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When the Most Potent Combination of Antibiotics Selects for the Greatest Bacterial Load: The Smile-Frown Transition

Figure 7

Coverage plots highlight the suspected duplication: a 2× increase in coverage suggests a gene duplication.

A 315 Kb region of the E. coli K12 (MC4100) genome contains the acrAB operon and is highlighted in red. The region was not duplicated for treatments with no antibiotic (‘No drug’), it was duplicated for monotherapies (both ‘ERY’ and ‘DOX’) but was duplicated most often for combination treatments with the greatest synergy (‘50-50’). The outer ring (black line) indicates genome position, grey blocks encompass the different replicates of each treatment (replicates are marked with an alphabetic label) and the reddest regions are most likely to have been duplicated.

Figure 7

doi: https://doi.org/10.1371/journal.pbio.1001540.g007