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Genetic Variation Shapes Protein Networks Mainly through Non-transcriptional Mechanisms

Figure 1

Three possibilities for regulating protein levels.

Protein levels can be regulated through control of transcript levels, translation, and protein stability. The weight of the arrows here indicates the size of the effect. In this example in which protein levels are controlled primarily non-transcriptionally, there will nonetheless be a correlation between protein and transcript levels.

Figure 1

doi: https://doi.org/10.1371/journal.pbio.1001144.g001