When the Most Potent Combination of Antibiotics Selects for the Greatest Bacterial Load: The Smile-Frown Transition
(a) Using an area under the curve (AUC) inhibition measure expressed as a percentage of growth without antibiotics, by design a combination of ERY and DOX is optimal on day 1 (red line, ‘50-50’) but an ERY monotherapy is optimal by day two (after the crossing points of the lines; c.f. Figure 4). The path of three extreme therapies are shown as lines, coloured dots represent the remaining thirteen treatments colour-coded from green (ERY) to blue (DOX). (b) Exponentially decaying datafits are superimposed upon three treatments from (a).