Promoter Sequence Determines the Relationship between Expression Level and Noise
Figure 7
The correlation of noise and noise strength with expression changes with TF concentration.
(A) Scatter plots of noise (top) and noise strength (bottom) graphed against expression for each promoter at low (left side) and high (right side) Zap1 induction points. A line fit to each set of points using linear regression shows that, across promoters, noise strength is uncorrelated with expression at low TF concentration, but is positively correlated with expression at high TF concentration. (B) Noise and noise strength graphed against expression for high and low TF as in (A) but for in silico promoters that differ in both KON and KTL. The change from low to high TF was simulated by multiplying the initial KON of each promoter by 20.