Genomic Fossils Calibrate the Long-Term Evolution of Hepadnaviruses
Avian hepadnaviruses are in red (endogenous) and blue (extant). The trees were obtained after maximum likelihood and Bayesian analyses of an amino acid alignment of two regions of the HBV genome: (A) from position 269 to 781 of DHBV, corresponding to group 1 sequences in Figure 1 (eZHBVe and eZHBVi were not included in the analyses because they overlap by only 46 bp) and (B) from position 1310 to 2521 of DHBV (GenBank accession number AY494851), corresponding to group 2 sequences in Figure 1. Numbers on the branches correspond to bootstrap values greater than 70 and posterior probabilities greater than 0.9. The alignments and accession numbers of the sequences are provided in Datasets S2 and S3.