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When the Most Potent Combination of Antibiotics Selects for the Greatest Bacterial Load: The Smile-Frown Transition

Figure 3

Dynamics of the optimal treatment: the greater the early inhibition, the faster efficacy decays and so the greater the resulting bacterial density.

(a) Using an area under the curve (AUC) inhibition measure expressed as a percentage of growth without antibiotics, by design a combination of ERY and DOX is optimal on day 1 (red line, ‘50-50’) but an ERY monotherapy is optimal by day two (after the crossing points of the lines; c.f. Figure 4). The path of three extreme therapies are shown as lines, coloured dots represent the remaining thirteen treatments colour-coded from green (ERY) to blue (DOX). (b) Exponentially decaying datafits are superimposed upon three treatments from (a).

Figure 3