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Commensal bacteria and essential amino acids control food choice behavior and reproduction

Fig 3

Loss of peripheral synthesis of nonessential amino acids (neAAs) increases yeast appetite.

(A) Schematic depicting the biosynthesis of tyrosine (Tyr) in Drosophila. (B) Feeding preference of control and Henna whole-animal knockdown flies upon removal of all amino acids (AAs), all neAAs, or all neAAs with 1x and 2x Tyr added back. (C) Feeding preference of control and Henna fat body knockdown flies upon removal of either all neAAs or all AAs. (B and C) Circles represent yeast preference in single assays, with a line representing the median and whiskers representing the interquartile range. n = 15–20. Significance was tested using the Kruskal–Wallis test followed by Dunn’s multiple comparison test. Not significant (ns) p > 0.05, * p < 0.05, ** p < 0.01, *** p < 0.001. Underlying data used in this Fig are provided in S1 Data.

Fig 3

doi: https://doi.org/10.1371/journal.pbio.2000862.g003