT31	0.8112	2	6	1.021	GTPase of the Ypt/Rab family, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi
YKL055C	OAR1	0.8111	NA	NA	0.953	Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p
YER044C-A	MEI4	0.8111	NA	NA	1.004	Meiosis-specific protein involved in recombination; required for chromosome synapsis; required for production of viable spores
YCR022C	YCR022C	0.8108	NA	NA	0.969	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene
YER140W	YER140W	0.8108	1	NA	1	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL033C	SLM3	0.8107	2	10	0.916	tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)
YLR428C	YLR428C	0.8107	NA	NA	0.969	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1
YBR068C	BAP2	0.8106	NA	NA	1.087	High-affinity leucine permease, functions as a branched-chain amino acid permease involved in the uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains
YHL041W	YHL041W	0.8103	NA	NA	0.986	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YOR368W	RAD17	0.8099	4	15	1.041	Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins
YLR288C	MEC3	0.8098	6	10	0.958	DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
YBR105C	VID24	0.8094	14	NA	0.964	Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YPR197C	YPR197C	0.8091	NA	NA	0.999	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLL053C	YLL053C	0.809	NA	NA	1.016	Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YDL117W	CYK3	0.8086	2	9	0.975	SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis
YDL214C	PRR2	0.8086	NA	NA	1.013	Protein kinase with a possible role in MAP kinase signaling in the pheromone response pathway
YER150W	SPI1	0.8086	NA	1	1.038	GPI-anchored, serine/threonine rich cell wall protein of unknown function; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YMR171C	YMR171C	0.8085	NA	NA	0.96	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to endosomes; mRNA is targeted to the bud via the mRNA transport system involving She2p: YMR171C is not an essential gene
YGR227W	DIE2	0.8083	NA	5	0.994	Dolichyl-phosphoglucose-dependent glucosyltransferase of the ER, functions in the dolichol pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1
YPR087W	YPR087W	0.8083	NA	NA	0.88	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect
YNR040W	YNR040W	0.808	NA	NA	1.054	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR417C	YDR417C	0.8078	NA	NA	0.831	Hypothetical protein
YKL143W	LTV1	0.8077	9	1	0.691	Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature
YLR016C	PML1	0.8073	5	NA	1.001	Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
YJR094C	IME1	0.8068	NA	NA	1.059	Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
YLR205C	HMX1	0.8067	NA	NA	0.974	ER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxygenase activity despite similarity to heme oxygenases; expression regulated by AFT1
YHR132W-A	IGO2	0.806	NA	NA	NA	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YER098W	UBP9	0.8059	3	NA	0.988	Ubiquitin-specific protease that cleaves ubiquitin-protein fusions
YKR011C	YKR011C	0.8057	3	NA	1.057	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YKL124W	SSH4	0.8051	3	NA	1.067	Vacuolar protein that presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane
YBL033C	RIB1	0.8048	NA	1	0.925	GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway
YIL163C	YIL163C	0.8045	NA	NA	1.005	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL168C	KKQ8	0.8044	2	NA	1.052	Putative serine/threonine protein kinase with unknown cellular role
YFL034W	YFL034W	0.8043	6	NA	0.983	Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
YDL156W	YDL156W	0.8043	10	NA	0.669	Putative protein of unknown function; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YMR244C-A	YMR244C-A	0.8038	NA	NA	0.99	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR244C-A is not an essential gene
YLR074C	BUD20	0.8037	67	1	0.687	Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YLR128W	DCN1	0.8036	NA	1	1.031	Putative Nedd8 ligase; binds Nedd8; involved in cullin neddylation; not essential; similar to C.elegans DCN-1; contains UBA-like ubiquitin-binding domain and a DUF298 domain
YJL066C	MPM1	0.8035	3	NA	1	Mitochondrial membrane protein of unknown function, contains no hydrophobic stretches
YOL075C	YOL075C	0.8035	NA	NA	1.07	Putative ABC transporter
YJR040W	GEF1	0.8033	1	2	0.968	Chloride channel localized to late- or post-Golgi vesicles, involved in iron metabolism; highly homologous to voltage-gated chloride channels in vertebrates
YML103C	NUP188	0.803	2	10	1.042	Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p
YDL134C	PPH21	0.8023	20	2	0.932	Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis
YDR028C	REG1	0.8017	16	3	0.749	Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes
YHR081W	LRP1	0.8016	14	30	0.755	Substrate-specific nuclear cofactor for exosome activity in the processing of stable RNAs; required for telomere length maintenance; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination
YMR167W	MLH1	0.8014	6	3	0.935	Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer
YJR129C	YJR129C	0.8013	NA	2	1.054	Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YDR083W	RRP8	0.801	7	1	0.935	Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutation
YBR232C	YBR232C	0.8006	NA	NA	0.996	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YFR055W	IRC7	0.8003	1	NA	1.002	Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52 foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YIL077C	YIL077C	0.8002	1	NA	0.932	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YBR107C	IML3	0.7995	11	14	NA	Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p
YMR315W	YMR315W	0.7995	5	NA	1.093	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR315W is not an essential gene
YOL055C	THI20	0.799	NA	NA	1.048	Multifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities; involved in thiamine biosynthesis and also in thiamine degradation; member of a gene family with THI21 and THI22; functionally redundant with Thi21p
YGL109W	YGL109W	0.7989	NA	NA	1.058	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C
YGL175C	SAE2	0.7986	1	5	1.011	Protein with a role in accurate meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
YNL012W	SPO1	0.7986	NA	NA	0.969	Meiosis-specific protein with similarity to phospholipase B, required for meiotic spindle pole body duplication and separation; required for spore formation
YAR015W	ADE1	0.7986	2	NA	0.977	N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine
YCR044C	PER1	0.7984	NA	12	0.862	Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1
YJL128C	PBS2	0.7978	12	1	0.97	MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress
YGL213C	SKI8	0.7976	18	2	0.943	Protein involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs as well as double-strand break formation during meiotic recombination; required for repressing propagation of dsRNA viruses
YGR162W	TIF4631	0.7974	61	6	0.535	Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4632p
YDL073W	YDL073W	0.7966	1	NA	0.948	Putative protein of unknown function; YDL073W is not an essential gene
YLL038C	ENT4	0.7966	NA	2	0.985	Protein of unknown function, contains an N-terminal epsin-like domain
YBL036C	YBL036C	0.796	9	NA	0.977	Single-domain racemase, possibly non-specific due to the lack of the second domain, which presumably determines specificity; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
YGL232W	TAN1	0.7958	5	NA	0.97	Putative tRNA acetyltransferase, RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA
YOR298C-A	MBF1	0.7954	NA	NA	0.971	Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations
YAL026C	DRS2	0.7942	7	17	0.937	Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease
YPL102C	YPL102C	0.7941	NA	NA	0.88	Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4
YNR069C	BSC5	0.7939	NA	NA	1.107	Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YNL016W	PUB1	0.7937	18	1	0.932	Poly(A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of a number of mRNAs; not reported to associate with polyribosomes
YGL167C	PMR1	0.7935	18	16	0.733	High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
YER091C-A	YER091C-A	0.7933	NA	NA	0.992	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCL038C	ATG22	0.793	NA	NA	0.937	Protein required for the breakdown of autophagic vesicles in the vacuole during autophagy, putative integral membrane protein that localizes to vacuolar membranes and punctate structures attached to the vacuole
YGR249W	MGA1	0.793	NA	1	0.987	Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YAL045C	YAL045C	0.7922	NA	NA	0.988	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A
YCL027W	FUS1	0.7921	NA	NA	0.982	Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate
YHR060W	VMA22	0.792	1	5	0.989	Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
YBL019W	APN2	0.792	2	3	0.99	Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII
YLR017W	MEU1	0.7918	NA	NA	0.953	Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression
YFR049W	YMR31	0.7915	4	NA	0.993	Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36
YEL054C	RPL12A	0.7913	33	NA	0.806	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YPR043W	RPL43A	0.7907	4	NA	0.665	Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype
YJL206C	YJL206C	0.7907	1	NA	0.988	Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment
YCR102C	YCR102C	0.7903	1	NA	0.994	Putative protein of unknown function; involved in copper metabolism; similar to C.carbonum toxD gene; YCR102C is not an essential gene
YBL071C	YBL071C	0.7903	NA	NA	0.905	Dubious open reading frame, predicted protein contains a peroxisomal targeting signal
YLR079W	SIC1	0.79	7	28	0.602	Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
YKL006W	RPL14A	0.7899	7	1	0.842	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Bp and has similarity to rat L14 ribosomal protein; rpl14a csh5 double null mutant exhibits synthetic slow growth
YBR228W	SLX1	0.7899	2	4	1.021	Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p
YGR081C	SLX9	0.7898	13	3	0.929	Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant
YMR080C	NAM7	0.7893	7	3	0.971	ATP-dependent RNA helicase of the SFI superfamily, required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons; involved in telomere maintenance
YIL138C	TPM2	0.7892	NA	NA	1.007	Minor isoform of tropomyosin, binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p
YKL011C	CCE1	0.7886	2	1	0.911	Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA
YDR025W	RPS11A	0.7882	80	NA	0.749	Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins
YPL262W	FUM1	0.7882	3	1	1	Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation
YKR044W	UIP5	0.7875	NA	NA	1.021	Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates
YBR215W	HPC2	0.7875	7	8	1.018	Highly charged, basic protein required for normal cell-cycle regulation of histone gene transcription; mutants display strong synthetic defects with subunits of FACT, a complex that allows RNA Pol II to elongate through nucleosomes
YER017C	AFG3	0.787	5	1	0.912	Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes
YGR213C	RTA1	0.787	NA	NA	1.043	Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions
YOR185C	GSP2	0.7868	16	NA	1.011	GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability
YMR143W	RPS16A	0.7865	7	NA	0.758	Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins
YDL130W-A	STF1	0.7865	1	NA	1.011	Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YDR536W	STL1	0.7863	NA	NA	0.968	Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YPL079W	RPL21B	0.7856	1	2	0.836	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Ap and has similarity to rat L21 ribosomal protein
YOR136W	IDH2	0.7855	25	NA	0.898	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle
YMR264W	CUE1	0.7855	2	1	0.984	Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination
YDR018C	YDR018C	0.785	1	1	1.001	Probable membrane protein with three predicted transmembrane domains; homologous to Ybr042cp, similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; null exhibits no apparent phenotype
YJR146W	YJR146W	0.7849	NA	NA	1.056	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YNL241C	ZWF1	0.7843	NA	1	0.62	Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia
YGL258W	VEL1	0.7842	NA	NA	0.979	Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants
YGR283C	YGR283C	0.7841	5	NA	0.936	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; deletion mutant is resistant to fluconazole; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YMR106C	YKU80	0.7841	63	3	1.04	Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YDR405W	MRP20	0.7838	20	1	0.764	Mitochondrial ribosomal protein of the large subunit
YDR540C	IRC4	0.7838	NA	NA	0.987	Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci
YMR304C-A	YMR304C-A	0.7837	NA	NA	1.114	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SCW10
YJL003W	COX16	0.7837	NA	1	0.87	Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase
YNL117W	MLS1	0.7835	NA	1	0.978	Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YER042W	MXR1	0.7835	1	NA	0.998	Peptide methionine sulfoxide reductase, reverses the oxidation of methionine residues; involved in oxidative damage repair, providing resistance to oxidative stress and regulation of lifespan
YOR054C	VHS3	0.7834	3	1	1.045	Functionally redundant (see also SIS2) inhibitory subunit of Ppz1p, a PP1c-related ser/thr protein phosphatase Z isoform; synthetically lethal with sis2; putative phosphopantothenoylcysteine decarboxylase involved in coenzyme A biosynthesis
YCL042W	YCL042W	0.7833	1	NA	1.001	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YIR021W	MRS1	0.7833	3	1	1.046	Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YPR133W-A	TOM5	0.7831	NA	1	0.958	Small mitochondrial outer membrane protein crucial to a binding relay for the import of proteins into mitochondria; subunit on the outer mouth of the TOM channel that accepts precursors from the receptors Tom20p and Tom22p
YKL137W	YKL137W	0.783	NA	NA	1.028	Putative protein of unknown function; mutation results in growth defect on a non-fermentable (respiratory) carbon source
YJL180C	ATP12	0.783	4	NA	0.996	Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency
YMR262W	YMR262W	0.783	NA	NA	1.018	Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
YCR087C-A	LUG1	0.783	8	1	1.041	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene
YPR014C	YPR014C	0.7827	NA	NA	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene
YML117W-A	YML117W-A	NA	NA	NA	NA	NA
YEL025C	YEL025C	0.7822	2	NA	0.993	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YMR186W	HSC82	0.7821	89	11	0.982	Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels that HSP82 and induced 2-3 fold by heat shock
YMR009W	ADI1	0.782	NA	NA	1.059	Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions
YDR128W	YDR128W	0.7818	15	NA	0.951	Putative protein of unknown function
YLR209C	PNP1	0.7816	NA	NA	1.002	Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides
YDR384C	ATO3	0.7815	NA	NA	1.046	Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; member of the TC 9.B.33 YaaH family of putative transporters
YKL116C	PRR1	0.7815	NA	1	0.999	Protein kinase with a possible role in MAP kinase signaling in the pheromone response pathway
YJL037W	YJL037W	0.7812	NA	NA	0.976	Putative protein of unknown function; expression induced in respiratory-deficient petite cells, in carbon-limited chemostat cultures, during meiosis, sporulation and after alpha factor treatment; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52 foci
YGR241C	YAP1802	0.7811	NA	1	0.957	Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family
YDR371W	CTS2	0.7811	NA	NA	1.041	Sporulation-specific chitinase
YCL010C	SGF29	0.7804	21	1	0.837	SaGa associated Factor 29kDa; Probable 29kKDa Subunit of SAGA histone acetyltransferase complex
YBR078W	ECM33	0.7804	1	2	0.977	GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; similar to Sps2p and Pst1p
YGR086C	PIL1	0.7803	53	NA	0.959	Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Lsp1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways
YOR132W	VPS17	0.7803	4	9	0.966	Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation
YHR061C	GIC1	0.78	1	2	0.972	Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain
YMR042W	ARG80	0.7797	NA	NA	1.039	Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p
YMR123W	PKR1	0.7797	6	5	1.011	V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V<sub>0</sub>); overproduction confers resistance to Pichia farinosa killer toxin
YLR286C	CTS1	0.7797	NA	1	1.228	Endochitinase, required for cell separation after mitosis; transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p
YKR017C	YKR017C	0.7796	1	NA	1.072	Putative protein of unknown function; contains a RING finger motif
YOR147W	MDM32	0.7795	NA	10	0.968	Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34
YOR072W	YOR072W	0.7794	NA	NA	1.011	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YBR101C	FES1	0.779	4	NA	NA	Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum
YNL286W	CUS2	0.779	3	NA	1.084	Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)
YOR316C	COT1	0.7786	NA	NA	1.06	Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium
YIL140W	AXL2	0.7783	1	NA	1.06	Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate
YKR029C	SET3	0.7783	10	12	0.968	Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains
YOL131W	YOL131W	0.7781	NA	NA	0.977	Putative protein of unknown function
YPL215W	CBP3	0.7779	1	1	0.791	Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp4p and function is partially redundant with that of Cbp4p
YDL082W	RPL13A	0.7778	93	NA	0.8	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein
YNL095C	YNL095C	0.7776	NA	NA	1.046	Putative protein of unknown function predicted to contain a transmembrane domain; YNL095C is not an essential gene
YDR111C	ALT2	0.7774	4	NA	0.98	Putative alanine transaminase (glutamic pyruvic transaminase)
YOR086C	TCB1	0.7771	4	NA	1.022	Lipid-binding protein containing three calcium and lipid binding domains; non-tagged protein localizes to mitochondria and GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact
YPL158C	YPL158C	0.7768	1	1	0.947	Hypothetical protein
YPR096C	YPR096C	0.7767	NA	NA	1.006	Protein of unknown function that may interact with ribosomes, based on co-purification experiments
YGR053C	YGR053C	0.7766	NA	NA	1.024	Putative protein of unknown function
YHR156C	LIN1	0.7765	3	1	1.008	Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication
YML014W	TRM9	0.7764	1	2	0.801	tRNA methyltransferase, catalyzes the esterification of modified uridine nucleotides in tRNAs, creating 5-methylcarbonylmethyluridine in tRNA(Arg3) and 5-methylcarbonylmethyl-2-thiouridine in tRNA(Glu); may have a role in stress response
YML010C-B	YML010C-B	NA	NA	NA	NA	NA
YGL014W	PUF4	0.7761	44	1	1.034	Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors
YBR221C	PDB1	0.776	19	4	0.88	E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria
YGR051C	YGR051C	0.7756	NA	NA	0.97	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YDR092W	UBC13	0.775	6	NA	1.009	Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus
YBL039C	URA7	0.7749	43	1	0.935	Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis
YDR186C	YDR186C	0.7748	3	NA	0.939	Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YDL197C	ASF2	0.7746	2	NA	1.004	Anti-silencing protein that causes derepression of silent loci when overexpressed
YNL285W	YNL285W	0.7743	NA	NA	1.09	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKR057W	RPS21A	0.7742	6	2	0.842	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Bp and has similarity to rat S21 ribosomal protein
YIL116W	HIS5	0.7739	NA	NA	0.978	Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
YAL012W	CYS3	0.7734	6	NA	0.997	Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine
YNL324W	YNL324W	0.7733	NA	NA	1.082	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER035W	EDC2	0.7733	6	NA	1.006	RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p
YPL189W	GUP2	0.773	NA	2	1.039	Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog
YKR076W	ECM4	0.773	NA	NA	0.976	Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YBR051W	YBR051W	0.7729	NA	NA	1.002	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YPL015C	HST2	0.7729	NA	NA	1.006	Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro
YLR405W	DUS4	0.7728	NA	NA	1.008	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
YKL105C	YKL105C	0.7727	NA	NA	1.061	Putative protein of unknown function
YHL036W	MUP3	0.7725	NA	NA	0.996	Low affinity methionine permease, similar to Mup1p
YCL058C	YCL058C	0.772	NA	NA	0.773	Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in ion homeostasis
YDR289C	RTT103	0.7719	8	11	0.984	Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition
YLL007C	YLL007C	0.7717	NA	3	0.903	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene
YPR038W	YPR038W	0.7716	NA	NA	1.034	Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci
YMR210W	YMR210W	0.7716	NA	NA	1.021	Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
YKL079W	SMY1	0.7713	NA	17	1.035	Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins
YOR113W	AZF1	0.7713	NA	NA	1.036	Zinc-finger transcription factor, involved in induction of CLN3 transcription in response to glucose; genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance
YMR034C	YMR034C	0.7712	2	NA	1.077	Putative protein of unknown function with similarity to transporters; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
YAR002W	NUP60	0.7711	11	29	0.9	Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance
YOR211C	MGM1	0.7708	NA	1	0.747	Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy
YGR121C	MEP1	0.7704	NA	2	0.966	Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YLR433C	CNA1	0.7698	3	1	0.892	Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
YMR306W	FKS3	0.7696	NA	1	1.067	Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL192C	PRM3	0.7694	NA	4	1.011	Pheromone-regulated protein required for karyogamy; localizes to the inner membrane of the nuclear envelope
YGR263C	YGR263C	0.7693	2	NA	0.959	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
YJR011C	YJR011C	0.7693	3	3	1.051	Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
YIL161W	YIL161W	0.7692	12	NA	1.008	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene
YHR161C	YAP1801	0.769	4	1	0.981	Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1802p, member of the AP180 protein family
YOR064C	YNG1	0.769	3	1	1.023	Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1
YLR168C	YLR168C	0.7688	NA	1	0.998	Putative protein of unknown function that may be involved in intramitochondrial sorting; has similarity to Ups1p and to human PRELI; the green fluorescent protein (GFP)-tagged protein localizes to mitochondria
YDR014W	RAD61	0.7685	NA	7	1.001	Protein of unknown function; mutation confers radiation sensitivity
YLL028W	TPO1	0.7684	NA	NA	0.986	Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
YIL146C	ECM37	0.7682	1	NA	1.012	Non-essential protein of unknown function
YPR065W	ROX1	0.7678	1	NA	1.005	Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YGL226C-A	OST5	0.7675	NA	5	1.023	Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YBR147W	YBR147W	0.7675	NA	NA	0.747	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays fluconazole resistance
YFR033C	QCR6	0.7674	NA	1	0.973	Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1
YPR007C	REC8	0.7669	2	NA	1.1	Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YNL068C	FKH2	0.7669	6	2	1.015	Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase
YHR017W	YSC83	0.7668	NA	NA	NA	Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83
YLR369W	SSQ1	0.7666	3	3	0.511	Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia
YDR085C	AFR1	0.7665	2	NA	0.985	Alpha-factor pheromone receptor regulator, negatively regulates pheromone receptor signaling; required for normal mating projection (shmoo) formation; interacts with Cdc12p
YKL212W	SAC1	0.7665	8	14	0.943	Lipid phosphoinositide phosphatase of the ER and Golgi, involved in protein trafficking and secretion
YGR202C	PCT1	0.7665	3	NA	1.047	Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding
YOL045W	PSK2	0.7664	4	NA	0.978	One of two (see also PSK1) PAS domain containing S/T protein kinases; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation)
YFL015C	YFL015C	0.7664	NA	NA	0.984	Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YBR173C	UMP1	0.7661	14	3	1.074	Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly
YKL134C	OCT1	0.7659	1	NA	0.953	Mitochondrial intermediate peptidase, cleaves N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis
YJL183W	MNN11	0.7659	8	15	0.944	Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p
YNL051W	COG5	0.7658	8	9	0.977	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YNL278W	CAF120	0.7657	2	NA	1.065	Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
YDR426C	YDR426C	0.7654	NA	NA	0.988	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41
YDL100C	GET3	0.7651	10	4	0.921	ATPase, subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; involved in resistance to heat and metal stress
YLR114C	AVL9	0.7651	NA	NA	0.845	Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms
YLR020C	YEH2	0.7649	NA	NA	0.985	Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
YPL032C	SVL3	0.7646	4	NA	0.996	Protein of unknown function, mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck
YMR048W	CSM3	0.7643	14	58	1.026	Protein required for accurate chromosome segregation during meiosis
YDR502C	SAM2	0.7642	9	1	1.02	S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YOR156C	NFI1	0.7642	5	3	0.965	SUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; involved in maintenance of proper telomere length
YLR289W	GUF1	0.7641	4	NA	0.967	Mitochondrial GTPase of unknown function, similar to E. coli elongation factor-type GTP-binding protein LepA and to LK1236.1 from Caenorhabditis elegans
YPR062W	FCY1	0.7641	4	NA	0.993	Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)
YEL052W	AFG1	0.7637	NA	1	1.002	Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localized to mitochondria
YOL128C	YGK3	0.7637	4	NA	1.013	Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation
YHR021C	RPS27B	0.7636	2	1	0.72	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein
YLR226W	BUR2	0.7636	4	20	0.792	Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II
YBR069C	TAT1	0.7634	13	NA	1.081	Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter; overexpression confers FK506 resistance
YCR010C	ADY2	0.7632	NA	NA	1.013	Acetate transporter required for normal sporulation
YGR285C	ZUO1	0.7627	33	3	0.581	Cytosolic ribosome-associated chaperone that acts, together with Ssz1p and the Ssb proteins, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
YDR169C	STB3	0.7626	6	NA	1.029	Protein that binds Sin3p in a two-hybrid assay
YNL191W	YNL191W	0.7626	NA	NA	1.009	Probable glutamine amidotransferase, forms a complex with Dug1p and Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
YGR070W	ROM1	0.7622	NA	1	0.988	GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
YDL066W	IDP1	0.762	10	NA	0.984	Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
YBL102W	SFT2	0.7617	NA	5	0.987	Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5
YER019C-A	SBH2	0.7617	NA	1	0.998	Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
YOL039W	RPP2A	0.7616	12	NA	0.921	Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YPL111W	CAR1	0.7615	7	NA	0.968	Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
YDL074C	BRE1	0.7615	7	65	NA	E3 ubiquitin ligase for Rad6p, required for the ubiquitination of histone H2B, recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on K4 and K79), contains RING finger domain
YFL016C	MDJ1	0.7614	4	1	NA	Protein involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix; localizes to the mitochondrial inner membrane; member of the DnaJ family of molecular chaperones
YCR090C	YCR090C	0.7614	1	1	0.985	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene
YKL197C	PEX1	0.7613	NA	1	1.078	AAA-family ATPase peroxin required for peroxisome biogenesis, contains two 230 amino acid ATP-binding AAA cassettes, upregulated in anaerobiosis; Pex1p and Pex6p interact via their N-terminal AAA-cassettes
YOL059W	GPD2	0.7609	9	NA	0.828	NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria
YPL254W	HFI1	0.7609	29	8	1.04	Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions
YOR315W	SFG1	0.7606	2	NA	1.027	Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YGR260W	TNA1	0.7602	NA	1	0.953	High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
YJR118C	ILM1	0.7599	NA	14	0.759	Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth
YJR080C	FMP26	0.7598	NA	NA	1.064	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR323C	PRO2	0.7597	4	NA	0.97	Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis
YJR039W	YJR039W	0.7595	NA	NA	1.013	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR001C	NTH2	0.7594	6	NA	0.998	Putative neutral trehalase, required for thermotolerance and may mediate resistance to other cellular stresses
YGL078C	DBP3	0.7593	17	1	0.953	Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
YBL027W	RPL19B	0.7593	57	2	0.734	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YNL123W	NMA111	0.759	NA	NA	0.984	Protein of unknown function which may contribute to lipid homeostasis and/or apoptosis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
YER097W	YER097W	0.7589	NA	NA	0.988	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBL086C	YBL086C	0.7589	2	NA	1.016	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YMR154C	RIM13	0.7588	1	10	0.96	Calpain-like protease involved in proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans palB
YPL241C	CIN2	0.7586	NA	36	1.057	Tubulin folding factor C (putative) involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
YLR292C	SEC72	0.7585	3	4	0.99	Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YDL061C	RPS29B	0.7584	4	NA	0.743	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Ap and has similarity to rat S29 and E. coli S14 ribosomal proteins
YJL176C	SWI3	0.7581	18	6	0.795	Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2
YOR114W	YOR114W	0.7579	NA	NA	1.051	Hypothetical protein
YJL120W	YJL120W	0.7579	NA	NA	0.877	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO
YML063W	RPS1B	0.7578	100	NA	0.689	Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein
YPR126C	YPR126C	0.7572	NA	NA	1.027	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR294W	SUL1	0.7571	NA	NA	1.095	High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
YFR018C	YFR018C	0.757	NA	NA	0.967	Putative protein of unknown function
YNL082W	PMS1	0.7568	3	1	0.955	ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL
YER074W	RPS24A	0.7563	75	1	0.791	Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
YML009C	MRPL39	0.7563	4	NA	0.955	Mitochondrial ribosomal protein of the large subunit
YKL155C	RSM22	0.7561	30	1	0.736	Mitochondrial ribosomal protein of the small subunit
YJL044C	GYP6	0.756	8	NA	0.994	GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport
YOR269W	PAC1	0.7559	2	18	0.991	Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1
YNL109W	YNL109W	0.7557	NA	NA	0.959	Hypothetical protein
YPR172W	YPR172W	0.7557	NA	NA	1.003	Protein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
YDR127W	ARO1	0.7557	30	NA	1.036	Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
YML042W	CAT2	0.7555	NA	NA	1.012	Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YER047C	SAP1	0.7555	3	NA	0.985	Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system
YBR137W	YBR137W	0.7553	3	NA	0.977	Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); YBR137W is not an essential gene
YGL019W	CKB1	0.7553	35	4	0.918	Beta regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB2, the many substrates include transcription factors and all RNA polymerases
YER161C	SPT2	0.7552	24	5	0.99	Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins
YDR297W	SUR2	0.7549	NA	1	1.029	Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis
YHR210C	YHR210C	0.7548	NA	NA	0.985	Putative protein of unknown function
YDR385W	EFT2	0.7548	34	2	0.974	Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YGR257C	MTM1	0.7544	NA	2	0.771	Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor
YNR033W	ABZ1	0.7544	1	NA	1.013	Para-aminobenzoate (PABA) synthase, has similarity to Escherichia coli PABA synthase components PabA and PabB
YPL152W	RRD2	0.7542	1	4	1.03	Activator of the phosphotyrosyl phosphatase activity of PP2A; regulates G1 phase progression, the osmoresponse and microtubule dynamics; implicated in the spindle assembly check; subunit of the Tap42p-Pph21p-Rrd2p complex
YBR164C	ARL1	0.7542	NA	41	1.02	Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
YLR056W	ERG3	0.7539	NA	16	0.862	C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources
YPL224C	MMT2	0.7539	1	1	1.031	Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p
YIL096C	YIL096C	0.7539	3	NA	0.984	Putative protein of unknown function; associates with precursors of the 60S ribosomal subunit
YOL119C	MCH4	0.7537	NA	1	1.006	Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YML086C	ALO1	0.7536	NA	NA	0.967	D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of D-erythroascorbic acid, which is protective against oxidative stress
YER166W	DNF1	0.7527	2	1	1.02	Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
YDR035W	ARO3	0.7524	2	NA	0.989	3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan
YIL018W	RPL2B	0.7522	76	NA	0.576	Protein component of the large (60S) ribosomal subunit, identical to Rpl2Ap and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression is upregulated at low temperatures
YDL039C	PRM7	0.7515	NA	NA	1.032	Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements
YDR244W	PEX5	0.7514	4	3	1.012	Peroxisomal membrane signal receptor for C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import, tetratricopeptide repeat protein, also involved in PTS1-independent import
YGR017W	YGR017W	0.7512	2	NA	0.993	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YBR245C	ISW1	0.7511	42	12	0.988	Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation
YHL021C	FMP12	0.7506	3	NA	0.983	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR010W	HHT1	0.7506	49	5	0.981	One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YBR026C	ETR1	0.7505	2	NA	0.861	2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis
YPL256C	CLN2	0.7499	20	15	1.062	G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YHL006C	SHU1	0.7499	NA	NA	0.959	Protein of unassigned function involved in mutation suppression, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu2p, Psy3p, and Csm2p
YDR476C	YDR476C	0.7498	NA	NA	1.039	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
YBR044C	TCM62	0.7496	5	NA	0.681	Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone
YKL222C	YKL222C	0.7495	NA	NA	1.003	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine
YLR034C	SMF3	0.7493	1	NA	0.974	Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins
YJR019C	TES1	0.7489	NA	NA	1.026	Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
YKR020W	VPS51	0.7488	3	18	0.912	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP)  complex to the SNARE Tlg1p
YHL011C	PRS3	0.7487	12	5	0.706	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of a five related enzymes, which are active as heteromultimeric complexes
YDL034W	YDL034W	0.7486	NA	NA	0.875	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene
YJL146W	IDS2	0.7486	2	NA	0.995	Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation
YNL184C	YNL184C	0.7483	NA	NA	0.821	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL081W	IRA2	0.7483	2	7	0.901	GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YDR480W	DIG2	0.7482	6	NA	1.023	Regulatory protein of unknown function, pheromone-inducible, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription
YOR201C	MRM1	0.7479	4	NA	0.887	Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA
YHR206W	SKN7	0.7478	1	3	1.015	Nuclear response regulator and transcription factor, part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation
YKL130C	SHE2	0.7477	6	NA	1.063	RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
YMR291W	YMR291W	0.7477	3	NA	0.989	Putative kinase of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR291W is not an essential gene
YMR263W	SAP30	0.7473	15	54	0.873	Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance
YFL053W	DAK2	0.7469	1	NA	0.974	Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YFL028C	CAF16	0.7468	1	NA	0.976	Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation; putative ABC ATPase; interacts with Ssn2p, Ssn3p, and Ssn8p
YKL005C	BYE1	0.7468	2	NA	1.054	Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit
YER101C	AST2	0.7468	NA	NA	0.961	Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions
YIR036C	YIR036C	0.7467	NA	NA	0.975	Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52 foci
YLR362W	STE11	0.7467	8	4	1.034	Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p
YOR014W	RTS1	0.7465	9	6	0.914	B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A
YHR013C	ARD1	0.7462	18	17	0.977	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YGL253W	HXK2	0.7461	5	5	0.865	Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene
YKR054C	DYN1	0.7456	3	24	0.97	Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
YNL081C	SWS2	0.7456	7	1	0.914	Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein
YLR250W	SSP120	0.7454	NA	NA	1.009	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YJL100W	LSB6	0.7451	NA	NA	0.994	Phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YDR142C	PEX7	0.7449	13	NA	1.03	Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)
YDR298C	ATP5	0.7448	1	1	0.56	Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein)
YBR149W	ARA1	0.7447	2	NA	0.977	NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product
YBR250W	YBR250W	0.7446	NA	NA	1.003	Protein of unknown function; associates with meiosis-specific protein Spo1p
YBR241C	YBR241C	0.7446	NA	NA	1.015	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene
YML097C	VPS9	0.7445	1	3	0.911	A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
YMR285C	NGL2	0.7445	1	NA	0.99	Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p
YIL071C	PCI8	0.7445	8	NA	0.98	Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain
YBR219C	YBR219C	0.7443	NA	NA	0.864	Putative protein of unknown function; YBR219C is not an essential gene
YLR028C	ADE16	0.744	7	NA	0.978	Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine
YLR281C	YLR281C	0.7439	NA	NA	1	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene
YDR097C	MSH6	0.7435	19	1	1.132	Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p
YMR304W	UBP15	0.7433	40	NA	1.043	Ubiquitin-specific protease that may play a role in ubiquitin precursor processing
YGR180C	RNR4	0.7433	8	26	0.744	Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YPR115W	YPR115W	0.7425	3	NA	0.999	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YBR156C	SLI15	0.7421	4	3	NA	Subunit of the Ipl1p-Sli15p-Bir1p complex that regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; regulates the activity and localization of the Ipl1p aurora kinase
YMR052C-A	YMR052C-A	0.7421	NA	NA	1.007	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL120W	VPS30	0.7421	4	2	0.952	Protein that forms a membrane-associated complex with Apg14p that is essential for autophagy; involved in a retrieval step of the carboxypeptidase Y receptor, Vps10p, to the late Golgi from the endosome; involved in vacuolar protein sorting
YGL226W	YGL226W	0.7417	NA	NA	1.051	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
YLR093C	NYV1	0.7415	NA	1	1.01	v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane
YDR421W	ARO80	0.7415	NA	NA	1.021	Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids
YOR205C	FMP38	0.7414	1	NA	0.832	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJR111C	YJR111C	0.7414	NA	NA	0.982	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
YDR354W	TRP4	0.7413	1	NA	1.041	Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
YLR112W	YLR112W	0.7412	NA	NA	0.987	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL198W	RPL7B	0.741	93	1	1.007	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Ap and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
YBL009W	YBL009W	0.7408	NA	NA	0.936	Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk1p and to mammalian haspins
YEL037C	RAD23	0.7407	40	6	0.975	Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins
YDL018C	ERP3	0.7407	4	NA	1.069	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
YJR056C	YJR056C	0.7405	NA	1	1.007	Hypothetical protein
YGL088W	YGL088W	0.7403	NA	NA	0.848	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing
YPL021W	ECM23	0.7401	NA	NA	1.016	Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p
YOR104W	PIN2	0.7399	NA	NA	1.036	Protein that induces appearance of [PIN+] prion when overproduced
YPL047W	SGF11	0.7398	19	11	0.91	Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
YHR025W	THR1	0.7396	2	NA	0.886	Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
YNL319W	YNL319W	0.7396	NA	NA	0.989	Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14
YDL040C	NAT1	0.7388	25	15	0.95	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YAL015C	NTG1	0.7387	12	2	1.041	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus and mitochondrion
YNL235C	YNL235C	0.7386	NA	NA	1.079	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex
YJL103C	GSM1	0.7383	NA	NA	1	Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YFL033C	RIM15	0.738	3	2	0.977	Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
YOR128C	ADE2	0.7379	1	NA	1.015	Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine
YOR028C	CIN5	0.7378	2	NA	1.055	Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YML033W	YML033W	NA	NA	NA	NA	NA
YLR402W	YLR402W	0.7374	NA	NA	0.693	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR118C	YLR118C	0.7373	NA	NA	1.027	Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS
YJL207C	LAA1	0.7372	5	1	1.015	AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
YNL069C	RPL16B	0.7369	90	5	0.838	N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YOL095C	HMI1	0.7367	NA	NA	0.655	Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
YLR352W	YLR352W	0.7366	2	1	1.014	Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene
YDR477W	SNF1	0.7366	26	4	NA	AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis
YNR031C	SSK2	0.7359	11	1	1.019	MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress
YDR541C	YDR541C	0.7359	NA	NA	0.994	Putative dihydrokaempferol 4-reductase
YLL062C	MHT1	0.7355	2	NA	0.961	S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
YBR197C	YBR197C	0.7354	1	NA	1.04	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene
YNL255C	GIS2	0.7354	5	1	1.052	Protein with seven cysteine-rich CCHC zinc-finger motifs, similar to human CNBP, proposed to be involved in the RAS/cAMP signaling pathway
YDR508C	GNP1	0.7352	NA	2	1.027	High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YJL102W	MEF2	0.7351	2	NA	0.924	Mitochondrial elongation factor involved in translational elongation
YDR306C	YDR306C	0.7351	7	NA	1.04	F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain
YOR090C	PTC5	0.735	4	NA	1.043	Mitochondrially localized type 2C protein phosphatase involved in regulation of pyruvate dehydrogenase activity; contains Mg2+/Mn2+-dependent casein phosphatase activity in vitro
YIL148W	RPL40A	0.7349	31	1	0.968	Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YPL110C	GDE1	0.7346	9	NA	1.024	Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes
YDR315C	IPK1	0.7346	NA	9	0.824	Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
YER176W	ECM32	0.7345	NA	NA	1.041	DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
YPL269W	KAR9	0.7345	NA	24	1.038	Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
YPL270W	MDL2	0.7343	NA	NA	1.023	Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane
YDR103W	STE5	0.7339	7	NA	1.031	Pheromone-responsive scaffold protein; shuttles from the nucleus to the plasma membrane and assembles kinases Ste11p, Ste7p, and Fus3p into a specific signaling complex; active oligomeric form interacts with Ste4p-Ste18p complex
YFL040W	YFL040W	0.7338	NA	NA	0.964	Putative protein of unknown function; YFL040W is not an essential gene
YDR469W	SDC1	0.7334	8	13	0.965	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; has similarity to C. elegans Dpy-30
YJR021C	REC107	0.7334	NA	NA	1.032	Protein involved in early stages of meiotic recombination; involved in altering chromatin structure at DNA double-stranded break sites and in coordination between the initiation of recombination and the first division of meiosis
YKL128C	PMU1	0.7334	2	NA	1.081	Putative phosphomutase, contains a region homologous to the active site of phsophomutases; overexpression of the gene suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YKR055W	RHO4	0.7329	1	1	0.987	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity
YNL076W	MKS1	0.7327	3	2	1.077	Pleiotropic regulatory factor involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling
YCL050C	APA1	0.7327	2	NA	1.027	Diadenosine 5',5'"'-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa2p
YMR015C	ERG5	0.7326	NA	NA	1.028	C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
YBR148W	YSW1	0.7325	3	NA	0.974	Protein expressed specifically in spores
YJR137C	ECM17	0.7325	NA	NA	0.976	Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
YBL049W	MOH1	0.7322	9	NA	0.981	Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YIR031C	DAL7	0.7322	1	NA	0.986	Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YOR109W	INP53	0.7321	NA	7	0.99	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in a TGN (trans Golgi network)-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches
YCR101C	YCR101C	0.7321	NA	NA	1.009	Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene
YGL025C	PGD1	0.732	27	9	0.653	Subunit of the Mediator global transcriptional cofactor complex, which is part of the RNA polymerase II holoenzyme and plays an essential role in basal and activated transcription; direct target of the Cyc8p-Tup1p transcriptional corepressor
YPR199C	ARR1	0.7319	NA	NA	0.983	Transcriptional activator of the bZIP family, required for transcription of genes involved in resistance to arsenic compounds
YJR010C-A	SPC1	0.7317	32	1	1.047	Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER), homolog of the SPC12 subunit of mammalian signal peptidase complex
YLR262C	YPT6	0.7315	13	153	0.892	GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
YJL182C	YJL182C	0.7309	NA	NA	1.024	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W
YMR115W	FMP24	0.7308	NA	NA	1.019	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YFL050C	ALR2	0.7304	NA	1	0.985	Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
YDR248C	YDR248C	0.7303	1	2	1.031	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YDL056W	MBP1	0.7302	4	1	0.982	Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
YLR319C	BUD6	0.7301	4	7	0.957	Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate
YJR073C	OPI3	0.7301	NA	14	0.45	Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis
YDR383C	NKP1	0.7299	11	2	1.047	Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p)
YJR120W	YJR120W	0.7296	NA	1	1.068	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
YGR049W	SCM4	0.7295	NA	NA	0.995	Potential regulatory effector of CDC4 function, suppresses a temperature-sensitive allele of CDC4, tripartite protein structure in which a charged region separates two uncharged domains, not essential for mitosis or meiosis
YOL132W	GAS4	0.7295	NA	NA	0.969	1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall
YNL141W	AAH1	0.7293	2	1	0.975	Adenine deaminase (adenine aminohydrolase), involved in purine salvage and nitrogen catabolism
YGR014W	MSB2	0.7293	NA	1	1.004	Mucin family member at the head of the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate
YER093C-A	YER093C-A	0.7291	NA	NA	0.991	Putative protein of unknown function; YER093C-A contains an intron
YJR050W	ISY1	0.7281	10	3	0.994	Component of the spliceosome complex involved in pre-mRNA splicing, auxiliary splicing factor that may modulate Syf1p activity and help optimize splicing; isy1 syf2 double mutation activates the spindle checkpoint, causing cell cycle arrest
YMR292W	GOT1	0.728	NA	2	0.978	Evolutionarily conserved non-essential protein present in early Golgi cisternae that may be involved in ER-Golgi transport at a step after vesicle tethering to Golgi membranes, exhibits membrane topology similar to that of Sft2p
YGR059W	SPR3	0.7279	NA	1	1.021	Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI
YOL017W	ESC8	0.7278	4	10	1.022	Protein involved in telomeric and mating-type locus silencing, interacts with Sir2p and also interacts with the Gal11p, which is a component of the RNA pol II mediator complex
YMR019W	STB4	0.7275	4	NA	1.046	Protein that binds Sin3p in a two-hybrid assay; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins
YPL059W	GRX5	0.7273	1	1	0.819	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p
YPL100W	ATG21	0.7269	NA	1	1.006	Phosphatidylinositol 3,5-bisphosphate-binding protein required for maturation of pro-aminopeptidase I, predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization
YBL078C	ATG8	0.7269	1	NA	0.971	Protein required for autophagy; modified by the serial action of Atg4p, Atg7p, and Atg3p, and conjugated at the C terminus with phosphatidylethanolamine, to become the form essential for generation of autophagosomes
YGR097W	ASK10	0.7268	6	NA	1.017	Component of the RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p, which relieves repression of stress-response genes
YNL091W	NST1	0.7261	4	NA	0.98	Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1
YJR100C	YJR100C	0.7259	1	NA	1.066	Putative protein of unknown function; appears related to murine NOR1, which is highly expressed in leukemogenic cell lines; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR122C-A	YGR122C-A	0.7257	NA	NA	1.062	Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W
YDL090C	RAM1	0.7252	2	2	0.84	Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
YGR084C	MRP13	0.7249	34	NA	0.991	Mitochondrial ribosomal protein of the small subunit
YEL029C	BUD16	0.7247	NA	1	0.483	Protein involved in bud-site selection and telomere maintenance; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; has similarity to pyridoxal kinases
YOL060C	MAM3	0.7247	NA	NA	1.043	Protein required for normal mitochondrial morphology, has similarity to hemolysins
YOR164C	YOR164C	0.7246	3	NA	1.01	Protein of unknown function; interacts with Mdy2p
YNR065C	YSN1	0.7245	1	NA	0.947	Sortilin homolog, interacts with proteins of the endocytic machinery
YML101C	CUE4	0.7244	2	NA	1.066	Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
YOL050C	YOL050C	0.7242	NA	NA	0.99	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YHR150W	PEX28	0.7241	NA	NA	1.033	Peroxisomal integral membrane protein, involved in regulation of peroxisome size and number; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p
YCL001W-A	YCL001W-A	0.7234	NA	NA	0.982	Putative protein of unknown function; YCL001W-A is not an essential gene
YDR484W	VPS52	0.7232	6	7	0.825	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin
YOR378W	YOR378W	0.7232	1	NA	1.034	Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YOR083W	WHI5	0.7228	3	1	0.972	Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1
YPL027W	SMA1	0.7227	1	NA	0.984	Protein of unknown function involved in the assembly of the prospore membrane during sporulation
YCR028C	FEN2	0.7226	NA	2	0.881	Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph
YIL084C	SDS3	0.7225	16	23	0.794	Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes
YPR054W	SMK1	0.7225	10	NA	0.976	Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p
YER041W	YEN1	0.7225	4	2	1.003	Protein of unknown function, has similarity to endonuclease Rth1p; potentially phosphorylated by Cdc28p
YML088W	UFO1	0.7225	2	NA	0.835	F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
YJR148W	BAT2	0.7223	5	1	1.042	Cytosolic branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase
YBL045C	COR1	0.7219	16	NA	0.853	Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain
YBL101C	ECM21	0.7215	1	5	1.002	Non-essential protein of unknown function; promoter contains several Gcn4p binding elements
YNL242W	ATG2	0.7215	3	NA	0.966	Peripheral membrane protein required for the formation of cytosolic sequestering vesicles involved in vacuolar import through both the Cvt pathway and autophagy; interacts with Atg9p and is necessary for its trafficking
YPL184C	MRN1	0.7214	NA	NA	0.979	Putative RNA binding protein
YMR158W-A	YMR158W-A	NA	NA	NA	NA	NA
YKL206C	ADD66	0.7212	5	NA	1.052	Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly
YCR065W	HCM1	0.721	3	11	0.992	Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role
YOR036W	PEP12	0.7209	2	7	0.637	Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
YDL179W	PCL9	0.7207	3	NA	0.961	Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p
YKL127W	PGM1	0.7203	1	NA	1.077	Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
YNR027W	BUD17	0.7201	NA	NA	1.076	Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YLR067C	PET309	0.7201	1	2	0.816	Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; located in the mitochondrial inner membrane
YMR036C	MIH1	0.72	4	1	1.04	Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
YGL194C	HOS2	0.7199	7	17	0.958	Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity
YLR279W	YLR279W	0.7196	NA	NA	0.96	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR129W	POM152	0.7196	1	7	1.042	Nuclear pore membrane glycoprotein; may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase;
YOR380W	RDR1	0.7195	1	NA	1.035	Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins
YBR178W	YBR178W	0.7192	NA	NA	1.064	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C
YML008C	ERG6	0.7191	2	5	0.985	Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane
YOR231W	MKK1	0.7187	NA	3	1.027	Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p
YHR129C	ARP1	0.7186	1	29	0.953	Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin
YOR076C	SKI7	0.7185	14	3	1.049	Antiviral adaptor protein that mediates interactions via its N-terminus between the exosome and Ski complex (Ski2p, Ski3p, Ski8p) which operate in the 3'-to-5' mRNA-decay pathway; cytoplasmic protein required for degrading nonstop mRNAs
YER054C	GIP2	0.7184	5	NA	0.989	Putative regulatory subunit of the protein phosphatase Glc7p, involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p
YJL159W	HSP150	0.7184	3	1	1.03	O-mannosylated heat shock protein that is secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation
YFL032W	YFL032W	0.7178	NA	NA	0.996	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
YHL024W	RIM4	0.7174	5	NA	NA	Putative RNA-binding protein required for the expression of early and middle sporulation genes
YOL126C	MDH2	0.7174	7	1	0.95	Cytoplasmic malate dehydrogenase, one of the three isozymes that catalyze interconversion of malate and oxaloacetate; involved in gluconeogenesis during growth on ethanol or acetate as carbon source; interacts with Pck1p and Fbp1p
YAL044C	GCV3	0.7172	1	NA	0.832	H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
YDR075W	PPH3	0.7172	16	14	1.104	Catalytic subunit of an evolutionarily conserved protein phosphatase complex containing Psy2p and the regulatory subunit Psy4p; required for cisplatin resistance; involved in activation of Gln3p
YLR059C	REX2	0.7169	5	NA	1.008	RNA exonuclease, required for U4 snRNA maturation; functions redundantly with Rnh70p in 5.8S rRNA maturation, and with Rnh70p and Rex3p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases
YOL070C	YOL070C	0.7169	3	NA	0.991	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, and bud neck; potential Cdc28p substrate
YPR004C	YPR004C	0.7169	NA	NA	1.007	Electron transfer flavoprotein complex subunit ETF-alpha; contains a FAD binding domain; interacts with YFH1, the yeast frataxin homolog
YPR146C	YPR146C	0.7167	NA	NA	0.956	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL002W	ERP6	0.7165	NA	NA	0.981	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR328W	PDR10	0.7159	1	NA	1.057	ABC (ATP-binding cassette) membrane pump involved in the pleiotropic drug resistance network, regulated by Pdr1p and Pdr3p, similar to Pdr5p
YBR048W	RPS11B	0.7159	76	NA	0.822	Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins
YKR067W	GPT2	0.7158	3	NA	0.963	Glycerol-3-phosphate acyltransferase located in both lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone, which are intermediate steps in lipid biosynthesis
YEL067C	YEL067C	0.7158	NA	NA	0.996	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR454W	FMP27	0.7156	2	NA	0.959	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR268C	YOR268C	0.7153	NA	NA	1.015	Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
YDR003W	RCR2	0.715	NA	NA	1.015	Vacuolar protein that presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; similar to Rcr1p
YER144C	UBP5	0.7149	NA	1	0.999	Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck
YLR270W	DCS1	0.7149	4	1	1.018	Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p
YEL072W	RMD6	0.7148	NA	NA	0.998	Protein required for sporulation
YHR009C	YHR009C	0.7147	2	NA	1.007	Putative protein of unknown function; not an essential gene
YML035C-A	YML035C-A	NA	NA	NA	NA	NA
YMR317W	YMR317W	0.7146	NA	1	1.073	Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene
YLR408C	YLR408C	0.7145	6	NA	0.993	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene
YDR537C	YDR537C	0.7136	NA	NA	1.02	Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
YJR150C	DAN1	0.7136	NA	NA	1.053	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YOR175C	YOR175C	0.7135	NA	NA	1.019	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the MBOAT family of putative membrane-bound O-acyltransferases
YLL015W	BPT1	0.7135	1	NA	1.017	ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p
YEL017C-A	PMP2	0.7131	NA	NA	1.005	Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; nearly identical to PMP1
YER046W-A	YER046W-A	0.7131	NA	NA	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR036W	VMA13	0.7128	10	3	1.046	Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase
YNL120C	YNL120C	0.7127	NA	NA	0.891	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene
YCR011C	ADP1	0.7127	NA	NA	0.971	Putative ATP-dependent permease of the ABC transporter family of proteins
YLR030W	YLR030W	0.7123	NA	NA	0.978	Putative protein of unknown function
YBL017C	PEP1	0.7123	5	NA	0.952	Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
YLR202C	YLR202C	0.7122	NA	NA	0.94	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
YHL014C	YLF2	0.7122	8	NA	0.995	Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOL124C	TRM11	0.7121	1	NA	0.991	Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YDL243C	AAD4	0.712	NA	2	0.914	Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response
YNL204C	SPS18	0.7118	NA	1	1.023	Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation
YER001W	MNN1	0.7117	2	1	1	Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YGL256W	ADH4	0.7117	7	NA	1.009	Alcohol dehydrogenase type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency; alcohol dehydrogenase isoenzyme IV
YNR018W	YNR018W	0.7116	NA	NA	1.007	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL229W	SSB1	0.7115	22	1	0.983	Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p
YLR235C	YLR235C	0.7114	NA	NA	0.854	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TOP3
YPL062W	YPL062W	0.7113	NA	NA	0.857	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
YKL090W	CUE2	0.7111	NA	NA	1.04	Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
YBR255W	YBR255W	0.7111	NA	5	1.028	Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YPL014W	YPL014W	0.711	2	NA	0.983	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YOL058W	ARG1	0.7107	2	NA	1.01	Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate
YLR027C	AAT2	0.7106	6	2	0.869	Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
YHR073W	OSH3	0.7103	3	1	0.97	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
YKL063C	YKL063C	0.71	NA	NA	1.06	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YDR349C	YPS7	0.7096	2	1	1.036	Putative GPI-anchored aspartic protease, located in the cytoplasm and endoplasmic reticulum
YBL090W	MRP21	0.7095	28	NA	0.721	Mitochondrial ribosomal protein of the large subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences
YLR104W	YLR104W	0.7093	NA	NA	1.003	Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate
YJL190C	RPS22A	0.7092	95	5	1.017	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins
YNL254C	YNL254C	0.7087	3	NA	1.005	Hypothetical protein
YBR208C	DUR1,2	0.7083	6	NA	1.024	Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YCL034W	LSB5	0.7082	NA	1	0.97	Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YPR084W	YPR084W	0.7081	NA	3	1.008	Putative protein of unknown function
YDL006W	PTC1	0.708	7	19	0.716	Type 2C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p; mutation delays mitochondrial inheritance; deletion reveals defects in precursor tRNA splicing, sporulation and cell separation
YFR012W	YFR012W	0.7077	NA	NA	0.974	Putative protein of unknown function
YGR117C	YGR117C	0.7077	NA	NA	1.001	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YNL005C	MRP7	0.7072	34	NA	0.833	Mitochondrial ribosomal protein of the large subunit
YGL115W	SNF4	0.7071	20	6	0.743	Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis
YBR225W	YBR225W	0.7071	6	NA	0.954	Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components
YNR028W	CPR8	0.7068	NA	NA	1.08	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
YDL119C	YDL119C	0.7066	NA	NA	0.878	Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria
YEL043W	YEL043W	0.7064	1	2	0.98	Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold
YJL152W	YJL152W	0.7064	NA	NA	1.008	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL194W	DDC1	0.7063	3	27	1.006	DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate
YJR062C	NTA1	0.7062	7	NA	1.041	Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation
YDL174C	DLD1	0.7061	NA	NA	1.004	D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
YOR286W	FMP31	0.7053	NA	NA	0.994	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR029W	YDR029W	0.7053	NA	NA	0.974	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
YIR004W	DJP1	0.705	1	NA	0.978	Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ
YER060W-A	FCY22	0.7048	NA	NA	0.811	Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
YLR350W	ORM2	0.7045	1	3	0.823	Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum
YDL076C	RXT3	0.7045	15	NA	0.976	Protein of unknown function, may be involved in chromatin silencing
YOR284W	HUA2	0.7044	1	NA	1.029	Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
YKR072C	SIS2	0.7044	7	6	0.945	Negative regulatory subunit of the protein phosphatase 1 Ppz1p; involved in ion homeostasis and cell cycle progression
YNL084C	END3	0.7042	6	13	0.725	EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
YLR239C	LIP2	0.7042	2	3	0.959	Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups
YLR206W	ENT2	0.7039	1	1	1.005	Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
YOR189W	IES4	0.7037	10	NA	0.999	Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
YOR320C	GNT1	0.7036	NA	NA	1.044	N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus
YNR032W	PPG1	0.7036	NA	2	1.054	Putative serine/threonine protein phosphatase, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases
YHL009C	YAP3	0.7035	NA	NA	1.068	Basic leucine zipper (bZIP) transcription factor
YPR046W	MCM16	0.7032	13	20	1	Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA
YBL061C	SKT5	0.7029	11	48	0.978	Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation
YKR066C	CCP1	0.7028	1	NA	0.967	Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
YKL044W	YKL044W	0.7028	NA	NA	1.034	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR048C	YDR048C	0.7028	NA	NA	1.005	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFR048W	RMD8	0.7026	1	NA	0.967	Cytosolic protein required for sporulation
YJL188C	YJL188C	0.7023	NA	NA	0.607	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YMR107W	SPG4	0.7022	NA	NA	1.04	Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YPL090C	RPS6A	0.702	68	1	0.714	Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein
YDL079C	MRK1	0.702	NA	NA	1.005	Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
YLR299W	ECM38	0.7019	1	NA	1.005	Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; expression induced mainly by nitrogen starvation
YIL055C	YIL055C	0.7017	1	NA	1.04	Putative protein of unknown function
YDR134C	YDR134C	NA	NA	NA	NA	NA
YDR410C	STE14	0.7014	NA	NA	1.002	Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane
YLR190W	MMR1	0.7013	1	5	0.881	Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
YML048W	GSF2	0.7012	3	1	1.028	ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression
YDR277C	MTH1	0.7012	NA	NA	1.011	Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YPL042C	SSN3	0.701	24	5	0.765	Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression
YKR087C	OMA1	0.7009	NA	NA	0.968	Metalloendopeptidase of the mitochondrial inner membrane, involved in turnover of membrane-embedded proteins; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes
YGR159C	NSR1	0.7008	17	3	0.67	Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
YOR158W	PET123	0.7006	28	NA	0.832	Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
YLR252W	YLR252W	0.7005	NA	NA	1.015	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism
YNL322C	KRE1	0.7005	NA	51	1.087	Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
YPL232W	SSO1	0.7004	NA	1	1.051	Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
YMR318C	ADH6	0.7004	2	1	1.063	NADPH-dependent cinnamyl alcohol dehydrogenase family member with broad substrate specificity; may be involved in fusel alcohol synthesis or in aldehyde tolerance
YPR128C	ANT1	0.7001	NA	NA	1	Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation
YPR123C	YPR123C	0.7	NA	NA	0.948	Hypothetical protein
YML099C	ARG81	0.6999	1	NA	1.053	Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p
YHR049W	FSH1	0.6997	NA	NA	0.445	Serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to Fsh2p and Fsh3p
YJL129C	TRK1	0.6997	3	1	0.677	Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation
YNL140C	YNL140C	0.6995	NA	NA	0.989	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene RLR1/YNL139C
YBR084W	MIS1	0.6991	32	NA	0.97	Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
YBR282W	MRPL27	0.699	14	NA	0.816	Mitochondrial ribosomal protein of the large subunit
YLR309C	IMH1	0.6984	5	2	0.98	Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi
YJL157C	FAR1	0.6981	10	2	0.984	Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate
YER007C-A	TMA20	0.698	6	NA	0.927	Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1
YGR256W	GND2	0.6978	4	NA	0.992	6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YDR163W	CWC15	0.6976	5	NA	0.998	Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p
YLR456W	YLR456W	0.6976	NA	NA	0.985	Putative protein of unknown function
YLR290C	YLR290C	0.6975	1	NA	1	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene
YMR295C	YMR295C	0.6971	NA	1	1.108	Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene
YOR300W	YOR300W	0.6969	NA	NA	1.017	Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
YNR072W	HXT17	0.6969	NA	2	0.957	Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose
YNL325C	FIG4	0.6967	3	1	1.096	Protein that forms a complex with Vac14p and is involved in turnover of PI3,5P2 (phosphatidylinositol 3,5-bisphosphate) after hyperosmotic shock; required for efficient mating; member of a protein family with a domain homologous to Sac1p
YMR230W	RPS10B	0.6966	18	3	0.883	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Ap and has similarity to rat ribosomal protein S10
YMR021C	MAC1	0.6966	1	4	1.034	Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
YDL091C	UBX3	0.6965	NA	NA	0.963	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YBR033W	EDS1	0.6964	NA	1	0.987	Putative zinc cluster protein; YBR033W is not an essential gene
YLR251W	SYM1	0.6964	NA	NA	1.013	Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17
YJR036C	HUL4	0.6959	2	NA	1.014	Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability
YOR125C	CAT5	0.6958	4	NA	0.942	Mitochondrial inner membrane protein directly involved in ubiquinone biosynthesis, essential for several other metabolic pathways including respiration and gluconeogenic gene activation
YMR193W	MRPL24	0.6954	30	NA	0.814	Mitochondrial ribosomal protein of the large subunit
YDR401W	YDR401W	0.6952	NA	NA	1.045	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR046C	ZTA1	0.6951	NA	NA	1.02	Zeta-crystallin homolog, found in the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin, which has quinone oxidoreductase activity
YBR216C	YBP1	0.6948	1	NA	0.868	Protein required for oxidation of specific cysteine residues of the transcription factor Yap1p, resulting in the nuclear localization of Yap1p in response to stress
YOL152W	FRE7	0.6946	1	NA	1.012	Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels
YJL130C	URA2	0.6945	43	NA	0.998	Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
YPR157W	YPR157W	0.6944	NA	NA	0.969	Putative protein of unknown function
YOL025W	LAG2	0.694	1	NA	1.024	Protein involved in determination of longevity; LAG2 gene is preferentially expressed in young cells; overexpression extends the mean and maximum life span of cells
YKR046C	PET10	0.6939	4	NA	1.051	Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange
YJL192C	SOP4	0.6937	1	NA	1.031	ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER
YML073C	RPL6A	0.6934	95	NA	1.185	N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA
YMR141C	YMR141C	0.6933	NA	NA	1.021	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCR006C	YCR006C	0.6932	NA	NA	0.968	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLL032C	YLL032C	0.693	2	NA	1.018	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
YIL094C	LYS12	0.693	47	NA	0.95	Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate
YJL126W	NIT2	0.6929	NA	NA	0.982	Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
YPL088W	YPL088W	0.6929	NA	NA	1.005	Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YOL008W	COQ10	0.6924	1	NA	1.012	Coenzyme Q binding protein, required for function of coenzyme Q in respiration by functioning in the delivery of Q<sub>6</sub> to its proper location for electron transport, START domain protein with homologs in bacteria and eukaryotes
YKL205W	LOS1	0.6923	3	5	1.08	Nuclear pore protein involved in nuclear export of pre-tRNA
YGR018C	YGR018C	0.6922	NA	NA	1.046	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR017W
YIL137C	TMA108	0.6921	4	NA	1.009	Protein that associates with ribosomes; putative metalloprotease
YNL063W	MTQ1	0.6921	1	1	1.003	S-adenosylmethionine-dependent Methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene
YCL045C	YCL045C	0.6914	1	NA	0.97	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; interacts with Gal80p; YCL045C is not an essential gene
YGR199W	PMT6	0.6913	NA	NA	1.039	Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases
YDR150W	NUM1	0.6911	2	39	0.924	Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex
YJR079W	YJR079W	0.6905	NA	NA	0.977	Putative protein of unknown function; mutation results in impaired mitochondrial respiration
YBR175W	SWD3	0.6904	21	27	0.865	Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5
YOL057W	YOL057W	0.6902	1	NA	1.076	Putative metalloprotease
YLR150W	STM1	0.6902	118	2	0.95	Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YMR088C	VBA1	0.6902	NA	NA	0.997	Permease of basic amino acids in the vacuolar membrane
YOR228C	YOR228C	0.69	NA	NA	1.071	Protein of unknown function, localized to the mitochondrial outer membrane
YDR479C	PEX29	0.6898	NA	NA	1.032	Peroxisomal integral membrane protein, involved in regulation of peroxisome size and number; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p
YIL162W	SUC2	0.6896	1	NA	1.011	Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YJR145C	RPS4A	0.6896	117	5	0.784	Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YCR001W	YCR001W	0.6895	NA	NA	0.98	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene
YFR014C	CMK1	0.6894	2	NA	0.968	Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II
YKL062W	MSN4	0.6892	2	1	1.063	Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YGR183C	QCR9	0.6891	NA	NA	0.991	Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
YNL021W	HDA1	0.689	8	NA	0.966	Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation
YOL116W	MSN1	0.6888	NA	2	0.994	Transcriptional activator involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus
YHR034C	PIH1	0.6887	4	1	0.77	Protein of unresolved function; may function in protein folding and/or rRNA processing, interacts with a chaperone (Hsp82p), two chromatin remodeling factors (Rvb1p, Rvb2p) and two rRNA processing factors (Rrp43p, Nop58p)
YOR124C	UBP2	0.6887	7	1	0.993	Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins, cleaves at the C terminus of ubiquitin fusions; capable of cleaving polyubiquitin and possesses isopeptidase activity
YBR103W	SIF2	0.6883	16	21	0.859	WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus
YGR131W	YGR131W	0.6881	NA	NA	0.982	Protein of unknown function; expression induced in response to ketoconazole; promoter region contains a sterol regulatory element motif, which has been identified as a Upc2p-binding site
YPR106W	ISR1	0.6881	NA	1	1.014	Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C
YOR155C	ISN1	0.688	1	NA	0.995	Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
YDR344C	YDR344C	0.6879	NA	NA	1.058	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIR037W	HYR1	0.6877	2	NA	0.966	Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor
YDR030C	RAD28	0.6877	4	NA	0.974	Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions; homolog of human CSA protein
YER053C	PIC2	0.6877	NA	NA	0.992	Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
YER153C	PET122	0.6876	1	2	0.951	Specific translational activator for the COX3 mRNA that acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane
YGR062C	COX18	0.6875	1	2	0.91	Mitochondrial inner membrane protein, required for export of the Cox2p C terminus from the mitochondrial matrix to the intermembrane space during its assembly into cytochrome c oxidase; similar to Oxa2p of N. crassa
YDL192W	ARF1	0.6875	17	19	0.8	ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p
YMR037C	MSN2	0.6872	1	1	1.033	Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YJL028W	YJL028W	0.6871	NA	NA	1.022	Protein of unknown function; may interact with ribosomes, based on co-purification experiments
YBL082C	ALG3	0.6865	2	2	0.981	Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
YLR055C	SPT8	0.6865	21	43	0.881	Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
YGR226C	YGR226C	0.6865	NA	NA	0.997	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W
YGL135W	RPL1B	0.6865	71	3	0.976	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal
YOR275C	RIM20	0.6863	NA	5	0.922	Protein involved in proteolytic activation of Rim101p in response to alkaline pH; member of the PalA/AIP1/Alix family; interacts with the ESCRT-III subunits Snf7p, suggesting a relationship between the response to pH and multivesicular body formation
YMR305C	SCW10	0.6863	NA	NA	1.104	Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
YFR030W	MET10	0.6861	11	1	1.035	Subunit alpha of assimilatory sulfite reductase, which is responsible for the conversion of sulfite into sulfide
YLR143W	YLR143W	0.686	1	NA	0.98	Putative protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; YLR143W is not an essential gene
YGL234W	ADE5,7	0.6858	9	NA	0.946	Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
YDR539W	YDR539W	0.6857	NA	NA	1.004	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR539W is not an essential gene
YFR035C	YFR035C	0.6857	NA	NA	0.981	Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein
YEL066W	HPA3	0.6857	NA	1	1.003	D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YGL243W	TAD1	0.6856	NA	NA	1.014	tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala
YDL072C	YET3	0.6856	NA	NA	0.964	Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein
YBL068W	PRS4	0.6855	1	1	0.953	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of a five related enzymes, which are active as heteromultimeric complexes
YMR153C-A	YMR153C-A	0.6853	NA	NA	0.648	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NUP53
YOR302W	YOR302W	0.6851	NA	NA	0.998	CPA1 uORF , Arginine attenuator peptide, regulates translation of the CPA1 mRNA
YCL063W	VAC17	0.685	NA	NA	0.922	Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p
YKL050C	YKL050C	0.6846	1	NA	1.052	Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p
YHR133C	NSG1	0.6845	NA	NA	1.017	Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins
YGL257C	MNT2	0.6838	NA	NA	0.991	Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans
YMR162C	DNF3	0.6838	NA	NA	1.037	Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase
YIL111W	COX5B	0.6834	NA	NA	0.993	Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth
YKL215C	YKL215C	0.6833	3	NA	0.991	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YLR176C	RFX1	0.6832	12	NA	0.983	Protein involved in DNA damage and replication checkpoint pathway; recruits repressors Tup1p and Cyc8p to promoters of DNA damage-inducible genes; similar to a family of mammalian DNA binding RFX1-4 proteins
YBR181C	RPS6B	0.683	60	1	0.826	Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein
YIL139C	REV7	0.683	NA	NA	1	Processivity subunit of DNA polymerase zeta, which is involved in DNA repair and translesion synthesis; required for mutagenesis induced by DNA damage
YNL200C	YNL200C	0.6824	NA	1	1.018	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJR103W	URA8	0.6824	1	1	0.952	Minor CTP synthase isozyme (see also URA7), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis
YML019W	OST6	0.6821	1	1	1.045	Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p
YDR272W	GLO2	0.682	3	NA	0.994	Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate
YER120W	SCS2	0.682	12	3	0.973	Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog
YJR102C	VPS25	0.6817	2	2	0.797	Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
YAL061W	YAL061W	0.6814	2	NA	0.998	Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene
YOR248W	YOR248W	0.6813	NA	NA	1.003	Hypothetical protein
YJL201W	ECM25	0.6813	1	NA	1.028	Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p
YDR430C	CYM1	0.6811	6	NA	0.935	Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology
YHR030C	SLT2	0.6811	33	95	0.966	Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway
YPR099C	YPR099C	0.6811	NA	NA	1.027	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W
YDL161W	ENT1	0.6811	NA	2	1	Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus
YJL024C	APS3	0.681	2	NA	1.044	Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function
YKL085W	MDH1	0.6808	24	NA	1.043	Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle
YOR052C	YOR052C	0.6807	5	NA	1.027	Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid
YPL118W	MRP51	0.6807	30	NA	0.887	Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences
YML005W	TRM12	0.6806	1	NA	1.048	S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA
YIR002C	MPH1	0.6803	4	1	0.997	Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, mutations confer a mutator phenotype
YLR312C	YLR312C	0.6801	1	3	0.939	Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YGR225W	AMA1	0.6796	NA	NA	1.019	Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis
YJL064W	YJL064W	0.6795	NA	NA	0.947	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1
YLL027W	ISA1	0.6791	6	2	0.983	Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources
YOR027W	STI1	0.6791	16	17	1.016	Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones; activates the ATPase activity of Ssa1p; homolog of mammalian Hop protein
YGR038W	ORM1	0.6787	NA	NA	0.988	Evolutionarily conserved protein with similarity to Orm2p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum
YKL016C	ATP7	0.6785	2	NA	0.885	Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YMR089C	YTA12	0.6784	5	7	0.905	Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes
YPR006C	ICL2	0.6784	NA	NA	1.02	2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
YLR260W	LCB5	0.6784	1	NA	0.651	Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
YIR025W	MND2	0.6779	13	1	0.982	Subunit of the anaphase-promoting complex (APC); needed for meiotic nuclear division
YOR285W	YOR285W	0.6778	NA	NA	1.021	Protein of unknown function, localized to the mitochondrial outer membrane
YLR412W	YLR412W	0.6778	NA	NA	0.956	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene
YLR092W	SUL2	0.6775	1	1	1.009	High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
YPL164C	MLH3	0.6773	2	NA	1.056	Protein involved in DNA mismatch repair; forms a complex with Mlh1p to promote meiotic crossing-over; mammalian homolog is implicated mammalian microsatellite instability
YDR124W	YDR124W	0.6773	11	NA	1.007	Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor
YPR020W	ATP20	0.6772	NA	NA	0.95	Subunit g of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase
YOL023W	IFM1	0.6771	NA	2	0.952	Mitochondrial translation initiation factor 2
YKR009C	FOX2	0.6769	4	NA	0.9	Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YMR075C-A	YMR075C-A	0.6769	NA	NA	0.964	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W
YIL038C	NOT3	0.6761	10	4	0.894	Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
YBR266C	YBR266C	0.6759	NA	NA	0.822	Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase
YBR174C	YBR174C	0.6758	NA	NA	0.915	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective
YGL105W	ARC1	0.6756	28	3	0.748	Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids
YIR007W	YIR007W	0.6753	10	NA	1.005	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene
YPR194C	OPT2	0.6752	NA	NA	0.898	Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans
YOR137C	SIA1	0.6749	1	NA	1.033	Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose
YHL029C	OCA5	0.6748	4	4	0.943	Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YJR104C	SOD1	0.6745	13	31	1.004	Cytosolic superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans
YFL003C	MSH4	0.6743	1	NA	NA	Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein
YER169W	RPH1	0.6742	NA	NA	0.877	JmjC domain-containing histone demethylase which can specifically demethylate H3K36 tri- and dimethyl modification states; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway
YGR057C	LST7	0.6741	NA	1	0.844	Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
YIL156W	UBP7	0.674	4	1	1.03	Ubiquitin-specific protease that cleaves ubiquitin-protein fusions
YFR016C	YFR016C	0.674	5	NA	0.947	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene
YML021C	UNG1	0.6738	NA	NA	0.961	Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
YIR003W	YIR003W	0.6737	5	2	0.992	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein colocalizes with Sac1p to the actin cytoskeleton; interacts with with the SH3 domain of Abp1p
YPL222W	FMP40	0.6735	2	NA	1.07	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKR065C	PAM17	0.6735	1	NA	0.941	Presequence translocase-associated motor subunit, required for stable complex formation between cochaperones Pam16p and Pam18p, promotes association of Pam16p-Pam18p with the presequence translocase
YOR379C	YOR379C	0.6733	NA	NA	0.948	Hypothetical protein
YDL170W	UGA3	0.673	NA	2	0.986	Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus
YMR261C	TPS3	0.6729	4	NA	1.03	Regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway
YPL257W	YPL257W	0.6729	NA	NA	1.068	Putative protein of unknown function;; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene
YIL085C	KTR7	0.6725	NA	NA	0.972	Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YLR308W	CDA2	0.6725	NA	NA	0.978	Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YNL295W	YNL295W	0.6725	NA	NA	1.099	Putative protein of unknown function
YKR053C	YSR3	0.6724	NA	NA	1.069	Dihydrosphingosine 1-phosphate phosphatase, membrane protein involved in sphingolipid metabolism; has similarity to Lcb3p
YEL068C	YEL068C	0.6723	NA	NA	0.989	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR097W	YPR097W	0.6719	NA	NA	1	Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL020C	SPT23	0.6717	NA	1	1.055	ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
YNR047W	YNR047W	0.6715	5	NA	0.99	Putative protein kinase that, when overexpressed, interferes with pheromone-induced growth arrest; localizes to the cytoplasm; potential Cdc28p substrate
YMR062C	ECM40	0.6713	NA	NA	0.396	Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine
YNL203C	YNL203C	0.671	NA	NA	1.033	Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YPL017C	IRC15	0.671	NA	11	0.969	Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; null mutant displays increased levels of spontaneous Rad52 foci
YPR077C	YPR077C	0.6709	NA	NA	1.018	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1
YNR006W	VPS27	0.6708	1	NA	0.873	Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
YHR143W	DSE2	0.6701	NA	NA	0.987	Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP
YHR134W	WSS1	0.6698	NA	6	0.982	Sumoylated protein of unknown function, identified based on genetic interactions with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response, processing stalled or collapsed replication forks
YGR269W	YGR269W	0.6696	NA	NA	0.982	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C
YJR134C	SGM1	0.6694	2	NA	1.053	Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus
YIL079C	AIR1	0.6694	8	2	0.994	RING finger protein that interacts with the arginine methyltransferase Hmt1p to regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and export; has similarity to Air2p
YJL154C	VPS35	0.6693	9	10	0.917	Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval
YAL034C	FUN19	0.6692	7	NA	1.002	Non-essential protein of unknown function
YDR032C	PST2	0.669	12	NA	0.996	Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIL103W	DPH1	0.6688	17	NA	0.991	Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p
YOR112W	YOR112W	0.6686	3	2	1.006	Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p
YHL047C	ARN2	0.6686	NA	NA	0.991	Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
YER039C	HVG1	0.6686	1	NA	1.001	Protein of unknown function, has homology to Vrg4p
YGR064W	YGR064W	0.6684	NA	NA	0.823	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C
YPR093C	ASR1	0.6684	15	NA	0.985	Protein involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain
YML107C	PML39	0.6681	1	2	1.038	Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes
YDR409W	SIZ1	0.668	3	1	1.04	SUMO ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring
YOR142W	LSC1	0.6679	4	NA	1.007	Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate
YPR191W	QCR2	0.6677	14	NA	0.935	Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme
YDR411C	DFM1	0.6676	NA	NA	1.043	ER localized derlin-like family member involved in ER stress and homeostasis; not involved in ERAD or substrate retrotranslocation; interacts with CDC48; contains four transmembrane domains and two SHP boxes
YOR085W	OST3	0.6674	NA	7	0.935	Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
YOR079C	ATX2	0.6673	NA	NA	1.031	Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation
YDR403W	DIT1	0.6672	NA	NA	0.996	Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure
YDL041W	YDL041W	0.6672	NA	NA	1.02	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C
YGR219W	YGR219W	0.6672	NA	NA	0.636	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C
YHL038C	CBP2	0.6668	1	1	0.993	Mitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA, binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
YOR179C	SYC1	0.6666	7	NA	1.025	Subunit of the APT subcomplex of cleavage and polyadenylation factor, may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs
YNL190W	YNL190W	0.6665	NA	NA	0.987	Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site
YFL013C	IES1	0.6664	22	1	NA	Subunit of the INO80 chromatin remodeling complex
YLR219W	MSC3	0.6661	2	1	0.996	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate
YLL056C	YLL056C	0.666	NA	NA	0.99	Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YOR385W	YOR385W	0.6659	NA	NA	1.056	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene
YDL025C	YDL025C	0.6657	7	NA	0.954	Putative protein kinase, potentially phosphorylated by Cdc28p; YDL025C is not an essential gene
YOR279C	RFM1	0.6655	2	NA	0.941	DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance
YER073W	ALD5	0.6654	1	NA	0.982	Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
YNL225C	CNM67	0.6654	1	3	0.793	Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration
YBL083C	YBL083C	0.6652	NA	NA	0.989	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3
YLR227C	ADY4	0.6651	NA	NA	1.023	Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane
YLR133W	CKI1	0.6647	3	2	0.991	Choline kinase, catalyzes the first step in the CDP-choline pathway phosphatidylcholine synthesis (Kennedy pathway); mRNA expression is regulated by inositol and choline, enzyme activity is stimulated by phosphorylation by protein kinase
YKL040C	NFU1	0.6645	1	1	1.05	Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria
YDR094W	YDR094W	0.6642	NA	NA	1.015	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
YDL023C	YDL023C	0.6641	NA	NA	1.06	Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YOR138C	RUP1	0.6641	6	NA	1.02	Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; required for binding of Rsp5p to Ubp2p; contains an UBA domain
YGL244W	RTF1	0.664	19	51	0.686	Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenance
YOR273C	TPO4	0.6637	NA	NA	1.163	Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
YPL202C	AFT2	0.6637	NA	1	1.035	Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; similar to Aft1p
YDR436W	PPZ2	0.6637	7	1	1.017	Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
YDL099W	BUG1	0.6635	1	NA	0.921	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YPR118W	YPR118W	0.6631	2	NA	1.011	Methylthioribose-1-phosphate isomerase, catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway
YDR144C	MKC7	0.663	NA	5	0.875	GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p
YIR044C	YIR044C	NA	NA	NA	NA	NA
YDR036C	EHD3	0.663	20	NA	1.036	Protein of unconfirmed function, plays an indirect role in endocytic membrane trafficking, member of a family of enoyl-CoA hydratase/isomerases; the non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR004W	MVP1	0.6629	NA	3	1.083	Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole
YLR011W	LOT6	0.6629	1	NA	1.027	FMN-dependent NAD(P)H:quinone reductase that may be involved in quinone detoxification; gene expression increases in cultures shifted to a lower temperature
YJL199C	YJL199C	0.6628	NA	NA	1.039	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
YCR106W	RDS1	0.6627	NA	NA	0.897	Zinc cluster protein involved in conferring resistance to cycloheximide
YAL037W	YAL037W	0.6627	NA	NA	0.999	Putative protein of unknown function
YOR163W	DDP1	0.6625	NA	NA	0.993	Diadenosine polyphosphate hydrolase, member of the MutT family of nucleotide hydrolases with high specificity for diadenosine hexa- and pentaphosphates, required for efficient hydrolysis of diphosphorylated inositol polyphosphates
YNL227C	JJJ1	0.6624	3	NA	0.898	Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
YKL015W	PUT3	0.6624	3	NA	1.036	Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences and undergoes a conformational change to form the active state; has a Zn(2)-Cys(6) binuclear cluster domain
YML129C	COX14	0.6623	NA	NA	1.025	Mitochondrial membrane protein, required for assembly of cytochrome c oxidase
YBR022W	POA1	0.6623	NA	NA	1	Phosphatase that is highly specific for ADP-ribose 1'"'-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing
YGR035C	YGR035C	0.6623	NA	NA	0.982	Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YGL050W	TYW3	0.6622	2	NA	1.051	Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
YIR014W	YIR014W	0.6621	NA	NA	0.998	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene
YAR014C	BUD14	0.6617	11	6	1.059	Protein involved in bud-site selection, Bud14p-Glc7p complex functions as a cortical regulator of dynein; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YLL013C	PUF3	0.6616	7	NA	1.053	Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins
YLR184W	YLR184W	0.6615	NA	NA	0.734	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR330C	MIP1	0.6613	NA	NA	0.969	Catalytic subunit of the mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome.
YBR104W	YMC2	0.6612	NA	NA	0.962	Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p
YJL210W	PEX2	0.6612	6	NA	1.049	RING-finger peroxin, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms putative translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import
YKR099W	BAS1	0.6612	NA	1	0.568	Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
YDR121W	DPB4	0.6608	14	4	1.001	Shared subunit of DNA polymerase epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing
YOR107W	RGS2	0.6607	NA	NA	1.031	Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
YEL063C	CAN1	0.6607	NA	NA	1.013	Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance
YPL058C	PDR12	0.6604	NA	NA	0.983	Plasma membrane weak-acid-inducible ATP-binding cassette (ABC) transporter, required for weak organic acid resistance, strongly induced by sorbate and benzoate, regulated by War1p, mutants exhibit sorbate hypersensitivity
YKR048C	NAP1	0.6599	59	6	0.996	Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus
YGR238C	KEL2	0.6598	2	NA	0.987	Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate
YOL047C	YOL047C	0.6596	NA	NA	1.026	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YGR229C	SMI1	0.6595	11	82	0.881	Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity
YLR450W	HMG2	0.6594	1	NA	1.045	One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks
YNL083W	SAL1	0.6591	NA	NA	1.027	Probable transporter, member of the Ca2+-binding subfamily of the mitochondrial carrier family, with two EF-hand motifs; Pet9p and Sal1p have an overlapping function critical for viability; polymorphic in different S. cerevisiae strains
YHR157W	REC104	0.6591	NA	NA	1.008	Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination
YGR107W	YGR107W	0.6587	NA	NA	1.001	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR456W	NHX1	0.6582	NA	3	0.967	Endosomal Na+/H+ exchanger, required for intracellular sequestration of Na+; required for osmotolerance to acute hypertonic shock
YNL281W	HCH1	0.6581	6	1	1.082	Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus
YPL009C	YPL009C	0.658	6	NA	0.993	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL009C is not an essential gene
YHR048W	YHR048W	0.6578	NA	NA	0.961	Putative protein of unknown function, has similarity to multidrug resistance proteins; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YGL067W	NPY1	0.6577	4	NA	1.071	NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes
YNL274C	YNL274C	0.6576	2	NA	1.05	Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YEL024W	RIP1	0.6574	1	1	0.863	Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
YDL127W	PCL2	0.6572	NA	1	0.937	G1 cyclin, associates with Pho85p cyclin-dependent kinase (Cdk) to contribute to entry into the mitotic cell cycle, essential for cell morphogenesis; localizes to sites of polarized cell growth
YKL093W	MBR1	0.6572	3	1	1.026	Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YBR066C	NRG2	0.6571	2	NA	0.988	Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p
YNL332W	THI12	0.6569	NA	NA	1.092	Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YPL180W	TCO89	0.6567	5	2	0.648	Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin
YCR020C-A	MAK31	0.6562	2	2	0.967	Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family
YNR045W	PET494	0.656	NA	NA	1.016	Specific translational activator for the COX3 mRNA that acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
YOR153W	PDR5	0.656	4	NA	1.008	Short-lived membrane ABC (ATP-binding cassette) transporter, actively exports various drugs, expression regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
YCR004C	YCP4	0.656	2	NA	0.957	Protein of unknown function, has sequence and structural similarity to flavodoxins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR228C	ECM22	0.6558	NA	4	0.996	Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p
YGL263W	COS12	0.6558	NA	NA	1.004	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YMR011W	HXT2	0.6557	NA	NA	1.031	High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YKL184W	SPE1	0.6557	NA	NA	0.948	Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines
YBL091C-A	SCS22	0.6556	NA	NA	0.987	Protein involved in regulation of phospholipid metabolism; homolog of Scs2p; similar to D. melanogaster inturned protein
YDR465C	RMT2	0.6554	1	NA	1.032	Arginine methyltransferase; ribosomal protein L12 is a substrate
YER002W	NOP16	0.6553	11	NA	0.978	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
YPR184W	GDB1	0.6553	7	NA	0.984	Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation
YJL141C	YAK1	0.6553	23	NA	1.02	Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal
YAL010C	MDM10	0.6552	3	4	0.896	Subunit of the mitochondrial sorting and assembly machinery (SAM complex); has a role in assembly of the TOM complex, which mediates protein import through the outer membrane; required for normal mitochondrial morphology and inheritance
YOR111W	YOR111W	0.6551	NA	NA	0.914	Putative protein of unknown function
YCL002C	YCL002C	0.6551	NA	NA	0.977	Putative protein of unknown function; YCL002C is not an essential gene
YNR036C	YNR036C	0.6551	11	1	0.923	Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins
YPR145W	ASN1	0.6547	3	NA	0.984	Asparagine synthetase, isozyme of Asn2p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
YJL046W	YJL046W	0.6545	1	4	0.93	Putative protein of unknown function, predicted to encode a lipoate-protein ligase A family member; deletion mutant has a respiratory growth defect
YML056C	IMD4	0.6545	48	NA	1.035	Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YNL208W	YNL208W	0.6545	3	NA	1.021	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; potential orthologs found in other fungi
YEL049W	PAU2	0.6543	NA	NA	1	Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YGR232W	NAS6	0.654	25	NA	0.99	Regulatory, non-ATPase subunit of the 26S proteasome; homolog of the human oncoprotein gankyrin, which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6
YER123W	YCK3	0.654	1	NA	0.987	Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of the HOPS complex subunit, Vps41p; shares overlapping essential functions with Hrr25p
YMR245W	YMR245W	0.6538	NA	NA	0.983	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR004C	SAG1	0.6537	1	1	0.994	Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
YGL164C	YRB30	0.6535	1	NA	1.036	RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes
YOR274W	MOD5	0.6535	NA	NA	0.924	Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms
YEL031W	SPF1	0.6535	2	20	0.842	P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1
YKL216W	URA1	0.6534	3	NA	1.034	Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
YGR207C	YGR207C	0.6534	8	NA	1.038	Protein that interacts with frataxin (Yfh1p); homolog of mammalian electron transfer flavoprotein complex subunit ETF-beta; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKR013W	PRY2	0.6531	NA	NA	1.08	Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YKR096W	YKR096W	0.6531	2	NA	1.08	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc (PilT N terminus) domain
YHL020C	OPI1	0.653	1	1	0.913	Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance
YKL147C	YKL147C	0.6528	NA	NA	1.083	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
YPL052W	OAZ1	0.6524	NA	NA	0.966	Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to regulate ubiquitin-independent degradation; ribosomal frameshifting during synthesis of Oaz1p and its ubiquitin-mediated degradation are both polyamine-regulated
YMR273C	ZDS1	0.6521	12	4	0.993	Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; has a role in localization of Bcy1p, a regulatory subunit of protein kinase A; implicated in mRNA nuclear export
YLR381W	CTF3	0.6517	11	18	0.989	Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules
YDR290W	YDR290W	0.6515	NA	NA	NA	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103
YDR156W	RPA14	0.6514	12	2	0.915	RNA polymerase I subunit A14
YNL328C	MDJ2	0.6514	NA	NA	1.086	Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain
YAL058W	CNE1	0.6511	NA	6	0.817	Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
YIL059C	YIL059C	0.6511	NA	NA	0.987	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
YPL119C	DBP1	0.651	1	NA	1.022	Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs
YMR223W	UBP8	0.651	22	11	0.953	Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B
YPL240C	HSP82	0.6509	132	275	0.799	Cytoplasmic chaperone (Hsp90 family) required for pheromone signaling and negative regulation of Hsf1p; docks with the mitochondrial import receptor Tom70p for preprotein delivery; interacts with co-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p
YLR035C	MLH2	0.6508	4	NA	0.981	Protein required for DNA mismatch repair in mitosis; involved in the repair of mutational intermediates; forms a complex with Pms1p and Msh1p to repair mismatched DNA
YLR012C	YLR012C	0.6507	NA	NA	1.008	Putative protein of unknown function; YLR012C is not an essential gene
YJL030W	MAD2	0.6504	11	98	0.993	Component of the spindle-assembly checkpoint complex, which delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p
YMR072W	ABF2	0.6503	25	1	0.953	Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
YJL209W	CBP1	0.6496	1	NA	0.971	Mitochondrial protein that interacts with the 5'-untranslated region of the COB mRNA and has a role in its stability and translation; found in a complex at the inner membrane along with Pet309p
YEL047C	YEL047C	0.6496	2	1	0.998	Soluble fumarate reductase, required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies
YJL215C	YJL215C	0.6495	NA	NA	0.993	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR241W	YLR241W	0.6495	2	NA	0.963	Putative protein of unknown function, may be involved in detoxification
YIL095W	PRK1	0.6494	8	7	0.995	Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex
YML029W	USA1	0.6494	12	NA	1.042	Protein involved in ER-associated protein degradation (ERAD); component of the Hrd1p complex; interacts with the U1 snRNP-specific protein, Snp1p
YDL227C	HO	0.6494	NA	NA	0.927	Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p
YOR235W	YOR235W	0.6493	NA	NA	0.889	Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci
YMR103C	YMR103C	0.6493	NA	NA	1.045	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL091C	MAP2	0.649	2	1	1.004	Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p
YGR196C	FYV8	0.6487	5	NA	1.023	Protein of unknown function, required for survival upon exposure to K1 killer toxin
YBR067C	TIP1	0.6484	1	NA	0.961	Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
YCR049C	YCR049C	0.6483	NA	NA	0.987	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL103C	FMP30	0.6483	NA	NA	1.02	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR338W	YOR338W	0.6483	NA	NA	1.061	Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen
YHL023C	RMD11	0.6479	NA	1	0.853	Protein required for sporulation
YIL072W	HOP1	0.6478	NA	NA	0.994	Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for homologous chromosome synapsis and chiasma formation
YIL125W	KGD1	0.6478	23	NA	0.974	Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YNL318C	HXT14	0.6475	NA	NA	1.089	Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL081W	RPS9A	0.6472	27	NA	1.001	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Bp and has similarity to E. coli S4 and rat S9 ribosomal proteins
YHR151C	YHR151C	0.647	NA	1	1.04	Putative protein of unknown function
YGR223C	HSV2	0.6469	2	1	0.927	Phosphatidylinositol 3,5-bisphosphate-binding protein, predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization
YIL090W	ICE2	0.6468	NA	1	0.783	Integral ER membrane protein with type-III transmembrane domains; mutations cause defects in cortical ER morphology in both the mother and daughter cells
YCR102W-A	YCR102W-A	0.6466	NA	NA	1.018	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL134C	ODC1	0.6466	NA	NA	1.055	Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
YHR209W	YHR209W	0.6466	NA	NA	1.001	Putative S-adenosylmethionine-dependent methyltransferase; mediates cantharidin resistance
YMR280C	CAT8	0.6465	2	NA	1.016	Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YDR350C	TCM10	0.6462	1	NA	1.02	Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YOL101C	IZH4	0.6462	NA	NA	1.005	Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YBR176W	ECM31	0.6461	1	NA	1.062	Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate
YIL159W	BNR1	0.646	2	2	1.002	Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1
YNL052W	COX5A	0.6458	3	NA	1.029	Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth
YLL029W	YLL029W	0.6455	6	NA	1.017	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL029W is not an essential gene but mutant is defective in spore formation
YFL044C	OTU1	0.6455	1	NA	0.955	Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family
YLR082C	SRL2	0.6454	2	NA	0.978	Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation
YOL151W	GRE2	0.6452	14	NA	1.01	NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YJL083W	TAX4	0.645	NA	NA	1.026	Protein involved in regulation of phosphatidylinositol 4,5-bisphosphate concentrations; Irs4p and Tax4p bind and activate the phosphatase Inp51p
YJR122W	CAF17	0.6448	NA	1	1.041	Mitochondrial protein that interacts with Ccr4p in the two-hybrid system; 3'-untranslated region contains a putative mRNA localization element common to genes encoding mitochondrial proteins
YDL009C	YDL009C	0.6446	NA	NA	0.853	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YDL010W; YDL009C is not an essential gene
YOL114C	YOL114C	0.6446	NA	NA	1.001	Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene
YCR107W	AAD3	0.6445	NA	NA	NA	Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role
YLR044C	PDC1	0.6445	27	1	1.014	Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
YPL086C	ELP3	0.6444	8	39	0.848	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin
YPL105C	YPL105C	0.6444	1	1	0.973	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR078C	YPR078C	0.6443	1	NA	1.059	Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
YOL033W	MSE1	0.6443	2	NA	0.71	Mitochondrial glutamyl-tRNA synthetase, encoded by a nuclear gene
YLR171W	YLR171W	0.644	NA	NA	1.008	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL121C	GPG1	0.6439	7	NA	1.044	Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Grp1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p
YJL151C	SNA3	0.6437	NA	NA	1.018	Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
YKL025C	PAN3	0.6436	2	4	1.097	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
YCL044C	MGR1	0.6434	1	NA	0.956	Subunit, with Yme1p, of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; required for growth of cells lacking the mitochondrial genome
YBR291C	CTP1	0.6433	2	1	0.994	Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family
YJL013C	MAD3	0.6433	1	25	1.031	Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover
YBR115C	LYS2	0.6431	5	NA	0.922	Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p
YIL119C	RPI1	0.6431	NA	NA	1.005	Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation
YDL048C	STP4	0.6431	1	3	0.941	Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
YLR049C	YLR049C	0.643	NA	NA	0.954	Putative protein of unknown function
YDR161W	YDR161W	0.643	5	NA	0.973	interacts with PP2C
YMR242C	RPL20A	0.6428	123	NA	0.594	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Bp and has similarity to rat L18a ribosomal protein
YNR070W	YNR070W	0.6428	NA	NA	0.954	Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL135C	APL2	0.6427	15	NA	0.923	Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting
YGR258C	RAD2	0.6422	1	NA	1.003	Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YNL266W	YNL266W	0.6415	NA	NA	1.093	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF IST1/YNL265C
YOR166C	SWT1	0.6408	NA	5	1.014	Putative protein of unknown function; predicted to contain a PINc domain (PilT N terminus)
YPR134W	MSS18	0.6407	2	NA	0.901	Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions
YOR013W	YOR013W	0.6407	NA	NA	1.005	Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci
YOR135C	YOR135C	0.6405	NA	NA	0.805	Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci
YGR110W	YGR110W	0.6405	NA	NA	0.997	Putative protein of unknown function; transcription is increased in response to genotoxic stress
YGR004W	PEX31	0.6401	NA	NA	0.996	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p
YLR368W	MDM30	0.64	1	1	0.946	F-box protein; physically associates with mitochondria and is required for normal mitochondrial fusion in rich medium, during sporulation, and in mating cells; promotes ubiquitin-mediated degradation of Gal4p in some strains
YAL029C	MYO4	0.64	26	NA	0.961	One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p
YLR392C	YLR392C	0.6399	1	NA	1.011	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR392C is not an essential gene
YOR229W	WTM2	0.6397	6	NA	1.027	Transcriptional repressor involved in regulation of meiosis and silencing; contains WD repeats
YOR140W	SFL1	0.6394	3	1	1.007	Transcription repressor involved in regulation of flocculation-related genes, inhibits transcription by recruiting general corepressor Cyc8p-Tup1p to different promoters; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
YOR225W	YOR225W	0.6394	NA	NA	1.031	Hypothetical protein
YDR146C	SWI5	0.6392	8	6	1.009	Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase
YOR230W	WTM1	0.6392	12	NA	1.023	Transcriptional repressor involved in regulation of meiosis and silencing, required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats
YKL043W	PHD1	0.6391	NA	NA	1.056	Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate
YER078C	YER078C	0.6389	3	NA	0.985	Metallopeptidase, localized to the mitochondrial matrix
YML075C	HMG1	0.6388	2	NA	0.997	One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
YPL263C	KEL3	0.6385	5	NA	1.041	Cytoplasmic protein of unknown function
YGR174C	CBP4	0.6383	NA	NA	0.995	Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp3p and function is partially redundant with that of Cbp3p
YHR037W	PUT2	0.638	NA	NA	0.97	Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism
YGL087C	MMS2	0.638	6	7	1.036	Protein involved in error-free postreplication DNA repair; forms a heteromeric complex with Ubc13p that has a ubiquitin-conjugating activity; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p
YPL046C	ELC1	0.6379	1	NA	1.03	Elongin C, forms heterodimer with Ela1p that participates in transcription elongation; required for ubiquitin-dependent degradation of the RNA Polymerase II subunit RPO21; expression dramatically upregulated during sporulation
YOL158C	ENB1	0.6378	NA	NA	1.05	Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment
YDR261C	EXG2	0.6377	NA	1	0.996	Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YDR184C	ATC1	0.6374	NA	NA	1.015	Nuclear protein, possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern
YPL148C	PPT2	0.6372	NA	NA	0.766	Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation
YML036W	CGI121	0.6371	3	NA	0.815	Protein involved in telomere uncapping and elongation as component of the KEOPS protein complex with Bud32p, Kae1p, Pcc1p, and Gon7p; also shown to be a component of the EKC protein complex; homolog of human CGI-121
YGL241W	KAP114	0.637	8	NA	1.004	Karyopherin, responsible for nuclear import of Spt15p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear
YKL070W	YKL070W	0.6369	NA	NA	1.016	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR071W	YPR071W	0.6366	NA	NA	1.022	Putative membrane protein; YPR071W is not an essential gene
YER063W	THO1	0.6365	6	1	1.059	Protein of unknown function; overproduction suppresses the transcriptional defect caused by an hpr1 mutation
YDR194C	MSS116	0.6364	7	NA	0.961	DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
YOR170W	YOR170W	0.6363	NA	NA	1.029	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4
YKR095W	MLP1	0.6362	3	6	1.058	Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
YML020W	YML020W	0.6362	1	NA	1.031	Putative protein of unknown function
YJL078C	PRY3	0.6361	NA	NA	1.074	Protein of unknown function, has similarity to Pry1p and Pry2p and to the plant PR-1 class of pathogen related proteins
YGL034C	YGL034C	0.6361	NA	NA	1.073	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR009W	TIR4	0.6361	2	1	0.982	Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock
YJL150W	YJL150W	0.636	NA	NA	0.997	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFR025C	HIS2	0.6359	1	NA	1.073	Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YNL044W	YIP3	0.6359	1	1	1.046	Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p
YLR225C	YLR225C	0.6358	NA	NA	0.983	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene
YDR444W	YDR444W	0.6358	NA	NA	1.054	Putative protein of unknown function
YKL046C	DCW1	0.6356	1	1	1.071	Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p
YOL153C	YOL153C	NA	NA	NA	NA	NA
YNL094W	APP1	0.6354	9	NA	0.998	Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization
YOR202W	HIS3	0.6352	1	NA	1.031	Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p
YBR077C	SLM4	0.6351	NA	3	0.862	Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YML027W	YOX1	0.6351	NA	NA	1.019	Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate
YDL125C	HNT1	0.6351	1	2	0.981	Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint
YOL098C	YOL098C	0.635	12	NA	0.993	Putative metalloprotease
YFR039C	YFR039C	0.635	1	NA	NA	Putative protein of unknown function; YFR039C is not an essential gene
YPL087W	YDC1	0.635	NA	NA	1.006	Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity
YML122C	YML122C	0.6345	NA	NA	0.899	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR043W	WHI2	0.6345	4	12	0.953	Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression
YOR093C	YOR093C	0.6344	8	NA	1.034	Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
YMR287C	MSU1	0.6341	4	1	0.759	RNase, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
YHR116W	COX23	0.634	NA	2	0.898	Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p
YMR196W	YMR196W	0.6339	2	NA	1.023	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene
YHL007C	STE20	0.6339	3	5	0.972	Signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases
YJR142W	YJR142W	0.6338	NA	1	1.066	Putative protein of unknown function; GST fusion protein is a Dbf2-Mob1 phosphoylation target in a proteome chip analysis; synthetic lethal with PH085 deletion
YDL241W	YDL241W	0.6334	1	NA	1.016	Putative protein of unknown function; YDL241W is not an essential gene
YDR274C	YDR274C	0.6332	NA	NA	1.005	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHL016C	DUR3	0.633	NA	NA	1.033	Plasma membrane urea transporter, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
YLR187W	SKG3	0.6327	5	NA	1.002	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Caf120p and Skg4p
YKL001C	MET14	0.6326	NA	NA	1.031	Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
YGL037C	PNC1	0.6325	4	NA	1.066	Nicotinamidase that converts nicotinamide to nicotinic acid as part of the NAD(+) salvage pathway, required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span
YER141W	COX15	0.6324	NA	NA	0.946	Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
YGR163W	GTR2	0.6324	7	4	0.874	Cytoplasmic GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; subunit of EGO complex, which is involved in microautophagy regulation, and of GSE complex, required for sorting of Gap1p; homolog of human RagC and RagD
YMR010W	YMR010W	0.6323	1	3	1.027	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1
YMR070W	MOT3	0.6318	1	5	1.011	Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes
YLR356W	YLR356W	0.6316	3	1	1.027	Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YBR240C	THI2	0.6313	NA	1	1.047	Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes
YGR289C	MAL11	0.6312	NA	NA	0.948	Maltose permease, inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters
YBR006W	UGA2	0.6312	NA	NA	0.949	Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm
YML081C-A	ATP18	0.6307	NA	NA	0.93	Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
YCR092C	MSH3	0.6305	6	NA	1.006	Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability
YPR051W	MAK3	0.6305	2	4	0.945	Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus
YPL049C	DIG1	0.6302	8	NA	0.923	Regulatory protein of unknown function, constitutively-expressed, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription
YLR294C	YLR294C	0.6301	NA	NA	0.961	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14
YIL100W	YIL100W	0.6301	NA	NA	0.987	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A
YPL001W	HAT1	0.6301	35	3	1.027	Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair
YDR098C	GRX3	0.63	2	NA	1.008	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YLR385C	SWC7	0.6299	17	NA	1.011	Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin
YNL078W	NIS1	0.6298	4	NA	1.062	Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
YDR006C	SOK1	0.6297	3	NA	1.002	Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13
YLR248W	RCK2	0.6294	5	NA	1.021	Protein kinase involved in the response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YOL087C	YOL087C	0.6293	19	NA	0.927	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid
YDL149W	ATG9	0.6291	3	NA	0.948	Transmembrane protein involved in formation of Cvt and autophagic vesicles; cycles between the pre-autophagosomal structure and other cytosolic punctate structures, not found in autophagosomes
YNL049C	SFB2	0.6289	7	NA	1.058	Probable component of COPII coated vesicles that binds to Sec23p; similar to and functionally redundant with Sec24p, but expressed at low levels; involved in ER to Golgi transport and in autophagy
YCL032W	STE50	0.6288	8	2	1.02	Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction
YPL113C	YPL113C	0.6287	1	NA	1.015	Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene
YML089C	YML089C	0.6287	NA	NA	0.995	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YLL001W	DNM1	0.6286	5	5	0.99	Dynamin-related GTPase required for mitochondrial fission and the maintenance of mitochondrial morphology, assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis
YCR095C	OCA4	0.6286	4	NA	1.003	Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YLR037C	DAN2	0.6284	NA	NA	0.956	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YPL125W	KAP120	0.6283	4	NA	0.863	Karyopherin with a role in the assembly or export of 60S ribosomal subunits
YNL166C	BNI5	0.6282	NA	4	1.012	Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
YOL006C	TOP1	0.6282	19	29	0.909	Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination
YBR035C	PDX3	0.6282	1	1	0.925	Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
YML010W-A	YML010W-A	NA	NA	NA	NA	NA
YAL064C-A	YAL064C-A	0.6281	NA	NA	0.996	Putative protein of unknown function; YAL064C-A is not an essential gene
YKL120W	OAC1	0.628	1	2	1.067	Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family
YBR295W	PCA1	0.6279	1	1	0.965	Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; S288C and most other lab strains contain a G970R mutation which eliminates normal cadmium transport function
YCR048W	ARE1	0.6279	1	1	1.073	Acyl-CoA:sterol acyltransferase, isozyme of Are2p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen
YGR270W	YTA7	0.6279	9	7	0.86	Protein of unknown function, member of CDC48/PAS1/SEC18 family of ATPases, potentially phosphorylated by Cdc28p
YDR528W	HLR1	0.6278	1	NA	1.009	Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A
YDR506C	YDR506C	0.6277	NA	NA	0.999	Possible membrane-localized protein
YOR374W	ALD4	0.6275	1	NA	1.033	Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YJR127C	RSF2	0.6274	1	NA	1.015	Zinc-finger protein involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions
YGR124W	ASN2	0.6271	4	NA	0.986	Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
YKL107W	YKL107W	0.6269	NA	NA	1.039	Putative protein of unknown function
YNR058W	BIO3	0.6269	5	NA	0.97	7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
YJR038C	YJR038C	0.6268	NA	NA	1.033	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR016W	YBR016W	0.6267	NA	NA	1.056	Plasma membrane protein of unknown function; has similarity to hydrophilins, which are hydrophilic, glycine-rich proteins involved in the adaptive response to hyperosmotic conditions
YGR235C	YGR235C	0.6264	NA	NA	1.004	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL112W	TRM3	0.6264	6	NA	0.973	2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
YKR064W	OAF3	0.6263	3	NA	1.003	Zinc cluster protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL079C	PRY1	0.6263	NA	NA	0.986	Protein of unknown function, has similarity to Pry2p and Pry3p and to the plant PR-1 class of pathogen related proteins
YHR162W	YHR162W	0.6261	NA	NA	NA	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
YDR015C	YDR015C	0.6259	NA	NA	1.018	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A
YGR167W	CLC1	0.6253	7	NA	1.041	Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function, two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component
YBR061C	TRM7	0.6251	3	NA	0.966	2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop
YNL097C	PHO23	0.6251	15	19	0.997	Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1)
YJR096W	YJR096W	0.625	3	NA	1.057	Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YBL056W	PTC3	0.625	14	2	0.976	Type 2C protein phosphatase; dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA checkpoint inactivation
YNL202W	SPS19	0.625	NA	1	1.024	Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate
YNR030W	ALG12	0.6246	NA	NA	1.081	Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation
YCL075W	YCL075W	NA	NA	NA	NA	NA
YDR377W	ATP17	0.624	NA	1	0.954	Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YDR446W	ECM11	0.6239	NA	1	1.031	Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
YLR125W	YLR125W	0.6239	NA	NA	1.021	Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YER183C	FAU1	0.6239	NA	NA	1.02	5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis
YPL114W	YPL114W	0.6237	NA	NA	1.038	Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index
YBL060W	YBL060W	0.6237	3	NA	1.02	Non-essential protein proposed to be a nucleotide exchange factor for Arf3
YLR130C	ZRT2	0.6237	NA	NA	1.014	Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YGR150C	YGR150C	0.6235	2	1	0.825	Protein of unknown function, contains PPR motifs; mutant has growth defects on both non-fermentable carbon sources and rich medium; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YEL038W	UTR4	0.6235	NA	1	0.955	Protein of unknown function, found in both the cytoplasm and nucleus
YDL222C	FMP45	0.6234	NA	NA	1.008	Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C
YDR034C	LYS14	0.6233	1	NA	0.955	Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YJR030C	YJR030C	0.6232	NA	NA	1.035	Putative protein of unknown function; expression repressed in carbon limited vs carbon replete chemostat cultures; YJR030C is a non-essential gene
YKR035W-A	DID2	0.6231	NA	1	0.896	Class E protein of the vacuolar protein-sorting (Vps) pathway, associates reversibly with the late endosome, has human ortholog that may be altered in breast tumors
YGL064C	MRH4	0.623	2	NA	0.747	Mitochondrial RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
YDL211C	YDL211C	0.6227	NA	NA	1.031	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YDR090C	YDR090C	0.6225	NA	NA	1.037	Putative protein of unknown function
YKL175W	ZRT3	0.6225	NA	NA	1.034	Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency
YPR040W	TIP41	0.6221	6	1	0.932	Protein that interacts physically and genetically with Tap42p, which regulates protein phosphatase 2A; component of the TOR (target of rapamycin) signaling pathway
YBR290W	BSD2	0.6217	NA	3	0.97	Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification
YHR194W	MDM31	0.6216	NA	9	1.038	Mitochondrial inner membrane protein with similarity to Mdm32p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34
YKL187C	YKL187C	0.6212	NA	NA	1.059	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YEL016C	NPP2	0.621	1	NA	1.001	Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation
YPL019C	VTC3	0.6209	1	NA	1.019	Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion
YIL164C	NIT1	0.6208	NA	NA	1.008	Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
YBL029W	YBL029W	0.6207	1	NA	1.029	Non-essential protein of unknown function
YMR161W	HLJ1	0.6207	NA	NA	1.031	Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Hdj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ
YDL053C	PBP4	0.6207	13	NA	0.971	Pbp1p binding protein, interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay
YGR275W	RTT102	0.6203	46	NA	0.983	Component of both the SWI/SNF and RSC chromatin remodeling complexes, suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition
YJR140C	HIR3	0.6202	10	7	1.019	Transcriptional corepressor involved in the cell cycle-regulated transcription of histone genes HTA1, HTB1, HHT1, and HHT2; involved in position-dependent gene silencing and nucleosome reassembly
YLR063W	YLR063W	0.6197	NA	NA	1.006	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
YGL084C	GUP1	0.6197	NA	14	0.909	Plasma membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases
YHR092C	HXT4	0.6196	NA	NA	0.972	High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YER167W	BCK2	0.6196	1	7	1.041	Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations
YPR185W	ATG13	0.6195	NA	NA	0.99	Phosphorylated protein that interacts with Vac8p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway and autophagy
YOL100W	PKH2	0.6193	5	1	0.812	Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p
YDR496C	PUF6	0.6193	78	NA	0.942	Pumilio-homology domain protein that binds ASH1 mRNA at PUF consensus sequences in the 3' UTR and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA
YMR209C	YMR209C	0.6192	2	NA	0.982	Putative protein of unknown function; YMR209C is not an essential gene
YKR056W	TRM2	0.6191	1	1	1.014	tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair
YGL162W	SUT1	0.6189	NA	NA	1.051	Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression
YIL128W	MET18	0.6188	17	5	0.645	DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; involved in telomere maintenance
YDR296W	MHR1	0.6186	32	NA	0.733	Protein involved in homologous recombination in mitochondria and in transcription regulation in nucleus; binds to activation domains of acidic activators; required for recombination-dependent mtDNA partitioning
YJL038C	YJL038C	0.6184	NA	NA	0.981	Putative protein of unknown function; expression induced during sporulation and repressed during vegetative growth by Sum1p and Hst1p; similar to adjacent open reading frame, YJL037W
YDR119W	YDR119W	0.6184	NA	NA	0.937	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to vacuolar membrane; YDR119W is not an essential gene
YLR415C	YLR415C	0.6184	NA	NA	1.013	Putative protein of unknown function; YLR415C is not an essential gene
YER055C	HIS1	0.6182	NA	NA	NA	ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YOR283W	YOR283W	0.6182	2	NA	1.044	Putative protein of unknown function with some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene
YNL092W	YNL092W	0.6176	4	NA	1.019	Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene
YBL069W	AST1	0.6175	NA	1	0.989	Peripheral membrane protein that interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane, possibly by influencing its incorporation into lipid rafts
YPL066W	YPL066W	0.6172	5	1	0.997	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source
YPR042C	PUF2	0.6172	NA	NA	1.034	Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins
YER046W	SPO73	0.6169	NA	NA	1.05	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
YDL032W	YDL032W	0.6168	NA	NA	0.937	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene
YJR109C	CPA2	0.6167	17	NA	1.043	Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor
YOR171C	LCB4	0.6164	NA	NA	1.027	Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes
YNL277W	MET2	0.6164	NA	NA	1.09	L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway
YPL116W	HOS3	0.6163	3	NA	1.033	Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
YHR163W	SOL3	0.6163	NA	NA	1	6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p
YIL052C	RPL34B	0.6162	2	3	0.998	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein
YMR127C	SAS2	0.6161	14	1	1.051	Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
YOR029W	YOR029W	0.616	NA	NA	1.045	Hypothetical protein
YJR035W	RAD26	0.6159	21	5	1.016	Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions; homolog of human CSB protein
YJL089W	SIP4	0.6158	NA	NA	1.021	C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YMR303C	ADH2	0.6155	15	NA	1.091	Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1
YFR045W	YFR045W	0.6153	NA	2	1.055	Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white
YDR270W	CCC2	0.6153	1	NA	0.952	Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases
YLR341W	SPO77	0.615	1	NA	1.019	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
YCR085W	YCR085W	0.615	NA	NA	0.989	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKR060W	UTP30	0.615	28	NA	0.994	Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YLL041C	SDH2	0.615	2	NA	0.963	Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YNL179C	YNL179C	0.6149	NA	NA	1.013	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YER037W	PHM8	0.6148	NA	NA	1.003	Protein of unknown function, expression is induced by low phosphate levels and by inactivation of Pho85p
YGR123C	PPT1	0.6147	3	NA	0.995	Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth
YKR075C	YKR075C	0.6145	NA	NA	0.949	Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YPR079W	MRL1	0.6144	NA	2	1	Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases
YLR015W	BRE2	0.6142	11	18	0.774	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; involved in telomere maintenance; similar to trithorax-group protein ASH2L
YJL139C	YUR1	0.6142	NA	5	0.947	Mannosyltransferase of the KTR1 family, involved in protein N-glycosylation; located in the Golgi apparatus
YOR042W	CUE5	0.6141	5	NA	1.017	Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YCR051W	YCR051W	0.6141	NA	NA	0.987	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene
YKL084W	HOT13	0.614	NA	NA	1.056	Mitochondrial intermembrane space protein, first component of a pathway mediating assembly of small TIM (Translocase of the Inner Membrane) complexes which escort hydrophobic inner membrane proteins en route to the TIM22 complex
YFR011C	YFR011C	0.614	2	NA	1.03	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YFR011C is not an essential gene
YJL088W	ARG3	0.6139	2	NA	0.991	Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine
YHR103W	SBE22	0.6138	1	NA	0.969	Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth
YJR037W	YJR037W	0.6136	NA	NA	1.037	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; YJR037W is not an essential gene.
YGR037C	ACB1	0.6133	7	NA	0.96	Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes
YPR063C	YPR063C	0.6132	NA	NA	1.004	ER-localized protein of unknown function
YPL247C	YPL247C	0.6131	3	NA	1.033	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; YPL247C is not an essential gene
YBR114W	RAD16	0.613	21	2	0.99	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4); member of the SWI/SNF family
YOL109W	ZEO1	0.613	6	1	1.013	Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p
YDL095W	PMT1	0.613	26	3	1.011	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt2p, can instead interact with Pmt3p in some conditions; target for new antifungals
YGL154W	YGL154W	NA	NA	NA	NA	NA
YOR357C	SNX3	0.6128	NA	NA	1.008	Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
YPL154C	PEP4	0.6127	5	NA	0.999	Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates
YGR242W	YGR242W	0.6125	NA	NA	0.947	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YDR285W	ZIP1	0.6124	NA	NA	1.005	Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate
YFL055W	AGP3	0.6123	NA	NA	0.976	Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation
YDL146W	LDB17	0.6123	NA	NA	0.585	Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface
YJR047C	ANB1	0.6123	1	1	1.009	Translation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions
YOR133W	EFT1	0.6123	48	1	1.011	Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YKL038W	RGT1	0.6121	1	NA	1.045	Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor
YMR023C	MSS1	0.6118	3	NA	1.013	Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3
YLR050C	YLR050C	0.6117	NA	NA	0.977	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene
YGR054W	YGR054W	0.6115	16	3	NA	Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A
YKL213C	DOA1	0.6112	7	5	0.831	WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase
YLL057C	JLP1	0.6109	NA	NA	1.005	Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
YHR185C	PFS1	0.6108	4	NA	1.029	Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies of a cell during meiosis II; not required for meiotic recombination or meiotic chromosome segregation
YLR036C	YLR036C	0.6107	NA	NA	0.985	Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein
YHR022C	YHR022C	0.6107	NA	NA	0.985	Putative protein of unknown function; YHR022C is not an essential gene.
YMR180C	CTL1	0.6107	NA	NA	1.001	RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm
YNL194C	YNL194C	0.6103	NA	NA	1.006	Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YER164W	CHD1	0.6102	37	4	0.97	Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SILK complexes
YIL073C	SPO22	0.6102	NA	NA	0.954	Meiosis-specific protein essential for chromosome synapsis, similar to phospholipase A2, involved in completion of nuclear divisions during meiosis; induced early in meiosis
YHR078W	YHR078W	0.6102	NA	NA	0.972	High osmolarity-regulated gene of unknown function
YDR193W	YDR193W	0.6098	NA	NA	1.043	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR081W	GAL2	0.6096	1	NA	0.997	Galactose permease, required for utilization of galactose; also able to transport glucose
YBR166C	TYR1	0.6096	4	2	NA	Prephenate dehydrogenase involved in tyrosine biosynthesis, expression is dependent on phenylalanine levels
YAL059W	ECM1	0.6095	8	3	0.887	Protein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export
YBR018C	GAL7	0.6095	6	NA	1.025	Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism
YPL171C	OYE3	0.6095	2	NA	1.018	Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YPL050C	MNN9	0.6094	9	4	0.651	Subunit of Golgi mannosyltransferase complex also containing Anp1p, Mnn10p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation
YBL038W	MRPL16	0.6089	37	NA	0.79	Mitochondrial ribosomal protein of the large subunit
YLR013W	GAT3	0.6089	NA	NA	1.011	Protein containing GATA family zinc finger motifs
YPL267W	ACM1	0.6089	2	NA	1.063	Cell cycle regulated protein of unknown function; associated with Cdh1p and may supress the APC/C[Cdh1]-mediated proteolysis of mitotic cyclins
YKR047W	YKR047W	0.6088	NA	NA	0.977	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1
YGR050C	YGR050C	0.6087	NA	NA	0.983	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCR105W	ADH7	0.6084	2	NA	0.994	NADPH-dependent cinnamyl alcohol dehydrogenase family member with broad substrate specificity; may be involved in fusel alcohol synthesis
YML080W	DUS1	0.6083	NA	NA	0.969	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17
YNL122C	YNL122C	0.6082	2	NA	0.969	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene
YGL237C	HAP2	0.6081	34	3	0.926	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
YLR109W	AHP1	0.6079	21	NA	1.012	Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
YHR012W	VPS29	0.6077	5	14	0.94	Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
YOR105W	YOR105W	0.6073	NA	NA	1.036	Hypothetical protein
YDR247W	VHS1	0.6073	9	NA	1.038	Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
YKL087C	CYT2	0.6073	NA	NA	0.997	Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
YDL051W	LHP1	0.6072	19	6	1.016	RNA binding protein required for maturation of tRNA and snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen
YER085C	YER085C	0.6069	NA	NA	1.081	Putative protein of unknown function
YIL024C	YIL024C	0.6068	NA	NA	0.986	Hypothetical protein
YBR244W	GPX2	0.6066	NA	NA	1.049	Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YDR304C	CPR5	0.6065	10	NA	1.052	Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER
YOR325W	YOR325W	0.6065	NA	NA	0.904	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1
YCL040W	GLK1	0.6063	5	NA	0.943	Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources
YER087W	YER087W	0.6061	NA	5	NA	Protein with similarity to tRNA synthetases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNR034W	SOL1	0.6058	6	NA	1.004	Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol2p, Sol3p, and Sol4p
YJL175W	YJL175W	0.6055	NA	NA	0.744	Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
YBR259W	YBR259W	0.6054	1	NA	1.033	Putative protein of unknown function; YBR259W is not an essential gene
YGL023C	PIB2	0.6054	2	NA	0.916	Protein binding phosphatidylinositol 3-phosphate, involved in telomere-proximal repression of gene expression; similar to Fab1 and Vps27
YOR099W	KTR1	0.6053	NA	NA	1.039	Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YGR266W	YGR266W	0.6053	2	NA	0.997	Protein of unknown function, predicted to contain a single transmembrane domain; localized to both the mitochondrial outer membrane and the plasma membrane
YBR186W	PCH2	0.6051	1	1	1.042	Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA
YNL023C	FAP1	0.6051	13	NA	0.997	Protein that binds to Fpr1p (FKBP12), conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; has similarity to putative transcription factors, including D. melanogaster shuttle craft and human NFX1
YDR058C	TGL2	0.605	1	NA	1.013	Protein with lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli; role in yeast lipid degradation is unclear
YNL339C	YRF1-6	0.6046	NA	NA	1.091	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
YIR020C	YIR020C	0.6045	NA	NA	0.98	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR003W	COQ1	0.6045	NA	NA	0.868	Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
YKL097C	YKL097C	0.6044	NA	NA	1.034	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species
YER067C-A	YER067C-A	0.6042	NA	NA	0.986	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
YPR022C	YPR022C	0.604	NA	NA	1.098	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
YGR016W	YGR016W	0.6038	2	NA	0.991	Putative protein of unknown function
YHL022C	SPO11	0.6037	NA	1	0.666	Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation
YER131W	RPS26B	0.6037	13	NA	0.934	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YBL064C	PRX1	0.6036	2	NA	0.942	Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress
YOR346W	REV1	0.6036	1	NA	1.005	Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YOL137W	BSC6	0.6035	NA	NA	1.005	Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YGR155W	CYS4	0.6035	31	NA	0.984	Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis
YER118C	SHO1	0.6034	NA	3	0.96	Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway
YMR310C	YMR310C	0.6033	8	NA	1.076	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene
YER187W	YER187W	0.6031	NA	1	1.015	Putative protein of unknown function; induced in respiratory-deficient cells
YGR244C	LSC2	0.6031	1	NA	1.004	Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate
YOR276W	CAF20	0.6028	7	1	1.014	Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E
YDL128W	VCX1	0.6028	NA	NA	0.977	Vacuolar H+/Ca2+ exchanger involved in control of cytosolic Ca2+ concentration; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter
YGL016W	KAP122	0.6027	12	1	0.899	Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance
YBL107C	YBL107C	0.6026	NA	1	0.995	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBL107C is not an essential gene
YOR356W	YOR356W	0.6021	1	NA	1.04	Mitochondrial protein with similarity to flavoprotein-type oxidoreductases; found in a large supramolecular complex with other mitochondrial dehydrogenases
YPR153W	YPR153W	0.6016	NA	2	0.971	Putative protein of unknown function
YGR134W	CAF130	0.6013	9	NA	0.938	Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
YJR031C	GEA1	0.6012	5	1	1.007	Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea2p
YBR131W	CCZ1	0.6011	1	2	0.997	Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway
YKL136W	YKL136W	0.6011	NA	NA	1.077	Hypothetical protein
YJR020W	YJR020W	0.6011	NA	NA	1.024	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR218C	PYC2	0.6009	7	NA	0.848	Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YDL078C	MDH3	0.6009	8	NA	1.001	Cytoplasmic malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle
YDR079W	PET100	0.6007	NA	NA	0.832	Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
YNL223W	ATG4	0.6006	1	NA	1.012	Cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation; mediates attachment of autophagosomes to microtubules through interactions with Tub1p and Tub2p
YNL199C	GCR2	0.6006	1	7	0.724	Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p
YMR163C	YMR163C	0.6004	1	NA	1.024	Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene
YHL046C	PAU13	0.6003	NA	NA	0.999	Putative protein of unknown function; not an essential gene
YDR337W	MRPS28	0.6001	32	NA	0.562	Mitochondrial ribosomal protein of the small subunit
YMR279C	YMR279C	0.6001	NA	NA	NA	Putative protein of unknown function; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene
YDR005C	MAF1	0.6	7	NA	0.954	Negative regulator of RNA polymerase III; component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment; targets the initiation factor TFIIIB
YLR296W	YLR296W	0.5998	NA	NA	0.924	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR050W	SMF2	0.5998	NA	NA	0.974	Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
YDL002C	NHP10	0.5996	21	5	0.779	Protein related to mammalian high mobility group proteins; likely component of the INO80 complex, which is an ATP-dependent chromatin-remodeling complex
YOR365C	YOR365C	0.5996	1	NA	1.035	Putative protein of unknown function; YOR365C is not an essential protein
YDR293C	SSD1	0.5994	13	16	0.967	Protein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence
YNL098C	RAS2	0.5993	3	18	1.021	GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes
YML104C	MDM1	0.5992	NA	NA	1.056	Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)
YPR151C	SUE1	0.5987	1	NA	1.077	Mitochondrial protein required for degradation of unstable forms of cytochrome c
YBR059C	AKL1	0.5987	6	1	NA	Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization
YPL253C	VIK1	0.5987	1	11	1.062	Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p
YBR159W	IFA38	0.5984	14	1	NA	Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides
YER135C	YER135C	0.5981	NA	NA	1.032	Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene
YGL043W	DST1	0.5981	12	46	0.883	General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites
YPL039W	YPL039W	0.5981	NA	NA	0.995	Putative protein of unknown function; YPL039W is not an essential gene
YER024W	YAT2	0.598	NA	NA	0.996	Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
YBR203W	COS111	0.5979	2	NA	1.052	Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGL032C	AGA2	0.5974	NA	NA	1.055	Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds
YGR008C	STF2	0.5974	NA	NA	1.011	Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YML016C	PPZ1	0.5974	7	5	0.99	Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
YBR213W	MET8	0.5973	NA	NA	0.97	Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme; also involved in the expression of PAPS reductase and sulfite reductase
YNL303W	YNL303W	0.5973	NA	NA	1.105	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL035C	MIG1	0.5972	8	NA	1.077	Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase
YBR030W	YBR030W	0.5972	3	1	1.027	Putative protein of unknown function; predicted protein contains a SET domain (S-adenosyl-L-methionine-binding fold)
YML120C	NDI1	0.5971	NA	NA	1.045	NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; homolog of human AMID
YLR070C	XYL2	0.5971	NA	NA	1.019	Xylitol dehydrogenase, converts xylitol to D-xylulose in the endogenous xylose utilization pathway
YFR046C	CNN1	0.5967	NA	NA	0.978	Kinetochore protein of unknown function; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by both Clb5-Cdk1 and, to a lesser extent, Clb2-Cdk1.
YHR029C	YHI9	0.5966	10	NA	0.996	Protein of unknown function that is a member of the PhzF superfamily, although unlike its bacterial homolog, is most likely not involved in phenazine production; possibly involved in a membrane regulation metabolic pathway
YGR248W	SOL4	0.5966	1	NA	0.999	6-phosphogluconolactonase with similarity to Sol3p
YLR413W	YLR413W	0.5964	2	NA	1.014	Putative protein of unknown function; YLR413W is not an essential gene
YKR073C	YKR073C	0.5964	NA	NA	0.951	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL048W	YBL048W	0.5964	NA	NA	0.982	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YBR040W	FIG1	0.5956	NA	NA	1.015	Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating
YBR183W	YPC1	0.5956	NA	NA	1.047	Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance
YLR432W	IMD3	0.5954	74	NA	0.981	Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YOL147C	PEX11	0.5954	NA	2	1.094	Peroxisomal membrane protein required for peroxisome proliferation and medium-chain fatty acid oxidation, most abundant protein in the peroxisomal membrane, regulated by Adr1p and Pip2p-Oaf1p, promoter contains ORE and UAS1-like elements
YMR243C	ZRC1	0.5952	NA	NA	1.03	Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm
YLR203C	MSS51	0.595	8	NA	0.91	Nuclear encoded protein required for translation of COX1 mRNA; binds to Cox1 protein
YOR152C	YOR152C	0.595	NA	NA	1.015	Hypothetical protein
YML106W	URA5	0.5949	5	NA	1.046	One of two orotate phosphoribosyltransferase isozymes (see also URA10) that catalyze the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate
YOL001W	PHO80	0.5948	3	2	0.726	Cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance
YOR303W	CPA1	0.5947	3	NA	0.822	Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader
YHR204W	MNL1	0.5946	4	1	1.003	Alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoproteins but not for processing of N-linked oligosaccharides
YDR395W	SXM1	0.5945	12	NA	1.061	Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1
YPL248C	GAL4	0.5944	NA	NA	1.08	DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p
YPR170C	YPR170C	0.5943	NA	NA	0.968	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B
YOL032W	OPI10	0.594	NA	NA	0.987	Protein with a possible role in phospholipid biosynthesis, based on inositol-excreting phenotype of the null mutant and its suppression by exogenous choline
YER119C-A	YER119C-A	0.5938	NA	NA	0.878	Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2
YGL033W	HOP2	0.5937	NA	2	1.141	Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
YGR236C	SPG1	0.5928	NA	NA	0.972	Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR149W	YGR149W	0.5928	NA	NA	1.036	Putative protein of unknown function; predicted to be an integal membrane protein
YER177W	BMH1	0.5927	38	11	0.926	14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YLR380W	CSR1	0.5927	5	NA	1.036	Phosphatidylinositol transfer protein with a potential role in lipid turnover; interacts specifically with thioredoxin peroxidase (Tsa2p) and may have a role in oxidative stress resistance
YPL273W	SAM4	0.5926	NA	NA	1.012	S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
YHL040C	ARN1	0.5925	NA	NA	0.954	Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YIR027C	DAL1	0.5924	NA	NA	1.027	Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YNL115C	YNL115C	0.592	NA	NA	1.025	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
YOR101W	RAS1	0.5918	2	2	1.046	GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YDR399W	HPT1	0.5918	NA	NA	1.039	Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
YGR106C	YGR106C	0.5917	NA	NA	1.036	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YPR052C	NHP6A	0.5917	8	9	0.988	High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters
YKL161C	YKL161C	0.5915	2	1	1.11	Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; associates with Rlm1p
YHR104W	GRE3	0.5915	2	1	0.988	Aldose reductase involved in methylglyoxal, d-xylose and arabinose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway
YER180C	ISC10	0.5915	NA	NA	1.02	Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells
YHR014W	SPO13	0.5914	2	9	0.965	Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II
YIR039C	YPS6	0.5912	NA	NA	0.966	Putative GPI-anchored aspartic protease
YKL160W	ELF1	0.5912	5	7	1.112	Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression
YNL144C	YNL144C	0.591	NA	NA	1.007	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YMR156C	TPP1	0.591	NA	1	1.031	DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; has similarity to the l-2-haloacid dehalogenase superfamily
YAL060W	BDH1	0.5909	1	NA	0.986	NAD-dependent (2R,3R)-2,3-butanediol dehydrogenase, a zinc-containing medium-chain alcohol dehydrogenase, produces 2,3-butanediol from acetoin during fermentation and allows using 2,3-butanediol as a carbon source during aerobic growth
YHR160C	PEX18	0.5906	NA	NA	1.019	Part of a two-member peroxin family (Pex18p and Pex21p) specifically required for peroxisomal targeting of the Pex7p peroxisomal signal recognition factor and PTS2 peroxisomal matrix proteins
YMR158W	MRPS8	0.5904	25	1	0.696	Mitochondrial ribosomal protein of the small subunit
YOR342C	YOR342C	0.5903	2	NA	0.996	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YIL136W	OM45	0.5902	1	NA	1.009	Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
YDL206W	YDL206W	0.59	NA	4	1.03	Putative protein of unknown function; YDL206W is not an essential protein
YBR062C	YBR062C	0.5899	1	NA	0.985	Hypothetical protein
YLR343W	GAS2	0.5898	NA	NA	1.072	1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p
YOR238W	YOR238W	0.5897	1	NA	1.024	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YBR119W	MUD1	0.5897	22	2	NA	U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing
YKL185W	ASH1	0.5896	12	NA	1.062	Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
YLR247C	YLR247C	0.5895	5	NA	1.015	Putative helicase; localized to mitochondria and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52 foci
YDL020C	RPN4	0.5895	1	49	0.91	Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses
YDR001C	NTH1	0.5891	7	NA	1.01	Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p
YGR204W	ADE3	0.5887	11	4	1.004	Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine
YEL041W	YEF1	0.5886	1	2	0.989	ATP-NADH kinase; phosophorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; sequence similarity to Utr1p and Pos5p; overexpression complements certain pos5 phenotypes
YOL129W	VPS68	0.5885	NA	NA	0.931	Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria
YOR347C	PYK2	0.5885	2	NA	1.008	Pyruvate kinase that appears to be modulated by phosphorylation; PYK2 transcription is repressed by glucose, and Pyk2p may be active under low glycolytic flux
YCL024W	KCC4	0.5885	4	NA	0.968	Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YOR161C	PNS1	0.5884	NA	NA	0.997	Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport
YNL046W	YNL046W	0.5883	NA	NA	1.073	Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YGR215W	RSM27	0.5882	27	NA	0.922	Mitochondrial ribosomal protein of the small subunit
YIL173W	VTH1	0.5875	3	NA	1.008	Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting
YNL155W	YNL155W	0.5872	6	NA	0.996	Putative protein of unknown function, contains DHHC domain, also predicted to have thiol-disulfide oxidoreductase active site
YMR159C	ATG16	0.5872	1	NA	1.023	Protein that interacts with the Atg12p-Atg5p conjugate during formation of the pre-autophagosomal structure; essential for autophagy
YDR209C	YDR209C	0.5872	NA	NA	1.009	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W.
YHR045W	YHR045W	0.5871	NA	1	NA	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
YNR009W	NRM1	0.5869	2	NA	1.058	Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase
YLL046C	RNP1	0.5869	NA	NA	1.031	Ribonucleoprotein that contains two RNA recognition motifs (RRM)
YML117W	NAB6	0.5869	9	2	1.065	Putative RNA-binding protein, based on computational analysis of large-scale protein-protein interaction data
YDL142C	CRD1	0.5867	NA	2	0.764	Cardiolipin synthase; produces cardiolipin, which is an important constituent of mitochondrial membranes; required for normal mitochondrial membrane potential and function
YPR156C	TPO3	0.5863	NA	1	0.995	Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily
YPL002C	SNF8	0.5863	5	5	0.835	Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
YMR029C	FAR8	0.5861	6	NA	1.041	Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
YHL002W	HSE1	0.5861	3	3	1.028	Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
YDR393W	SHE9	0.5859	NA	2	0.823	Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex
YOR215C	YOR215C	0.5858	1	NA	1.041	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR363C	PIP2	0.5855	1	1	1.043	Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes
YIL132C	CSM2	0.5853	NA	NA	0.964	Protein required for accurate chromosome segregation during meiosis
YPR069C	SPE3	0.5849	4	NA	0.21	Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells
YMR144W	YMR144W	0.5849	2	NA	1.055	Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
YDL038C	YDL038C	0.5847	NA	NA	0.987	Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YNL239W	LAP3	0.5846	1	NA	1.044	Aminopeptidase of cysteine protease family, has a DNA binding activity and acts as bleomycin hydrolase in vitro; transcription is regulated by galactose via Gal4p
YNL157W	IGO1	0.5845	3	NA	1.003	Hypothetical protein
YJR121W	ATP2	0.5843	13	NA	1.075	Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YDL178W	DLD2	0.5843	NA	NA	1.017	D-lactate dehydrogenase, located in the mitochondrial matrix
YFR041C	ERJ5	0.5841	NA	NA	0.976	Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response
YGL141W	HUL5	0.5841	3	NA	1.015	Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability
YBR113W	YBR113W	0.5839	NA	NA	NA	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8
YOR162C	YRR1	0.5839	2	NA	0.986	Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes
YLR183C	TOS4	0.5839	1	NA	0.985	Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF
YOR092W	ECM3	0.5838	1	NA	1.038	Non-essential protein of unknown function
YDR494W	RSM28	0.5838	4	NA	1.025	Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation
YJL163C	YJL163C	0.5838	NA	NA	1.006	Putative protein of unknown function
YNR071C	YNR071C	0.5838	NA	NA	0.973	Putative protein of unknown function
YDR158W	HOM2	0.5836	4	NA	0.818	Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
YPL097W	MSY1	0.5835	NA	2	0.946	Mitochondrial tyrosyl-tRNA synthetase
YLR126C	YLR126C	0.5835	NA	NA	1.01	Putative protein of unknown function with similarity to glutamine amidotransferase proteins; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein
YOR067C	ALG8	0.5835	NA	10	1.017	Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p
YDR500C	RPL37B	0.5834	1	NA	0.929	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein
YHL008C	YHL008C	0.5833	3	NA	0.98	Putative protein of unknown function, does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YKR059W	TIF1	0.5833	22	6	0.943	Translation initiation factor eIF4A, identical to Tif2p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G
YDL189W	RBS1	0.5832	NA	NA	0.988	Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain
YLR090W	XDJ1	0.5832	4	1	0.959	Putative chaperone, homolog of E. coli DnaJ, closely related to Ydj1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL011C	YNL011C	0.5829	NA	NA	1.072	Putative protein of unknown function; YNL011C is not an essential gene
YPL074W	YTA6	0.5827	6	NA	1.083	Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localized to the cortex of mother cells but not to daughter cells
YKL067W	YNK1	0.5827	17	NA	1.07	Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate
YAL068C	PAU8	0.5826	NA	NA	0.937	Hypothetical protein
YJR059W	PTK2	0.5824	1	1	0.961	Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
YMR003W	YMR003W	0.5823	NA	2	1.065	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria; YMR003W is not an essential gene
YNL280C	ERG24	0.5822	NA	2	1.083	C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions
YOR131C	YOR131C	0.5818	NA	NA	1.023	Hypothetical protein
YOR367W	SCP1	0.5818	1	NA	1.053	Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin
YLR165C	PUS5	0.5817	NA	1	1.026	Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability
YJL132W	YJL132W	0.5817	1	NA	0.997	Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene
YPL013C	MRPS16	0.5814	29	NA	0.931	Mitochondrial ribosomal protein of the small subunit
YGR288W	MAL13	0.5811	NA	NA	0.981	MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C
YLR077W	FMP25	0.581	NA	NA	1.013	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR030W	RSF1	0.581	NA	1	1.074	Protein required for respiratory growth; localized to both the nucleus and mitochondrion; mutant displays decreased transcription of specific nuclear and mitochondrial genes whose products are involved in respiratory growth
YPL176C	TRE1	0.581	NA	1	1.029	Plasma membrane protein that binds to Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; function is redundant with that of Tre2p; has similarity to transferrin receptors
YPL055C	LGE1	0.5808	2	74	0.875	Protein of unknown function; null mutant forms abnormally large cells
YDL187C	YDL187C	0.5807	NA	NA	1.021	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIR029W	DAL2	0.5806	NA	1	0.987	Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YLR387C	REH1	0.5805	1	NA	0.997	Protein of unknown function, similar to Rei1p but not involved in bud growth; contains dispersed C2H2 zinc finger domains
YLR004C	THI73	0.5803	NA	NA	1.004	Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YGR234W	YHB1	0.5799	29	NA	1.002	Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
YBR125C	PTC4	0.5798	7	NA	1.04	Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
YPL036W	PMA2	0.5795	4	NA	1.025	Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
YER027C	GAL83	0.5795	11	2	1.013	One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain
YGR240C	PFK1	0.5794	26	NA	0.782	Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YHR132C	ECM14	0.579	NA	NA	1.019	Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly
YAL051W	OAF1	0.5786	10	1	0.997	Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis
YLR416C	YLR416C	0.5784	NA	NA	1.01	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR087C	PDC6	0.5783	10	NA	1.012	Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, involved in amino acid catabolism
YGR022C	YGR022C	0.5781	NA	NA	1.063	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
YER083C	GET2	0.5781	2	74	0.808	Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function
YIL170W	HXT12	NA	NA	NA	NA	NA
YDR129C	SAC6	0.5779	20	24	0.727	Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton
YOR322C	LDB19	0.5779	1	4	0.992	Protein of unknown function involved in maintenance of proper telomere length; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface
YOR280C	FSH3	0.5778	NA	NA	1.032	Serine hydrolase; sequence is similar to Fsh1p and Fsh2p
YDR439W	LRS4	0.5777	1	15	0.929	Protein involved in rDNA silencing; positively charged coiled-coil protein with limited similarity to myosin
YFL054C	YFL054C	0.5775	2	1	0.977	Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YER032W	FIR1	0.5774	3	1	0.987	Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate
YPL136W	YPL136W	0.5769	NA	NA	1.033	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C
YNL053W	MSG5	0.5769	3	NA	1.316	Dual-specificity protein phosphatase required for maintenance of a low level of signaling through the cell integrity pathway; regulates and is regulated by Slt2p; also required for adaptive response to pheromone
YIL037C	PRM2	0.5767	1	NA	1.011	Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p
YLR410W	VIP1	0.5765	16	3	0.775	Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of IP7 by Vip1p is important for phosphate signaling; likely involved in cortical actin cytoskeleton function, by analogy with S. pombe ortholog asp1
YDR070C	FMP16	0.5764	NA	NA	1.011	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR017W	PET127	0.5764	4	NA	1.041	Protein with a role in mitochondrial RNA stability and/or processing, located in the mitochondrial membrane
YPL159C	PET20	0.5764	NA	NA	1.026	Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome
YBR274W	CHK1	0.5763	13	4	1.003	DNA damage checkpoint effector kinase, mediates mitotic cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer kinase Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
YDL219W	DTD1	0.5763	1	NA	0.98	D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes
YGR011W	YGR011W	0.5762	NA	NA	1.057	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR057W	YLR057W	0.576	1	2	0.98	Putative protein of unknown function; YLR050C is not an essential gene
YDR266C	YDR266C	0.5759	4	NA	0.987	Protein of unknown function that may interact with ribosomes, based on co-purification experiments;green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; contains a RING finger domain
YDR374C	YDR374C	0.5758	1	NA	1.039	Putative protein of unknown function
YLR221C	RSA3	0.5757	11	3	0.995	Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus
YOR030W	DFG16	0.5757	NA	4	1.034	Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p
YDR471W	RPL27B	0.5754	83	NA	0.937	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein
YJL165C	HAL5	0.5753	3	NA	0.987	Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters
YMR259C	YMR259C	0.5752	7	NA	1.004	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR259C is not an essential gene
YBR036C	CSG2	0.5752	NA	6	0.996	Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations
YMR102C	YMR102C	0.5752	1	1	1.048	Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
YOL083W	YOL083W	0.5749	NA	NA	1.067	Hypothetical protein
YDR522C	SPS2	0.5748	NA	NA	0.978	Protein expressed during sporulation, redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component
YOR298W	MUM3	0.5748	NA	NA	1.008	Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases
YKL129C	MYO3	0.5747	7	3	1.065	One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
YKR042W	UTH1	0.5746	2	4	1.008	Mitochondrial outer membrane and cell wall localized SUN family member required for mitochondrial autophagy; involved in the oxidative stress response, life span during starvation, mitochondrial biogenesis, and cell death
YAL024C	LTE1	0.5745	57	28	NA	Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates with Ras2p-GTP
YLR438W	CAR2	0.5745	17	NA	0.931	L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YMR306C-A	YMR306C-A	0.5744	NA	NA	1.097	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL155W	CLB3	0.5744	15	10	0.97	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
YJR099W	YUH1	0.5743	NA	NA	1.06	Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p
YHR139C	SPS100	0.5738	NA	NA	1.032	Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YMR192W	GYL1	0.5736	7	NA	1.019	Putative GTPase activating protein (GAP) that may have a role in polarized exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p
YGL151W	NUT1	0.5736	29	5	0.964	Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
YGL250W	YGL250W	0.5733	NA	3	0.993	Putative protein of unknown function; deletion mutant results in reduced PIS1 expression and has growth defects on non-fermentable carbon sources and on minimal media; GFP-fusion protein localizes to both the cytoplasm and the nucleus
YIR024C	YIR024C	0.5732	2	NA	0.987	Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect
YAL030W	SNC1	0.5731	NA	8	0.966	Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins
YPL145C	KES1	0.5731	1	NA	1.023	Member of the oxysterol binding protein family, which includes seven yeast homologs; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex
YMR056C	AAC1	0.5731	3	1	1.015	Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator
YGR021W	YGR021W	0.5729	NA	NA	0.982	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL011C	YDL011C	0.5727	NA	NA	1.027	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W
YOR034C	AKR2	0.5727	NA	NA	1.017	Ankyrin repeat-containing protein similar to Akr1p; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p
YLR451W	LEU3	0.572	1	NA	1.053	Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis
YDL210W	UGA4	0.5714	NA	NA	1.024	Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YPL056C	YPL056C	0.5714	NA	NA	0.981	Putative protein of unknown function; deletion mutant is fluconazole resistant
YOL155C	YOL155C	0.5713	NA	NA	1.016	Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines
YDR136C	YDR136C	0.5711	NA	NA	0.919	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect
YIR034C	LYS1	0.5709	4	NA	0.995	Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway
YGR138C	TPO2	0.5706	NA	NA	0.97	Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YOL042W	NGL1	0.5705	NA	NA	0.994	Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL156C	NSG2	0.5705	NA	NA	1.012	Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins
YFL011W	HXT10	0.5703	1	NA	0.978	Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YOR355W	GDS1	0.5702	4	NA	0.931	Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL037W	YKL037W	0.5702	1	7	1.019	Putative protein of unknown function
YML121W	GTR1	0.5702	4	1	0.9	Cytoplasmic GTP binding protein and negative regulator, with homolog Gtr2p, of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport; has homology to human RagA and RagB
YPR198W	SGE1	0.5702	1	NA	0.987	Membrane-associated multidrug transporter, acts as an extrusion permease, member of the drug-resistance protein family within the major facilitator superfamily (MFS), partial multicopy suppressor of gal11 mutations
YDL231C	BRE4	0.5701	NA	NA	0.978	Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport
YMR086C-A	YMR086C-A	0.57	NA	NA	0.995	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR095C	SYT1	0.57	NA	1	0.98	Guanine nucleotide exchange factor (GEF) for Arf proteins; involved in vesicular transport; suppressor of ypt3 mutations; member of the Sec7-domain family
YPR127W	YPR127W	0.5699	NA	NA	0.984	Putative protein of unknown function; expression is activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YMR006C	PLB2	0.5699	NA	NA	1.058	Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
YBR041W	FAT1	0.5698	NA	3	0.939	Fatty acid transporter and very long-chain fatty acyl-CoA synthetase, may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids
YNL125C	ESBP6	0.5697	NA	NA	1.046	Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YLR421C	RPN13	0.5695	26	NA	0.928	Subunit of the 19S regulatory particle of the 26S proteasome lid
YDL216C	RRI1	0.5694	6	NA	0.971	Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling
YCR076C	YCR076C	0.5687	3	NA	1.001	Putative protein of unknown function; YCR076C is not an essential gene
YEL059W	YEL059W	0.5687	NA	NA	0.818	Dubious open reading frame unlikely to encode a functional protein
YDR140W	MTQ2	0.5686	2	NA	0.757	S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; methylates release factor eRF1 (Sup45p) in vitro; is not an essential gene; similar to E.coli PrmC
YGR003W	CUL3	0.5686	1	NA	1.01	Ubiquitin-protein ligase, member of the cullin family with similarity to Cdc53p and human CUL3; required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21
YHR079C	IRE1	0.5685	2	5	1.004	Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
YDR452W	PPN1	0.568	3	1	1.025	Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer
YOR050C	YOR050C	0.5678	NA	NA	1.03	Hypothetical protein
YLR264W	RPS28B	0.5677	7	NA	0.802	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Ap and has similarity to rat S28 ribosomal protein
YLR346C	YLR346C	0.5672	NA	NA	1.065	Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YNL288W	CAF40	0.5672	9	3	1.026	Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
YPL274W	SAM3	0.5671	NA	NA	1.051	High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
YGR220C	MRPL9	0.567	42	NA	0.805	Mitochondrial ribosomal protein of the large subunit
YMR326C	YMR326C	0.567	NA	NA	0.831	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13
YIL149C	MLP2	0.567	15	5	0.985	Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length
YBL079W	NUP170	0.5667	8	10	0.62	Abundant subunit of the nuclear pore complex (NPC), required for proper localization of specific nucleoporins within the NPC, involved in nuclear envelope permeability and in chromosome segregation, has similarity to Nup157p
YNR073C	YNR073C	0.5667	NA	NA	0.978	Putative mannitol dehydrogenase
YDR008C	YDR008C	0.5666	NA	NA	0.981	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL176C	YGL176C	0.5666	NA	NA	1.026	Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype
YDR100W	TVP15	0.5665	NA	NA	1.002	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p
YMR233W	YMR233W	0.5665	2	NA	1.03	Protein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; YMR233W is not an essential gene
YOR031W	CRS5	0.566	NA	NA	0.972	Copper-binding metallothionein, required for wild-type copper resistance
YBR296C	PHO89	0.5659	1	1	0.978	Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YMR173W	DDR48	0.5659	11	NA	1.029	DNA damage-responsive protein, expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS
YKR034W	DAL80	0.5659	NA	NA	0.994	Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p
YGL090W	LIF1	0.5658	5	NA	1.074	Protein involved in DNA double-strand break repair; physically interacts with DNA ligase 4 (Lig4p); homologous to mammalian XRCC4 protein
YLR089C	ALT1	0.5657	2	6	0.875	Putative alanine transaminase (glutamic pyruvic transaminase); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR100W	MDR1	0.5656	4	NA	1.013	Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function
YGL051W	MST27	0.5656	NA	NA	1.044	Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
YJL119C	YJL119C	0.5656	NA	NA	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCL035C	GRX1	0.5655	1	3	0.974	Hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair; protects cells from oxidative damage
YER062C	HOR2	0.5655	12	1	0.982	One of two redundant DL-glycerol-3-phosphatases (RHR2/GPP1 encodes the other) involved in glycerol biosynthesis; induced in response to hyperosmotic stress and oxidative stress, and during the diauxic transition
YOR334W	MRS2	0.5653	2	NA	0.999	Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns
YOR297C	TIM18	0.5653	NA	4	0.817	Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane; may function to stabilize the complex
YDR279W	RNH202	0.5651	4	7	0.984	Ribonuclease H2 subunit, required for RNase H2 activity
YLR224W	YLR224W	0.5649	NA	NA	0.996	F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene
YCR008W	SAT4	0.5649	19	1	0.938	Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p
YHR091C	MSR1	0.5646	NA	1	0.859	Mitochondrial arginyl-tRNA synthetase
YBR023C	CHS3	0.5646	1	64	1.02	Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
YDL213C	NOP6	0.5643	67	NA	1	Putative RNA-binding protein implicated in ribosome biogenesis; contains an RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
YEL064C	AVT2	0.5643	1	1	0.967	Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YGL231C	YGL231C	0.5643	NA	NA	1.021	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
YBR034C	HMT1	0.5643	2	2	1.013	Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, thus facilitating nuclear export of these proteins; required for viability of npl3 mutants
YKL051W	SFK1	0.5641	1	1	1.045	Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
YDR019C	GCV1	0.5641	NA	NA	1.001	T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
YDR258C	HSP78	0.564	NA	NA	0.99	Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YOL105C	WSC3	0.5639	NA	1	0.96	Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis
YER162C	RAD4	0.5635	14	4	1.03	Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human XPC protein
YHR117W	TOM71	0.5634	NA	1	1	Mitochondrial outer membrane protein with similarity to Tom70p; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins
YDR043C	NRG1	0.5634	1	NA	1.095	Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YCL025C	AGP1	0.5631	NA	1	0.99	Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YDL077C	VAM6	0.5629	7	5	0.849	Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
YCR082W	AHC2	0.5629	6	2	1.016	Protein of unknown function, putative transcriptional regulator; proposed to be a Ada Histone acetyltransferase complex component; GFP tagged protein is localized to the cytoplasm and nucleus
YNL273W	TOF1	0.5628	9	42	1.045	Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase
YMR044W	IOC4	0.5628	6	NA	1.041	Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PWWP motif
YIL014W	MNT3	0.5627	NA	NA	0.988	Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation
YMR119W	ASI1	0.5624	NA	NA	NA	Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
YKL071W	YKL071W	0.5623	NA	NA	1.027	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YOR220W	WSP1	0.5623	4	NA	1.045	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS
YJL211C	YJL211C	0.5623	NA	NA	1.058	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2
YLR031W	YLR031W	0.5622	NA	NA	0.995	Putative protein of unknown function
YGL094C	PAN2	0.5621	4	NA	1.117	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
YDR346C	SVF1	0.5618	4	1	1.006	Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis
YNR021W	YNR021W	0.5618	1	NA	1.013	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene
YJR105W	ADO1	0.5618	6	NA	0.529	Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YDR220C	YDR220C	0.5617	NA	NA	1.038	Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein
YDR061W	YDR061W	0.5617	NA	NA	1.09	Mitochondrial protein, member of the ATP-binding cassette (ABC) transporter family; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
YNL249C	MPA43	0.5617	2	NA	0.979	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR147C	YPR147C	0.5617	NA	NA	1.008	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS
YGL021W	ALK1	0.5616	NA	NA	1.05	Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk2p and to mammalian haspins
YNL066W	SUN4	0.5616	NA	1	1.061	Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YBR085W	AAC3	0.5615	12	1	1.098	Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration
YER034W	YER034W	0.5614	NA	NA	0.984	Hypothetical protein
YHR112C	YHR112C	0.5612	2	NA	1.016	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YMR294W	JNM1	0.5609	1	28	0.978	Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B
YKL163W	PIR3	0.5606	NA	1	1.1	O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YJR130C	STR2	0.5605	NA	1	1.054	Cystathionine gamma-synthase, converts cysteine into cystathionine
YPR119W	CLB2	0.5605	31	18	1.01	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YNL253W	TEX1	0.5604	7	NA	0.975	Protein involved in mRNA export, component of the transcription export (TREX) complex
YOR005C	DNL4	0.5604	16	NA	1.062	DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, catalyzes DNA ligation as part of a complex with Lif1p and Nej1p; involved in meiosis, not essential for vegetative growth
YHR130C	YHR130C	0.5602	NA	NA	0.998	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR069W	YGR069W	0.5601	NA	NA	1.009	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL027C	KRE27	0.5601	NA	NA	0.995	Protein of unknown function; null mutant shows K1 killer toxin resistance
YLL023C	YLL023C	0.5599	1	NA	1.008	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
YHR003C	YHR003C	0.5599	NA	NA	1.033	Protein of unknown function, localized to the mitochondrial outer membrane
YBR226C	YBR226C	0.5598	NA	NA	0.957	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W
YAL019W	FUN30	0.5597	10	9	0.895	Protein whose overexpression affects chromosome stability, potential Cdc28p substrate; homolog of Snf2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR300C	ADE4	0.5597	4	NA	0.769	Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway
YCR083W	TRX3	0.5596	NA	NA	1.026	Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p
YLR280C	YLR280C	0.5596	NA	NA	1.015	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL164C	IBD2	0.5595	2	NA	1.044	Component of the BUB2-dependent spindle checkpoint pathway, interacts with Bfa1p and functions upstream of Bub2p and Bfa1p
YPR196W	YPR196W	0.5595	NA	NA	0.975	Putative maltose activator
YBL042C	FUI1	0.5594	NA	2	0.986	High affinity uridine permease, localized to the plasma membrane; not involved in uracil transport
YDR263C	DIN7	0.559	1	NA	1.002	Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination
YNL301C	RPL18B	0.5589	57	NA	1.097	Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein
YNR024W	YNR024W	0.5589	10	NA	1.085	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YGL063W	PUS2	0.5586	1	NA	1.037	Putative pseudouridine synthase
YMR302C	YME2	0.5585	2	NA	1.052	Integral inner mitochondrial membrane protein with similarity to exonucleases; mutants exhibit an increased rate of mitochondrial DNA escape
YLR437C	YLR437C	0.5585	NA	NA	1.025	Putative protein of unknown function; epitope tagged protein localizes to the cytoplasm
YCL011C	GBP2	0.5584	37	NA	0.95	Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Hrb1p and Npl3p; also binds single-stranded telomeric repeat sequence in vitro
YJL122W	ALB1	0.5581	8	NA	1.013	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
YGR055W	MUP1	0.5579	NA	NA	0.92	High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
YBL054W	YBL054W	0.5576	4	NA	1.023	Protein of unknown function involved in rRNA and ribosome biosynthesis
YDR538W	PAD1	0.5576	1	NA	1.001	Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives
YER143W	DDI1	0.5574	1	NA	1.015	DNA damage-inducible v-SNARE binding protein, contains a ubiquitin-associated (UBA) domain, may act as a negative regulator of constitutive exocytosis, may play a role in S-phase checkpoint control
YDL124W	YDL124W	0.5573	2	NA	0.974	NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family
YKL151C	YKL151C	0.5573	1	1	1.11	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YPR149W	NCE102	0.5571	2	NA	0.968	Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)
YMR228W	MTF1	0.5571	7	NA	0.566	Mitochondrial RNA polymerase specificity factor with structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors, interacts with mitochondrial core polymerase Rpo41p
YAL013W	DEP1	0.557	11	68	0.803	Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation
YKR021W	ALY1	0.5569	1	NA	1.054	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YGL108C	YGL108C	0.5569	1	NA	1.075	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YFL026W	STE2	0.5567	1	NA	0.982	Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells
YML058C-A	YML058C-A	NA	NA	NA	NA	NA
YPL225W	YPL225W	0.5564	1	NA	1.033	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YHR110W	ERP5	0.5563	2	NA	1.016	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
YIR009W	MSL1	0.5563	15	6	1.003	U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro; does not contain the conserved C-terminal RNA binding domain found in other family members
YGL129C	RSM23	0.5562	31	1	0.733	Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p
YDR391C	YDR391C	0.556	NA	NA	1.033	Hypothetical protein
YPR154W	PIN3	0.5559	NA	NA	0.979	Protein that induces appearance of [PIN+] prion when overproduced
YER050C	RSM18	0.5558	34	NA	0.804	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
YDR148C	KGD2	0.5558	15	NA	0.856	Dihydrolipoyl transsuccinylase, a component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA
YIL028W	YIL028W	0.5556	NA	NA	1.044	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR107W	YJR107W	0.5555	NA	NA	1.077	Putative protein of unknown function; has sequence or structural similarity to lipases
YNL304W	YPT11	0.5553	2	3	1.092	Rab-type small GTPase that interacts with the C-terminal tail domain of Myo2p to mediate distribution of mitochondria to daughter cells
YDL183C	YDL183C	0.555	NA	NA	1.042	Putative protein of unknown function; YBR063C is not an essential gene
YDR147W	EKI1	0.555	1	NA	0.955	Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; also exhibits choline kinase activity
YPL155C	KIP2	0.5548	3	17	0.99	Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle
YDR431W	YDR431W	0.5547	NA	NA	0.9	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR056W	YBR056W	0.5543	NA	NA	0.996	Putative cytoplasmic protein of unknown function
YGR286C	BIO2	0.5543	1	NA	0.986	Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
YDL054C	MCH1	0.5543	1	1	0.972	Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YGR157W	CHO2	0.5541	NA	6	0.586	Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
YNL330C	RPD3	0.5539	28	19	1.089	Histone deacetylase; regulates transcription and silencing
YNL292W	PUS4	0.5539	3	NA	1.119	Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)
YBR076W	ECM8	0.5537	NA	2	0.743	Non-essential protein of unknown function
YLR083C	EMP70	0.5536	1	2	1.004	Protein whose 24kDa cleavage product is found in endosome-enriched membrane fractions, predicted to be a transmembrane protein
YPR193C	HPA2	0.5532	NA	NA	0.975	Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity
YPL130W	SPO19	0.5532	NA	NA	1.04	Meiosis-specific protein of unknown function, involved in completion of nuclear divisions; identified as a weak high-copy suppressor of the spo1-1 ts mutation; putative GPI-dependent cell-wall protein
YMR251W	GTO3	0.553	1	NA	1.036	Omega class glutathione transferase; putative cytosolic localization
YPR008W	HAA1	0.5529	4	NA	1.049	Transcriptional activator involved in the transcription of TPO2, HSP30 and other genes encoding membrane stress proteins; despite sequence similarity with the transcription factor Ace1p, it is not subject to metalloregulation
YPR009W	SUT2	0.5529	NA	NA	1.016	Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p
YJR009C	TDH2	0.5528	29	2	1.041	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YML124C	TUB3	0.5527	36	27	1.052	Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p
YGR214W	RPS0A	0.5525	37	4	0.874	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YER092W	IES5	0.5525	14	8	0.831	Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
YGR254W	ENO1	0.5523	8	NA	1.031	Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose
YBR188C	NTC20	0.5523	8	2	1.052	Member of a complex, including Prp19p, that binds to the spliceosome; required for pre-mRNA splicing
YDL134C-A	YDL134C-A	NA	NA	NA	NA	NA
YOL041C	NOP12	0.5522	54	1	0.977	Nucleolar protein, required for pre-25S rRNA processing; contains an RNA recognition motif (RRM) and has similarity to Nop13p, Nsr1p, and putative orthologs in Drosophila and S. pombe
YOL071W	EMI5	0.5522	NA	NA	0.966	Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation
YML087C	YML087C	0.5521	NA	NA	0.996	Putative protein of unknown function
YLR324W	PEX30	0.5521	NA	NA	1.017	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
YLR046C	YLR046C	0.5519	NA	1	1.015	Putative membrane protein, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YAL065C	YAL065C	0.5516	NA	NA	0.968	Putative protein of unknown function; has homology to FLO1; possible pseudogene
YPL220W	RPL1A	0.5516	78	1	1.044	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Bp and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal
YDR120C	TRM1	0.5515	4	NA	1.096	tRNA methyltransferase, localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
YBR111C	YSA1	0.5515	NA	2	NA	Nudix hydrolase family member with ADP-ribose pyrophosphatase activity
YGL149W	YGL149W	0.5514	NA	NA	0.943	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.
YHR105W	YPT35	0.5513	1	NA	1.004	Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport
YBR168W	PEX32	0.5511	1	NA	0.735	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
YGL144C	ROG1	0.551	NA	NA	1.028	Protein with putative serine active lipase domain
YGR170W	PSD2	0.5509	4	2	1.019	Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
YNL268W	LYP1	0.5509	1	2	1.035	Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
YNL300W	YNL300W	0.5508	NA	NA	1.066	Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid
YDR229W	IVY1	0.5507	1	NA	1.033	Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase
YGL260W	YGL260W	0.5506	NA	NA	1.012	Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium
YDR210W	YDR210W	0.5504	NA	NA	1.008	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YGL005C	COG7	0.5504	8	8	1.002	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YMR184W	ADD37	0.5503	NA	NA	0.846	Protein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene
YHL034C	SBP1	0.5502	59	NA	0.914	Nucleolar single-strand nucleic acid binding protein; associates with small nuclear RNAs
YOR295W	UAF30	0.5496	1	4	0.418	Subunit of UAF (upstream activation factor), which is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate
YGR181W	TIM13	0.5496	1	3	1.028	Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner
YER011W	TIR1	0.5493	1	NA	1.001	Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
YPL149W	ATG5	0.5493	3	NA	1.033	Conserved autophagy-related protein that undergoes conjugation with Atg12p and then associates with Atg16p to form a cytosolic complex essential for autophagosome formation
YGR291C	YGR291C	0.5491	NA	NA	1.048	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL067C	RTG1	0.5489	2	3	0.353	Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus
YBR012C	YBR012C	0.5489	NA	NA	0.973	Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p
YGR184C	UBR1	0.5488	6	6	1.017	Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway; binds to the Rpn2p, Rpt1p, and Rpt6p proteins of the 19S particle of the 26S proteasome
YKL132C	RMA1	0.5488	1	NA	1.086	Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR027C	YPR027C	0.5487	NA	NA	0.994	Putative protein of unknown function
YOR271C	YOR271C	0.5486	NA	NA	0.96	Putative protein, predicted by computational methods to be an alpha-isopropylmalate carrier; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR210W	ERV15	0.5486	NA	NA	1.055	Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YHR038W	RRF1	0.5486	1	NA	0.716	Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria
YDR463W	STP1	0.5484	5	NA	0.991	Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing
YJL197W	UBP12	0.5482	2	NA	1.041	Ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins
YLR377C	FBP1	0.5481	2	NA	1.025	Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YMR147W	YMR147W	0.5475	NA	NA	1.007	Putative protein of unknown function
YDL045W-A	MRP10	0.5475	8	NA	0.806	Mitochondrial ribosomal protein of the small subunit
YBR073W	RDH54	0.5474	1	NA	1.032	DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during mitosis and meiosis; proposed to be involved in crossover interference
YPL025C	YPL025C	0.5473	NA	NA	0.919	Hypothetical protein
YMR204C	INP1	0.5473	NA	NA	1.041	Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance
YPL138C	SPP1	0.5472	9	12	1.02	Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein
YNL218W	MGS1	0.5472	2	6	1.01	Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP)
YJR084W	CSN12	0.5472	9	3	1.068	Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
YBR007C	DSF2	0.547	1	NA	0.97	Deletion suppressor of mpt5 mutation
YLR069C	MEF1	0.5467	3	NA	0.561	Mitochondrial elongation factor involved in translational elongation
YML100W	TSL1	0.5466	9	NA	1.071	Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function
YBR222C	PCS60	0.5466	NA	NA	1.015	Peroxisomal AMP-binding protein, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase
YLR194C	YLR194C	0.5465	1	NA	1.007	Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress
YJL148W	RPA34	0.5463	20	19	0.926	RNA polymerase I subunit A34.5
YNR068C	YNR068C	0.5463	NA	NA	0.885	Putative protein of unknown function
YPL195W	APL5	0.5462	6	3	0.987	Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function
YKR040C	YKR040C	0.5459	NA	NA	1.035	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W
YDL131W	LYS21	0.5458	5	NA	0.981	Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p
YDL194W	SNF3	0.5457	NA	1	1.047	Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YBL046W	PSY4	0.5456	11	NA	1.013	Putative regulatory subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and a third subunit Psy2p; required for cisplatin resistance; GFP-fusion protein localizes to the nucleus
YOR051C	YOR051C	0.5456	3	NA	0.983	Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YJR034W	PET191	0.5454	NA	1	0.973	Protein required for assembly of cytochrome c oxidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YML094W	GIM5	0.5452	5	154	0.868	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
YKL190W	CNB1	0.545	5	39	1.084	Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1
YMR252C	YMR252C	0.5449	NA	NA	1.041	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene
YNL020C	ARK1	0.5449	NA	1	1.086	Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis
YCL028W	RNQ1	0.5448	15	NA	0.974	[PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate
YCR067C	SED4	0.5447	NA	1	1.027	Integral endoplasmic reticulum membrane protein, functions as a positive regulator of Sar1p probably through inhibition of GTPase activation by Sec23p; binds Sec16p, participates in vesicle formation, similar to Sec12p
YCR046C	IMG1	0.5446	30	2	0.777	Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome
YKR041W	YKR041W	0.5445	NA	NA	1.059	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YMR109W	MYO5	0.5444	12	12	0.995	One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
YDR230W	YDR230W	0.5441	NA	NA	0.98	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
YJL200C	ACO2	0.5439	1	NA	0.998	Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YNL047C	SLM2	0.5437	3	1	1.298	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; subunit of and phosphorylated by the TORC2 complex
YFR001W	LOC1	0.5436	50	NA	0.602	Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles
YKL166C	TPK3	0.5436	14	2	1.068	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk2p
YIR032C	DAL3	0.5436	1	NA	NA	Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YDL239C	ADY3	0.5435	2	NA	1.02	Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p
YFR008W	FAR7	0.5434	2	NA	1.045	Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p
YOR384W	FRE5	0.5433	NA	NA	1.031	Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL092W	SSU1	0.5433	NA	NA	1.015	Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
YGR096W	TPC1	0.5433	NA	NA	0.998	Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
YJL058C	BIT61	0.5432	2	1	1.008	Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p-Slm1p-Slm2p), a membrane-associated complex that regulates cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity
YGL180W	ATG1	0.543	1	NA	1.045	Protein serine/threonine kinase, required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway
YPR059C	YPR059C	0.543	NA	NA	0.995	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W
YER188W	YER188W	0.5429	NA	NA	0.972	Hypothetical protein
YCL039W	GID7	0.5425	12	NA	0.982	Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions
YDR093W	DNF2	0.5425	NA	1	0.95	Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
YMR053C	STB2	0.5425	NA	NA	1.008	Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p
YGL083W	SCY1	0.5423	NA	NA	1.063	Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
YKL061W	YKL061W	0.5422	5	NA	1.049	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endosome
YNL013C	YNL013C	0.5417	NA	NA	0.997	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W
YDL022W	GPD1	0.5416	3	NA	1.014	NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YLR366W	YLR366W	0.5416	NA	NA	0.946	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
YHR195W	NVJ1	0.5415	NA	NA	0.938	Nuclear envelope protein that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)
YIL101C	XBP1	0.5413	2	NA	0.992	Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YKR088C	TVP38	0.5411	NA	NA	0.938	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YJL178C	ATG27	0.5411	NA	NA	1.014	Type II membrane protein involved in autophagy; binds phosphatidylinositol 3-phosphate, required for the cytoplasm-to-vacuole targeting (Cvt) pathway
YNR014W	YNR014W	0.541	1	NA	1.043	Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible
YMR201C	RAD14	0.5408	6	2	1.001	Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
YJL065C	DLS1	0.5407	5	NA	0.958	Subunit of ISW2/yCHRAC chromatin accessibility complex along with Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing
YGR112W	SHY1	0.5407	NA	3	0.9	Mitochondrial inner membrane protein required for normal respiration, possible chaperone involved in assembly of cytochrome c oxidase; similar to SURF1 from mammals, chickens, and D. melanogaster
YIL041W	GVP36	0.5407	2	NA	0.944	Golgi vesicle protein of unknown function; localizes to both early and late Golgi vesicles; may interact with ribosomes, based on co-purification experiments
YGR066C	YGR066C	0.5402	1	NA	0.987	Putative protein of unknown function
YPL197C	YPL197C	0.5402	NA	NA	1.005	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
YKL142W	MRP8	0.5401	11	NA	1.041	Putative mitochondrial ribosomal protein, has similarity to E. coli ribosomal protein S2
YMR132C	JLP2	0.54	NA	NA	1.045	Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
YNR059W	MNT4	0.5398	NA	NA	0.938	Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation
YKL179C	COY1	0.5396	1	NA	1.057	Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
YAR027W	UIP3	0.5396	NA	NA	0.95	Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family
YJR154W	YJR154W	0.5395	2	NA	1.045	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YKL008C	LAC1	0.5394	NA	1	1.048	Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p
YKR050W	TRK2	0.5391	NA	1	1.026	Component of the Trk1p-Trk2p potassium transport system
YEL028W	YEL028W	0.5391	NA	NA	0.983	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL065W	YBL065W	0.5386	NA	NA	0.904	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
YDR055W	PST1	0.5386	1	NA	1.018	Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
YDR352W	YDR352W	0.5385	NA	NA	1.066	Putative protein of unknown function
YKL220C	FRE2	0.5385	NA	NA	0.997	Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
YMR118C	YMR118C	0.5384	1	NA	1.062	Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YPL173W	MRPL40	0.538	7	NA	0.841	Mitochondrial ribosomal protein of the large subunit
YMR157C	FMP39	0.538	NA	1	1.003	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR395C	COX8	0.5378	NA	NA	0.978	Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YEL011W	GLC3	0.5377	NA	NA	1.019	Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YML057W	CMP2	0.5376	9	2	0.976	Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
YNL234W	YNL234W	0.5375	1	NA	0.987	Similar to globins and has a functional heme-binding domain; involved in glucose signaling or metabolism; regulated by Rgt1p
YNL275W	BOR1	0.5375	NA	NA	1.06	Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1
YLR332W	MID2	0.5371	NA	11	1.016	O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YDL184C	RPL41A	0.5369	1	1	0.996	Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Bp and has similarity to rat L41 ribosomal protein; comprised of only 25 amino acids; rpl41a rpl41b double null mutant is viable
YGR041W	BUD9	0.5368	2	NA	1.022	Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole
YNL142W	MEP2	0.5366	NA	2	1.078	Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YLL063C	AYT1	0.5365	1	NA	1.008	Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis
YLL059C	YLL059C	0.5359	NA	NA	0.969	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL077C	ICS3	0.5359	NA	NA	1.008	Protein of unknown function
YER033C	ZRG8	0.5358	1	1	0.989	Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YGR164W	YGR164W	0.5358	NA	NA	1.048	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL148C	SDH1	0.5357	1	NA	1.075	Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YPL185W	YPL185W	0.5356	NA	NA	1.034	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YOR199W	YOR199W	0.5355	NA	NA	0.826	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YML035C	AMD1	0.5354	2	NA	1.081	AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools
YHR146W	CRP1	0.5353	4	NA	1.071	Protein that binds to cruciform DNA structures
YIL045W	PIG2	0.5352	2	NA	0.996	Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YER128W	YER128W	0.5352	NA	NA	1.014	Putative protein of unknown function
YIL168W	YIL168W	NA	NA	NA	NA	NA
YJL004C	SYS1	0.5351	NA	5	1.035	Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
YIL006W	YIA6	0.5348	NA	1	0.969	Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs
YML095C	RAD10	0.5348	11	4	1.061	Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
YDR051C	YDR051C	0.5347	1	NA	1.065	Protein of unknown function; interacts with Hsp82p in two-hybrid assay; deletion confers sensitivity to Nickel
YGL039W	YGL039W	0.5346	3	NA	1.058	Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YBR084C-A	RPL19A	0.5345	8	1	0.867	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YML059C	NTE1	0.5345	4	NA	0.974	Serine esterase that deacylates exogenous lysophospholipids, homolog of human neuropathy target esterase (NTE); mammalian NTE1 deacylates phosphatidylcholine to glycerophosphocholine
YPL034W	YPL034W	0.5345	NA	NA	1.008	Putative protein of unknown function; YPL034W is not essential gene
YER185W	YER185W	0.5344	NA	NA	1.034	Putative protein of unknown function; topology models predict that YER185W may encode an integral membrane protein; similar in sequence to RSB1, which is involved in sphingoid long-chain base release
YFL056C	AAD6	0.5343	NA	NA	0.974	Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response
YNL108C	YNL108C	0.5343	NA	NA	1.016	Putative protein of unknown function with similarity to TFC7 and phosphotranfer enzymes in prokaryotes; a deletion mutant shows alterations in glucose metabolism; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YBL059W	YBL059W	0.5342	1	NA	1.018	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR191W	HST4	0.5342	NA	2	1.023	Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
YDR286C	YDR286C	0.5339	NA	NA	0.998	Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site
YLR436C	ECM30	0.5339	3	NA	0.983	Non-essential protein of unknown function
YBR246W	YBR246W	0.5338	NA	NA	0.934	Putative protein of unknown function; deletion results in a weak carboxypeptidase Y missorting/secretion phenotype; YBR246W is not an essential gene
YOL009C	MDM12	0.5335	NA	11	0.722	Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; exists in a complex with Mmm1p and Mdm10p
YDR154C	YDR154C	0.5333	NA	NA	1.054	Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein
YMR284W	YKU70	0.5332	13	6	1	Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YOL043C	NTG2	0.5332	NA	2	1.017	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus
YIL131C	FKH1	0.5329	26	1	0.985	Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switching
YPL065W	VPS28	0.5328	2	2	0.813	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; involved in transport of precursors for soluble vacuolar hydrolases from the late endosome to the vacuole
YPL259C	APM1	0.5328	25	NA	1.013	Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting
YBL099W	ATP1	0.5326	4	NA	0.858	Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YHR051W	COX6	0.5326	2	NA	0.866	Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels
YBR239C	YBR239C	0.5326	NA	NA	1.047	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR239C is not an essential gene
YKR027W	BCH2	0.5323	3	1	0.827	Member of the Chs5p-Arf1p-binding proteins (ChAPs), a group of 4 related, interacting proteins (Bch1p, Fmp50p, Bud7p, Chs6p) that mediate export of specific cargo proteins, including chitin synthase Chs3p, from the Golgi to plasma membrane
YBL080C	PET112	0.5322	1	NA	0.733	Protein required for mitochondrial translation; mutation is functionally complemented by a Bacillus subtilis ortholog
YML131W	YML131W	0.5321	12	NA	1.069	Putative protein of unknown function with similarity to oxidoreductases; HOG1 and SKO1-dependent mRNA expression is induced after osmotic shock; GFP-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS
YBL106C	SRO77	0.5321	2	NA	1.021	Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro7p and Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p
YOL160W	YOL160W	0.532	NA	NA	1.043	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR071W	YBR071W	0.5318	NA	NA	1.031	Putative protein of unknown function; (GFP)-fusion and epitope-tagged proteins localize to the cytoplasm; mRNA expression may be regulated by the cell cycle and/or cell wall stress
YJL208C	NUC1	0.5317	2	3	1.001	Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy
YER071C	YER071C	0.5317	5	NA	0.984	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YGL157W	YGL157W	0.5316	6	NA	1.035	Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YOL079W	YOL079W	0.5313	NA	NA	1.013	Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YGR228W	YGR228W	0.5309	NA	NA	0.936	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C
YKL075C	YKL075C	0.5309	4	NA	1.004	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin
YLR434C	YLR434C	0.5308	NA	NA	0.929	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W
YML022W	APT1	0.5306	1	NA	1.017	Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis
YPL172C	COX10	0.5306	NA	1	0.91	Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders
YER049W	TPA1	0.5305	10	1	0.984	Protein of unknown function; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; has a role in translation termination efficiency, mRNA poly(A) tail length and mRNA stability
YBR187W	GDT1	0.5305	7	NA	1.036	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YBR187W is an essential gene
YMR172C-A	YMR172C-A	0.5304	NA	NA	1.008	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL141C	YPL141C	0.5304	3	NA	1.01	Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL141C is not an essential gene
YPR111W	DBF20	0.5303	7	1	1.012	Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis
YGL249W	ZIP2	0.5303	NA	NA	1.005	Meiosis-specific protein involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis
YOL099C	YOL099C	0.5301	NA	NA	1.029	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes
YBR019C	GAL10	0.53	1	1	1.029	UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers
YER119C	AVT6	0.53	NA	NA	0.969	Vacuolar transporter, exports aspartate and glutamate from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YHR176W	FMO1	0.5299	NA	NA	1.006	Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins
YPR192W	AQY1	0.5298	NA	NA	0.975	Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
YJL055W	YJL055W	0.5298	NA	NA	1.011	Putative protein of unknown function; deletion mutants are sensitive to purine base analogs, 6-hydroxylaminopurine (HAP) and 2-amino-6-hydroxylaminopurine (AHA) and are AHA-hypermutable
YBR145W	ADH5	0.5295	1	NA	NA	Alcohol dehydrogenase isoenzyme V; involved in ethanol production
YDR520C	YDR520C	0.5295	2	NA	1.029	Putative transcription factor; contains the (Zn(II)2Cys6 motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is viable and sensitive to caffeine
YGL080W	FMP37	0.5294	NA	NA	1	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR138C	MEP3	0.5292	1	2	0.969	Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease
YBR009C	HHF1	0.5291	132	4	0.939	One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YDL162C	YDL162C	0.5291	NA	NA	0.993	Hypothetical protein
YMR221C	FMP42	0.5289	NA	NA	1.02	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIL122W	POG1	0.5288	NA	NA	0.97	Putative transcriptional activator that promotes recovery from pheromone induced arrest; inhibits both alpha-factor induced G1 arrest and repression of CLN1 and CLN2 via SCB/MCB promoter elements; potential Cdc28p substrate; SBF regulated
YMR124W	YMR124W	0.5288	2	NA	1.041	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene
YDL167C	NRP1	0.5287	2	NA	0.757	Protein of unknown function, rich in asparagine residues
YNL050C	YNL050C	0.5285	1	NA	1.087	Putative protein of unknown function; YNL050c is not an essential gene
YMR174C	PAI3	0.5285	NA	NA	0.977	Cytoplasmic proteinase A inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact
YML050W	YML050W	0.5283	NA	NA	1.05	Putative protein of unknown function; non-essential gene
YJL073W	JEM1	0.5281	NA	2	1.018	DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2
YIL012W	YIL012W	0.5281	NA	NA	1.015	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR073C	YLR073C	0.528	NA	NA	1.011	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to endosomes; YLR073C is not an esssential gene
YDR155C	CPR1	0.5277	35	5	1.049	Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A
YEL023C	YEL023C	0.5277	15	NA	1.002	Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene
YML119W	YML119W	0.5276	NA	NA	1.051	Putative protein of unknown funtion; YML119W is not an essential gene; potential Cdc28p substrate
YNL010W	YNL010W	0.5275	NA	NA	0.981	Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation
YKL207W	YKL207W	0.5275	NA	NA	1.093	Putative protein of unknown function; non-essential gene
YLR307W	CDA1	0.5275	NA	1	0.974	Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YEL060C	PRB1	0.5275	19	2	1.011	Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation
YOR100C	CRC1	0.5274	2	NA	1.022	Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YER090W	TRP2	0.5274	6	NA	0.665	Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
YPR171W	BSP1	0.5273	15	NA	1	Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
YFR043C	IRC6	0.5273	1	NA	1.009	Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci
YDL001W	RMD1	0.527	NA	NA	0.871	Cytoplasmic protein required for sporulation
YGL154C	LYS5	0.527	1	NA	0.962	Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine
YHR179W	OYE2	0.5269	18	NA	0.969	Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YDL154W	MSH5	0.5269	NA	1	0.968	Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans
YNR001C	CIT1	0.5268	NA	2	1.023	Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein
YGR281W	YOR1	0.5268	16	1	0.954	Plasma membrane transporter of the ATP-binding cassette (ABC) family, mediates export of many different organic anions including oligomycin
YBR286W	APE3	0.5267	2	NA	0.976	Vacuolar aminopeptidase Y, processed to mature form by Prb1p
YLR448W	RPL6B	0.5267	89	NA	0.758	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA
YDL046W	NPC2	0.5266	NA	NA	0.959	Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes
YNL104C	LEU4	0.5263	2	NA	1.046	Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway
YOR223W	YOR223W	0.5262	NA	NA	1.021	Putative protein of unknown function
YHR035W	YHR035W	0.5262	1	NA	0.962	Putative protein of unknown function; not an essential gene
YGL215W	CLG1	0.5259	1	1	1.004	Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2
YBR162C	TOS1	0.5259	4	NA	NA	Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
YMR294W-A	YMR294W-A	0.5259	NA	NA	1.108	Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents
YGL020C	GET1	0.5258	2	69	0.8	Subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance
YKL041W	VPS24	0.5256	1	7	0.891	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway
YOL013C	HRD1	0.5253	40	NA	1.057	Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger
YMR121C	RPL15B	0.5252	6	NA	1.031	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YDR178W	SDH4	0.5252	NA	NA	1.018	Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YOL061W	PRS5	0.5249	3	2	0.963	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of a five related enzymes, which are active as heteromultimeric complexes
YMR135W-A	YMR135W-A	0.5249	NA	NA	0.842	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR022C	CIS1	0.5247	3	NA	1.001	Protein required for autophagosome formation in concert with Atg17p; may be involved in microtubule organization; high-copy suppressor of CIK1 deletion
YDR268W	MSW1	0.5247	NA	NA	0.768	Mitochondrial tryptophanyl-tRNA synthetase
YNL265C	IST1	0.5245	13	NA	1.081	Putative translation initiation factor, as suggested by computational analysis of large-scale protein-protein interaction data
YMR097C	MTG1	0.5243	1	1	1.022	Peripheral GTPase of the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals
YNR004W	YNR004W	0.524	NA	NA	1.013	Putative protein of unknown function; haploid disruptant exhibits slow growth rate on glucose-minimal medium at 15 C
YGL254W	FZF1	0.524	NA	NA	0.994	Transcription factor involved in sulfite metabolism, sole identified regulatory target is SSU1, overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers
YNR039C	ZRG17	0.5239	1	NA	0.972	Endoplasmic reticulum protein of unknown function, transcription is induced under conditions of zinc deficiency; mutant phenotype suggests a role in uptake of zinc
YGR135W	PRE9	0.5237	30	19	0.76	20S proteasome beta-type subunit; the only nonessential 20S subunit
YOR134W	BAG7	0.5235	NA	NA	0.999	Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p
YOR061W	CKA2	0.5232	43	2	0.92	Alpha' catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases
YDR115W	YDR115W	0.5232	1	NA	0.792	Putative mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins
YBR248C	HIS7	0.523	1	NA	0.979	Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor
YLR404W	YLR404W	0.5229	NA	NA	0.979	Putative protein of unknown function; may be an integral membrane protein; YLR404W is not an essential gene
YHR177W	YHR177W	0.5229	NA	NA	NA	Putative protein of unknown function
YNL143C	YNL143C	0.5228	NA	NA	0.974	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR048W	RPS0B	0.5228	20	1	0.677	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YLR261C	YLR261C	0.5226	NA	NA	0.913	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
YLR039C	RIC1	0.5224	8	137	0.903	Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
YOL108C	INO4	0.5223	13	2	0.958	Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain
YOR173W	DCS2	0.5223	5	NA	1.018	Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p.
YNL284C	MRPL10	0.5221	35	1	0.833	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels
YMR040W	YET2	0.5221	NA	NA	1.04	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YKL026C	GPX1	0.522	NA	NA	1.053	Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YFL019C	YFL019C	0.5215	NA	NA	1.081	Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YCL023C	YCL023C	0.5213	NA	NA	0.978	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
YLR360W	VPS38	0.5212	3	8	0.933	Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity
YKR098C	UBP11	0.521	2	NA	0.967	Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins
YKL211C	TRP3	0.5209	17	NA	1.049	Bifunctional enzyme exhibiting both indole-3-glycerol-phosphate synthase and anthranilate synthase activities, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
YOR270C	VPH1	0.5207	15	1	0.876	Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes
YIL167W	SDL1	NA	NA	NA	NA	NA
YDL012C	YDL012C	0.5204	NA	NA	1.039	Plasma membrane protein of unknown function; YDL012C is not an essential gene
YPL123C	RNY1	0.5202	NA	NA	1.007	RNAse; member of the T(2) family of endoribonucleases
YKL047W	YKL047W	0.5201	3	NA	1.06	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YGL118C	YGL118C	0.5201	NA	NA	1.049	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML115C	VAN1	0.52	4	17	1.024	Component of the mannan polymerase I; forms a complex with Mnn9p, which is involved in in mannan synthesis; mutants are vanadate-resistant
YDL203C	ACK1	0.5197	4	NA	0.952	Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria
YPL199C	YPL199C	0.5195	1	NA	1.034	Hypothetical protein
YDL089W	YDL089W	0.5193	NA	NA	0.963	Protein of unknown function; interacts with meiotic division protein Csm1p; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery, potential Cdc28p substrate
YJL172W	CPS1	0.5191	NA	1	0.96	Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions
YML108W	YML108W	0.519	NA	NA	1.044	Putative protein of unknown function whose structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene
YER019W	ISC1	0.5189	NA	7	0.64	Inositol phosphosphingolipid phospholipase C, hydrolyzes inositolphosphosphingolipids, activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol, mediates Na+ and Li+ halotolerance, contains a P loop-like domain
YBR020W	GAL1	0.5188	NA	1	1.024	Galactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p
YKR102W	FLO10	0.5188	NA	NA	1.016	Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YKR012C	YKR012C	0.5183	NA	NA	1.062	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
YPL208W	RKM1	0.5183	8	NA	1.028	SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit protein L23a (RPL23A and RPL23B)
YDL144C	YDL144C	0.5183	1	NA	0.965	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene.
YOR233W	KIN4	0.5182	3	1	1.003	Kinase that acts by inhibiting the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck
YMR195W	ICY1	0.5182	NA	NA	1.063	Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA
YLR278C	YLR278C	0.5181	4	NA	0.912	Zinc-cluster protein; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; YLR278C is not an essential gene
YMR027W	YMR027W	0.5181	2	NA	1.041	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene
YOR184W	SER1	0.5179	1	1	1.019	3-phosphoserine aminotransferase, catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p
YJL098W	SAP185	0.5179	33	NA	0.97	Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p
YML096W	YML096W	0.5179	NA	NA	1.043	Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10
YJL168C	SET2	0.5177	15	79	0.941	Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
YNL071W	LAT1	0.5174	4	2	1.036	Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
YGR200C	ELP2	0.5174	12	33	0.952	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
YFR053C	HXK1	0.5173	9	NA	0.985	Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YAL031C	GIP4	0.517	2	NA	0.983	Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate
YGR079W	YGR079W	0.5169	NA	NA	0.943	Putative protein of unknown function; YGR079W is not an essential gene
YPL150W	YPL150W	0.5169	7	NA	1.07	Putative protein kinase of unknown cellular role
YLR431C	ATG23	0.5165	NA	NA	0.915	Peripheral membrane protein, required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway
YNL056W	OCA2	0.5161	1	NA	1.023	Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
YNL054W	VAC7	0.516	2	1	1.003	Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock
YLR312W-A	MRPL15	0.516	23	NA	0.696	Mitochondrial ribosomal protein of the large subunit
YCR020C	PET18	0.516	NA	NA	0.972	Protein required for respiratory growth and stability of the mitochondrial genome
YGR233C	PHO81	0.5159	8	NA	1.009	Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p
YPL183C	YPL183C	0.5156	3	NA	0.993	Cytoplasmic protein of unknown function
YJR133W	XPT1	0.5154	NA	NA	1.057	Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine
YBR205W	KTR3	0.5153	5	1	0.965	Putative alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YDR179C	CSN9	0.5152	7	NA	1.001	Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
YNL211C	YNL211C	0.5152	NA	NA	1.007	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene
YNL099C	OCA1	0.515	6	NA	1.042	Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA
YOR010C	TIR2	0.5148	NA	NA	1.081	Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
YAR035W	YAT1	0.5148	NA	NA	1.008	Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix
YDR255C	RMD5	0.5148	7	NA	0.997	Cytosolic protein required for sporulation; also required for the ubiquitination of the gluconeogenetic enzyme fructose-1,6-bisphosphatase, which is degraded rapidly after the switch from gluconeogenesis to glycolysis
YNR067C	DSE4	0.5147	1	NA	0.943	Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
YDR080W	VPS41	0.5146	8	5	0.877	Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
YBR027C	YBR027C	0.5146	NA	NA	1.039	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL093W	PMT5	0.5145	1	NA	0.967	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals
YJL153C	INO1	0.5143	NA	NA	0.491	Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
YDR338C	YDR338C	0.5142	NA	NA	1.064	Hypothetical protein
YJR066W	TOR1	0.514	7	3	0.94	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis
YPL196W	OXR1	0.514	NA	2	0.991	Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes but not in prokaryotes
YNL228W	YNL228W	0.5139	NA	NA	0.94	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1
YGL007W	YGL007W	0.5138	NA	NA	0.877	Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1
YHL042W	YHL042W	0.5138	NA	NA	1.012	Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YML048W-A	YML048W-A	NA	NA	NA	NA	NA
YBL093C	ROX3	0.5137	30	NA	0.225	RNA polymerase II holoenzyme component
YDR319C	YDR319C	0.5136	NA	NA	1.021	Putative protein of unknown function; identified as interacting with Sst2p and Hsp82p in high-throughput two-hybrid screens
YOR234C	RPL33B	0.5135	17	NA	0.94	Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable
YCR089W	FIG2	0.5135	1	2	NA	Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating
YBR013C	YBR013C	0.5134	NA	NA	0.992	Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein
YGR077C	PEX8	0.5134	6	NA	1.017	Intraperoxisomal organizer of the peroxisomal import machinery, tightly associated with the lumenal face of the peroxisomal membrane, essential for peroxisome biogenesis, binds PTS1-signal receptor Pex5p
YFL018C	LPD1	0.5133	10	NA	0.896	Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes
YML068W	ITT1	0.5132	NA	NA	1.032	Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins
YKL069W	YKL069W	0.5132	2	NA	1.027	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YNL291C	MID1	0.5131	1	5	1.061	N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
YOL015W	IRC10	0.513	NA	NA	0.996	Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci
YFR007W	YFR007W	0.5128	NA	NA	0.944	Putative protein of unknown function with similarity to pantothenate kinases from other organisms; YFR007W is not an essential gene
YGR224W	AZR1	0.5126	2	NA	1.002	Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole
YER072W	VTC1	0.5125	3	NA	1.023	Vacuolar transporter chaperon (VTC) involved in distributing V-ATPase and other membrane proteins; together with other VTC proteins, forms a heterotetrameric complex that associates with the SNARE Nyv1p and the V0 sector of the V-ATPase
YJL036W	SNX4	0.5125	2	3	0.916	Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX domain; forms complex with Snx41p and Atg20p
YKR026C	GCN3	0.5124	34	4	0.847	Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
YGL117W	YGL117W	0.5122	1	NA	1.049	Putative protein of unknown function
YEL010W	YEL010W	0.5121	NA	NA	1.015	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR209C	TRX2	0.512	11	4	1.033	Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against both oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance
YNR002C	ATO2	0.512	NA	NA	1.075	Putative transmembrane protein, involved in the export of ammonia, a starvation signal that promotes cell death in the center of aging colonies; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YBR189W	RPS9B	0.5119	96	NA	0.586	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins
YPL163C	SVS1	0.5119	NA	NA	1.044	Cell wall and vacuolar protein, required for wild-type resistance to vanadate
YDL070W	BDF2	0.5118	5	NA	0.935	Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p
YER028C	MIG3	0.5117	NA	NA	NA	Probable transcriptional repressor involved in response to toxic agents such as hydroxyurea that inhibit ribonucleotide reductase; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes
YPL205C	YPL205C	0.5115	NA	NA	0.843	Hypothetical protein; deletion of locus affects telomere length
YJR131W	MNS1	0.5115	1	1	1.03	Alpha-1,2-mannosidase involved in ER quality control; catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc in N-linked oligosaccharide biosynthesis; integral to ER membrane
YEL020C	YEL020C	0.5113	NA	NA	1.006	Hypothetical protein with low sequence identity to Pdc1p
YEL012W	UBC8	0.511	2	NA	1.029	Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YOL011W	PLB3	0.511	1	NA	0.982	Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
YOR002W	ALG6	0.5108	NA	7	1.01	Glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease
YPR140W	TAZ1	0.5106	3	NA	0.922	Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; similar to human tafazzin, which is implicated in Barth syndrome
YER181C	YER181C	0.5106	NA	NA	1.015	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies
YDR514C	YDR514C	0.5102	NA	NA	0.967	Putative protein of unknown function
YPL057C	SUR1	0.5096	NA	7	1.006	Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p
YJL093C	TOK1	0.5095	NA	NA	1.001	Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
YPL170W	DAP1	0.5093	4	1	1.042	Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
YGR109C	CLB6	0.5091	NA	1	0.996	B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1
YDR206W	EBS1	0.509	NA	NA	0.978	Cytoplasmic protein of unknown function, involved in inhibition of translation; interacts with cap binding protein Cdc33; contains an RNA recognition motif and similarity to Est1p; mRNA abundance regulated by mRNA decay factors
YBR264C	YPT10	0.5089	3	NA	1.005	GTP binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles
YIL160C	POT1	0.5089	NA	NA	1.009	3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
YGL252C	RTG2	0.5088	19	2	0.461	Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p
YHR184W	SSP1	0.5087	NA	NA	0.867	Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis
YAR031W	PRM9	0.5087	NA	NA	0.986	Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family
YHR047C	AAP1	0.5086	5	NA	0.981	Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation
YDR387C	YDR387C	0.5086	NA	NA	1.025	Putative transporter protein; YDR387C is not an essential gene
YLL019C	KNS1	0.5086	5	NA	0.982	Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YNL029C	KTR5	0.5084	1	NA	1.036	Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YLR108C	YLR108C	0.5079	NA	NA	0.965	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene
YBR151W	APD1	0.5079	1	NA	1.008	Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
YJR124C	YJR124C	0.5077	1	NA	1.056	Putative protein of unknown function; expression induced under calcium shortage
YGL028C	SCW11	0.5077	NA	NA	1.105	Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p
YDR265W	PEX10	0.5076	3	1	1.009	RING finger peroxisomal membrane peroxin required for peroxisomal matrix protein import, interacts with Pex12p, links ubiquitin-conjugating Pex4p to protein import machinery; mutations in human homolog cause a variety of peroxisomal disorders
YPL064C	CWC27	0.5074	1	NA	1.006	Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p
YLR449W	FPR4	0.5074	31	NA	0.914	Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
YOR097C	YOR097C	0.5073	3	NA	1.022	Hypothetical protein
YHR039C	MSC7	0.5073	8	NA	0.918	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids
YPL156C	PRM4	0.5072	NA	NA	1.037	Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
YBR224W	YBR224W	0.5071	NA	NA	0.966	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1
YDR408C	ADE8	0.507	1	NA	1.02	Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
YML058W	SML1	0.507	30	4	0.977	Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
YNL043C	YNL043C	0.5066	NA	NA	1.067	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YGR247W	CPD1	0.5066	NA	NA	1.032	Cyclic nucleotide phosphodiesterase, hydrolyzes ADP-ribose 1'"', 2'"'-cyclic phosphate to ADP-ribose 1'"'-phosphate; no detectable phenotype is conferred by null mutation or by overexpression
YNL055C	POR1	0.5065	43	NA	0.749	Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability
YBR285W	YBR285W	0.5065	NA	NA	0.982	Putative protein of unknown function; YBR285W is not an essential gene and deletion of YBR285W leads to poor growth on glucose-minimal medium at 15C
YNL015W	PBI2	0.5064	4	NA	0.943	Cytosolic inhibitor of vacuolar proteinase B, required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion
YOR069W	VPS5	0.5063	7	9	0.962	Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p
YGL057C	YGL057C	0.5061	1	NA	1.079	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant exhibits a growth defect on a non-fermentable (respiratory) carbon source
YMR226C	TMA29	0.5058	10	NA	1.039	NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments
YLR443W	ECM7	0.5057	NA	1	0.89	Non-essential protein of unknown function
YLR179C	YLR179C	0.5056	5	NA	1.038	Protein of unknown function, transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus; YLR179C is not essential
YFR054C	YFR054C	0.5055	NA	NA	0.99	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR147W	HMS2	0.5054	NA	NA	1.059	Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YKL066W	YKL066W	0.5054	NA	NA	1.044	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene YNK1
YNR012W	URK1	0.5054	NA	NA	1.063	Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP
YPR028W	YOP1	0.5053	NA	NA	0.977	Membrane protein that interacts with Yip1p to mediate membrane traffic; overexpression results in cell death and accumulation of internal cell membranes; regulates vesicular traffic in stressed cells
YJL170C	ASG7	0.5051	NA	1	1.015	Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor
YOL163W	YOL163W	0.5051	NA	NA	1.026	Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
YKL056C	TMA19	0.505	11	1	0.934	Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress
YGL101W	YGL101W	0.5046	NA	NA	1.054	Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p
YPL201C	YIG1	0.5046	5	1	0.996	Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
YBR273C	UBX7	0.5045	1	1	1.001	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
YPR015C	YPR015C	0.5043	6	1	0.97	Putative protein of unknown function
YLR327C	TMA10	0.5042	NA	NA	1.036	Protein of unknown function that associates with ribosomes
YCL046W	YCL046W	0.5041	NA	NA	0.994	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C
YNL279W	PRM1	0.5039	NA	NA	1.071	Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p
YLR199C	YLR199C	0.5038	12	NA	0.938	Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
YHR066W	SSF1	0.5036	50	1	0.931	Constituent of 66S pre-ribosomal particles, required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family
YBR050C	REG2	0.5032	NA	NA	0.933	Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YHR096C	HXT5	0.5032	1	NA	1.019	Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YPR012W	YPR012W	0.5031	NA	NA	1.024	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene
YIL076W	SEC28	0.5031	20	6	0.733	Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth
YHR159W	YHR159W	0.5028	NA	NA	0.926	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate
YJL142C	YJL142C	0.5028	NA	NA	1	Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci
YLR236C	YLR236C	0.5027	NA	NA	1.004	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAL008W	FUN14	0.5025	1	NA	0.974	Mitochondrial protein of unknown function
YJL043W	YJL043W	0.5025	NA	NA	0.975	Putative protein of unknown function; YJL043W is a non-essential gene
YGL261C	PAU11	0.5024	NA	NA	1	Putative protein of unknown function; mRNA expression appears to be regulated by SUT1 and UPC2
YFL041W	FET5	0.5021	2	NA	0.957	Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
YPL099C	FMP14	0.5021	1	NA	1.025	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL117W	PHO86	0.502	4	2	0.818	Endoplasmic reticulum (ER) resident protein required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles
YDR242W	AMD2	0.5018	NA	NA	1.05	Putative amidase
YKL162C	YKL162C	0.5016	NA	1	1.112	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
YDR199W	YDR199W	0.5016	NA	NA	1.017	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
YMR232W	FUS2	0.5016	NA	NA	1.027	Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating
YOL049W	GSH2	0.5015	NA	NA	0.311	Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
YKR049C	FMP46	0.5015	1	NA	1.027	Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL139C	UME1	0.5015	18	NA	1.003	Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p
YBR083W	TEC1	0.5014	5	NA	1.073	Transcription factor required for full Ty1 epxression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth; TEA/ATTS DNA-binding domain family member
YER129W	SAK1	0.5013	5	2	1.016	Upstream kinase for the SNF1 complex; partially redundant function with Elm1p and Tos3p; members of this family of kinases have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YLR361C	DCR2	0.5012	NA	11	1.018	Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START
YNL333W	SNZ2	0.5011	NA	NA	1.096	Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p
YIL042C	PKP1	0.501	NA	NA	0.968	Mitochondrial kinase, phosphorylates pyruvate dehydrogenase alpha subunit Pda1p
YOR033C	EXO1	0.5009	1	4	0.62	5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains
YBR054W	YRO2	0.5009	4	NA	0.995	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p
YJL052W	TDH1	0.5008	19	NA	0.906	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YDR152W	GIR2	0.5007	4	NA	0.942	Highly-acidic cytoplasmic RWD domain-containing protein of unknown function, sensitive to proteolysis, N-terminal region has high content of acidic amino acid residues, putative IUP (intrinsically unstructured protein)
YAL043C-A	YAL043C-A	NA	NA	NA	NA	NA
YML051W	GAL80	0.5005	1	NA	1.053	Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding
YBR158W	AMN1	0.5004	4	1	0.983	Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YDR517W	GRH1	0.5003	7	NA	0.991	Protein involved in the spindle assembly checkpoint; homolog of human GRASP65, which is a Golgi localized protein that functions in postmitotic reassembly of Golgi stacks
YGL229C	SAP4	0.5002	1	NA	1.014	Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p
YDR470C	UGO1	0.5001	1	NA	0.521	Protein of unknown function; outer membrane component of the mitochondrial fusion machinery; Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases during mitochondrial fusion
YJL213W	YJL213W	0.4996	NA	NA	0.992	Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
YPR066W	UBA3	0.4996	1	NA	1.005	Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
YER075C	PTP3	0.4995	3	2	1.039	Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm
YBR063C	YBR063C	0.4995	1	NA	0.73	Putative protein of unknown function; YBR063C is not an essential gene
YGR187C	HGH1	0.4994	6	NA	1	Protein of unknown function with similarity to human HMG1 and HMG2; localizes to the cytoplasm
YIL010W	DOT5	0.4994	NA	NA	0.901	Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
YOR040W	GLO4	0.4992	1	NA	1.008	Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate
YOL106W	YOL106W	0.4991	NA	NA	1.016	Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YJL070C	YJL070C	0.499	3	NA	1.054	Putative protein of unknown function with similarity to AMP deaminases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YJL070C is a non-essential gene
YGL159W	YGL159W	0.4989	NA	NA	1.033	Putative protein of unknown function; deletion mutant has no detectable phenotype
YLR095C	IOC2	0.4988	2	1	1.011	Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif
YBR043C	QDR3	0.4987	NA	NA	1.026	Multidrug transporter required for resistance to quinidine, barban, cisplatin, and bleomycin; member of the major facilitator superfamily of transporters conferring multiple drug resistance (MFS-MDR)
YMR086W	YMR086W	0.4987	6	NA	0.997	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; cAMP represses YMR086W expression
YGR068C	YGR068C	0.4987	2	NA	1	Putative protein of unknown function; YGR068C is not an essential gene.
YLR001C	YLR001C	0.4984	NA	NA	1.024	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR001C is not an essential gene
YOR008C-A	YOR008C-A	0.4984	NA	1	0.897	diepoxybutane and mitomycin C resistance
YNL014W	HEF3	0.4984	14	NA	1.129	Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YOR032C	HMS1	0.4982	1	1	1.025	Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YHR109W	CTM1	0.498	NA	NA	1.018	Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth
YKR033C	YKR033C	0.4979	NA	NA	1.057	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80
YDR010C	YDR010C	0.4978	NA	NA	0.986	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNR025C	YNR025C	0.4978	NA	NA	1.009	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase
YML084W	YML084W	0.4978	NA	NA	0.989	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR519W	FPR2	0.4974	3	1	1.026	Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking
YLR351C	NIT3	0.4974	NA	NA	1.018	Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
YNL025C	SSN8	0.4973	7	3	0.936	Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance
YEL006W	YEA6	0.4973	NA	NA	1.02	Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog
YKL149C	DBR1	0.4972	NA	NA	1.005	RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition
YDR078C	SHU2	0.4969	NA	NA	0.89	Protein of unassigned function involved in mutation suppression, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu1p, Psy3p, and Csm2p
YDL088C	ASM4	0.4969	NA	2	0.981	Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p
YKR032W	YKR032W	0.4968	NA	NA	1.031	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR099C	ICT1	0.4967	NA	2	1.022	Protein of unknown function, null mutation leads to an increase in sensitivity to Calcofluor white; expression of the gene is induced in the presence of isooctane
YCR091W	KIN82	0.4966	1	NA	1.018	Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
YGL235W	YGL235W	0.4962	NA	NA	1.04	Putative protein of unknown function; potential Cdc28p substrate
YIL056W	VHR1	0.4962	2	NA	0.992	Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YBL043W	ECM13	0.4961	NA	NA	0.994	Non-essential protein of unknown function
YDR109C	YDR109C	0.4961	NA	NA	1.061	Putative kinase
YDR425W	SNX41	0.4961	2	NA	0.965	Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; forms a complex with Snx4p and Atg20p
YCR075C	ERS1	0.496	NA	NA	1.048	Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains
YER103W	SSA4	0.496	10	3	0.757	Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YER117W	RPL23B	0.496	9	NA	0.956	Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins
YIL069C	RPS24B	0.496	84	NA	1.023	Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein
YDL036C	PUS9	0.4958	2	NA	0.982	Mitochondrial tRNA pseudouridine synthase involved in pseudouridylation of mitochondrial tRNAs at position 32
YIR038C	GTT1	0.4957	NA	NA	0.967	ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p
YGR001C	YGR001C	0.4955	NA	NA	0.984	Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae
YMR316W	DIA1	0.4954	NA	NA	0.964	Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YOR106W	VAM3	0.4954	NA	7	0.935	Syntaxin-related protein required for vacuolar assembly; functions with Vam7p in vacuolar protein trafficking; member of the syntaxin family of proteins
YLR134W	PDC5	0.4953	7	NA	1.009	Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism
YOR351C	MEK1	0.4953	3	NA	1.065	Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, phosphorylates Red1p, interacts with Hop1p; required for meiotic recombination and normal spore viability
YOR094W	ARF3	0.4953	NA	NA	1.038	Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity
YMR160W	YMR160W	0.4951	NA	NA	0.992	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene
YNL326C	PFA3	0.4951	NA	NA	1.059	Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions
YLR364W	YLR364W	0.4951	NA	NA	1.03	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR364W is not an essential gene
YHR075C	PPE1	0.495	2	NA	0.983	Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein
YOR265W	RBL2	0.4949	1	16	1.057	Protein involved in microtubule morphogenesis, required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin
YEL053C	MAK10	0.4948	2	6	0.973	Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible
YOR007C	SGT2	0.4946	3	NA	1.049	Glutamine-rich cytoplasmic protein of unknown function; contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions; has similarity to human SGT, which is a cochaperone that negatively regulates Hsp70
YKL131W	YKL131W	0.494	NA	NA	1.068	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL087W	TCB2	0.4939	1	2	1.032	Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud via the mRNA transport system involving She2p
YEL013W	VAC8	0.4939	4	1	0.77	Phosphorylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions
YMR319C	FET4	0.4936	16	NA	1.037	Low-affinity Fe(II) transporter of the plasma membrane
YOR139C	YOR139C	0.4935	NA	NA	1.017	Hypothetical protein
YIL099W	SGA1	0.4935	1	NA	0.991	Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YJR005W	APL1	0.4934	4	1	1.036	Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex
YLR265C	NEJ1	0.4934	1	NA	1.002	Protein involved in regulation of nonhomologous end joining; repressed by MAT heterozygosity; associates with Lif1p and regulates its cellular distribution
YMR322C	SNO4	0.4933	1	NA	1.014	Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Hsp33p; member of the DJ-1/ThiJ/PfpI superfamily; may have a role in pyridoxine metabolism
YDR165W	TRM82	0.4931	2	NA	1.042	Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA
YDR370C	YDR370C	0.4927	NA	NA	1.061	Putative protein of unknown function
YDR418W	RPL12B	0.4927	56	NA	0.902	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YMR082C	YMR082C	0.4924	NA	NA	1.025	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL214W	YGL214W	0.4924	NA	NA	0.975	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion mutation phenotype is likely due to the overlapping verified ORF SKI8/YGL213C
YER048C	CAJ1	0.4922	1	NA	0.982	Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
YJR078W	BNA2	0.4922	NA	1	1.011	Tryptophan 2,3-dioxygenase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway
YJL105W	SET4	0.4922	1	NA	1.093	Protein of unknown function, contains a SET domain
YLR003C	YLR003C	0.492	3	NA	0.99	Putative protein of unknown function that may participate in DNA replication; green fluorescent protein (GFP)-fusion protein is localized to the nucleus; YLR003C is not an essential gene
YFL049W	SWP82	0.4919	9	NA	0.963	Member of the SWI/SNF chromatin remodeling complex in which it plays an as yet unidentified role; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p
YLL058W	YLL058W	0.4916	NA	NA	1.022	Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene
YOR082C	YOR082C	0.4916	NA	NA	0.988	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
YER045C	ACA1	0.4916	NA	NA	0.99	Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, may regulate transcription of genes involved in utilization of non-optimal carbon sources
YDL180W	YDL180W	0.4914	NA	NA	0.974	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YLR335W	NUP2	0.4913	21	11	1.019	Protein involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization
YOR041C	YOR041C	0.4913	NA	NA	1.014	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance
YAL049C	YAL049C	0.4911	1	NA	0.992	Cytoplasmic protein of unknown function, potential Hsp82p interactor
YPL029W	SUV3	0.491	2	NA	0.727	ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
YDR271C	YDR271C	0.491	NA	NA	NA	Hypothetical protein
YDR130C	FIN1	0.491	1	1	1.019	Spindle pole body-related intermediate filament protein, forms cell cycle-specific filaments between spindle pole bodies in mother and daughter cells, able to self-assemble, expression induced during S/G2, localization cell-cycle dependent
YPR130C	YPR130C	0.491	NA	NA	0.955	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER052C	HOM3	0.4909	5	NA	0.719	Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
YOR066W	YOR066W	0.4908	NA	1	1.056	Protein of unknown function; potential Cdc28p substrate
YOL136C	PFK27	0.4907	1	NA	0.995	6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
YFL014W	HSP12	0.4906	6	NA	0.963	Plasma membrane localized protein that protects membranes from desiccation; induced by heat shock, oxidative stress, osmostress, stationary phase entry, glucose depletion, oleate and alcohol; regulated by the HOG and Ras-Pka pathways
YOR015W	YOR015W	0.4903	NA	NA	1.042	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER091C	MET6	0.4902	10	NA	0.991	Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
YDL044C	MTF2	0.4902	5	NA	0.845	Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription
YPL187W	MF(ALPHA)1	0.4899	NA	NA	1.029	Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor
YKL094W	YJU3	0.4899	NA	NA	1.034	Serine hydrolase with sequence similarity to monoglyceride lipase (MGL), localizes to lipid particles
YDR482C	CWC21	0.4898	9	NA	0.993	Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; may bind RNA; has similarity to S. pombe Cwf21p
YMR320W	YMR320W	0.4897	NA	NA	1.052	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL089C	MF(ALPHA)2	0.4896	NA	NA	1.068	Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
YBR280C	SAF1	0.4895	6	1	1.074	F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1
YPL162C	YPL162C	0.4894	NA	NA	1.035	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology
YER066C-A	YER066C-A	0.4893	NA	NA	0.991	Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W
YDR326C	YSP2	0.4893	3	NA	1.051	Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification
YBR138C	YBR138C	0.4893	NA	1	0.977	Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene
YPL236C	YPL236C	0.4888	1	NA	1.061	Putative protein kinase that exhibits Akr1p-dependent palmitoylation
YHR135C	YCK1	0.4887	43	4	1.031	Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p
YBL005W	PDR3	0.4886	1	NA	0.981	Transcriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements)
YHR180W	YHR180W	0.4886	NA	NA	1.025	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCR043C	YCR043C	0.4886	13	NA	1.034	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene
YDL200C	MGT1	0.4884	18	NA	1.008	DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage
YDR419W	RAD30	0.4883	6	NA	1.008	DNA polymerase eta, involved in the predominantly error-free bypass replication of DNA lesions, catalyzes the efficient and accurate synthesis of DNA opposite cyclobutane pyrimidine dimers; homolog of human POLH and bacterial DinB proteins
YDR153C	ENT5	0.4882	5	3	1.039	Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin
YDR423C	CAD1	0.4881	NA	NA	1.033	AP-1-like bZIP transcriptional activator involved in multiple stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins, binds consensus sequence TTACTAA; 5' UTR contains uORFs
YBR212W	NGR1	0.4881	6	NA	0.926	RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; expressed in stationary phase
YBL013W	FMT1	0.4881	NA	NA	0.954	Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate
YJL121C	RPE1	0.4881	NA	1	0.957	D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress
YMR182C	RGM1	0.488	NA	NA	0.985	Putative transcriptional repressor with proline-rich zinc fingers; overproduction impairs cell growth
YKR030W	GMH1	0.488	NA	3	1.055	Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
YOR191W	RIS1	0.488	7	1	0.947	Member of the SWI/SNF family of DNA-dependent ATPases, plays a role in antagonizing silencing during mating-type switching, contains an N-terminal domain that interacts with Sir4p and a C-terminal SNF2 domain
YHR028C	DAP2	0.488	NA	NA	0.962	Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p
YOR311C	HSD1	0.4879	NA	1	1.01	Endoplasmic reticulum (ER)-resident membrane protein, overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation
YNL009W	IDP3	0.4879	4	NA	0.99	Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids
YNR063W	YNR063W	0.4878	NA	NA	0.955	Putative zinc-cluster protein of unknown function
YDL237W	YDL237W	0.4876	NA	NA	0.999	Putative protein of unknown function; YDL237W is not an essential gene
YMR191W	SPG5	0.4875	19	NA	1.027	Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YBR129C	OPY1	0.4873	1	NA	1.006	Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL177C	CUP9	0.4871	1	NA	1.034	Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YNL309W	STB1	0.4871	NA	2	1.093	Protein with a role in regulation of MBF-specific transcription at Start, phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p and binding is required for Stb1p function; expression is cell-cycle regulated
YGL036W	YGL036W	0.4869	3	NA	1.051	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YGL036W is not an essential gene
YDL085W	NDE2	0.4868	4	NA	0.991	Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YDR511W	ACN9	0.4868	NA	NA	0.975	Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes
YDR457W	TOM1	0.4865	15	1	0.931	E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators
YDR440W	DOT1	0.4862	6	8	0.994	Nucleosomal histone H3-Lys79 methylase, associates with transcriptionally active genes, functions in gene silencing at telomeres, most likely by directly modulating chromatin structure and Sir protein localization
YBR150C	TBS1	0.4861	2	NA	1.047	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL305C	YNL305C	0.4858	NA	NA	1.093	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YPR188C	MLC2	0.4853	4	NA	1.013	Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring
YOR252W	TMA16	0.4853	4	NA	1.014	Protein of unknown function that associates with ribosomes
YER077C	YER077C	0.485	3	NA	0.989	Hypothetical protein
YHR171W	ATG7	0.485	1	NA	1.045	Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation
YOR012W	YOR012W	0.4849	NA	NA	1.029	Putative protein of unknown function
YBR270C	BIT2	0.4848	NA	NA	1.07	Hypothetical protein
YIL074C	SER33	0.4848	2	NA	0.99	3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p
YLR189C	ATG26	0.4846	2	NA	1.031	UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids, involved in autophagy
YDL065C	PEX19	0.4843	7	2	1.026	Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), binds PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane
YMR207C	HFA1	0.4842	1	NA	0.93	Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis
YDR063W	YDR063W	0.484	NA	NA	1.076	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDR063W is not an essential gene
YMR075W	RCO1	0.484	18	NA	0.933	Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p
YDR046C	BAP3	0.484	NA	NA	1.069	Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine
YDL130W	RPP1B	0.484	3	NA	0.796	Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component
YGR034W	RPL26B	0.484	70	NA	0.921	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YLR407W	YLR407W	0.4836	3	NA	0.988	Putative protein of unknown function; YLR407W is not an essential gene
YJR098C	YJR098C	0.4836	2	NA	1.058	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YEL065W	SIT1	0.4835	NA	2	1.005	Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
YLR333C	RPS25B	0.4833	8	NA	0.956	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein
YPL178W	CBC2	0.4832	25	15	0.616	Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
YHR077C	NMD2	0.4832	7	2	0.996	Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance
YBR184W	YBR184W	0.4831	1	NA	1.067	Putative protein of unknown function; YBR184W is not an essential gene
YPL216W	YPL216W	0.4827	12	NA	1.056	Putative protein of unknown function; YPL216W is not an essential gene
YGL054C	ERV14	0.4826	NA	4	1.065	Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon
YDR099W	BMH2	0.4825	40	1	1.057	14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YFL004W	VTC2	0.4825	1	NA	1.025	Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in protein localization and non-autophagic vacuolar fusion
YLR211C	YLR211C	0.4825	1	NA	1.01	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron
YHR106W	TRR2	0.4824	1	NA	1.039	Mitochondrial thioredoxin reductase involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p, contains active-site motif (CAVC) present in prokaryotic thioredoxin reductases, binds NADPH and FAD
YEL009C	GCN4	0.4824	NA	NA	0.699	Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YDR533C	HSP31	0.4824	3	NA	1.01	Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp32p, Hsp33p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer
YDR139C	RUB1	0.4823	5	NA	0.93	Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)
YGL165C	YGL165C	0.4823	NA	NA	1.043	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
YIR017C	MET28	0.4822	NA	NA	0.99	Transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism
YER170W	ADK2	0.482	NA	NA	1.003	Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background
YOR304C-A	YOR304C-A	0.4819	2	NA	0.933	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck
YGL062W	PYC1	0.4818	7	NA	1.002	Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YOR183W	FYV12	0.4815	NA	NA	0.822	Protein of unknown function, required for survival upon exposure to K1 killer toxin
YHR076W	PTC7	0.4813	6	NA	0.997	Mitochondrially localized type 2C protein phosphatase; expression induced by growth on ethanol and by sustained osmotic stress; possible role in carbon source utilization in low oxygen environments
YHR093W	YHR093W	0.4811	NA	NA	1.016	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region
YCR073C	SSK22	0.4809	2	1	1.046	MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p
YMR183C	SSO2	0.4808	NA	NA	0.999	Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
YPL200W	CSM4	0.4807	NA	NA	1.03	Protein required for accurate chromosome segregation during meiosis
YDR213W	UPC2	0.4803	2	4	1.023	Sterol regulatory element binding protein, induces transcription of sterol transport and biosynthetic genes; involved in the anaerobic induction of DAN/TIR mannoproteins and seripauperins; binucleate zinc cluster protein; Ecm22p homolog
YGR230W	BNS1	0.4802	NA	NA	0.976	Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis
YMR286W	MRPL33	0.4802	NA	NA	0.641	Mitochondrial ribosomal protein of the large subunit
YKR078W	YKR078W	0.4801	3	NA	0.963	Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)
YKL100C	YKL100C	0.4799	2	NA	1.029	Putative protein of unknown function with similarity to a human minor histocompatibility antigen; YKL100C is not an essential gene
YKR093W	PTR2	0.4799	NA	NA	0.989	Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YAR018C	KIN3	0.4797	3	NA	1.037	Nonessential protein kinase with unknown cellular role
YGR261C	APL6	0.4796	5	2	0.973	Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
YJR094W-A	RPL43B	0.4795	7	NA	0.955	Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YOL117W	RRI2	0.4792	8	NA	0.98	Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response
YDR406W	PDR15	0.4792	1	NA	1.045	ATP binding cassette (ABC) transporter of the plasma membrane; general stress response factor implicated in cellular detoxification; target of Pdr1p, Pdr3p and Pdr8p transcription regulators; promoter contains a PDR responsive element
YDR011W	SNQ2	0.4791	1	NA	0.98	ABC transporter protein involved in multidrug resistance and resistance to singlet oxygen species
YLR014C	PPR1	0.4791	3	NA	0.935	Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of genes involved in uracil biosynthesis; activity may be modulated by interaction with Tup1p
YPL188W	POS5	0.4789	NA	2	1.033	Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress
YPL167C	REV3	0.4789	1	2	1.025	Catalytic subunit of DNA polymerase zeta, which is involved in DNA repair and translesion synthesis; required for mutagenesis induced by DNA damage
YNL311C	SKP2	0.4786	9	NA	1.079	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; putative F-box protein; analysis of integrated high-throughput datasets predicts involvement in ubiquitin-dependent protein catabolism
YPL147W	PXA1	0.4785	1	NA	1.041	Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
YBR204C	YBR204C	0.4785	NA	NA	1.111	Serine hydrolase; YBR204C is not an essential gene
YGL026C	TRP5	0.4783	6	NA	1.039	Tryptophan synthase involved in tryptophan biosynthesis, regulated by the general control system of amino acid biosynthesis
YLR152C	YLR152C	0.4782	1	NA	0.987	Putative protein of unknown function; YLR152C is not an essential gene
YLR154C	RNH203	0.4782	4	2	0.992	Ribonuclease H2 subunit, required for RNase H2 activity
YNL135C	FPR1	0.4781	26	4	0.924	Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function
YFR040W	SAP155	0.4778	12	3	1.014	Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p
YLL051C	FRE6	0.4774	NA	NA	0.888	Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels
YMR081C	ISF1	0.4774	NA	NA	0.994	Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YDR281C	PHM6	0.4773	NA	NA	1.023	Protein of unknown function, expression is regulated by phosphate levels
YDR278C	YDR278C	0.4772	NA	NA	1.007	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR453C	TSA2	0.4771	8	1	1.031	Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants
YOR008C	SLG1	0.4771	NA	9	0.956	Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway involved in maintenance of cell wall integrity; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response
YPR021C	AGC1	0.477	NA	NA	1.057	Mitochondrial transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism, ornithine synthesis, and the malate-aspartate NADH shuttle
YPR064W	YPR064W	0.4769	NA	NA	1.06	Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YHL032C	GUT1	0.4769	5	NA	0.991	Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
YJR125C	ENT3	0.4768	1	1	1.047	Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p
YGR146C	YGR146C	0.4768	NA	NA	1.034	Putative protein of unknown function; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of a temperature sensitive <i>hsf1</i> mutant
YPL109C	YPL109C	0.4767	NA	NA	1.025	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR344W	RPL26A	0.4767	11	NA	0.976	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YGL224C	SDT1	0.4764	NA	NA	1.033	Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives
YMR145C	NDE1	0.4764	3	NA	0.943	Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YNL032W	SIW14	0.4763	6	2	1.043	Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm
YAL028W	FRT2	0.4762	1	NA	0.981	Tail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate
YNL030W	HHF2	0.4761	35	2	1.065	One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YMR254C	YMR254C	0.476	NA	NA	1.025	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER173W	RAD24	0.4758	10	18	0.987	Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein
YGL029W	CGR1	0.4757	NA	NA	1.004	Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress
YJL133W	MRS3	0.4757	NA	1	1	Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs4p; functions under low-iron conditions; may transport other cations in addition to iron
YNL269W	BSC4	0.4756	NA	2	1.084	Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p
YJL049W	YJL049W	0.4751	NA	NA	0.975	Putative protein of unknown function; YJL049W is a non-essential gene
YAL053W	FLC2	0.4751	5	3	0.97	Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
YIL133C	RPL16A	0.4747	96	2	0.909	N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YOL107W	YOL107W	0.4747	NA	NA	0.959	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein
YML061C	PIF1	0.4747	NA	1	0.658	DNA helicase involved in telomere formation and elongation; acts as a catalytic inhibitor of telomerase; also plays a role in repair and recombination of mitochondrial DNA
YJL185C	YJL185C	0.4745	NA	NA	0.993	Putative protein of unknown function; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene
YLR043C	TRX1	0.4745	10	4	0.997	Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against both oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance
YPR075C	OPY2	0.4744	NA	NA	1.011	Integral membrane protein that functions in the signaling branch of the high-osmolarity glycerol (HOG) pathway; interacts with Ste50p; overproduction blocks cell cycle arrest in the presence of mating pheromone
YLR426W	YLR426W	0.4744	1	NA	0.944	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin
YFL021W	GAT1	0.4743	2	NA	0.996	Transcriptional activator of genes involved in nitrogen catabolite repression, member of the GATA family of DNA binding proteins; activity and localization regulated by nitrogen limitation and Ure2p
YHR182W	YHR182W	0.4741	1	1	0.968	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm
YHR155W	YSP1	0.474	2	NA	1.006	Mitochondrial protein with a potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone
YHR168W	MTG2	0.474	NA	1	NA	Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
YDL233W	YDL233W	0.4738	NA	NA	1.017	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL233W is not an essential gene
YMR068W	AVO2	0.4734	3	1	1.001	Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
YKL183W	LOT5	0.4734	NA	NA	1.092	Protein of unknown function; gene expression increases in cultures shifted to a lower temperature
YMR119W-A	YMR119W-A	0.4733	NA	NA	1.05	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR040C	YLR040C	0.4733	NA	NA	0.99	Putative protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; YLR040C is not essential
YDR216W	ADR1	0.4733	7	NA	1.013	Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YOR354C	MSC6	0.4728	NA	NA	1.063	Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR024W	YOR024W	0.4724	NA	NA	1.042	Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci
YCL009C	ILV6	0.4723	7	1	1.007	Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria
YDR101C	ARX1	0.4722	55	NA	0.958	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
YHR046C	INM1	0.4721	2	1	0.982	Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
YGR154C	GTO1	0.472	1	NA	1.028	Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization
YDR513W	GRX2	0.472	NA	3	1.024	Cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress
YER088C	DOT6	0.4718	4	NA	0.999	Protein of unknown function, involved in telomeric gene silencing and filamentation
YER124C	DSE1	0.4718	NA	NA	1.021	Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
YGR102C	YGR102C	0.4717	1	1	0.73	Putative protein of unknown function; transposon insertion mutant is salt sensitive and deletion mutant has growth defects; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR177W	MMT1	0.4717	1	NA	1.006	Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p
YDR162C	NBP2	0.4709	1	36	0.629	Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p
YHL043W	ECM34	0.4706	NA	NA	1.001	Putative protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YNL170W	YNL170W	0.4705	NA	NA	0.7	Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YEL005C	VAB2	0.4704	4	NA	1.015	Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YOR003W	YSP3	0.4704	NA	NA	1.084	Putative precursor to the subtilisin-like protease III
YGR279C	SCW4	0.4703	2	NA	0.953	Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
YLR328W	NMA1	0.4702	4	NA	1.025	Nicotinic acid mononucleotide adenylyltransferase, involved in NAD(+) salvage pathway
YBR047W	FMP23	0.47	1	1	0.978	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR295C	COS6	0.4699	NA	NA	1.034	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YDL224C	WHI4	0.4699	NA	NA	0.967	Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division
YPR023C	EAF3	0.4697	20	15	1.052	Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3
YBR064W	YBR064W	0.4697	NA	NA	0.983	Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C
YDR104C	SPO71	0.4697	NA	NA	0.999	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
YBR146W	MRPS9	0.4695	31	NA	0.95	Mitochondrial ribosomal protein of the small subunit
YBR122C	MRPL36	0.4694	26	2	0.522	Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region
YDR530C	APA2	0.469	NA	NA	0.984	Diadenosine 5',5'"'-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p
YML030W	YML030W	0.4687	1	1	1.027	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YML030W is not an essential gene
YPR058W	YMC1	0.4687	NA	NA	0.94	Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc2p
YBR045C	GIP1	0.4687	1	NA	0.995	Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p
YMR139W	RIM11	0.4686	21	NA	0.971	Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta
YGR089W	NNF2	0.4685	NA	NA	0.954	Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation
YFR036W	CDC26	0.4684	8	15	0.915	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YCR023C	YCR023C	0.4681	NA	NA	0.976	Putative protein of unknown function; YCR023C is not an essential gene
YBL072C	RPS8A	0.4681	112	3	0.677	Protein component of the small (40S) ribosomal subunit; identical to Rps8Bp and has similarity to rat S8 ribosomal protein
YKR085C	MRPL20	0.468	24	NA	0.948	Mitochondrial ribosomal protein of the large subunit
YGR108W	CLB1	0.468	2	4	1.007	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YNL270C	ALP1	0.4678	NA	NA	1.081	Basic amino acid transporter, involved in uptake of cationic amino acids
YJR087W	YJR087W	0.4677	NA	NA	1.039	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene STE18 and uncharacterized ORF YJR088C
YDR273W	DON1	0.4677	NA	NA	1.004	Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II
YGL196W	YGL196W	0.4675	NA	2	0.993	Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype
YDL024C	DIA3	0.4675	NA	NA	1.01	Protein of unknown function, involved in invasive and pseudohyphal growth
YPR109W	YPR109W	0.4674	NA	NA	1.026	Predicted membrane protein; dipoid deletion strain has high budding index
YLR210W	CLB4	0.4672	2	12	1.008	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
YGL148W	ARO2	0.4669	3	1	0.989	Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids
YBL044W	YBL044W	0.4666	3	NA	0.672	Putative protein of unknown function; YBL044W is not an essential protein
YOL112W	MSB4	0.4665	NA	4	0.977	GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization
YIL020C	HIS6	0.4663	2	NA	0.974	Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
YPL112C	PEX25	0.4663	NA	2	1.049	Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
YOL036W	YOL036W	0.4663	NA	NA	1.009	Protein of unknown function; potential Cdc28p substrate
YNL159C	ASI2	0.4663	NA	NA	0.996	Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
YDR466W	PKH3	0.4663	1	NA	1.046	Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
YDR329C	PEX3	0.466	NA	2	1.043	Peroxisomal membrane protein (PMP) required to recruit Pex19p chaperone to peroxisomes; plays selective, essential, direct role in PMP import as a docking factor for Pex19p
YPR061C	JID1	0.4657	1	NA	1.024	Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
YPR167C	MET16	0.465	3	NA	0.996	3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism
YJL144W	YJL144W	0.4648	1	NA	1.008	Cytoplasmic hydrophilin of unknown function, possibly involved in the dessication response; expression induced by osmotic stress, starvation and during stationary phase; GFP-fusion protein is induced by the DNA-damaging agent MMS
YLR121C	YPS3	0.4648	NA	NA	1.003	Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YIL064W	YIL064W	0.4645	NA	NA	0.935	Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family
YOR059C	YOR059C	0.4643	1	NA	1.018	Hypothetical protein
YMR054W	STV1	0.4643	NA	3	1.016	Subunit of vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole
YHR142W	CHS7	0.4642	NA	31	1.025	Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER
YLR139C	SLS1	0.464	1	1	0.807	Mitochondrial membrane protein required for assembly of respiratory-chain enzyme complexes III and IV; coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery
YCR007C	YCR007C	0.4639	NA	NA	0.993	Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YIL044C	AGE2	0.4639	NA	1	1.003	ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif
YGL179C	TOS3	0.4638	3	1	1.026	Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YGL095C	VPS45	0.4638	8	2	1.034	Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment
YJR106W	ECM27	0.4637	1	NA	1.055	Non-essential protein of unknown function
YDL199C	YDL199C	0.4636	4	NA	1.003	Putative protein of unknown function with sequence similarity to members of the sugar permease family
YIL097W	FYV10	0.4635	8	NA	0.983	Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains CTLH domain
YDR521W	YDR521W	0.4634	NA	NA	NA	Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
YGR085C	RPL11B	0.4631	95	NA	0.889	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11
YOL024W	YOL024W	0.463	NA	NA	1.026	Putative protein of unknown function, predicted to have thiol-disulfide oxidoreductase active site
YDR095C	YDR095C	0.4629	NA	NA	0.988	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL141W	PPM2	0.4629	NA	NA	1.039	Putative carboxymethyltransferase, similar to Ppm1p but biochemical activity not yet demonstrated; required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA
YGL042C	YGL042C	0.4629	NA	NA	0.949	Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
YIL049W	DFG10	0.4628	NA	NA	1.063	Protein of unknown function, involved in filamentous growth
YMR084W	YMR084W	0.4626	NA	NA	0.923	Putative protein of unknown function
YOR344C	TYE7	0.4623	1	NA	1.023	Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression
YGR039W	YGR039W	0.4622	NA	NA	1.002	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
YBR139W	YBR139W	0.4622	6	NA	NA	Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
YOL104C	NDJ1	0.462	NA	NA	1.001	Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution (interference), sister chromatid cohesion at meiotic telomeres, and segregation of small chromosomes
YDR205W	MSC2	0.462	NA	2	1.036	Member of the cation diffusion facilitator family, localizes to the endoplasmic reticulum and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
YER184C	YER184C	0.4619	1	NA	1.002	Hypothetical protein
YDR438W	THI74	0.4618	NA	1	1.035	Mitochondrial transporter repressible by thiamine
YBR053C	YBR053C	0.4616	NA	NA	0.991	Putative protein of unknown function; induced by cell wall perturbation
YNL093W	YPT53	0.4611	10	NA	1.037	GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis
YKL068W	NUP100	0.4608	27	5	1.055	Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup116p
YLL052C	AQY2	0.4608	NA	NA	0.951	Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YDR157W	YDR157W	0.4603	NA	NA	0.187	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLL016W	SDC25	NA	NA	NA	NA	NA
YHR097C	YHR097C	0.46	3	NA	0.991	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YBR262C	FMP51	0.46	NA	NA	1.024	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR141W	VPS62	0.4598	NA	NA	0.984	Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins
YMR170C	ALD2	0.4595	3	NA	1.009	Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
YGL004C	RPN14	0.4594	19	NA	1.07	Putative non-ATPase subunit of the 19S regulatory particle of the 26S proteasome; localized to the cytoplasm
YOR314W	YOR314W	0.4594	NA	NA	1.066	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKR045C	YKR045C	0.4593	NA	NA	1.033	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YDR441C	APT2	0.4593	NA	NA	0.986	Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
YGR111W	YGR111W	0.4592	1	NA	0.925	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YLR019W	PSR2	0.4591	4	NA	0.988	Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
YPR179C	HDA3	0.4588	4	NA	0.949	Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p
YNL130C	CPT1	0.4586	NA	NA	1.013	Cholinephosphotransferase, required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription
YJL094C	KHA1	0.4584	NA	NA	1.036	Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
YLL014W	YLL014W	0.4582	NA	NA	1	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLL014W is not an essential gene
YIL135C	VHS2	0.4582	1	NA	0.977	Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
YBR249C	ARO4	0.4579	7	NA	1.027	3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
YNL220W	ADE12	0.4576	3	NA	1.233	Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
YGL152C	YGL152C	0.4574	NA	NA	1.054	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
YNL276C	YNL276C	0.4573	NA	NA	1.091	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W
YLL005C	SPO75	0.4571	4	NA	0.969	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
YML026C	RPS18B	0.4569	5	1	0.875	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins
YPL104W	MSD1	0.4569	1	1	0.819	Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene
YDL242W	YDL242W	0.4568	NA	NA	0.985	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL107C	YJL107C	0.4568	4	NA	0.984	Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
YDR524C	AGE1	0.4568	NA	NA	0.972	ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif
YHR113W	YHR113W	0.4567	NA	NA	1.015	Cytoplasmic aspartyl aminopeptidase; cleaves unblocked N-terminal acidic amino acid residues from peptide substrates; forms a 12 subunit homo-oligomeric complex; M18 metalloprotease family member; may interact with ribosomes
YGL195W	GCN1	0.4566	48	NA	0.659	Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA
YGL216W	KIP3	0.4565	2	22	1.012	Kinesin-related motor protein involved in mitotic spindle positioning
YML078W	CPR3	0.4564	2	NA	1.018	Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria
YDR451C	YHP1	0.4563	1	NA	1.016	One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval
YPL227C	ALG5	0.4562	2	7	1.054	UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum
YMR018W	YMR018W	0.456	NA	NA	1.042	Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene
YKL150W	MCR1	0.4556	2	NA	1.061	Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis
YLL055W	YLL055W	0.4555	1	NA	0.999	High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YMR066W	SOV1	0.4552	NA	1	0.904	Mitochondrial protein of unknown function
YER010C	YER010C	0.4547	NA	NA	0.998	Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction
YER066W	YER066W	0.4546	NA	NA	1.012	Hypothetical protein
YNL100W	YNL100W	0.4544	NA	NA	1.012	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL100W is not an essential gene
YER134C	YER134C	0.4541	NA	NA	1.028	Putative protein of unknown function; non-essential gene
YDR222W	YDR222W	0.454	NA	NA	1.013	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YOR180C	DCI1	0.4539	NA	NA	0.948	Peroxisomal delta(3,5)-delta(2,4)-dienoyl-CoA isomerase, involved in fatty acid metabolism, contains peroxisome targeting signals at amino and carboxy termini
YDR317W	HIM1	0.4533	NA	NA	1.05	Protein of unknown function involved in DNA repair
YDL019C	OSH2	0.4533	9	1	0.957	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
YDR074W	TPS2	0.4532	5	1	0.873	Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway
YBL055C	YBL055C	0.4528	2	NA	0.968	3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases
YNL031C	HHT2	0.4528	31	5	1.054	One of two identical histone H3 proteins (see also HHT1); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YNL283C	WSC2	0.4526	NA	NA	1.069	Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response
YBR171W	SEC66	0.4525	4	14	0.905	Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YJL145W	SFH5	0.4525	NA	NA	0.994	Putative phosphatidylinositol transfer protein (PITP), exhibits phosphatidylinositol- but not phosphatidylcholine-transfer activity, mainly localized to cytosol and microsomes, similar to Sec14p; may be PITP regulator rather than actual PITP
YDR185C	YDR185C	0.4524	NA	NA	1.021	Mitochondrial protein of unknown function; has similarity to Ups1p, which is involved in regulation of alternative topogenesis of the dynamin-related GTPase Mgm1p
YGL210W	YPT32	0.4523	1	2	0.983	GTPase of the Ypt/Rab family, very similar to Ypt31p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi
YMR199W	CLN1	0.4519	3	11	1.005	G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YOR120W	GCY1	0.4515	1	NA	1.026	Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YGL009C	LEU1	0.4513	9	NA	1.051	Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
YEL057C	YEL057C	0.4511	1	NA	0.955	Protein of unknown function involved in telomere maintenance; target of UME6 regulation
YGR072W	UPF3	0.4511	2	4	0.977	Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
YOR195W	SLK19	0.4509	2	12	1.011	Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate
YGL139W	FLC3	0.4509	NA	NA	1.044	Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER
YIL152W	YIL152W	0.4508	3	NA	1.001	Putative protein of unknown function
YIL002C	INP51	0.4507	NA	3	0.983	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth
YJL108C	PRM10	0.4505	NA	NA	1	Pheromone-regulated protein, predicted to have 5 transmembrane segments
YNL314W	DAL82	0.4505	NA	NA	1.103	Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
YAR003W	SWD1	0.4504	12	28	0.925	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7
YGR178C	PBP1	0.4502	7	NA	1.022	Protein interacting with poly(A)-binding protein Pab1p; likely involved in controlling the extent of mRNA polyadenylation; forms a complex with Mkt1p that may regulate HO translation; interacts with Lsm12p in a copurification assay
YDL172C	YDL172C	0.4501	NA	NA	1.021	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
YCR059C	YIH1	0.4501	4	NA	1.013	Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT gene
YDL223C	HBT1	0.4501	NA	5	0.961	Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
YLR237W	THI7	0.45	NA	NA	0.951	Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
YJR110W	YMR1	0.4494	2	1	0.996	Phosphatidylinositol 3-phosphate [PI(3)P] phosphatase, regulates the localization and levels of PI(3)P; involved in cytoplasm to vacuole (CVT) transport; has similarity to the conserved myotubularin dual specificity phosphatase family
YDR102C	YDR102C	0.4492	NA	NA	0.992	Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index
YER060W	FCY21	0.4492	1	NA	0.995	Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
YMR193C-A	YMR193C-A	0.4492	NA	NA	0.915	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL212C	PUS1	0.4489	4	2	1.025	tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA
YCR060W	TAH1	0.4488	5	NA	1.047	HSP90 cofactor; interacts with Hsp82p, Pih1p, Rvb1 and Rvb2, contains a single TPR domain with at least two TPR motifs
YGL049C	TIF4632	0.4487	32	1	1.053	Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4631p
YMR313C	TGL3	0.4486	NA	1	1.045	Triacylglycerol lipase of the lipid particle, responsible for all the TAG lipase activity of the lipid particle; contains the consensus sequence motif GXSXG, which is found in lipolytic enzymes
YIL035C	CKA1	0.4485	104	2	0.968	Alpha catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases
YNL201C	PSY2	0.4484	17	2	1.035	Putative subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and the regulatory subunit Psy4p; required for cisplatin and oxaliplatin resistance; localizes to nucleus
YPL157W	TGS1	0.4483	NA	NA	0.849	Trimethyl guanosine synthase, conserved nucleolar methyl transferase responsible for conversion of the m(7)G cap structure of snRNAs and snoRNAs to m(2,2,7)G; also required for ribosome synthesis and nucleolar morphology
YJL116C	NCA3	0.4482	NA	NA	1.01	Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YOR381W	FRE3	0.4482	1	NA	1.027	Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YMR247C	RKR1	0.448	1	NA	1.001	Nuclear RING domain protein with functional connections to chromatin modification; may interact with ribosomes, based on co-purification experiments; YMR247C is not an essential gene
YJL179W	PFD1	0.4478	5	6	0.921	Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin
YJR117W	STE24	0.4477	NA	8	1.061	Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
YLR142W	PUT1	0.4476	NA	NA	1.006	Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YPL265W	DIP5	0.4475	1	NA	1.036	Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly
YDL168W	SFA1	0.4474	8	NA	0.689	Bifunctional enzyme containing both alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase activities, functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p
YCR019W	MAK32	0.4472	NA	NA	1.04	Protein necessary for structural stability of L-A double-stranded RNA-containing particles
YBR238C	YBR238C	0.4471	3	NA	0.981	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and mitochondrion; YBR238C is not an essential gene; transcriptionally up-regulated by TOR and deletion increases life span
YJL110C	GZF3	0.447	2	NA	0.996	GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p
YJR095W	SFC1	0.4468	NA	NA	1.035	Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YHR126C	YHR126C	0.4468	NA	NA	1.025	Putative protein of unknown function; transcription dependent upon Azf1p
YGR161C	RTS3	0.4464	8	1	1.048	Putative component of the protein phosphatase type 2A complex
YIL088C	AVT7	0.4463	NA	NA	0.991	Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YMR137C	PSO2	0.4462	3	NA	1.035	Required for a post-incision step in the repair of DNA single and double-strand breaks that result from interstrand crosslinks produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation
YKL072W	STB6	0.446	NA	NA	1.258	Protein that binds Sin3p in a two-hybrid assay
YDR256C	CTA1	0.4459	NA	NA	1.009	Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation
YGR045C	YGR045C	0.4456	NA	NA	0.993	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR090C	YBR090C	0.4456	NA	NA	1.087	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YBL011W	SCT1	0.4452	NA	NA	0.965	Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed
YLL017W	YLL017W	NA	NA	NA	NA	NA
YKL033W-A	YKL033W-A	0.445	NA	NA	NA	Putative protein of unknown function; similar to uncharacterized proteins from other fungi
YER121W	YER121W	0.4448	NA	NA	1.042	Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
YFL051C	YFL051C	0.4448	NA	NA	0.977	Putative protein of unknown function; YFL051C is not an essential gene
YDR492W	IZH1	0.4447	NA	NA	1.019	Membrane protein involved in zinc metabolism, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
YNL293W	MSB3	0.4447	6	4	1.069	GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its action on Sec4p, also required for proper actin organization; similar to Msb4p; both Msb3p and Msb4p localize to sites of polarized growth
YCR014C	POL4	0.4446	15	NA	0.996	DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta
YMR065W	KAR5	0.4443	NA	NA	1.032	Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone
YGR031W	YGR031W	0.4443	2	NA	1.023	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR357C	YDR357C	0.4441	2	NA	1.054	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YNL175C	NOP13	0.4438	56	1	1.019	Protein of unknown function, localizes to the nucleolus and nucleoplasm; contains an RNA recognition motif (RRM) and has similarity to Nop12p, which is required for processing of pre-18S rRNA
YLR269C	YLR269C	0.4437	NA	NA	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR040W	KSS1	0.4435	37	NA	0.982	Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response
YLR192C	HCR1	0.4433	13	3	0.704	Dual function protein involved in translation initiation as a substoichiometric component of eukaryotic translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA
YAR050W	FLO1	0.4431	NA	NA	1.026	Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YLR144C	ACF2	0.4431	9	NA	1.027	Intracellular beta-1,3-endoglucanase, expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly
YAL046C	YAL046C	0.4428	1	NA	0.988	Putative protein of unknown function; YAL046C is not an essential gene
YAR023C	YAR023C	0.4427	NA	NA	0.808	Putative integral membrane protein, member of DUP240 gene family
YDR249C	YDR249C	0.4425	NA	2	1.016	Putative protein of unknown function
YDR026C	YDR026C	0.4423	4	NA	1.011	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein that may bind to the Ter region of rDNA; interacts physically with Fob1p
YNL067W	RPL9B	0.4419	7	NA	0.939	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins
YPL060W	LPE10	0.4416	1	NA	0.959	Mitochondrial inner membrane magnesium transporter, involved in maintenance of magnesium concentrations inside mitochondria; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p
YNL193W	YNL193W	0.4413	NA	NA	1.026	Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis
YHR138C	YHR138C	0.4413	2	NA	0.991	Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles
YDR379W	RGA2	0.4409	5	NA	1.03	GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth
YDL086W	YDL086W	0.4409	1	NA	0.978	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
YDR312W	SSF2	0.4408	4	1	1.073	Protein required for ribosomal large subunit maturation, functionally redundant with Ssf1p; member of the Brix family
YER109C	FLO8	0.4408	1	NA	0.948	Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
YGR144W	THI4	0.4407	NA	NA	1.029	Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YIL117C	PRM5	0.4405	NA	NA	0.992	Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling
YGR192C	TDH3	0.4405	20	1	0.972	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YPL033C	YPL033C	0.4399	NA	NA	1.009	Putative protein of unknown function; may be involved in DNA metabolism; expression is induced by Kar4p
YJL216C	YJL216C	0.4396	NA	NA	1.029	Protein of unknown function, similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p, along with transporters and other genes involved in the pleiotropic drug resistance (PDR) phenomenon
YPL073C	YPL073C	0.4395	NA	NA	0.985	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with verified gene UBP16/YPL072W; may interact with ribosome based on co-purification experiments
YMR234W	RNH1	0.4394	3	NA	1.036	Ribonuclease H1, removes RNA primers during Okazaki fragment synthesis; degrades RNA attached to the 5'-end of a DNA strand
YNL127W	FAR11	0.4393	12	1	0.985	Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p
YBL028C	YBL028C	0.4391	NA	NA	0.996	Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
YDL010W	YDL010W	0.4391	NA	NA	0.927	Putative thiol-disulfide oxidoreductase; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YDL010W is not an essential gene
YLR257W	YLR257W	0.439	1	NA	1.007	Putative protein of unknown function
YLR098C	CHA4	0.4388	NA	1	1.037	DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain
YKL117W	SBA1	0.4386	12	2	0.949	Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity
YDL238C	GUD1	0.4382	1	NA	0.984	Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures
YPR030W	CSR2	0.438	3	2	1	Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YOR242C	SSP2	0.438	1	NA	0.976	Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis
YKL098W	YKL098W	0.4379	NA	1	1.036	Putative protein of unknown function
YER064C	YER064C	0.4378	7	NA	0.992	Non-essential nuclear protein; null mutation has global effects on transcription
YNL027W	CRZ1	0.4374	3	1	1.072	Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation
YPR173C	VPS4	0.4374	10	2	0.818	AAA-type ATPase required for efficient late endosome to vacuole transport; catalyzes the release of an endosomal membrane-associated class E VPS protein complex; regulates cellular sterol metabolism; cytoplasmic and endosomal localization
YGL255W	ZRT1	0.4373	NA	2	0.993	High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YKL091C	YKL091C	0.4372	1	NA	1.04	Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus
YGR026W	YGR026W	0.4371	NA	NA	1.003	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YGL146C	YGL146C	0.4371	2	NA	1.036	Putative protein of unknown function, contains two putative transmembrane spans, shows no significant homology to any other known protein sequence, YGL146C is not an essential gene
YMR151W	YMR151W	0.4369	NA	NA	0.971	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
YOL159C	YOL159C	0.4367	NA	NA	1.031	Hypothetical protein
YHR202W	YHR202W	0.4365	1	NA	0.995	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization
YFR057W	YFR057W	0.4364	NA	NA	0.991	Putative protein of unknown function
YFL047W	RGD2	0.4364	NA	1	0.973	GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p
YLR389C	STE23	0.4363	2	NA	1.014	Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; member of the insulin-degrading enzyme family
YML072C	TCB3	0.4362	13	NA	1.036	Lipid-binding protein, localized to the bud via specific mRNA transport; non-tagged protein localizes to mitochondria and GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact
YOR021C	YOR021C	0.4357	1	NA	0.998	Hypothetical protein
YJL138C	TIF2	0.4344	53	1	0.999	Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G
YDR227W	SIR4	0.4344	10	NA	1.056	Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan
YNL034W	YNL034W	0.4343	NA	NA	1.092	Putative protein of unknown function; YNL034W is not an essential gene
YKR015C	YKR015C	0.4342	1	NA	1.057	Putative protein of unknown function
YKL214C	YRA2	0.4342	7	1	1.062	Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus
YNL299W	TRF5	0.4341	7	5	1.025	Poly (A) polymerase involved in nuclear RNA quality control based on: homology with Trf4p, genetic interactions with TRF4 mutants, physical interaction with Mtr4p (TRAMP subunit), and by direct assay; disputed role as a sigma DNA polymerase
YLR084C	RAX2	0.4336	3	NA	1.025	N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p
YER158C	YER158C	0.4336	1	NA	1.01	Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YEL007W	YEL007W	0.4335	1	2	1.058	Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)
YKL077W	YKL077W	0.4334	NA	NA	1.025	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YER154W	OXA1	0.4333	NA	NA	0.939	Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals
YPL096W	PNG1	0.4331	1	NA	1.031	Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation, localizes to the cytoplasm and nucleus, interacts with the DNA repair protein Rad23p
YOR073W	SGO1	0.4331	5	6	0.849	Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
YGL248W	PDE1	0.4327	NA	NA	1.036	Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation
YOR266W	PNT1	0.4325	2	7	1.01	Mitochondrial inner membrane protein involved in export of proteins from the mitochondrial matrix; overexpression of PNT1 confers resistance to the anti-Pneumocystis carinii drug pentamidine, and deletion confers increased sensitivity
YDR295C	HDA2	0.4324	5	1	0.933	Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance
YGR126W	YGR126W	0.4322	6	1	0.986	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
YDR233C	RTN1	0.4322	4	1	0.979	ER membrane protein that interacts with exocyst subunit Sec6p and with Yip3p; null mutant has an altered (mostly cisternal) ER morphology; has similarity to mammalian reticulon proteins and member of the RTNLA (reticulon-like A) subfamily
YDL236W	PHO13	0.4321	1	NA	1.016	Alkaline phosphatase specific for p-nitrophenyl phosphate, involved in dephosphorylation of histone II-A and casein
YPL191C	YPL191C	0.432	2	NA	1.015	Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YER079W	YER079W	0.4319	NA	NA	1.066	Putative protein of unknown function
YLR313C	SPH1	0.4319	1	NA	0.958	Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p
YDR262W	YDR262W	0.4319	NA	NA	0.979	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment
YHR123W	EPT1	0.4319	NA	NA	1.012	sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability
YFR023W	PES4	0.4318	NA	NA	0.947	Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation, similar to Mip6p
YDR389W	SAC7	0.4317	NA	5	0.94	GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate
YJL131C	YJL131C	0.4317	2	NA	1.008	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YJL131C is not an essential gene
YER175C	TMT1	0.4315	NA	NA	1.017	Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle
YPR031W	NTO1	0.4313	2	NA	1.069	Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3
YGL140C	YGL140C	0.4312	1	NA	1.042	Hypothetical protein
YLR271W	YLR271W	0.4311	1	NA	1.005	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
YKL096W	CWP1	0.431	NA	NA	1.048	Cell wall mannoprotein, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; involved in cell wall organization
YJR144W	MGM101	0.4309	10	1	0.711	Protein involved in mitochondrial genome maintenance; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage
YLR214W	FRE1	0.4306	NA	NA	1.016	Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels
YDR504C	SPG3	0.4304	NA	NA	1.038	Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YDR223W	CRF1	0.4304	NA	NA	1.022	Transcriptional corepressor involved in the regulation of ribosomal protein gene transcription via the TOR signaling pathway and protein kinase A, phosphorylated by activated Yak1p which promotes accumulation of Crf1p in the nucleus
YOR318C	YOR318C	0.4302	NA	NA	1.034	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo
YEL014C	YEL014C	0.4301	NA	NA	1.009	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR064W	AEP1	0.4298	3	NA	0.915	Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase
YGL222C	EDC1	0.4297	NA	NA	1.012	RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p
YMR215W	GAS3	0.4296	NA	1	0.989	Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
YJL057C	IKS1	0.4296	NA	NA	0.994	Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p
YDR105C	TMS1	0.4293	NA	NA	0.954	Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance
YPL051W	ARL3	0.4289	4	30	0.981	GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor
YGL096W	TOS8	0.4288	2	NA	1.029	Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YLR376C	PSY3	0.4288	NA	NA	1.019	Protein of unknown function; deletion results in a mutator phenotype suggesting a role for this protein as a mutational suppressor; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C
YGR206W	YGR206W	0.4285	2	1	0.973	ESCRT-I subunit necessary for the efficient transport of cargo proteins to the vacuolar lumen; deletion mutant sensitive to rapamycin and nystatin; green fluorescent protein (GFP)-fusion protein localizes to endosome
YLR400W	YLR400W	0.4284	NA	NA	0.996	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR003C	YJR003C	0.4284	NA	NA	1.013	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR067C	OCA6	0.4281	1	NA	1.007	Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YKL191W	DPH2	0.4277	10	NA	1.058	Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p
YGL010W	YGL010W	0.4277	NA	NA	1.065	Putative protein of unknown function; YGL010W is not an essential gene
YJR126C	VPS70	0.4276	NA	NA	1.058	Protein of unknown function involved in vacuolar protein sorting
YNL106C	INP52	0.4275	16	8	1.029	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in endocytosis; hyperosmotic stress causes translocation to actin patches
YKR084C	HBS1	0.4271	NA	NA	0.921	GTP binding protein with sequence similarity to the elongation factor class of G proteins, EF-1alpha and Sup35p; associates with Dom34p, and shares a similar genetic relationship with genes that encode ribosomal protein components
YMR316C-B	YMR316C-B	0.4271	NA	NA	1.062	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR231C	PHB2	0.4269	12	4	0.969	Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
YGL181W	GTS1	0.4269	1	4	1.007	Protein containing a zinc-finger in the N-terminus and a long Gln-rich region in the C-terminus; regulates ultradian rhythm, cell size, cell cycle, lifespan, sporulation, heat tolerance, and multidrug transport
YNL334C	SNO2	0.4268	1	NA	1.076	Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin
YGL110C	CUE3	0.4262	1	4	1.056	Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
YKL032C	IXR1	0.4262	1	8	0.959	Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b
YPR017C	DSS4	0.426	8	8	NA	Nucleotide release factor functioning in the post-Golgi secretory pathway, required for ER-to-Golgi transport, binds zinc, found both on membranes and in the cytosol; guanine nucleotide dissociation stimulator
YPR011C	YPR011C	0.4259	NA	NA	1.186	Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YEL048C	YEL048C	0.4257	NA	3	0.99	Putative protein of unknown function; synthetic lethal with gcs1delta
YLL060C	GTT2	0.4255	10	NA	1.024	Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p
YJR015W	YJR015W	0.4255	NA	NA	1.042	Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene
YGR212W	SLI1	0.4252	NA	NA	1.041	N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
YDR050C	TPI1	0.4251	6	NA	1.059	Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region
YJL187C	SWE1	0.4249	7	13	1.004	Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
YBL075C	SSA3	0.4249	21	1	0.996	ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm
YDR257C	SET7	0.4247	NA	NA	0.933	Nuclear protein that contains a SET-domain, which have been shown to mediate methyltransferase activity in other proteins
YCR099C	YCR099C	0.4244	NA	NA	1.031	Putative protein of unknown function
YMR052W	FAR3	0.4244	2	2	0.985	Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p
YDR515W	SLF1	0.4242	3	1	1.004	RNA binding protein that associates with polysomes; proposed to be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts
YER106W	MAM1	0.4236	NA	NA	0.991	Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle
YLL061W	MMP1	0.4232	1	NA	1.028	High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p
YBL067C	UBP13	0.4231	3	1	0.885	Putative ubiquitin-specific protease
YBR093C	PHO5	0.4229	1	2	0.819	Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YKR028W	SAP190	0.4229	8	NA	0.983	Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p
YOR299W	BUD7	0.4228	6	NA	0.975	Member of the Chs5p-Arf1p-binding proteins (ChAPs), a group of 4 related, interacting proteins (Bch1p, Fmp50p, Bud7p, Chs6p) that mediate export of specific cargo proteins, including chitin synthase Chs3p, from the Golgi to plasma membrane
YDR422C	SIP1	0.4227	7	NA	1.004	Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions
YOL138C	YOL138C	0.4224	NA	1	0.829	Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YDL063C	YDL063C	0.4224	1	1	NA	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL063C is not an essential gene
YLR068W	FYV7	0.4223	NA	NA	0.684	Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in processing the 35S rRNA primary transcript to generate the 20S and 27SA2 pre-rRNA transcripts
YGL143C	MRF1	0.422	1	NA	0.702	Mitochondrial polypeptide chain release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability
YDL169C	UGX2	0.4215	NA	NA	0.991	Protein of unknown function, transcript accumulates in response to any combination of stress conditions
YPR114W	YPR114W	0.4215	2	NA	0.954	Putative protein of unknown function
YDR057W	YOS9	0.4214	7	NA	1.067	ER quality-control lectin; integral subunit of the HRD ligase; serves as a receptor for misfolded N-glycosylated proteins, participates in their targeting to ERAD; member of the OS-9 protein family
YER058W	PET117	0.4207	NA	NA	0.899	Protein required for assembly of cytochrome c oxidase
YBR288C	APM3	0.4204	3	6	1.059	Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
YDR269C	YDR269C	0.4202	NA	NA	NA	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBL051C	PIN4	0.4202	4	5	0.928	Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
YER039C-A	YER039C-A	0.4202	NA	NA	0.998	Putative protein of unknown function; YER039C-A is not an essential gene
YPL214C	THI6	0.4201	NA	1	0.935	Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
YGR271W	SLH1	0.4199	NA	NA	0.981	Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses
YHR147C	MRPL6	0.4198	15	1	0.813	Mitochondrial ribosomal protein of the large subunit
YNL187W	YNL187W	0.4195	1	NA	1	Putative protein of unknown function; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; may interact with or be fuctionally redundant with Prp40p
YBR206W	YBR206W	0.4193	NA	NA	1.004	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3
YCL064C	CHA1	0.4191	1	NA	0.96	Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
YGL053W	PRM8	0.419	NA	NA	1.065	Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family
YLL025W	PAU17	0.419	NA	NA	0.981	Putative protein of unknown function; YLL025W is not an essential gene
YNL090W	RHO2	0.4183	5	1	1.05	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
YNL183C	NPR1	0.4183	NA	NA	1.043	Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation
YNL057W	YNL057W	0.4183	NA	NA	0.982	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR250C	YDR250C	0.4181	NA	NA	1.011	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YOL082W	ATG19	0.4181	1	NA	1.048	Protein involved in the cytoplasm-to-vacuole targeting pathway and in autophagy, recognizes cargo proteins and delivers them to the preautophagosomal structure for eventual engulfment by the autophagosome and degradation
YMR026C	PEX12	0.418	3	1	1.09	RING-finger peroxisomal membrane peroxin that plays an essential role in peroxisome biogenesis and peroxisomal matrix protein import, forms translocation subcomplex with Pex2p and Pex10p
YER007W	PAC2	0.4177	3	22	1	Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
YHR181W	SVP26	0.4175	NA	8	NA	Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YGR125W	YGR125W	0.4175	NA	NA	1.004	Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YLR455W	YLR455W	0.4173	20	NA	NA	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YOR187W	TUF1	0.4172	6	1	0.743	Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans
YOR382W	FIT2	0.417	NA	NA	1.054	Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YKL188C	PXA2	0.4168	NA	NA	1.043	Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
YLR058C	SHM2	0.4166	17	4	0.281	Cytosolic serine hydroxymethyltransferase, involved in one-carbon metabolism
YHR087W	YHR087W	0.4165	3	5	0.913	Protein of unknown function involved in RNA metabolism; this single domain protein has structural similarity to the N-terminal domain of SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1/YLR022C)
YLR091W	YLR091W	0.4164	1	1	0.751	Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR091W is not an esssential gene
YMR250W	GAD1	0.4161	1	NA	1.029	Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YDR497C	ITR1	0.416	NA	4	0.854	Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p
YFR015C	GSY1	0.4158	7	NA	0.977	Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase
YCR098C	GIT1	0.4155	NA	NA	1.021	Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability
YLR401C	DUS3	0.4154	2	NA	1.025	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region
YNL231C	PDR16	0.4153	NA	2	1.069	Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p
YFR032C-A	RPL29	0.4151	30	3	0.951	Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate
YGL147C	RPL9A	0.4149	66	2	0.836	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins
YIL005W	EPS1	0.4149	NA	2	0.904	Pdi1p (protein disulfide isomerase)-related protein involved in endoplasmic reticulum retention of resident ER proteins
YCR032W	BPH1	0.4148	2	NA	1.039	PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting
YDR534C	FIT1	0.4148	NA	NA	1.002	Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YBR163W	DEM1	0.4147	NA	NA	1.042	Protein of unknown function, shows similarity to RNA-processing protein Pta1p
YOR222W	ODC2	0.4147	NA	NA	1.069	Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
YOL125W	YOL125W	0.4146	NA	NA	NA	2'-O-methyltransferase responsible for modification of tRNA at position 4; exhibits no obvious similarity to other known methyltransferases
YNL045W	YNL045W	0.4146	6	NA	1.044	Leucyl aminopeptidase (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; role in vivo is not defined; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YML017W	PSP2	0.4145	2	1	1.02	Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing
YGR032W	GSC2	0.4144	1	2	1.02	Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YML116W	ATR1	0.4144	NA	NA	1.076	Multidrug efflux pump of the major facilitator superfamily, required for resistance to aminotriazole and 4-nitroquinoline-N-oxide
YKR052C	MRS4	0.4142	NA	1	0.987	Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs3p; functions under low-iron conditions; may transport other cations in addition to iron
YDR307W	YDR307W	0.4141	NA	NA	1.034	Putative protein of unknown function
YBR014C	YBR014C	0.4138	1	NA	1.021	Putative membrane-localized protein of unknown function, contains glutaredoxin domain
YGL262W	YGL262W	0.4133	NA	NA	1	Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene
YNL316C	PHA2	0.4132	NA	NA	1.104	Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway
YLL012W	YEH1	0.4132	NA	NA	1.014	Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
YPL135W	ISU1	0.4131	1	1	NA	Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YDL230W	PTP1	0.413	NA	NA	0.997	Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria
YJL162C	JJJ2	0.4127	1	NA	1.005	Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YGR166W	KRE11	0.4127	8	34	1.056	Protein involved in biosynthesis of cell wall beta-glucans; subunit of the TRAPP (transport protein particle) complex, which is involved in the late steps of endoplasmic reticulum to Golgi transport
YOR308C	SNU66	0.4124	36	4	1.006	Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; has homology to human SART-1 and to an S. pombe protein; snu66 null mutation confers cold-sensitivity but is not lethal at normal growth temperatures
YDR309C	GIC2	0.412	NA	6	1.052	Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain
YER068C-A	YER068C-A	0.4119	NA	NA	0.872	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL046C	YOL046C	0.4119	NA	NA	1.008	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data;almost completely overlaps the verified gene PSK2/YOL045W
YDL106C	PHO2	0.4118	16	NA	0.66	Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p
YOR352W	YOR352W	0.4116	3	NA	1.086	Putative protein of unknown function; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YGR052W	FMP48	0.4116	4	NA	0.971	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR148C	RPL24B	0.4114	1	NA	0.972	Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YGR290W	YGR290W	0.4114	NA	NA	0.965	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)
YER004W	FMP52	0.411	2	NA	1.01	Protein of unknown function, localized to the mitochondrial outer membrane
YIR018W	YAP5	0.4109	NA	NA	0.985	Basic leucine zipper (bZIP) transcription factor
YMR100W	MUB1	0.4109	2	1	0.962	Protein of unknown function, deletion causes multi-budding phenotype; has similarity to Aspergillus nidulans samB gene
YGL203C	KEX1	0.4107	3	1	1.017	Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
YLR042C	YLR042C	0.4107	NA	NA	1	Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene
YCR100C	YCR100C	0.4107	NA	NA	1.024	Putative protein of unknown function
YDR330W	UBX5	0.4106	1	NA	1.051	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
YMR101C	SRT1	0.4103	NA	1	1.052	Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
YBR293W	VBA2	0.4101	NA	NA	0.97	Permease of basic amino acids in the vacuolar membrane
YFR022W	ROG3	0.41	1	NA	0.973	Protein that binds to Rsp5p, which is a hect-type ubiquitin ligase, via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant
YBR251W	MRPS5	0.4099	50	NA	0.807	Mitochondrial ribosomal protein of the small subunit
YCR003W	MRPL32	0.4098	2	NA	0.894	Mitochondrial ribosomal protein of the large subunit
YBR287W	ZSP1	0.4091	1	NA	1.043	Protein of unknown function; mutation results in a zinc sensitive phenotype
YGR127W	YGR127W	0.4091	NA	NA	0.972	Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response
YKL221W	MCH2	0.4088	NA	NA	1.029	Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YDR347W	MRP1	0.4087	29	NA	0.978	Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein
YIL165C	YIL165C	0.408	NA	NA	0.987	Putative protein of unknown function; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene
YDR059C	UBC5	0.4074	1	1	1.016	Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins, central component of the cellular stress response; expression is heat inducible
YPL166W	ATG29	0.4072	4	NA	1.005	Protein specifically required for autophagy; may function in autophagosome formation at the pre-autophagosomal structure in collaboration with other autophagy proteins
YDL109C	YDL109C	0.4072	NA	NA	0.993	Putative lipase; involved in lipid metabolism; YDL109C is not an essential gene
YOR016C	ERP4	0.4072	1	NA	0.991	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
YEL051W	VMA8	0.4068	16	2	0.56	Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
YHR153C	SPO16	0.4064	NA	NA	0.998	Protein of unknown function, required for spore formation
YOR288C	MPD1	0.4064	NA	NA	1.022	Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation
YIR001C	SGN1	0.4061	20	NA	1.025	Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation
YDR516C	EMI2	0.406	4	NA	1.026	Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p
YML090W	YML090W	0.4055	NA	NA	1.057	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YDR077W	SED1	0.4055	NA	2	1.07	Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites
YLR429W	CRN1	0.4055	85	1	0.942	Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity
YMR169C	ALD3	0.4053	1	NA	0.981	Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose
YGR061C	ADE6	0.405	3	NA	0.938	Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
YNR015W	SMM1	0.405	NA	NA	1.033	Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs
YOR047C	STD1	0.4046	NA	NA	1.028	Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p
YNL022C	YNL022C	0.4046	2	NA	1.091	Putative protein of unknown function with seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to a single spot in the nucleus; YNL022C is not an essential gene
YLR254C	NDL1	0.4042	NA	3	1.004	homolog of nuclear distribution factor NudE, NUDEL
YLR460C	YLR460C	0.4041	NA	NA	0.983	Putative protein of unknown function, possibly up-regulated by iodine
YNL101W	AVT4	0.4039	1	NA	1.009	Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YAR043C	YAR043C	NA	NA	NA	NA	NA
YMR175W	SIP18	0.4038	NA	NA	0.999	Protein of unknown function whose expression is induced by osmotic stress
YBR072W	HSP26	0.4037	13	NA	0.993	Small heat shock protein with chaperone activity that is regulated by a heat induced transition from an inactive oligomeric (24-mer) complex to an active dimer; induced by heat, upon entry into stationary phase, and during sporulation
YOR130C	ORT1	0.4036	NA	NA	1.023	Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome
YOL030W	GAS5	0.4036	1	NA	0.947	1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
YDR321W	ASP1	0.4035	NA	NA	1.048	Cytosolic L-asparaginase, involved in asparagine catabolism
YGL202W	ARO8	0.4031	NA	NA	0.977	Aromatic aminotransferase, expression is regulated by general control of amino acid biosynthesis
YOR044W	YOR044W	0.4028	NA	1	1.028	Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52 foci
YKL031W	YKL031W	0.4028	NA	NA	1.048	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YKR092C	SRP40	0.4027	10	2	0.865	Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YDR283C	GCN2	0.4027	24	1	0.934	Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex
YLL047W	YLL047W	0.4025	NA	NA	1.023	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1
YPL003W	ULA1	0.4023	4	4	1.004	Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation
YOR108W	LEU9	0.4023	3	NA	1.022	Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant
YPL048W	CAM1	0.4022	12	NA	0.978	Homolog of translational cofactor elongation factor-1 gamma, participates in the regulation of GTP-binding protein EF-1 alpha, may play a redundant role in the regulation of protein synthesis or another GTP-dependent process
YHR203C	RPS4B	0.402	81	1	0.819	Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein
YGR142W	BTN2	0.4018	2	2	0.941	v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase
YPR026W	ATH1	0.4015	NA	NA	1.064	Acid trehalase required for utilization of extracellular trehalose
YER186C	YER186C	0.4014	NA	NA	1.028	Putative protein of unknown function
YBR141C	YBR141C	0.4014	NA	NA	1.035	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene
YFL020C	PAU5	0.4013	NA	NA	0.991	Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YDL202W	MRPL11	0.4012	3	NA	0.923	Mitochondrial ribosomal protein of the large subunit
YIR042C	YIR042C	0.4009	NA	NA	0.971	Putative protein of unknown function; YIR042C is a non-essential gene
YOL027C	MDM38	0.4009	51	2	0.978	Mitochondrial inner membrane protein, involved in membrane integration of a subset of mitochondrial proteins; required for K+/H+ exchange; associates with mitochondrial ribosomes; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome
YOR364W	YOR364W	0.4006	NA	NA	1.029	Hypothetical protein
YGL161C	YIP5	0.4005	1	3	1.029	Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
YDL123W	SNA4	0.4005	NA	NA	0.961	Protein of unknown function, localized to the vacuolar outer membrane
YLR394W	CST9	0.4005	NA	NA	1.011	SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate
YNL086W	YNL086W	0.4004	2	6	1.041	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to endosomes
YBR057C	MUM2	0.4004	4	7	0.962	Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex
YLR177W	YLR177W	0.4	NA	NA	0.9	Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; YLR177W is not an essential gene
YOR011W	AUS1	0.4	1	NA	1.098	Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth
YBR292C	YBR292C	0.3997	NA	NA	1.002	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YMR126C	DLT1	0.3997	NA	NA	1.044	Protein of unknown function, deletion causes sensitivity to thermal stress
YBR161W	CSH1	0.399	1	1	1.001	Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p
YOR208W	PTP2	0.3989	1	4	1.037	Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus
YBR261C	YBR261C	0.3988	NA	NA	0.984	Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBR261C is not an essential gene
YMR071C	TVP18	0.3985	3	NA	0.98	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
YHR125W	YHR125W	0.3983	NA	NA	1.018	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR122C	YLR122C	0.3979	NA	NA	1.016	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YMR099C	YMR099C	0.3978	4	NA	1.014	Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
YNR032C-A	HUB1	0.3976	NA	NA	0.916	Ubiquitin-like protein modifier, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
YGL006W	PMC1	0.3976	2	2	1.073	Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a
YNL089C	YNL089C	0.3974	NA	NA	0.991	Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins
YDL133C-A	RPL41B	0.3973	1	NA	0.986	Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Ap and has similarity to rat L41 ribosomal protein; comprised of only 25 amino acids; rpl41a rpl41b double null mutant is viable
YKL064W	MNR2	0.3971	1	NA	1.048	Putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations
YPR005C	HAL1	0.3969	NA	NA	0.981	Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p
YGL138C	YGL138C	0.3969	NA	NA	1.037	Putative protein of unknown function; has no significant sequence similarity to any known protein
YFR038W	IRC5	0.3966	NA	NA	1.011	Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52 foci
YBR272C	HSM3	0.3966	15	NA	1.016	Protein of unknown function, involved in DNA mismatch repair during slow growth; has weak similarity to Msh1p
YHL019C	APM2	0.3965	4	NA	0.971	Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
YML074C	FPR3	0.3965	15	NA	1.059	Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
YLL042C	ATG10	0.3963	NA	NA	0.993	E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy
YJR001W	AVT1	0.3962	1	NA	1.051	Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YBR258C	SHG1	0.3959	7	1	1.013	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
YLR363C	NMD4	0.3958	NA	NA	1.002	Protein interacting with Nam7p, may be involved in the nonsense-mediated mRNA decay pathway
YDR450W	RPS18A	0.3957	38	1	0.781	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
YOR089C	VPS21	0.3956	9	16	0.999	GTPase required for transport during endocytosis and for correct sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog
YBL081W	YBL081W	0.3956	1	1	0.95	Non-essential protein of unknown function
YNL070W	TOM7	0.3954	NA	1	0.995	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
YDR305C	HNT2	0.395	NA	NA	1.053	Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins
YDR171W	HSP42	0.3948	28	1	1.005	Small cytosolic stress-induced chaperone that forms barrel-shaped oligomers and suppresses the aggregation of non-native proteins; oligomer dissociation is not required for function; involved in cytoskeleton reorganization after heat shock
YDR386W	MUS81	0.3948	31	12	1.034	Helix-hairpin-helix protein, involved in DNA repair and replication fork stability; functions as an endonuclease in complex with Mms4p; interacts with Rad54p
YGR101W	PCP1	0.3948	NA	NA	0.95	Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases
YKL171W	YKL171W	0.3947	NA	NA	1.098	Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm
YHL044W	YHL044W	0.3946	NA	NA	0.988	Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern
YDR358W	GGA1	0.3942	NA	4	1.057	Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi
YGR044C	RME1	0.3942	NA	2	1.007	Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-a2 regulator; mediates cell type control of sporulation
YCL051W	LRE1	0.394	NA	1	0.972	Protein involved in control of cell wall structure and stress response; inhibits Cbk1p protein kinase activity; overproduction confers resistance to cell-wall degrading enzymes
YER069W	ARG5,6	0.3938	3	NA	0.776	Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p
YDR110W	FOB1	0.3936	NA	NA	0.965	Nucleolar protein required for DNA replication fork blocking and recombinational hotspot activities; binds to the replication fork barrier site in the rDNA region; related to retroviral integrases
YKR035C	YKR035C	0.3936	NA	NA	0.97	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A
YML055W	SPC2	0.3933	2	2	1.034	Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25
YMR096W	SNZ1	0.3932	NA	1	1.066	Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
YIL114C	POR2	0.393	NA	NA	0.983	Putative mitochondrial porin (voltage-dependent anion channel), related to Por1p but not required for mitochondrial membrane permeability or mitochondrial osmotic stability
YOR053W	YOR053W	0.393	NA	NA	1.036	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C
YOR267C	HRK1	0.393	5	NA	1.023	Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis
YNL129W	NRK1	0.3923	NA	NA	1.013	Nicotinamide riboside kinase, catalyzes the synthesis of nicotinamide nucleotide (NMN) from nicotinamide riboside; involved in a salvage pathway for NAD+ biosynthesis
YMR176W	ECM5	0.3918	1	NA	1.061	Non-essential protein of unknown function, contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks
YGL205W	POX1	0.3917	1	NA	1.025	Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
YKR104W	YKR104W	0.3916	NA	NA	0.962	Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds
YFR044C	YFR044C	0.3914	3	NA	0.998	Probable di- and tri-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
YHR094C	HXT1	0.3914	NA	NA	1.015	Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YER096W	SHC1	0.3914	NA	2	1.004	Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH
YML054C	CYB2	0.391	NA	NA	1.05	Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
YGR287C	YGR287C	0.3909	NA	NA	0.969	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to alpha-D-glucosidase (maltase); authentic, non-tagged protein detected in purified mitochondria in high-throughput studies
YIL060W	YIL060W	0.3907	NA	NA	0.999	Putative protein of unknown function; mutant accumulates less glycogen than does wild type; YIL060W is not an essential gene
YJL160C	YJL160C	0.3906	NA	NA	1.016	Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis
YMR057C	YMR057C	0.3903	NA	NA	0.94	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1
YLR258W	GSY2	0.3902	13	NA	1.013	Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase
YIL015C-A	YIL015C-A	NA	NA	NA	NA	NA
YIL050W	PCL7	0.3895	4	1	0.968	Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated
YGL017W	ATE1	0.3892	4	NA	1.026	Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
YNL323W	LEM3	0.389	7	1	1.097	Membrane protein of the plasma membrane and ER, involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane
YDR042C	YDR042C	0.3889	NA	NA	0.68	Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
YMR181C	YMR181C	0.3888	1	NA	0.973	Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene
YFL048C	EMP47	0.3888	2	NA	0.996	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
YDL215C	GDH2	0.3887	11	NA	1.002	NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
YPL107W	YPL107W	0.3883	NA	NA	1.026	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene
YIL007C	NAS2	0.388	2	NA	0.95	Protein with similarity to the p27 subunit of mammalian proteasome modulator; not essential; interacts with Rpn4p
YLR390W	ECM19	0.388	NA	NA	1	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL096C	YDL096C	0.3877	NA	NA	0.996	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
YDL075W	RPL31A	0.3876	75	NA	NA	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YNL321W	YNL321W	0.3874	NA	NA	1.101	Protein of unknown function, potential Cdc28p substrate
YDR420W	HKR1	0.3874	NA	15	1.022	Serine/threonine rich cell surface protein that contains an EF hand motif; involved in the regulation of cell wall beta-1,3 glucan synthesis and bud site selection; overexpression confers resistance to Hansenula mrakii killer toxin, HM-1
YAL036C	RBG1	0.3865	9	NA	0.968	Member of the DRG family of GTP-binding proteins; interacts with translating ribosomes and with Tma46p
YLR178C	TFS1	0.3863	3	NA	1.02	Carboxypeptidase Y inhibitor, function requires acetylation by the NatB N-terminal acetyltransferase; phosphatidylethanolamine-binding protein involved in protein kinase A signaling pathway
YMR111C	YMR111C	0.3861	1	NA	1.039	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene
YLR375W	STP3	0.3861	1	NA	0.967	Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids
YNL072W	RNH201	0.386	2	4	1.041	Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis; cooperates with Rad27p nuclease
YML006C	GIS4	0.3857	5	NA	1.006	CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway
YNL162W	RPL42A	0.3856	9	NA	0.823	Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein
YDL050C	YDL050C	0.3851	NA	NA	0.996	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
YFR021W	ATG18	0.3847	8	3	0.95	Phosphatidylinositol 3,5-bisphosphate-binding protein of the vacuolar membrane, predicted to fold as a seven-bladed beta-propeller; required for recycling of Atg9p through the pre-autophagosomal structure
YOL016C	CMK2	0.3847	1	NA	1.023	Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II
YHR137W	ARO9	0.3846	4	NA	1.025	Aromatic aminotransferase, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
YNR064C	YNR064C	0.3845	NA	NA	0.914	Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides
YGL071W	AFT1	0.3844	NA	NA	0.797	Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability
YPR083W	MDM36	0.3844	1	NA	0.983	Protein required for normal mitochondrial morphology and inheritance
YDL104C	QRI7	0.3842	NA	NA	0.658	Putative metalloprotease, similar to O-sialoglycoprotein metallopeptidase from P. haemolytica; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR212W	STE4	0.3838	18	NA	1.027	G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats
YJL063C	MRPL8	0.3831	33	NA	0.825	Mitochondrial ribosomal protein of the large subunit
YML067C	ERV41	0.3831	10	NA	1.04	Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein
YLR201C	COQ9	0.383	NA	NA	1.009	Mitochondrial inner membrane protein required for ubiquinone (coenzyme Q) biosynthesis, which in turn is required for respiratory growth; exhibits genetic interaction with ABC1, suggesting a possible common function
YOR006C	YOR006C	0.3821	NA	NA	0.848	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YDL190C	UFD2	0.382	11	NA	1	Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3
YPL121C	MEI5	0.382	NA	NA	1.044	Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p
YML123C	PHO84	0.3818	9	4	1.03	High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
YDR402C	DIT2	0.3813	NA	NA	1.037	N-formyltyrosine oxidase, sporulation-specific microsomal enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall, homologous to cytochrome P-450s
YBR289W	SNF5	0.3812	17	5	1.026	Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p
YIL086C	YIL086C	0.3811	NA	NA	0.994	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCR021C	HSP30	0.381	NA	NA	0.964	Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YOL088C	MPD2	0.381	4	NA	1.002	Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p
YML066C	SMA2	0.3808	NA	NA	1.061	Protein of unknown function involved in the assembly of the prospore membrane during sporulation
YDL052C	SLC1	0.3806	11	NA	1.01	1-acyl-sn-gylcerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; located in lipid particles and endoplasmic reticulum
YPR024W	YME1	0.3805	NA	4	0.653	Subunit, with Mgr1p, of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover
YPL018W	CTF19	0.3804	12	28	0.978	Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YJL027C	YJL027C	0.3803	NA	NA	0.678	Putative protein of unknown function
YHR044C	DOG1	0.3802	4	NA	0.997	2-deoxyglucose-6-phosphate phosphatase, similar to Dog2p, member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified
YEL004W	YEA4	0.3801	NA	NA	1.027	Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
YER156C	YER156C	0.38	1	NA	0.824	Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YOR049C	RSB1	0.3797	2	NA	0.995	Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
YDR284C	DPP1	0.3796	NA	NA	0.994	Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism
YLR354C	TAL1	0.3796	5	NA	0.986	Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate
YOL052C	SPE2	0.3795	2	NA	1.094	S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
YDR345C	HXT3	0.3794	NA	NA	1.036	Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YER114C	BOI2	0.3791	3	6	0.912	Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YPL008W	CHL1	0.3789	7	34	0.899	Conserved nuclear protein required to establish sister-chromatid pairing during S-phase, probable DNA helicase with similarity to human BACH1, which associates with tumor suppressor BRCA1; associates with acetyltransferase Ctf7p
YBR217W	ATG12	0.3787	44	1	0.753	Ubiquitin-like modifier, conjugated via an isopeptide bond to a lysine residue of Atg5p by the E1 enzyme, Atg7p, and the E2 enzyme, Atg10p, a step that is essential for autophagy
YLR441C	RPS1A	0.3785	81	1	0.847	Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein
YOR188W	MSB1	0.3783	2	3	1.016	Protein involved in positive regulation of both 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway, potential Cdc28p substrate; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4
YJR082C	EAF6	0.3782	15	NA	0.966	Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3
YGR205W	YGR205W	0.3782	1	NA	1.041	ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases
YMR002W	MIC17	0.3779	NA	NA	1.023	Mitochondrial intermembrane space cysteine motif protein; MIC17 is not an essential gene
YLL024C	SSA2	0.3776	31	3	0.996	ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall
YJL106W	IME2	0.3774	2	NA	0.994	Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
YHR140W	YHR140W	0.3773	NA	NA	NA	Putative integral membrane protein of unknown function
YJR061W	YJR061W	0.3773	1	NA	1.005	Putative protein of unknown function; non-essential gene with similarity to Mnn4, a putative membrane protein involved in glycosylation; transcription repressed by Rm101p
YDR027C	VPS54	0.3769	5	5	0.722	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; potentially phosphorylated by Cdc28p
YPL068C	YPL068C	0.3764	NA	NA	0.972	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS
YGR028W	MSP1	0.3761	NA	NA	1.009	Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase
YPR129W	SCD6	0.3754	NA	NA	0.963	Protein containing an Lsm domain, may bind RNA and have a role in RNA processing; overproduction suppresses a null mutation in CHC1, which encodes the heavy chain of clathrin
YLR300W	EXG1	0.3752	2	NA	0.977	Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
YKR001C	VPS1	0.3748	39	17	0.972	Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, late Golgi-retention of some proteins, regulating peroxisome biogenesis
YER145C	FTR1	0.3747	1	NA	0.947	High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron
YPL245W	YPL245W	0.3747	5	NA	0.993	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YOR118W	YOR118W	0.3747	NA	NA	1.029	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR118W is not an essential gene
YGR033C	TIM21	0.3744	3	NA	1.013	Constituent of the mitochondrial inner membrane presequence translocase (TIM23 complex); may regulate protein import by binding to both the translocase of the outer membrane (TOM) and presequence-associated motor (PAM) complexes
YBR028C	YBR028C	0.3742	2	NA	0.989	Putative protein kinase, possible substrate of cAMP-dependent protein kinase (PKA)
YBL057C	PTH2	0.3739	1	NA	1.012	One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth
YGR201C	YGR201C	0.3738	NA	NA	1.033	Putative protein of unknown function
YOR190W	SPR1	0.373	NA	NA	1.033	Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
YOR091W	TMA46	0.373	5	NA	1.043	Protein of unknown function that associates with ribosomes; interacts with GTPase Rbg1p
YOL118C	YOL118C	0.3728	NA	NA	1.011	Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YNR061C	YNR061C	0.3728	NA	NA	0.927	Putative protein of unknown function
YKR070W	YKR070W	0.3727	2	NA	0.959	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR121W	THI22	0.3725	5	NA	1.009	Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis
YLR231C	BNA5	0.3723	4	1	1.009	Kynureninase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway
YPR050C	YPR050C	0.3722	NA	NA	1.013	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W
YLR306W	UBC12	0.3721	2	3	1.019	Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes
YKR090W	PXL1	0.372	NA	NA	1	LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin
YBR207W	FTH1	0.3718	6	NA	1.074	Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis
YIL089W	YIL089W	0.3717	NA	NA	1.009	Putative protein of unknown function
YDL027C	YDL027C	0.3716	NA	NA	0.99	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene
YDR458C	HEH2	0.3713	NA	1	1.033	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery
YGL158W	RCK1	0.3713	7	NA	1.02	Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YER179W	DMC1	0.3713	8	1	1.027	Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein
YGL085W	YGL085W	0.3706	NA	NA	1.049	Putative protein of unknown function, has homology to Staphylococcus aureus nuclease; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS
YKL076C	YKL076C	0.3703	NA	NA	1.016	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
YCR017C	CWH43	0.3698	NA	1	0.984	Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion
YDR112W	YDR112W	0.3698	NA	NA	0.983	Hypothetical protein, null mutant displays increased levels of spontaneous Rad52 foci
YDL175C	AIR2	0.3694	16	1	1.024	RING finger protein that interacts with the arginine methyltransferase Hmt1p; may regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and export; has similarity to Air1p
YMR189W	GCV2	0.3694	NA	NA	0.984	P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
YGL242C	YGL242C	0.3689	4	2	0.928	Putative protein of unknown function; deletion mutant is viable
YIL153W	RRD1	0.3683	1	5	0.951	Activator of the phosphotyrosyl phosphatase activity of PP2A; regulates G1 phase progression, the G2/M phase transition, microtubule dynamics, the osmoresponse, bud morphogenesis and DNA repair; subunit of the Tap42p-Sit4p-Rrd1p complex
YDR221W	GTB1	0.3682	3	NA	0.968	Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p, involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER
YBL001C	ECM15	0.368	NA	1	0.941	Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
YGL081W	YGL081W	0.3677	10	6	1.066	Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
YCL076W	YCL076W	0.3677	NA	NA	1.018	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL230C	ELA1	0.3675	28	1	0.976	Elongin A, F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21
YLR172C	DPH5	0.3672	2	NA	0.966	Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm
YDR175C	RSM24	0.3672	35	2	0.768	Mitochondrial ribosomal protein of the small subunit
YBR144C	YBR144C	0.3669	NA	NA	0.937	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene
YLR284C	ECI1	0.3669	NA	NA	0.999	Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced
YOR081C	TGL5	0.3668	14	NA	1.035	Triacylglycerol lipase involved in TAG mobilization; localizes to lipid particles; potential Cdc28p substrate
YPL041C	YPL041C	0.3659	NA	3	0.982	Protein of unknown function involved in maintenance of proper telomere length
YGR177C	ATF2	0.3656	1	NA	1.016	Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important in brewing
YEL008W	YEL008W	0.3652	NA	NA	0.95	Hypothetical protein predicted to be involved in metabolism
YJL096W	MRPL49	0.365	3	NA	0.79	Mitochondrial ribosomal protein of the large subunit
YER067W	YER067W	0.3644	1	NA	1.002	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YER067W is not an essential gene
YJL022W	YJL022W	0.364	NA	NA	1.02	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
YKL029C	MAE1	0.3639	48	NA	0.983	Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids
YER089C	PTC2	0.3638	5	1	1.032	Type 2C protein phosphatase; dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; role in DNA checkpoint inactivation
YPL207W	TYW1	0.3633	4	NA	1.032	Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
YKL110C	KTI12	0.3633	1	2	0.885	Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YAR028W	YAR028W	0.3632	NA	NA	0.945	Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YDR372C	VPS74	0.3627	2	3	1.011	Non-essential protein of unknown function involved in vacuolar protein sorting; belongs to a family of cytosolic Golgi-associated proteins suggesting that it may play a role in secretion; also detected in the nucleus
YPL077C	YPL077C	0.3622	NA	2	1.07	Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene
YHR082C	KSP1	0.3622	11	NA	0.995	Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation
YPR155C	NCA2	0.362	1	1	0.972	Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p
YJR024C	YJR024C	0.3618	1	1	1.008	Putative protein of unknown function; localizes to the cytoplasm; potential substrate of Smt3p sumoylation; expression downregulated by the antifungal drug caspofungin and deletion mutant exhibits enhanced caspofungin resistance
YGR133W	PEX4	0.3617	NA	4	0.99	Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis
YLR216C	CPR6	0.3617	20	5	0.994	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
YHR057C	CPR2	0.3617	NA	NA	0.993	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway
YER014C-A	BUD25	0.3614	NA	3	0.694	Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YMR178W	YMR178W	0.3611	NA	NA	1.01	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR178W is not an essential gene
YDR183W	PLP1	0.3611	NA	4	1.039	Protein with a possible role in folding of beta-tubulin; has weak similarity to phosducins, which are G-protein regulators
YGR143W	SKN1	0.361	1	8	1.004	Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p
YLR297W	YLR297W	0.3607	NA	NA	0.987	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene
YCR005C	CIT2	0.3606	1	1	0.976	Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YMR083W	ADH3	0.3603	14	NA	1.044	Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YIL158W	YIL158W	0.36	NA	NA	0.975	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YBR214W	SDS24	0.3598	1	NA	1.04	One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis
YBL021C	HAP3	0.3597	5	1	0.838	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding
YDL204W	RTN2	0.3597	2	NA	0.947	Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YGL056C	SDS23	0.3596	NA	1	1.071	One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation
YNR056C	BIO5	0.3595	NA	NA	0.986	Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
YMR110C	HFD1	0.3594	1	NA	1.044	Putative fatty aldehyde dehydrogenase, located in the mitochondrial outer membrane and also in lipid particles; has similarity to human fatty aldehyde dehydrogenase (FALDH) which is implicated in Sjogren-Larsson syndrome
YPL140C	MKK2	0.3593	16	1	1.03	Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p
YPR148C	YPR148C	0.3592	NA	NA	1.016	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YLR453C	RIF2	0.3591	1	NA	0.987	Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
YIL034C	CAP2	0.359	7	17	0.94	Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches
YPR029C	APL4	0.359	7	NA	0.987	Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
YOR177C	MPC54	0.359	4	NA	1.039	Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate
YDR340W	YDR340W	0.359	NA	NA	1.038	Putative protein of unknown function
YBR260C	RGD1	0.3585	4	9	1.022	GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
YLR382C	NAM2	0.3582	2	NA	0.801	Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance
YLR283W	YLR283W	0.3582	NA	NA	1.018	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene
YLR326W	YLR326W	0.3581	1	NA	1.026	Hypothetical protein
YHR086W	NAM8	0.3579	27	2	1.007	RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA
YPL260W	YPL260W	0.3578	NA	NA	1.069	Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene
YDR202C	RAV2	0.3573	3	3	1.044	Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme
YBR301W	DAN3	0.3571	NA	1	1.059	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YOL092W	YOL092W	0.3569	NA	NA	0.976	Putative protein of unknown function; predicted to contain six transmembrane domains and is 58% similar to the uncharacterized ORF YBR147W; deletion mutant has no detectable phenotype
YJL084C	ALY2	0.3567	6	NA	1.021	Cytoplasmic protein of unknown function that interacts with the cyclin Pcl7p; phosphorylated in vitro by the cyclin-CDK complex, Pcl7p-Pho85p; identified as a potential Cdc28p substrate; mRNA is cell cycle regulated, peaking in M phase
YLR304C	ACO1	0.3566	23	NA	0.988	Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
YER051W	JHD1	0.3564	NA	NA	0.999	JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
YFL063W	YFL063W	0.3564	NA	NA	1.075	Dubious open reading frame, based on available experimental and comparative sequence data
YKR091W	SRL3	0.3562	2	NA	0.938	Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate
YGL228W	SHE10	0.356	NA	NA	0.989	Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest
YIL030C	SSM4	0.356	5	1	NA	Ubiquitin-protein ligase of the ER/nuclear envelope, required for degradation of Alpha2p and other proteins containing a Deg1 degradation signal; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
YGL156W	AMS1	0.3556	2	NA	1.028	Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
YOL048C	YOL048C	0.3556	NA	NA	1.04	Putative protein of unknown function
YCL069W	VBA3	0.3556	NA	NA	0.958	Permease of basic amino acids in the vacuolar membrane
YGL170C	SPO74	0.3555	NA	NA	1.02	Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
YDL121C	YDL121C	0.3554	NA	NA	0.975	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic retiuculum; YDL121C is not an essential protein
YAL054C	ACS1	0.3553	NA	NA	1.03	Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YDR217C	RAD9	0.3553	3	25	1.013	DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate
YLR123C	YLR123C	0.3553	NA	NA	1.048	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YMR271C	URA10	0.3551	1	NA	0.975	One of two orotate phosphoribosyltransferase isozymes (see also URA5) that catalyze the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate
YJR083C	ACF4	0.3549	NA	NA	1	Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate
YLR137W	YLR137W	0.3547	NA	NA	1.032	Putative protein of unknown function
YNR055C	HOL1	0.3547	1	NA	1.105	Putative ion transporter similar to the major facilitator superfamily of transporters; mutations in membrane-spanning domains permit nonselective cation uptake
YDR207C	UME6	0.3545	15	13	0.461	Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
YBR108W	YBR108W	0.3544	4	4	NA	Protein interacting with Rsv167p
YAR040C	YAR040C	NA	NA	NA	NA	NA
YGL227W	VID30	0.3542	11	1	1.022	Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); shifts the balance of nitrogen metabolism toward the production of glutamate; localized to the nucleus and the cytoplasm
YDR096W	GIS1	0.3541	NA	NA	1.017	JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YLR102C	APC9	0.3538	11	4	1.017	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YNL226W	YNL226W	0.3537	NA	NA	0.89	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C
YIR035C	YIR035C	0.3536	3	NA	0.963	Putative cytoplasmic protein of unknown function
YMR069W	NAT4	0.3532	NA	NA	1.007	N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A
YKL217W	JEN1	0.353	NA	NA	1.083	Lactate transporter, required for uptake of lactate and pyruvate; expression is derepressed by transcriptional activator Cat8p under nonfermentative growth conditions, and repressed in the presence of glucose, fructose, and mannose
YBL052C	SAS3	0.3529	8	6	1.011	Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; sas3 gcn5 double mutation confers lethality
YGR203W	YGR203W	0.3528	1	NA	1.043	Putative protein with sequence similarity to protein tyrosine phosphatases of the CDC25-like phosphatase family; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YER108C	YER108C	NA	NA	NA	NA	NA
YOR246C	YOR246C	0.3526	NA	NA	0.972	Protein with similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YDR135C	YCF1	0.3524	NA	NA	0.911	Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin; similar to human cystic fibrosis protein CFTR
YKL156W	RPS27A	0.352	2	NA	1.037	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Bp and has similarity to rat S27 ribosomal protein
YPL264C	YPL264C	0.3519	NA	NA	1.072	Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene
YFL030W	AGX1	0.3519	2	NA	1.009	Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YOR247W	SRL1	0.3518	NA	1	0.987	Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants
YIL066C	RNR3	0.3517	12	NA	0.99	Ribonucleotide-diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YKL057C	NUP120	0.3514	15	39	0.925	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for even distribution of NPCs around the nuclear envelope, involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p
YGR130C	YGR130C	0.3511	6	NA	0.983	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
YNL165W	YNL165W	0.3509	NA	NA	1.018	Putative protein of unknown function; YNL165W is not an essential gene
YML083C	YML083C	0.3507	NA	NA	0.997	Putative protein of unknown function; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
YLR253W	YLR253W	0.3502	NA	NA	1.014	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene
YNL146W	YNL146W	0.3501	NA	NA	1.002	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene
YPL179W	PPQ1	0.35	1	NA	0.966	Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors
YDR215C	YDR215C	0.35	NA	NA	1.018	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
YNL195C	YNL195C	0.3496	NA	NA	1.027	Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR348C	PUT4	0.3495	NA	NA	1.018	Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YJR008W	YJR008W	0.3494	NA	NA	1.056	Putative protein of unknown function; expression repressed by inosine and choline in an Opi1p-dependent manner; expression induced by mild heat-stress on a non-fermentable carbon source.
YOL029C	YOL029C	0.3493	NA	NA	1.018	Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens
YNL105W	YNL105W	0.3493	NA	NA	1.053	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene INP52
YNL296W	YNL296W	0.3493	NA	NA	0.83	Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog
YNL167C	SKO1	0.3492	3	NA	1.012	Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, forms a complex with Tup1p and Ssn6p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses
YGR042W	YGR042W	0.349	NA	NA	1.006	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YNL008C	ASI3	0.3488	1	NA	0.983	Putative integral membrane E3 ubiquitin ligase; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
YIL025C	YIL025C	0.3487	NA	NA	1.011	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR021W-A	ECM12	0.3485	NA	NA	1.004	Non-essential protein of unknown function
YJL051W	IRC8	0.3483	1	NA	1.013	Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52 foci
YPR174C	YPR174C	0.3482	2	NA	1.001	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate
YNL028W	YNL028W	0.3478	NA	NA	1.091	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL085C	YOL085C	0.3467	NA	NA	1.029	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YOL019W	YOL019W	0.3466	NA	NA	0.993	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YGR189C	CRH1	0.3466	NA	NA	1.048	Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan, putative chitin transglycosidase
YKR106W	YKR106W	0.3463	NA	NA	1.012	Protein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YCL073C
YDR132C	YDR132C	0.3463	NA	1	0.994	Putative protein of unknown function
YJL177W	RPL17B	0.346	81	NA	0.902	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins
YNL173C	MDG1	0.3457	NA	NA	1.001	Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations
YML018C	YML018C	0.3456	NA	NA	1.068	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; YML018C is not an essential gene
YKL039W	PTM1	0.3454	6	NA	1.033	Protein of unknown function, copurifies with late Golgi vesicles containing the v-SNARE Tlg2p
YOR154W	SLP1	0.3453	2	NA	0.997	Hypothetical protein
YDR143C	SAN1	0.3447	10	NA	0.944	Ubiquitin-protein ligase, involved in the proteasome-dependent degradation of aberrant nuclear proteins; san1 mutations suppress sir4, spt16, and cdc68 mutations, suggesting a role in chromatin silencing
YOL020W	TAT2	0.3446	NA	1	1.015	High affinity tryptophan and tyrosine permease, overexpression confers FK506 resistance
YPR013C	YPR013C	0.3444	NA	NA	1.071	Putative zinc finger protein; YPR013C is not an essential gene
YJL217W	YJL217W	0.3441	1	NA	1.026	Cytoplasmic protein of unknown function; expression induced by calcium shortage and via the copper sensing transciption factor Mac1p during conditons of copper deficiency; mRNA is cell cycle regulated, peaking in G1 phase
YDR359C	VID21	0.3441	14	36	0.937	Component of the NuA4 histone acetyltransferase complex
YMR253C	YMR253C	0.3441	NA	NA	1.038	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
YOR343C	YOR343C	0.3441	NA	NA	1.044	Hypothetical protein
YBR052C	RFS1	0.3439	3	NA	0.991	Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YOL068C	HST1	0.3439	11	6	0.971	NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance
YFL052W	YFL052W	0.3432	NA	NA	0.948	Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YEL017W	GTT3	0.3423	1	NA	1.004	Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery
YER081W	SER3	0.3421	2	NA	0.895	3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser33p
YHR114W	BZZ1	0.3419	3	2	1.004	SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins
YER084W	YER084W	0.3416	NA	NA	1.044	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YML004C	GLO1	0.3413	NA	NA	1.05	Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress
YOR337W	TEA1	0.3411	NA	1	0.971	Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein
YER137C	YER137C	0.341	NA	NA	0.997	Putative protein of unknown function
YDR192C	NUP42	0.341	27	5	0.969	Subunit of the nuclear pore complex (NPC) that localizes exclusively to the cytoplasmic side; involved in RNA export, most likely at a terminal step; interacts with Gle1p
YOR068C	VAM10	0.3403	NA	6	0.963	Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering
YDL226C	GCS1	0.3403	2	31	0.767	ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
YGL198W	YIP4	0.3403	NA	NA	1.032	Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
YHR124W	NDT80	0.3401	3	NA	1.015	Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)
YIR013C	GAT4	0.3399	NA	NA	0.978	Protein containing GATA family zinc finger motifs
YKR077W	YKR077W	0.3399	1	NA	0.982	Putative transcriptional activator, identified by high-throughput two-hybrid experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YKR077W is not an essential gene
YPL030W	YPL030W	0.3392	NA	NA	1.012	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL030W is not an essential gene
YCR088W	ABP1	0.3389	15	3	NA	Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization
YMR258C	YMR258C	0.3386	2	NA	1.014	Protein of unknown function with similarity to F-box proteins; physically interacts with Skp1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR258C is not an essential gene
YBR199W	KTR4	0.3383	1	NA	1.055	Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YPL026C	SKS1	0.3382	1	NA	0.986	Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YOL028C	YAP7	0.3382	2	NA	1.011	Putative basic leucine zipper (bZIP) transcription factor
YPR189W	SKI3	0.3381	27	4	0.936	Protein involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs; forms complex with Ski2p and Ski8p; required for repressing propagation of dsRNA viruses
YIL032C	YIL032C	0.3378	NA	NA	0.967	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL115C	YKL115C	0.3377	NA	NA	0.994	Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
YDR203W	YDR203W	0.3377	NA	NA	0.967	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR080W	EMP46	0.3375	1	NA	0.97	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
YAL039C	CYC3	0.3375	NA	NA	0.933	Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-Cyc1p in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YDL201W	TRM8	0.3374	2	NA	1.001	Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA
YDR336W	YDR336W	0.3374	NA	NA	1.072	Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene
YOR383C	FIT3	0.3372	NA	NA	1.032	Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YGR197C	SNG1	0.3371	NA	NA	1.066	Protein involved in nitrosoguanidine (MNNG) resistance; expression is regulated by transcription factors involved in multidrug resistance
YHR131C	YHR131C	0.3369	4	NA	1.048	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YKR061W	KTR2	0.3364	NA	2	0.932	Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YOR018W	ROD1	0.3357	4	NA	0.85	Membrane protein; overexpression confers resistance to the GST substrate o-dinitrobenzene as well as to zinc and calcium; contains 2 PY motifs, which are required for Rod1p interaction with Rsp5p, a hect-type ubiquitin ligase
YLR054C	OSW2	0.3356	NA	NA	0.991	Protein of unknown function proposed to be involved in the assembly of the spore wall
YJL147C	YJL147C	0.335	1	1	0.971	Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene
YDR007W	TRP1	0.3348	NA	NA	1.028	Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
YOR219C	STE13	0.3347	1	NA	1.032	Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor
YAR002C-A	ERP1	0.3343	5	NA	1.037	Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
YGR043C	YGR043C	0.3341	3	NA	1.016	Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YGR058W	YGR058W	0.3341	NA	NA	1.002	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
YIL166C	YIL166C	0.334	NA	1	0.985	Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
YDR033W	MRH1	0.3338	1	NA	0.995	Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; has similarity to Hsp30p and Yro2p, which are induced during heat shock
YIL039W	YIL039W	0.3336	2	2	1.01	Putative protein of unknown function; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YNL024C	YNL024C	0.3334	4	NA	1.098	Putative protein of unknown function with seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL024C is not an essential gene
YGR239C	PEX21	0.3333	NA	NA	0.997	Part of a two-member peroxin family (Pex18p and Pex21p) specifically required for peroxisomal targeting of the Pex7p peroxisomal signal recognition factor and PTS2-type peroxisomal matrix proteins
YEL033W	YEL033W	0.3329	NA	NA	0.909	Predicted to have metabolic role based on analysis of gene networks derived from chromatin immunoprecipitation experiments, experiments on gene deletion mutants, and localization of transcription factor binding sites
YLR038C	COX12	0.3328	NA	NA	0.951	Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of fully active cytochrome c oxidase but not required for activity after assembly
YGR210C	YGR210C	0.3328	1	NA	0.972	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YDR131C	YDR131C	0.3312	5	NA	1.019	F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex
YOR055W	YOR055W	0.331	NA	NA	1.037	Hypothetical protein
YKL201C	MNN4	0.331	1	NA	1.027	Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases
YIR020W-B	YIR020W-B	NA	NA	NA	NA	NA
YBR065C	ECM2	0.3305	22	4	1	Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p
YOR037W	CYC2	0.3299	NA	1	1.019	Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
YPR001W	CIT3	0.3298	NA	1	1.01	Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, mitochondrial isozyme involved in the TCA cycle
YPL053C	KTR6	0.3294	2	NA	0.978	Probable mannosylphosphate transferase involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family
YLR263W	RED1	0.3292	1	NA	1.021	Protein component of the axial elements of the synaptonemal complex, involved in chromosome segregation during the first meiotic division; interacts with Hop1p; required for wild-type levels of Mek1p kinase activity
YER020W	GPA2	0.3292	6	3	0.878	Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YNL041C	COG6	0.3291	14	12	1.04	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YDR126W	SWF1	0.329	NA	39	0.902	Palmitoyltransferase that acts on the SNAREs Snc1p, Syn8p, Tlg1p and likely on all SNAREs; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion
YKR023W	YKR023W	0.329	1	NA	0.504	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YML113W	DAT1	0.3288	NA	NA	1.11	DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability
YBR165W	UBS1	0.3287	NA	2	NA	Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity
YGR292W	MAL12	0.3287	2	NA	0.964	Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus
YDR089W	YDR089W	0.3283	NA	NA	1.036	Protein of unknown function; deletion confers resistance to Nickel
YOR129C	YOR129C	0.3282	NA	NA	1.013	Putative component of the outer plaque of the spindle pole body; may be involved in cation homeostasis or multidrug resistance
YDR071C	PAA1	0.3278	9	3	1.031	Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication
YDL138W	RGT2	0.3273	1	NA	0.98	Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
YDR073W	SNF11	0.3267	5	NA	1.086	Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p
YMR155W	YMR155W	0.3267	1	NA	1.038	Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen
YHR033W	YHR033W	0.3265	18	NA	0.98	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YOR070C	GYP1	0.3258	NA	38	0.971	Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion
YOR251C	YOR251C	0.3256	1	NA	0.977	Putative protein of unknown function with similarity to human thiosulfate sulfurtransferase, an enzyme that catalyzes the transfer of sulfur from thiosulfate to cyanide, forming sulfite and thiocyanate; YOR251C is a non-essential gene
YDR151C	CTH1	0.3253	NA	NA	0.91	Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis
YDR133C	YDR133C	0.3249	NA	NA	1.017	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YPL203W	TPK2	0.3249	6	3	1.045	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk3p
YPL035C	YPL035C	0.3239	NA	NA	1.008	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
YMR188C	MRPS17	0.3239	28	NA	1	Mitochondrial ribosomal protein of the small subunit
YML071C	COG8	0.3237	9	11	1.03	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YMR246W	FAA4	0.3236	15	2	1.031	Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YGL041C	YGL041C	0.3236	NA	NA	1.062	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL013C	PDR11	0.3235	1	NA	0.998	Membrane protein of the ATP-binding cassette (ABC) transporter superfamily, involved in multiple drug resistance, mediates sterol uptake when sterol biosynthesis is compromised, regulated by Pdr1p, required for anaerobic growth
YGR137W	YGR137W	0.3234	NA	NA	0.975	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL079W	YGL079W	0.3234	3	NA	1.064	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endosome; identified as a transcriptional activator in a high-throughput yeast one-hybrid assay
YNL257C	SIP3	0.3229	NA	NA	1.066	Protein that activates transcription through interaction with DNA-bound Snf1p, C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate
YHR121W	LSM12	0.3227	50	NA	1.006	Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS
YLR348C	DIC1	0.3225	NA	NA	0.996	Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
YFR056C	YFR056C	0.3223	NA	NA	0.986	Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YIL023C	YKE4	0.3221	NA	1	NA	Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family
YHR049C-A	YHR049C-A	0.3215	NA	NA	0.949	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL103W	ITR2	0.3212	1	NA	0.979	Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively
YNR007C	ATG3	0.3211	1	NA	1.034	Protein involved in autophagy; E2-like enzyme that plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy
YLR303W	MET17	0.3211	2	NA	0.964	O-acetyl homoserine-O-acetyl serine sulfhydrylase, required for sulfur amino acid synthesis
YBR263W	SHM1	0.3207	1	1	0.985	Mitochondrial serine hydroxymethyltransferase, involved in one-carbon metabolism
YML034W	SRC1	0.3205	2	8	1.007	Protein with a putative role in sister chromatid segregation, potentially phosphorylated by Cdc28p; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery
YPL089C	RLM1	0.3205	3	3	0.979	MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p
YLR213C	CRR1	0.3199	NA	NA	1.014	Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
YKL074C	MUD2	0.3193	1	3	0.966	Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
YEL018W	EAF5	0.3191	13	8	NA	Esa1p-associated factor, subunit of the NuA4 acetyltransferase complex
YDR495C	VPS3	0.319	2	4	0.664	Cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
YHR120W	MSH1	0.3186	2	NA	0.864	DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis
YIL093C	RSM25	0.3179	31	1	0.994	Mitochondrial ribosomal protein of the small subunit
YJL214W	HXT8	0.3175	NA	1	1.029	Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YJL075C	YJL075C	0.3174	NA	NA	0.462	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate
YER130C	YER130C	0.3173	NA	1	1.004	Hypothetical protein
YPL221W	FLC1	0.3172	NA	1	1.055	Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
YJL124C	LSM1	0.3172	27	18	0.816	Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs
YDR509W	YDR509W	0.3171	NA	NA	1.046	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR206W	YMR206W	0.3171	NA	NA	1.012	Putative protein of unknown function; YMR206W is not an essential gene
YER132C	PMD1	0.317	3	NA	1.015	Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions
YKL034W	TUL1	0.3169	NA	NA	1.063	Golgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane proteins that contain polar transmembrane domains to multivesicular bodies for delivery to the vacuole for quality control purposes
YKR089C	TGL4	0.3164	NA	NA	0.947	Triacylglycerol lipase involved in triacylglycerol mobilization and degradation; found in lipid particles; potential Cdc28p substrate
YPL244C	HUT1	0.3162	NA	1	1.052	Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
YGL126W	SCS3	0.3155	NA	NA	0.967	Protein required for inositol prototrophy, appears to be involved in the synthesis of inositol phospholipids from inositol but not in the control of inositol synthesis
YPL067C	YPL067C	0.3149	NA	NA	0.989	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene
YKR005C	YKR005C	0.3149	NA	NA	1.085	Putative protein of unknown function
YPL054W	LEE1	0.3147	NA	NA	0.959	Zinc-finger protein of unknown function
YOR307C	SLY41	0.3144	NA	NA	1.009	Protein involved in ER-to-Golgi transport
YNL145W	MFA2	0.3143	NA	NA	0.994	Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1
YKR069W	MET1	0.314	NA	1	0.952	S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in sulfate assimilation, methionine metabolism, and siroheme biosynthesis
YJL196C	ELO1	0.3137	NA	1	1.032	Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids
YGR208W	SER2	0.3137	NA	1	1.006	Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
YDR445C	YDR445C	0.3133	NA	NA	1.02	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL240W	LRG1	0.3131	NA	NA	0.996	Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis
YDL094C	YDL094C	0.3127	NA	NA	0.972	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential
YGL166W	CUP2	0.3123	1	NA	1.032	Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations
YKR010C	TOF2	0.3123	1	NA	0.986	Nonessential mitochondrial protein of unknown function with sequence similarity to Net1p; identified as a topoisomerase I (Top1p) binding protein; displays synthetic genetic interactions with TOP1 and HPR1
YOR200W	YOR200W	0.3122	NA	NA	0.869	Hypothetical protein
YAL062W	GDH3	0.3121	7	NA	0.977	NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YNR042W	YNR042W	0.3119	NA	NA	1.062	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
YBR227C	MCX1	0.3118	2	NA	1.022	Mitochondrial ATP-binding protein, possibly a mitochondrial chaperone with non-proteolytic function; similar to bacterial ClpX proteins
YNL074C	MLF3	0.3114	NA	NA	0.98	Serine-rich protein of unknown function; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
YGL104C	VPS73	0.3111	1	NA	1.058	Mitochondrial protein of unknown function involved in vacuolar protein sorting
YMR311C	GLC8	0.311	3	7	1.05	Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2
YBR275C	RIF1	0.3109	4	NA	1.046	Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
YHL030W	ECM29	0.3107	39	NA	0.964	Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome
YDR314C	RAD34	0.3105	7	1	1.04	Protein involved in nucleotide excision repair (NER); homologous to RAD4
YDL171C	GLT1	0.3096	15	NA	1.005	NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
YPL070W	MUK1	0.3094	2	NA	0.996	Protein of unknown function, localized to the cytoplasm; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation
YLR439W	MRPL4	0.3093	29	NA	0.921	Mitochondrial ribosomal protein of the large subunit
YGR165W	MRPS35	0.3092	31	NA	0.65	Mitochondrial ribosomal protein of the small subunit
YDR424C	DYN2	0.309	2	16	0.98	Cytoplasmic light chain dynein, microtubule motor protein
YJR051W	OSM1	0.309	1	NA	1.031	Fumarate reductase, catalyzes the reduction of fumarate to succinate, required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity
YIL043C	CBR1	0.3087	18	NA	0.992	Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia
YML076C	WAR1	0.3082	1	2	1.003	Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively
YDR084C	TVP23	0.308	NA	NA	1.034	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YJL082W	IML2	0.3079	1	NA	0.964	Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGL197W	MDS3	0.3075	8	NA	1.002	Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions
YPL127C	HHO1	0.3074	7	NA	0.992	Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA repair involving homologous recombination; not required for telomeric silencing, basal transcriptional repression, or efficient sporulation
YFR031C-A	RPL2A	0.3071	108	4	0.95	Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins
YBL063W	KIP1	0.3068	1	1	0.973	Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p
YDR481C	PHO8	0.3068	NA	NA	1.018	Repressible alkaline phosphatase, a glycoprotein localized to the vacuole; regulated by levels of inorganic phosphate and by a system consisting of Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides
YJL134W	LCB3	0.3066	NA	3	0.971	Long-chain base-1-phosphate phosphatase, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids
YPR037C	ERV2	0.3066	1	NA	1.08	Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER
YGL013C	PDR1	0.3064	4	NA	1.035	Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes
YDR197W	CBS2	0.3063	NA	NA	0.848	Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
YMR077C	VPS20	0.3057	NA	3	0.827	Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes
YNR005C	YNR005C	0.3056	NA	NA	0.95	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR282C	YDR282C	0.3052	NA	NA	0.978	Putative protein of unknown function
YFL046W	FMP32	0.3043	1	NA	0.982	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGL208W	SIP2	0.3043	7	1	1.012	One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane
YMR120C	ADE17	0.3043	5	NA	0.846	Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidine
YPL137C	GIP3	0.3042	2	1	0.998	Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments
YLR435W	TSR2	0.3041	12	1	0.808	Protein with a potential role in pre-rRNA processing
YFR032C	YFR032C	0.3041	1	NA	1.006	Putative protein of unknown function; transcribed during sporulation; YFR032C is not an essential gene
YKL009W	MRT4	0.3039	50	2	0.599	Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
YDL137W	ARF2	0.3037	5	1	0.998	ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf1p
YIL157C	FMP35	0.3031	NA	1	1.009	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant is defective in cytochrome oxidase and is respiratory deficient
YIL155C	GUT2	0.3029	NA	NA	1.016	Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
YKL133C	YKL133C	0.3022	NA	NA	1.098	Putative protein of unknown function
YLR446W	YLR446W	0.3012	NA	NA	0.947	Putative protein of unknown function with similarity to hexokinases; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene
YLR461W	PAU4	0.3012	NA	NA	0.956	Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YMR316C-A	YMR316C-A	0.301	NA	NA	1.062	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene DIA1/YMR316W
YNL213C	YNL213C	0.3009	1	NA	0.798	Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKR019C	IRS4	0.3008	NA	1	0.96	Protein involved in regulation of phosphatidylinositol 4,5-bisphosphate concentrations; Irs4p and Tax4p bind and activate the phosphatase Inp51p; mutation confers an increase in rDNA silencing
YPR002W	PDH1	0.3007	1	NA	0.997	Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
YDL037C	BSC1	0.3006	NA	NA	0.979	Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YKL169C	YKL169C	0.3001	NA	NA	0.88	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38
YMR020W	FMS1	0.3001	1	NA	1.042	Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
YDR313C	PIB1	0.2989	2	NA	1.055	RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain
YGL114W	YGL114W	0.2988	NA	NA	1.055	Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YDR490C	PKH1	0.2979	7	2	0.988	Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p
YKR074W	YKR074W	0.2978	NA	1	0.807	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YML011C	RAD33	0.2976	8	NA	1.002	Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YDR181C	SAS4	0.2974	3	1	1.007	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which  acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
YDL188C	PPH22	0.2972	37	1	0.992	Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis
YGL200C	EMP24	0.2971	13	10	1.021	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
YGR173W	RBG2	0.2971	6	NA	1.032	Protein with similarity to mammalian developmentally regulated GTP-binding protein
YIL058W	YIL058W	0.297	NA	NA	NA	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR058C	APS2	0.2968	3	NA	1.011	Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
YMR012W	CLU1	0.2966	48	NA	1.026	eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant
YML118W	NGL3	0.2965	NA	NA	1.049	Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p and Ngl2p
YOR226C	ISU2	0.2957	NA	NA	1.027	Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YBR024W	SCO2	0.2947	NA	NA	1.015	Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p
YPR091C	YPR091C	0.2946	NA	NA	0.988	Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YPR091C is not an essential gene
YOR126C	IAH1	0.2945	NA	NA	1.013	Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing
YNR049C	MSO1	0.2944	NA	9	1.095	Probable component of the secretory vesicle docking complex, acts at a late step in secretion; shows genetic and physical interactions with Sec1p and is enriched in microsomal membrane fractions; required for sporulation
YHR032W	YHR032W	0.2941	NA	NA	NA	Putative protein of unknown function; putative substrate of the cAMP-dependent protein kinase (PKA)
YGL131C	SNT2	0.2935	3	NA	1.022	DNA binding protein with similarity to the S. pombe Snt2 protein
YOR306C	MCH5	0.2932	NA	NA	0.909	Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport
YGR076C	MRPL25	0.2926	6	NA	0.868	Mitochondrial ribosomal protein of the large subunit
YKR043C	YKR043C	0.2925	1	NA	0.982	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YMR085W	YMR085W	0.2923	NA	NA	1.004	Putative protein of unknown function
YPL038W	MET31	0.292	1	NA	0.969	Zinc-finger DNA-binding protein, involved in regulating expression of the methionine biosynthetic genes, similar to Met32p
YGL160W	YGL160W	0.2916	NA	NA	0.992	Putative protein of uknown function with sequence similarity to iron/copper reductases (FRE1-8), possibly involved in iron homeostasis; may interact with ribosomes, based on co-purification experiments
YPR116W	YPR116W	0.2916	9	1	0.884	Putative protein of unknown function
YNL001W	DOM34	0.2914	NA	NA	0.922	Probable RNA-binding protein, functions in protein translation to promote G1 progression and differentiation, required for meiotic cell division
YNR062C	YNR062C	0.2914	1	NA	0.982	Putative membrane protein of unknown function
YMR158C-B	YMR158C-B	NA	NA	NA	NA	NA
YDL062W	YDL062W	0.2909	NA	NA	0.558	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential
YHL010C	YHL010C	0.2907	3	NA	0.969	Putative protein of unknown function, contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
YNR008W	LRO1	0.2906	1	NA	1.048	Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
YOL035C	YOL035C	0.2905	NA	NA	0.991	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR152C	URN1	0.2889	1	NA	0.98	Pre-mRNA splicing factor associated with the U2-U5-U6 snRNPs, the RES complex, and the Prp19-associated complex (NTC); null mutation displays synthetic genetic interactions with mutations affecting U2 snRNA and pre-mRNA splicing factors
YNL037C	IDH1	0.2884	14	NA	0.887	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle
YMR194C-A	YMR194C-A	0.2883	NA	NA	0.858	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR277C	YOR277C	0.2882	NA	NA	1.003	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20
YAL014C	SYN8	0.2881	NA	NA	0.987	Endosomal SNARE related to mammalian syntaxin 8
YLR217W	YLR217W	0.2876	NA	NA	0.955	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6
YAL056W	GPB2	0.287	NA	NA	1.036	Proposed beta subunit of the heterotrimeric G protein; interacts with the receptor Grp1p, affects signaling by altering the level of phosphorylation of PKS substrates; regulates pseudohyphal growth through cAMP levels; homolog of Gpb1p
YFR026C	YFR026C	0.287	NA	NA	0.985	Putative protein of unknown function
YMR293C	YMR293C	0.2868	NA	1	1.05	Putative protein similar to bacterial glutamyl-tRNA amidotransferases; may be involved in aerobic respiration; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL096C	RPS7B	0.2865	56	1	0.916	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Ap; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YFR006W	YFR006W	0.2865	1	NA	0.966	Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene
YGR176W	YGR176W	0.2861	NA	NA	1.081	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR115C	DMA1	0.2858	20	5	1.022	Protein involved in regulating spindle position and orientation, functionally redundant with Dma2p; homolog of S. pombe Dma1 and H. sapiens Chfr
YGL177W	YGL177W	0.2857	NA	NA	1.059	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR227W	YOR227W	0.2851	3	NA	1.006	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLL039C	UBI4	0.284	19	5	0.971	Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response
YHR006W	STP2	0.2838	NA	NA	1.052	Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes
YKR080W	MTD1	0.2831	NA	NA	0.894	NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
YDL177C	YDL177C	0.2828	NA	NA	1.014	Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
YHR001W-A	QCR10	0.2825	NA	NA	0.986	Subunit of the ubiqunol-cytochrome c oxidoreductase complex, involved in aerobic respiration
YGR250C	YGR250C	0.2824	18	NA	1.012	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YMR133W	REC114	0.282	NA	1	1.039	Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
YKL102C	YKL102C	0.2818	NA	NA	1.035	Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YDL234C	GYP7	0.2813	1	NA	1.011	GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking
YDR333C	YDR333C	0.281	NA	NA	1.035	Putative protein of unknown function
YLR107W	REX3	0.2797	NA	NA	1.008	RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases
YMR136W	GAT2	0.2788	NA	NA	1.05	Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
YLL054C	YLL054C	0.2788	3	NA	1.006	Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
YMR130W	YMR130W	0.2786	NA	NA	1.047	Putative protein of unknown function; YMR130W is not an essential gene
YML047C	PRM6	0.2782	NA	3	1.004	Pheromone-regulated protein, predicted to have 2 transmembrane segments; regulated by Ste12p during mating
YNL327W	EGT2	0.277	1	NA	1.109	Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
YHL035C	VMR1	0.2768	2	NA	1.048	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ATP-binding cassette (ABC) family; potential Cdc28p substrate; detected in purified mitochondria in high-throughput studies
YLR164W	YLR164W	0.2764	NA	NA	1.01	Mitochondrial inner membrane of unknown function; similar to Tim18p and Sdh4p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YLR442C	SIR3	0.276	16	NA	1.088	Silencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails, to establish a transcriptionally silent chromatin state; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p
YLR232W	YLR232W	0.2758	NA	NA	1.013	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5
YOR121C	YOR121C	0.2757	NA	NA	1.031	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W
YOR045W	TOM6	0.2756	NA	2	0.989	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
YOR289W	YOR289W	0.2748	2	NA	1.034	Hypothetical protein
YGL059W	YGL059W	0.2747	NA	NA	1.048	Protein kinase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR058W	FET3	0.2745	6	NA	0.971	Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases
YDR518W	EUG1	0.2743	NA	NA	0.838	Protein disulfide isomerase of the endoplasmic reticulum lumen, function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
YKR036C	CAF4	0.2737	13	NA	1.02	WD40 repeat-containing protein associated with the CCR4-NOT complex, interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission
YLR420W	URA4	0.273	NA	NA	0.991	Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
YNL212W	VID27	0.2728	7	NA	0.998	Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth
YPL005W	AEP3	0.2724	1	NA	0.658	Peripheral mitochondrial inner membrane protein, located on the matrix face of the membrane; stabilizes the bicistronic AAP1-ATP6 mRNA encoding subunits 6 and 8 of the ATP synthase complex
YGR129W	SYF2	0.2723	10	2	0.998	Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression
YJL045W	YJL045W	0.2723	1	NA	0.993	Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YLR444C	YLR444C	0.272	NA	NA	0.892	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR139W	YGR139W	0.2719	NA	NA	0.98	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL182C	YPL182C	0.2718	NA	NA	0.983	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W
YDR066C	YDR066C	0.2717	NA	NA	0.981	Hypothetical protein
YOL031C	SIL1	0.2716	1	3	0.991	Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein
YIL130W	ASG1	0.2713	NA	NA	1.007	Proposed transcriptional activator, member of the Gal4p family of zinc cluster proteins
YER030W	CHZ1	0.271	5	NA	0.974	Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif
YOR304W	ISW2	0.2709	21	2	1.08	Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
YMR122C	YMR122C	0.2709	NA	NA	1.232	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL095C	EEB1	0.2701	NA	NA	1.019	Acyl-coenzymeA:ethanol O-acyltransferase responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short chain esterase activity; may be involved in lipid metabolism and detoxification
YGL107C	RMD9	0.27	NA	4	0.76	Mitochondrial protein required for sporulation
YDR322W	MRPL35	0.2698	32	NA	0.843	Mitochondrial ribosomal protein of the large subunit
YBR271W	YBR271W	0.2698	NA	NA	1.007	Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBR271W is not as essential gene
YPL091W	GLR1	0.2682	NA	1	1.01	Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione
YMR114C	YMR114C	0.2682	NA	NA	1.051	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene
YOR317W	FAA1	0.2679	6	2	1.065	Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids; involved in the activation of imported fatty acids; localized to both lipid particles and mitochondrial outer membrane; essential for stationary phase
YLR191W	PEX13	0.2668	3	1	1.012	Integral peroxisomal membrane receptor for the PTS1 peroxisomal matrix protein signal recognition factor Pex5p, required for the translocation of peroxisomal matrix proteins, also interacts with Pex7p and Pex14p, contains a C-terminal SH3 domain
YNR037C	RSM19	0.2666	20	NA	0.602	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein
YBL012C	YBL012C	0.2663	NA	NA	0.833	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YFR047C	BNA6	0.266	NA	1	0.996	Quinolinate phosphoribosyl transferase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway
YMR095C	SNO1	0.2655	NA	2	1.05	Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
YGR171C	MSM1	0.2654	1	NA	0.881	Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
YBR031W	RPL4A	0.2648	108	NA	0.953	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Bp and has similarity to E. coli L4 and rat L4 ribosomal proteins
YJR116W	YJR116W	0.2644	NA	NA	1.048	Putative protein of unknown function
YNL217W	YNL217W	0.2642	NA	NA	1.012	Hypothetical protein
YLR246W	ERF2	0.2624	1	NA	0.998	Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole
YGR243W	FMP43	0.2621	NA	NA	0.98	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL181W	YJL181W	0.2619	NA	NA	1.031	Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis
YDR351W	SBE2	0.2618	NA	2	1.06	Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
YGR284C	ERV29	0.2614	NA	1	0.983	Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo
YOR324C	FRT1	0.2612	NA	NA	0.987	Tail-anchored endoplasmic reticulum membrane protein that is a substrate of the phosphatase calcineurin, interacts with homolog Frt2p, promotes cell growth in conditions of high Na+, alkaline pH, and cell wall stress
YCL030C	HIS4	0.2605	7	NA	0.961	Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis
YDR137W	RGP1	0.2602	7	12	0.948	Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p
YAL018C	YAL018C	0.2602	NA	NA	0.971	Putative protein of unknown function
YNR022C	MRPL50	0.2587	4	NA	1.07	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
YDR072C	IPT1	0.2583	1	NA	1.043	Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YKL103C	LAP4	0.2583	10	NA	0.991	Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YER174C	GRX4	0.2571	3	NA	1.003	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage
YGR168C	YGR168C	0.2571	NA	NA	0.958	Putative protein of unknown function; YGR168C is not an essential gene
YBR242W	YBR242W	0.257	1	NA	1.018	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene
YDR056C	YDR056C	0.2551	NA	NA	1.02	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic retiuculum; YDR056C is not an essential protein
YMR187C	YMR187C	0.2549	1	NA	1.004	Putative protein of unknown function; YMR187C is not an essential gene
YDR400W	URH1	0.2543	3	NA	1.053	Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in recycling pyrimidine deoxy- and ribonucleosides via the pyrimidine salvage pathway
YOR237W	HES1	0.2538	NA	NA	1.003	Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP)
YLR135W	SLX4	0.2534	9	5	1.02	Subunit of a complex, with Slx1p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p
YPL229W	YPL229W	0.2529	NA	NA	1.061	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL229W is not an essential gene
YLR398C	SKI2	0.2522	17	6	0.916	Putative RNA helicase, involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs; forms complex with Ski3p and Ski8p; required for repressing propagation of dsRNA viruses
YMR098C	YMR098C	0.2515	3	NA	0.827	Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YMR098C is not an essential gene
YDR218C	SPR28	0.2514	NA	NA	1.02	Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation
YOR084W	YOR084W	0.2513	NA	NA	1.026	Putative lipase of the peroxisomal matrix; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
YER068W	MOT2	0.2512	4	11	0.975	Component of the CCR4-NOT complex, which has multiple roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitylates subunits of the nascent polypeptide-associated complex (NAC)
YGL236C	MTO1	0.2499	NA	NA	1.015	Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
YER080W	FMP29	0.2498	NA	NA	1.064	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR150W	MRPL23	0.2494	20	NA	0.935	Mitochondrial ribosomal protein of the large subunit
YGL219C	MDM34	0.2491	NA	4	0.702	Mitochondrial outer membrane protein, required for normal mitochondrial morphology and inheritance; localizes to dots on the mitochondrial surface near mtDNA nucleoids; interacts genetically with MDM31 and MDM32
YNL320W	YNL320W	0.2485	NA	NA	1.082	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL237W	YTP1	0.2485	NA	NA	1.031	Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
YLR422W	YLR422W	0.2482	1	NA	0.949	Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein
YKL017C	HCS1	0.2478	NA	NA	1.058	Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities
YBR177C	EHT1	0.2471	1	NA	1.082	Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; contains esterase activity; localizes to lipid particles and the mitochondrial outer membrane
YGL221C	NIF3	0.2464	NA	NA	1.007	Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHL028W	WSC4	0.246	NA	1	0.969	ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
YGR136W	LSB1	0.2455	4	NA	0.976	Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YNL035C	YNL035C	0.2452	3	NA	1.091	Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene
YGR023W	MTL1	0.2451	NA	NA	1.016	Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations
YML001W	YPT7	0.2446	3	4	0.976	GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7
YGR067C	YGR067C	0.2443	6	NA	0.997	Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YEL050C	RML2	0.2433	3	3	0.967	Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
YIL036W	CST6	0.2429	9	NA	0.97	Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, activates transcription of genes involved in utilization of non-optimal carbon sources; involved in telomere maintenance
YKL202W	YKL202W	0.2427	NA	NA	1.015	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR268W	MRPL37	0.2418	2	1	0.742	Mitochondrial ribosomal protein of the large subunit
YBR162W-A	YSY6	0.2415	NA	NA	1.026	Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion
YDR535C	YDR535C	0.2406	NA	NA	0.983	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.
YDR108W	GSG1	0.2406	17	5	0.972	Subunit of TRAPP (transport protein particle), a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment; protein has late meiotic role, following DNA replication
YLR204W	QRI5	0.2405	NA	3	0.769	Mitochondrial protein of unknown function
YJL155C	FBP26	0.2401	1	NA	0.948	Fructose-2,6-bisphosphatase, required for glucose metabolism
YDR107C	YDR107C	0.2397	NA	2	1.026	Multispanning membrane protein of unknown function
YDL157C	YDL157C	0.2393	NA	NA	0.951	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKR105C	YKR105C	0.2391	NA	NA	1.018	Putative transporter of the Major Facilitator Superfamily (MFS)
YGL259W	YPS5	0.2384	NA	NA	0.977	Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p
YNL198C	YNL198C	0.2381	NA	NA	0.721	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL012W	ERG4	0.236	NA	NA	0.828	C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
YAL004W	YAL004W	0.236	NA	NA	0.984	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C
YCR068W	ATG15	0.2355	NA	NA	0.958	Lipase, required for intravacuolar lysis of autophagic bodies; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
YPL219W	PCL8	0.2354	2	1	1.049	Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation
YKL176C	LST4	0.2351	1	4	0.921	Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
YKL106W	AAT1	0.2349	NA	NA	1.018	Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis
YLR282C	YLR282C	0.2333	NA	NA	0.986	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR428C	YDR428C	0.2332	NA	NA	0.993	Putative alpha/beta-serine hydrolase belonging to the subfamily of hormone-sensitive lipase-like hydrolases
YER065C	ICL1	0.2326	4	NA	0.996	Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YKL146W	AVT3	0.2316	NA	NA	1.092	Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YPL186C	UIP4	0.2315	NA	NA	1.034	Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates
YDR114C	YDR114C	0.2308	NA	NA	0.991	Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium
YGR194C	XKS1	0.2305	1	NA	0.997	Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains
YBL010C	YBL010C	0.23	2	NA	0.96	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
YGR193C	PDX1	0.2298	6	1	1.044	Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
YGL125W	MET13	0.2293	1	NA	0.914	Isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
YAL042W	ERV46	0.2288	5	NA	0.93	Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport
YBR169C	SSE2	0.2282	9	1	1.059	Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; highly homologous to the heat shock protein Sse1p
YIL001W	YIL001W	0.228	NA	NA	0.993	Hypothetical protein
YOL162W	YOL162W	0.2276	NA	NA	1.014	Hypothetical protein, member of the Dal5p subfamily of the major facilitator family
YNL004W	HRB1	0.2265	18	NA	1.005	Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Gbp2p and Npl3p
YMR138W	CIN4	0.2246	NA	14	1.031	GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
YJL171C	YJL171C	0.2244	NA	NA	0.957	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein
YGL230C	YGL230C	0.2241	NA	NA	1.001	Putative protein of unknown function; non-essential gene
YHR008C	SOD2	0.2239	5	2	1.028	Mitochondrial superoxide dismutase; protects cells against oxygen toxicity
YNL196C	YNL196C	0.2226	NA	NA	1.009	Sporulation-specific protein with a leucine zipper motif
YDL173W	YDL173W	0.2221	2	NA	0.99	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDL173W is not an essential gene
YJL136C	RPS21B	0.2219	1	3	0.955	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein
YBR042C	YBR042C	0.221	1	1	0.992	Protein of unknown function, affects chromosome stability when overexpressed
YLR097C	HRT3	0.2209	8	NA	0.904	Putative nuclear ubiquitin ligase, based on computational analysis of large-scale protein-protein interaction data; has similarity to F-box proteins; identified in association with Cdc53p, Skp1p and Ubi4 in large-scale studies
YGR093W	YGR093W	0.2203	1	NA	0.997	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YPR125W	YLH47	0.2202	45	NA	1.027	Mitochondrial inner membrane protein exposed to the mitochondrial matrix, associates with mitochondrial ribosomes, NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome
YNL294C	RIM21	0.2199	1	12	1.037	Component of the RIM101 pathway, has a role in cell wall construction and alkaline pH response; has similarity to A. nidulans PalH
YDL186W	YDL186W	0.2179	NA	NA	0.987	Putative protein of unknown function; YDL186W is not an essential gene
YBR201W	DER1	0.2178	2	NA	0.911	Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p
YIL124W	AYR1	0.2169	2	NA	0.987	NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones
YCL001W	RER1	0.2163	NA	2	0.95	Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER
YGR169C	PUS6	0.2142	NA	NA	1.018	Pseudouridine synthase responsible for modification of cytoplasmic and mitochondrial tRNAs at position 31; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability
YNL136W	EAF7	0.2125	18	10	0.986	Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A
YDR122W	KIN1	0.211	1	NA	1.036	Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
YLR267W	BOP2	0.2106	1	NA	0.945	Protein of unknown function, overproduction suppresses a pam1 slv3 double null mutation
YIL123W	SIM1	0.2095	NA	NA	0.98	Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
YDR237W	MRPL7	0.2089	28	NA	0.837	Mitochondrial ribosomal protein of the large subunit
YOR313C	SPS4	0.2063	NA	1	1.059	Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
YKL003C	MRP17	0.2057	11	1	0.89	Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator
YOR197W	MCA1	0.2051	1	NA	1.037	Putative cysteine protease similar to mammalian caspases, involved in regulation of apoptosis upon hydrogen peroxide treatment
YGL132W	YGL132W	0.2042	NA	NA	1.038	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C
YIR019C	MUC1	0.202	1	NA	0.986	GPI-anchored cell surface glycoprotein required for diploid pseudohyphal formation and haploid invasive growth, transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p)
YIR028W	DAL4	0.2019	NA	NA	0.981	Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YML079W	YML079W	0.2011	NA	NA	0.986	Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm
YLL033W	YLL033W	0.1999	1	NA	0.879	Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52 foci
YOR115C	TRS33	0.1972	10	5	1.045	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
YNL040W	YNL040W	0.1972	1	NA	0.964	Putative protein of unknown function with strong similarity to alanyl-tRNA synthases from Eubacteria; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL040W is not an essential gene
YOR209C	NPT1	0.197	9	12	0.79	Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus
YBL070C	YBL070C	0.1967	NA	NA	0.966	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR121C	GRS1	0.1963	7	4	0.991	Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation
YOR345C	YOR345C	0.1959	NA	NA	0.952	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene REV1
YOR019W	YOR019W	0.1953	NA	NA	1.023	Protein of unknown function that may interact with ribosomes, based on co-purification experiments
YPL133C	RDS2	0.1942	1	NA	1.035	Zinc cluster protein involved in conferring resistance to ketoconazole
YOR022C	YOR022C	0.1926	NA	NA	1.039	Protein with similarity to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR124W	YLR124W	0.1917	NA	NA	1.011	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL082W	YGL082W	0.1906	2	NA	1.06	Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene
YIL067C	YIL067C	0.1906	1	NA	1.007	Uncharacterized protein of unknown function
YKL194C	MST1	0.1895	NA	4	0.981	Mitochondrial threonyl-tRNA synthetase
YOR001W	RRP6	0.1877	25	7	0.891	Exonuclease component of the nuclear exosome; contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus
YPR166C	MRP2	0.1873	4	NA	0.76	Mitochondrial ribosomal protein of the small subunit
YER038W-A	YER038W-A	0.1867	NA	NA	1.002	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria
YBL002W	HTB2	0.1866	75	NA	0.815	One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
YPL181W	CTI6	0.186	16	15	NA	Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
YGL124C	MON1	0.18	4	10	1.001	Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate
YGR237C	YGR237C	0.1799	6	2	0.982	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YML007W	YAP1	0.1773	40	2	1.047	Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; mediates pleiotropic drug and metal resistance; localized to the nucleus in response to the presence of oxidants
YOL044W	PEX15	0.174	1	2	1.058	Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly
YLR262C-A	TMA7	0.1736	NA	NA	0.985	Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin
YIL120W	QDR1	0.1735	NA	NA	0.976	Multidrug transporter required for resistance to quinidine, ketoconazole, fluconazole, and barban; member of the major facilitator superfamily of transporters conferring multiple drug resistance (MFS-MDR)
YOR186W	YOR186W	0.173	NA	NA	1.011	Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent
YJR091C	JSN1	0.171	1	NA	1.061	Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; overexpression suppresses a tub2-150 mutation and causes increased sensitivity to benomyl in wild-type cells
YPR003C	YPR003C	0.1707	2	NA	1.004	Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene
YDR486C	VPS60	0.1705	1	NA	0.981	Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting specific cargo proteins for degradation
YMR251W-A	HOR7	0.1688	NA	NA	1.021	Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor
YER163C	YER163C	0.1668	NA	NA	1.029	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YGL133W	ITC1	0.1664	17	2	1.009	Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1
YOL065C	INP54	0.1663	1	NA	1.008	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
YLR041W	YLR041W	0.1651	NA	NA	0.987	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C
YNL176C	YNL176C	0.1639	1	NA	1.014	Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p
YOR214C	YOR214C	0.1638	NA	NA	1.036	Hypothetical protein
YKR039W	GAP1	0.1633	NA	3	1.052	General amino acid permease; localization to the plasma membrane is regulated by nitrogen source
YNL177C	MRPL22	0.16	11	NA	0.733	Mitochondrial ribosomal protein of the large subunit
YMR025W	CSI1	0.1597	5	NA	1.031	Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
YAL066W	YAL066W	0.1568	NA	NA	1.009	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR214W	AHA1	0.1556	33	1	1.001	Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock
YNR029C	YNR029C	0.1553	3	NA	0.989	Putative protein of unknown function, deletion confers reduced fitness in saline
YDR294C	DPL1	0.1552	NA	2	1.013	Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
YBR032W	YBR032W	0.1545	NA	NA	0.999	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YOL084W	PHM7	0.1543	NA	NA	1.012	Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YLR255C	YLR255C	0.1537	NA	NA	0.968	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL160W	YGP1	0.1521	1	NA	0.869	Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YEL071W	DLD3	0.1516	2	NA	0.973	D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm
YML038C	YMD8	0.1505	NA	1	1	Putative nucleotide sugar transporter, has similarity to Vrg4p
YGL086W	MAD1	0.1499	1	77	1.046	Coiled-coil protein involved in the spindle-assembly checkpoint; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p
YML002W	YML002W	0.1495	1	NA	1.044	Putative protein of unknown function; expression induced by heat and by calcium shortage
YNL154C	YCK2	0.1486	2	3	1.016	Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p
YDR435C	PPM1	0.143	NA	1	1.025	Carboxyl methyl transferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
YHR139C-A	YHR139C-A	0.1377	NA	NA	1.011	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL112W	MDV1	0.1261	1	NA	1.015	Peripheral protein of the cytosolic face of the mitochondrial outer membrane, required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats
YPL246C	RBD2	0.1259	NA	1	1.024	Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
YHR080C	YHR080C	0.1255	1	NA	1.018	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIL102C	YIL102C	0.1253	NA	NA	0.983	Putative protein of unknown function
YPL023C	MET12	0.123	2	NA	0.989	Isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
YGR153W	YGR153W	0.1207	NA	NA	1.016	Putative protein of unknown function
YJL042W	MHP1	0.1137	2	1	1.061	Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
YGL027C	CWH41	0.1133	1	15	1.058	Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress
YNR060W	FRE4	0.1125	NA	NA	1.286	Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YOR221C	MCT1	0.1112	NA	NA	0.741	Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling
YBL085W	BOI1	0.1024	2	NA	0.987	Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YNL168C	FMP41	0.09883	3	NA	1.017	Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIL057C	YIL057C	0.09849	NA	NA	0.996	Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YNR066C	YNR066C	0.09847	NA	NA	0.939	Putative membrane-localized protein of unknown function
YDL026W	YDL026W	0.09795	NA	NA	0.997	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
YDR447C	RPS17B	0.09737	97	NA	0.926	Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein
YOL018C	TLG2	0.09588	2	9	0.962	Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation
YMR104C	YPK2	0.09533	8	1	1.023	Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK
YOL080C	REX4	0.06903	NA	1	1.025	Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly
YLR138W	NHA1	0.05651	2	NA	0.975	Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH
YIL113W	SDP1	0.05214	2	1	0.995	Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
YLR220W	CCC1	0.03432	NA	NA	1.01	Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation
YDR068W	DOS2	-0.004578	1	NA	1.064	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YEL062W	NPR2	-0.03401	1	4	0.867	Protein with a possible role in regulating expression of nitrogen permeases; transcription is induced in response to proline and urea; contains two PEST sequences; null mutant is resistant to cisplatin and doxorubicin
YLR119W	SRN2	-0.055	4	1	0.893	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus