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Using a Sequential Regimen to Eliminate Bacteria at Sublethal Antibiotic Dosages

Fig 4

A nonreciprocal collateral sensitivity at IC70 dosages with respect to population densities.

(A) The concentration of each drug was calibrated to ensure IC70 was achieved for both drugs, here at 18 h. (B) A nonreciprocal collateral sensitivity (NCS) determined using the (n+1)-protocol described in the text, where n = 3,4,…,7: the change in densities following a change in antibiotic demonstrates ERY → DOX cross-resistance but DOX → ERY cross sensitivity (p-values from t tests, n = 5). (S1 Data contains the data used in this figure.)

Fig 4

doi: https://doi.org/10.1371/journal.pbio.1002104.g004