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Quantifying the Determinants of Evolutionary Dynamics Leading to Drug Resistance

Fig 3

Resistance variability is similar for diverse antibiotics but extremely low for nitrofurantoin.

(A) Schematic: the effective drug concentration ceff experienced by each mutant is inferred from its response R via the WT dose-response curve (arrows). This transforms the DFE (y-axis) into the DEC of the drug (x-axis); the dose-sensitivity n determines the change in distribution width as shown. (B) DEC for different antibiotics; arrows show IQR; effective drug concentrations are normalized to the actual concentration. (C) DEC width (IQR) for different antibiotics. (D) Width of the distribution of relative IC50 changes determined directly from dose-response curves of 78 deletion mutants (S1 Fig). Error bars show bootstrap standard error (C) and 95% confidence interval from bootstrap (D), respectively; lighter bars show distribution width resulting from measurement noise alone (Materials and Methods). Note that the difference for chloramphenicol between panels C and D is not significant. Numerical data is in S1 Data.

Fig 3

doi: https://doi.org/10.1371/journal.pbio.1002299.g003