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Using a Sequential Regimen to Eliminate Bacteria at Sublethal Antibiotic Dosages

Fig 6

A collateral sensitivity at IC70 with respect to per capita growth rate, R.

(A) Optical density time series data used in Fig. 4 was reused by fitting a logistic growth model (defined in the text) to estimate growth rates. For clarity, both the growth rate parameter R and the regression coefficient R2 from exemplar fits are indicated alongside modelled dynamics. (B) The resulting dataset shows significant and nonsignificant collateral sensitivities with respect to growth rate (R) following an exchange of antibiotic (t tests, n = 5). (S1 Data contains the data used in this figure.)

Fig 6