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IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition

Figure 1

Exercise induces appetite-suppressive actions in different models of obesity.

(A) 12 h of food intake (kcal) in lean and diet-induced obesity (DIO) Wistar rats under resting conditions or after swimming exercise (SW Exe) or treadmill running (TR Exe) (n = 20–35 animals per group). Rats were fasted during 9 h and the hypothalamic levels (B) NPY and (C) POMC mRNA were examined using real time PCR assay. (D) Body weight, (E) epididymal fat pad weight, (F) 12-h food intake of leptin-deficient mice (Leptob/ob) and respective wild type group. (G) NPY and (H) POMC mRNA were examined using real time PCR assay. (I) Body weight and (J) epididymal fat pad weight of wild type and leptin-deficient mice under resting conditions or immediately after the exercise protocols (n = 10 animals per group). Data are the means ± SEM. # p<0.05 versus respective lean group at rest; * p<0.05 versus respective obese group at rest. Lean animals (white bars) and obese animals (black bars).

Figure 1

doi: https://doi.org/10.1371/journal.pbio.1000465.g001