Advertisement

< Back to Article

Common Disease, Multiple Rare (and Distant) Variants

Genome-wide association studies have implicated hundreds of common variants of miniscule effect in diverse traits but a new study suggests that rare variants of much stronger effect may underlie some of these associations. Thus, large-scale sequencing may uncover more definitive leads about disease pathophysiology than the study of common variation has afforded.

doi: https://doi.org/10.1371/journal.pbio.1000293.g001