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Alternating Antibiotics Render Resistant Bacteria Beatable

Fig 1

Can the sequential treatment of a bacterium with two antibiotics, in blue and green, have a greater efficacy than when the same antibiotics are combined into a cocktail, shown in red?

The circles depict each of eight sequential “seasons,” with diameter reflecting population density in that season. Black bars at the right indicate the total cumulative bacterial population density, ΣOD(T).

Fig 1

doi: https://doi.org/10.1371/journal.pbio.1002105.g001